Granular Effect of Fly Ash Repairs Damage of Recycled Coarse Aggregate

Repairing effect of fly ash （FA） on damage of recycled coarse aggregate was evaluated by characteristics of pores and cracks in the vicinity of interracial transition zone （ITZ）. The interracial structure between the virgin aggregate and the attached old mortar was investigated and compared with ITZ of recycled aggregate concrete in the presence of FA or ultra-fine FA（UFA） by means of scanning electron microscope （SEM）. Diameter and plumpness frequency distribution of pores as well as width of the old ITZ, length of contacting points and cracks density were analyzed. The SEM results reveal that the diameter of pores is decreases significantly but pores plumpness increases. A decreased ITZ width and cracks density as well as an increased bonding zone length can also been observed, which indicates that FA or UFA repairs damage of recycled coarse aggregate due to its granular effect.

Effect of Boundary Condition on Impact Response and Damage Meso-mechanism for Scarf Bonded Repair of Load-bearing Composite Structures

Composite scarf repair is applied in airplane load-bearing structures. But the repairs would have different boundary supports in real situation, such as simply support, clamped support and flexible support. With different boundary supports, the bonded scarf repair of composite structures could have diverse damage mechanisms and responses. This work intends to study the impact performance of different boundaries. For this purpose, experimental tests were carried out on the specimens with two sides support and four sides support. The impact load and deflection was monitored during the tests. After impact being finished, the meso-mechanism was studied by means of micro-cracks of the side section for two sides support condition and cross section for the four sides support condition. It was possible to conclude that the four sides boundary possess higher impact resistance maximum loads, lower displacements and lower extent load dropping. In terms of damage modes, as the impact energy relative low 12 J and 16 J, the central position of scarf bonding zone for two sides support appears adhesive cohesive failure and adhesive-composite interface failure. When the energy increases to 20 J, the dominated damage of two sides support moves down to the feathered tip. For four sides support, the critical energy level is 25 J, under which the scarf adhesive begins to be damaged.

Cost effective use of mosquito net mesh in inguinal hernia repair

Mesh hernia repair is one of the commonest open techniques of inguinal hernia repair.The main limiting factor in the use of new meshes is the cost.We carried out a prospective randomized double blind study and comprising of a hundred patients with 100 inguinal hernias admitted consecutively for elective surgery,divided into the polypropylene mesh(PPM)group and the mosquito net mesh(MNM)group each containing fifty patients.All cases were completed successfully and results revealed no difference in two groups.The results of the present study,in consistent with the published literature,reveal that the cheap indigenous mosquito mesh,which has similar properties of an imported mesh,can be safely used for tension-free inguinal hernia repair in adults.Further trials with a larger number of patients and longer follow-ups are justified and recommended.

STIMULATING EFFECT OF LOW DOSE ^(147)Pm ON DNA REPAIR IN SPERMIOGENIC STAGES

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Burow's楔形推进皮瓣与V-Y推进皮瓣对面部皮肤肿瘤切除术后修复的效果比较

目的 比较Burow's楔形推进皮瓣与皮下蒂皮瓣V-Y推进皮瓣对面部皮肤肿瘤切除术后修复效果的影响。方法 选取2018年3月—2022年3月宝鸡高新医院收治的92例面部皮肤肿瘤切除术后皮肤缺损患者,将患者分为两组,其中采取Burow's楔形推进皮瓣修复患者45例(对照组),采取皮下蒂皮瓣V-Y推进皮瓣修复患者47例(研究组),术后随访12个月。对比两组皮瓣存活情况、咀嚼活动状况、焦虑及抑郁情绪、生活质量、术后并发症及患者满意情况。结果 两组皮瓣存活优良率比较,差异无统计学意义(P>0.05)。两组术后静息时、最大力咬合时咬肌、颞肌肌电活动比较,差异均无统计学意义(P>0.05)。两组手术前后焦虑自评量表(SAS)、抑郁自评量表(SDS)评分差值比较,差异均无统计学意义(P>0.05)。两组术后心理功能、生理功能、社会功能、物质生活状态评分比较,差异均无统计学意义(P>0.05)。两组并发症总发生率、满意度比较,差异均无统计学意义(P>0.05)。结论 Burow's楔形推进皮瓣与皮下蒂皮瓣VY推进皮瓣对面部皮肤肿瘤切除术后修复效果相近,均可获得满意修复效果,均可改善患者焦虑、抑郁情绪及生活质量,安全性及患者满意度均较高。

