A Set of Acupuncture Needles in the Late Qing Dynasty Collected by George Souliéde Morant

In the early 20th century,French vice-consul George Souliéde Morant encountered acupuncture during his visit to China,and then brought it back to France.After more than a century,his collection was transported from Paris,France to Kunming,China,and later recognized as a Chinese national third-class precious cultural heritage.Currently housed in the Museum of Western Studies on Chinese Medicine at Yunnan University of Chinese Medicine,this set of instruments includes one needle holder converted from a fan-shaped holder,ten acupuncture needles,and eleven paper tags handwritten in English with names of diseases and body parts.This article attempts to present the foundational information and historical significance of this collection of this set of late Qing dynasty acupuncture instruments by reviewing the collection and related research on acupuncture instruments,consulting acupuncture professionals,measuring the detailed information of the set of instruments,and employing a method of translating and summarizing the content of the attached tags.

Ancient DNA Study Reveals Population History of Western Qingzang Plateau

According to a study published in Current Biology on May 22,the genetic components of the ancient populations in the western Qingzang Plateau are closest to that of the ancient populations in the southern Qingzang Plateau,and have been maintained over the past 3,500 years.In addition,these ancient populations in the western Qingzang Plateau had complex and frequent interactions with ancient populations inside and outside the plateau.

Looking up Prescriptions to Treat Infectious Disease:Anti-epidemic Books of Medical Formularies and Epidemic Prevention and Control in the Qing Dynasty

Copying,compiling,publishing,disseminating,and referencing anti-epidemic books of medical formularies were common activities during the outbreak of epidemics in the Qing dynasty.Its emergence,motivated by epidemic disease again and again,was important component parts of epidemic prevention and control.They played a unique role as media on affairs such as treating patients suffering from infectious diseases,mobilizing peoples to make contributions to anti-epidemic activities,integrating and popularizing knowledge of epidemic prevention.Anti-epidemic books of medical formularies were important to link peoples,things,and substances related with epidemic prevention and control,and were a kind of motivation to actively deal with the infectious disease,control the epidemic,and maintain health.Compared to other common measures,anti-epidemic books of medical formularies participated in many prevention and control practices deeply,which actually built a low cost,spontaneous,dispersed and non-institutional system to respond to epidemic,and the system had characteristics of stronger conductibility,bigger coverage area,and better external benefits.

Functions of Karez to Xinjiang Agriculture in the Qing Dynasty from the Perspective of Historical Documents

Desertification is increasingly serious in Xinjiang,and the construction of water conservancy is a precondition for the development of agriculture.The main project for the development of agriculture and water conservancy in Xinjiang is to build Karez,which played a vital role in the development of Xinjiang agriculture in the Qing Dynasty.It has been recorded many times in historical documents of the Qing Dynasty,such as Lin Zexu s Diary,Tao Baolian s Diary,Xinjiang Atlas and Zuo Zongtang s Memorial to the Emperor,etc.,which recorded the situation and historical origin of Karez.Karez made a significant contribution to the development of agriculture in the Qing Dynasty.It increased the cultivated land in Xinjiang at that time,and increased the types and yields of crops.It is conducive to the stability and development of Xinjiang s economy.Until today,Karez is still an important water source for agricultural irrigation in Xinjiang.

Jiexiu's Cold Food Qingming Customs

QINGMING Festival is one of the most important traditional festivals in China. According to records, it is also related to the Cold Food Festival. Qingming and Cold Food were originally two different festivals-one is a solar term and the other is an allusion.Because of the proximity of the two festivals.

A New Inquiry Into the Contents of the Late Qing Dynasty Pictorial News Publication-The Core of “Entertainment Life” in Dianshizhai Pictorial

After the opening of ports in the late Qing Dynasty,Western culture was introduced into China.The local entertainment life presented the phenomenon of the coexistence of the East and the West.A large number of folk entertainment activities were recorded in the Dianshizhai Pictorial which have the function of cultural choice and value dissemination as well as current affairs.This research attempts to use literary analysis and case study to collate the entertainment life in the Dianshizhai Pictorial,combing the characteristics of the late Qing dynasty,and summarizing the value of entertainment in Dianshizhai Pictorial publishing.