类人胶原蛋白修复敷料联合度普利尤单抗治疗中重度特应性皮炎患儿的效果

目的探讨类人胶原蛋白修复敷料联合度普利尤单抗治疗中重度特应性皮炎患儿的效果。方法选取2021年2月至2023年8月西北妇女儿童医院收治的116例中重度特应性皮炎患儿进行随机对照试验。采用抽签法将其分为对照组和试验组,各58例。对照组男29例,女29例,年龄(5.78±2.34)岁。试验组男29例,女29例,年龄(5.82±2.28)岁。对照组度普利尤单抗治疗,试验组类人胶原蛋白修复敷料联合度普利尤单抗治疗。比较两组疗效、症状改善状况(皮肤干燥、皮肤瘙痒、皮损)、皮肤屏障状况[皮脂含量、含水量、经表皮水份丢失(transepidermal water loss,TEWL)]、特应性皮炎量表(Scoring Atopic Dermatitis,SCORAD)评分、研究者整体(Investigator's Global Assessment,IGA)评分、湿疹面积及严重度指数(Eczema Area and Severity Index,EASI)评分、生活质量[儿童皮肤病生活质量指数(Children's Dermatology Life Quality Index,CDLQI)、婴儿皮炎生活质量指数(Infant Dermatitis Quality of Life Index,IDQOL)]。采用t检验、χ^(2)检验进行统计分析。结果试验组总有效率高于对照组[96.55%(56/58)比81.03%(47/58)],差异有统计学意义(χ^(2)=7.017,P=0.008)。试验组皮肤干燥、皮肤瘙痒、皮损改善时间均短于对照组[(5.56±1.77)d比(7.06±2.16)d、(10.56±2.73)d比(12.09±2.16)d、(7.58±2.06)d比(10.73±2.27)d],差异均有统计学意义(t=4.091、3.347、7.826,均P<0.05)。治疗后,试验组皮脂含量、含水量均高于对照组[(84.22±12.24)μg/cm^(2)比(65.47±10.31)μg/cm^(2)、(46.35±8.17)%比(37.40±7.75)%],TEWL低于对照组[(15.87±2.14)g(/h·cm^(2))比(19.76±2.94)g(/h·cm^(2))],差异均有统计学意义(t=8.923、6.053、8.147,均P<0.05)。治疗后,试验组SCORAD、IGA、EASI评分均低于对照组[(18.52±7.98)分比(23.12±8.49)分、(1.53±0.74)分比(2.02±0.61)分、(5.75±0.94)分比(7.92±1.26)分],差异均有统计学意义(t=3.007、3.891、10.513,均P<0.05)。治疗后,试验组CDLQI、IDQOL评分均低于对照组[(3.92±0.53)分比(9.19±1.31)分、(4.68±0.37)分比(8.83±1.26)分],差异均有统计学意义(t=28.401、24.067,均P<0.05)。结论类人胶原蛋白修复敷料联合度普利尤单抗治疗中重度特应性皮炎患儿能改善其皮肤症状和皮肤屏障功能,降低相关评分,并提高患儿生活质量。

“S”形组织蒂皮瓣修复面部软组织缺损82例

目的:探讨“S”形组织蒂皮瓣在颜面部各种病变组织切除缺损修复中的应用效果。方法:笔者医院2017年8月-2022年8月共收治82例颜面部软组织缺损患者,在缺损部位一侧,沿皮肤纹理设计“S”形组织蒂皮瓣,以皮下组织为蒂,以斜形方向移位修复面部软组织缺损,供瓣区牵拉缝合,随访6个月~1年,观察术后面部软组织缺损修复效果。结果:本组82例患者手术过程均顺利,术后80例患者皮瓣成活,未发生坏死;2例患者术后创口边缘裂开,经重新缝合、局部换药、抗感染后皮瓣存活。术后6个月复查本组82例患者面部非对称率为5%~16%,平均为(10.72±1.38)%,颜面部器官未见明显牵拉或移位,局部外形良好。术后6个月,术区质地、颜色接近正常皮肤,皮瓣外形美观,瘢痕不明显,达到良好的形态学和美学效果。结论:对于面部器官周围皮肤软组织缺损患者采用“S”形组织蒂皮瓣修复简单易行,损伤小,皮瓣血运稳定,修复外形满意,是一种值得选用的方式。