Contribution and Modern Public Debt:On the Nature of Patriotic Public Debt in the Late Qing Dynasty and the Early Republic of China

There are different opinions about the first modern domestic debt in China.The theorists judge whether a certain public debt has modernity according to whether it has modern public debt form,ignoring the inconsistency between form and content,institutional provisions and actual implementation.The modern nature of public debt must have both the form and content of modern public debt.Based on the analysis of the issuing background,system design,collection and repayment of patriotic bonds in the late Qing Dynasty and the early Republic of China,it is considered that the part of patriotic bonds subscribed by the Qing royal family is still the nature of donation and return,while the part subscribed by ordinary businessmen and people in the early Republic of China has a modern nature.The dual nature of patriotic bonds is closely related to the social background when the bonds are issued.

Review of Dietary Therapy Development in Ming and Qing Dynasties

In the Ming and Qing Dynasties,with the development of politics,economy and culture,the development of health maintenance of traditional Chinese medicine entered a heyday.Food therapy is an important part of the health theory of traditional Chinese medicine.In the 5,000 years of Chinese civilization,you can see the record of food therapy everywhere.It can be said that food therapy of traditional Chinese medicine develops together with traditional Chinese medicine.As a treasure in the treasure-house of Chinese medicine,food therapy has a long history and rich practice.Based on the current research,further research on relevant theories remains to be carried out.Focusing on the historical period of Ming and Qing dynasties,this paper takes the works related to food,nutrition and therapy(including general works and monographs on diet),the health thoughts and practice characteristics of representative health practitioners as the research perspective,and sorts out the above research contents in the past 20 years,analyzes the research overview and trend.It is found that in the study of food nourishing in Ming and Qing dynasties,there are few studies on the contents of diet nourishing in the general works.This suggests that when we study the development of diet nourishing in Ming and Qing Dynasties,we should not only study the monograph of diet nourishing and the thoughts of doctors,but also pay attention to the diet nourishing thought reflected in the general works.The study of diet monographs in Ming Dynasty mainly focused on the textual research of wild plants,and the study of diet monographs in Qing Dynasty mainly focused on the application.The study on the health care thought of doctors in Ming and Qing Dynasties mainly focused on the views of food nourishing and personal health care.These studies are summarized in order to provide reference for further theoretical research and provide reference for contemporary research on food nourishing diet.

Structural Carpentry in Qing Dynasty-A Framework for the Hierarchically Modularized Chinese Timber Structural Design

This article, by using mathematical expressions, offers a scientific framework for understanding how the grading system of Qing′s structural carpentry determines the design and construction in the grand style timber architecture.The Qing′s grand style timber structure, which is ready for prefabrication and assembly, is extremely hierarchical oriented and significantly standardized. The general procedure in designing a grand style timber structure is to start with the grade that defines the basic module (dou kou); next comes with the number of bracket set (cuan), the number of longitudinal bays and the number of purlins which affect its plan and cross section; thirdly choose a roof type that determines its longitudinal section and the facade as well. A series of formulae are conducted to help depict the layout, cross sectional roof curvature and special longitudinal treatments in 4 sloped and 9 spined roofs respectively.

稳幅范围、稳幅精度与De-Qing电路的设计

De—Qing电路的设计历来都是从它的稳定工作的必要条件出发,求得网络元件参数。本文从理论分析证明De-Qing工作有一限制的范围,这一范围既决定于所选元件参数,更大程度上取决于设计者所期望的稳幅精度。

Visualization analysis of the research status of FU Qingzhu’s Obstetrics and Gynecology based on bibliometrics

Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.Methods Retrieved all related literature in the research field of FQZNK from the domestic and foreign databases:China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,and Web of Science(WOS)core database,including Science Citation Index Expanded(SCIE),Social Sciences Citation Index(SSCI),and Arts&Humanities Citation Index(A&HCI).The search range was from January 1,1980 to March 10,2021.In addition,bibliometrics and CiteSpace 5.7.R2 software were used to analyze literature types,published journals,cited literature,the number of author publica-tions,co-author networks,co-institution networks,keyword co-occurrence networks,keyword clusters,and keyword bursts.Results A total of 678 valid records were included in the final dataset.Literature types,high publication journals,highly cited literature,high-yield institutions,high-yield research teams,and high-productivity scholars in this research field were found through bibliometrics.Liter-ature types can be divided into four categories,among which 451 are theoretical studies on academic thoughts of FQZNK,accounting for 66.5%of the included journals.The Journal of Shanxi Traditional Chinese Medicine had the largest volume of published articles(61),ac-counting for 9.0%of the total number of the included journals.The most cited literature was ZHOU Mingxin’s article“Using the quantitative method to discuss author’s authenticity and formula characteristics of FU Qingzhu’s Obstetrics and Gynecology”,which was cited 94 times.Hunan University of Chinese Medicine,the institution with the most publications,published 45 articles,and YOU Zhaoling,the most published author,published 33 articles.Moreover,it was found that most high-yield researchers came from high-yield institutions and that Hun-an University of Chinese Medicine had the most research on FQZNK.Keyword co-occur-rence analysis revealed that the keyword“FQZNK”had the highest frequency(597 times)and the highest centrality(1.00).Keyword cluster analysis used the Log-Likelihood Ratio(LLR)al-gorithm to form eleven important clusters:#0 treatment aiming at its root causes,#1 gynecopathy,#2 Siwu Decoction(四物汤),#3 FU Qingzhu,#4 post-partum,#5 infertility,#6 dysmenorrhea,#7 sterility,#8 coordinate the heart and kidney,#9 Danggui Buxue Decoction(当归补血汤),and#10 treatment.It was found that the prescriptions of FQZNK were studied mainly before 2000,the theoretical studies were mainly conducted before 2010,and its clinic-al application was mainly explored from 2010 until now.Diseases such as dysmenorrhea,morbid vaginal discharge,infertility,metrorrhagia,and polycystic ovarian syndrome(PCOS)have recently become popular topics in this field.Conclusion The current study provides more scientific,accurate,and comprehensive sci-entific support for further research and development of traditional Chinese medicine(TCM)in FQZNK.With this foundation,people can use burst detection to ascertain the current hot-spots in research,get their development trends,and forecast future research directions.In ad-dition,infertility,morbid vaginal discharge,flooding,and PCOS treatments based on TCM syndrome differentiation are currently popular research topics for FQZNK.

远红外FEL微波源调制器De-Qing稳幅电路设计

远红外自由电子激光(FEL)对微波源的幅度稳定度有特殊要求,因此,选用有突出优点的阻容振荡型[(De)22.7(-)]Qing电路作为微波源的脉间稳幅控制线路。电路设计采用新的设计路线,首先引入电压调整深度概念,用归一化设计,分析推导出与稳幅精度有关的各种因素和相互关系,然后以稳幅精度0.2%为条件求出电路各参数的限制范围,最后通过实验确定各元件参数的标称值。最终实现了微波源高压脉冲幅度稳定精度0.15%,满足了远红外自由电子激光实验需求。

管弦乐Qing-Diao(《清调》)研究——贾国平音乐创作的观念、技术与文化

20世纪90年代,十二音创作技术与序列思维依然对中国作曲家的创作产生着影响。他们在借用这种思维与技巧进行创作的同时,亦采用了各种方式来阐释民族文化。贾国平的管弦乐Qing-Diao(《清调》)便是这样一部作品。其中,无论是从作品“标签化”的标题、对传统音乐素材的处理、作品中单声思维的观念,还是整体音乐语言的组织与陈述方式,无不显示出作曲家在传承中国民族文化过程中观念的形成与技术的创新。

关于de-Qing电路失灵保护

一、引言在电子直线加速器领域,基于能量稳定性的考虑,在雷达领域,由于信号稳定度要求,它们的功率脉冲发生器普遍采用脉间稳幅电路。而在电子直线加速器范围内,几乎无例外地采用de-Qing电路作为脉间稳幅手段。实践表明,任何电路都有失误的可能。

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

Traditional Chinese medicine “Qing Yi Tang” alleviates oxygen free radical injury in acute necrotizing pancreatitis

AIM To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine 'Qing Yi Tang' in acute necrotizing pancreatitis (ANP).METHODS After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were observed.RESULTS As compared with control group, the serum level of amylase (734U/L vs 2783U/L) and MDA (7.8nmol/ml vs 14.8nmol/ml) in Chinese medicine group were decreased on day 7 (P＜0.05), while SOD increased significantly (281nU/ml vs 55nU/ml, P＜0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as well.CONCLUSION 'Qing Yi Tang' is effective in clearing OFRs and alleviating pathological changes in ANP.

Effect of Qing'e Formula on Circulating Sclerostin Levels in Patients with Postmenopausal Osteoporosis

Summary： Serum sclerostin is positively associated with serum 25 hydroxyvitamin D concentration. Our preliminary studies confirmed that Qing＇e formula （QEF） could effectively increase serum 25 hy- droxyvitamin D concentration in patients with postmenopausal osteoporosis （PMOP）, but the effect of supplementation with QEF on serum sclerostin is unknown. This study investigated the effects of sup- plementation of QEF on serum sclerostin levels in patients with PMOP. Totally 120 outpatients and in- patients with PMOP treated in our hospital between January and October 2012 were randomly divided into QEF＋calcium group, alfacalcidol＋calcium group, and placebo＋calcium group （n=40 each）, with a follow-up period of 2 years. The serum levels of sclerostin, 25 hydroxyvitamin D, and bone turnover markers （β-CTX, N-MID and T-PINP） at baseline and at the 6th month, 1st year, 1.5th year, and 2nd year after treatment were measured. The results showed that the levels of circulating sclerostin were in- creased significantly at the 6th month after treatment in QEF＋calcium group and alfacalcidol＋calcium group as compared with placebo＋calcium group （P〈0.05）, but there was no significant difference be- tween the former two groups （P〉0.05）. The levels of β-CTX, N-MID and T-PINP in serum were de- creased in both QEF＋calcium group and alfacalcidol＋calcium group at the 6th month after treatment, without significant difference between the two groups （P〉0.05）. BUt the levels were significantly lower than that in placebo＋calcium group （P〈0.05）. These results suggest that the mechanism by which QEF modulates bone metabolism in patients with PMOP might be related with the effect of QEF in increas- ing sclerostin expression. Our findings provide a scientific rationale for using QEF as an effective drug to prevent bone loss in PMOP.

Qing Dai, a traditional Chinese medicine for the treatment of chronic hemorrhagic radiation proctitis

Objective： To evaluate the efficacy and safety of Qing Dai （indigo naturalis）, a traditional Chinese medicine, in the treatment for chronic hemorrhagic radiation proctitis. Methods： Ten patients with chronic hemorrhagic radiation proctitis between January 2005 to January 2008 were treated with Qing Dai. Qing Dai was administered orally at a dose of 1.5 g, bid for 5 consecutive days, every 2 weeks for two courses. Patients were followed up every 3 months. The clinical response and side-effects were evaluated. Results： Six patients showed improvement of rectal bleeding to grade 0-1 after 1 course of Qing Dai therapy. Four patients had reduced rectal bleeding to grade 0-1 after 2 courses of the therapy. The median follow-up time was 10 months （range： 6-24）. During the follow-up period, 1 patient experienced recurrent rectal bleeding and was managed with topical formalin dabbing, which controlled the symptom. No treatment toxicity was observed. Conclusion： Qing Dai may be a safe and effective treatment for chronic hemorrhagic radiation proctitis.

Effects of Qing’E Formula on the Expression of Bone Metabolic Markers and VDR mRNA in Postmenopausal Osteoporosis Patients

Objectives: To study the partial mechanism of treating postmenopausal osteoporosis patients (POPs) using the ancient recipe of Qing’E Formula (QEF) by observing its effects on bone metabolic markers and VDR mRNA expression in primary POPs. Methods: Analysis was performed on 120 outpatient and inpatient POPs treated in our hospital between January and October 2013, where the patients were randomly divided into Qing’E group (QEF + Caltrate), Calcitriol group (Caltrate + Calcitriol soft capsules), and Compare group (Caltrate), each with a follow-up period of 1 year. Statistical analysis was then performed on bone mineral density, blood bone metabolic markers (β-CTX, N-MID, T-PINP) and changes in VDR mRNA expressions in the POPs before and after the treatments. Results: Prior to the treatments, bone mineral density and blood β-CTX, N-MID, T-PINP and VDR mRNA expression in the 3 groups of POPs exhibited no statistically significant differences, and the blood β-CTX, N-MID, T-PINP and VDR mRNA expression in the control group showed no statistically significant differences before and after the treatments. There were no significant differences in bone mineral density in the Qing’E group and the Calcitriol group before and after the treatments whereas the bone mineral density decreased in the control group after the treatments. As for blood β-CTX, N-MID, T-PINP and VDR mRNA expression, the measurements in POPs in the Qing’E group and the Calcitriol group were significantly higher than that of the control group. Conclusion: By adjusting the VDR mRNA expression, the QEF, a kidney-invigorating Chinese herbal formula, is capable of activating bone metabolism to prohibit further losses of bone mass, thereby preventing the deterioration of osteoporosis.

Qingfei Paidu Decoction for COVID-19: A Bibliometric Analysis

Traditional Chinese medicine(TCM)has been used for thousands of years in fighting epidemics and has achieved remarkable therapeutic effects[1].The coronavirus disease 2019(COVID-19)pandemic has been effectively controlled in China under a series of policies.