Influence of Mineral Admixtures on the Electrodeposition Healing Effect of Concrete Cracks

Two types of solutions（Zn SO4, Mg SO4） were selected to study the influence of mineral admixtures on the electro-deposition healing effect of concrete cracks. Four parameters（i e, rates of weight gain, surface coating, crack closure and crack filling depth） were measured. The mineral composition of electro-deposits in the cracks was analyzed. The study shows that the healing effect of mortar specimens with 10% fly ash is the worst, while the healing effect of mortar specimens with 20% fly ash is better than that of the specimens without fly ash. The rates of weight gain, surface coating, crack closure and crack filling depth decrease with increasing content of the ground granulated blast-furnace slag（GGBS）. The mineral admixtures have no influence on the composition of deposits.

Grey Repairable System Analysis

In this paper, we systematically discuss the basic concepts of grey theory, particularly the grey differential equation and its mathematical foundation, which is essentially unknown in the reliability engineering community. Accordingly, we propose a small-sample based approach to estimate repair improvement effects by partitioning system stopping times into intrinsic functioning times and repair improvement times. An industrial data set is used for illustrative purposes in a stepwise manner.

Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice

Mecobalamin, a form of vitamin B12 containing a central metal element （cobalt）, is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve crush injury in mice, followed by daily intraperitoneal administra-tion of mecobalamin （65 μg/kg or 130 μg/kg） or saline （negative control）. Walking track analysis, histomorphological examination, and quantitative real-time PCR showed that mecobalamin signiifcantly improved functional recovery of the sciatic nerve, thickened the myelin sheath in myelinated nerve ifbers, and increased the cross-sectional area of target muscle cells. Further-more, mecobalamin upregulated mRNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury, and of neurotrophic factors （nerve growth factor, brain-derived nerve growth factor and ciliary neurotrophic factor） in the L4–6 dorsal root ganglia. Our ifndings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes.

The characteristics of DNA repair synthesis induced by DNA polymerase β in hepatoma cells after γ rays irradiation

AIM To investigate the effects of DNA repair synthesis induced by DNA polymerase β in hepatoma cells after γ ray irradiation. METHODS Cell nuclei were prepared from SMMC LTNM hepatoma which is a transplanted human liver cancer born on nude mice. Samples were irradiated with 60 Co γ rays at different doses or dose rates. N ethylmaleimide (NEM) and ddTTP were used as selective inhibitors to DNA polymerases. The reaction of DNA repair synthesis was carried out with the selective inhibitor test. RESULTS It was found that the 3H TTP incorporation in irradiated nuclei or calf thymus DNA was significantly higher than that in the non irradiated ones, under the conditions of DNA polymerase α or γ being inhibited. When NEM and ddTTP which selectively inhibits DNA polymerase β both existed in the DNA repair synthesis reaction mixture, the 3H TTP incorporation in irradiated DNA did not significantly increased. Furthermore, 3H TTP incorporation into DNA of SMMC LTNM hepatoma nuclei was higher than that of normal hepatocyte nuclei ( P <0 01). The DNA repair synthesis induced by DNA polymerase β reacted more fast in hepatoma nuclei than in hepatocyte nuclei. CONCLUSION The effects of DNA repair synthesis induced by DNA polymerase β in some tumor cells might be stronger than that in normal cells, which may facilitate the cells to repair DNA damages from radiation.

基于Rockfall数值模拟的边坡落石防护网修复加固方案研究

某水电站尾水支洞边坡多次发生落石灾害,原被动防护网已发生局部破损,严重威胁着尾水支洞施工期和运行期的安全,需对原防护网进行修复加固。由于山体陡峭、地貌复杂,人工调查无法确定落石源,采用高精度无人机航摄初步排查出四处可疑危险源区域,利用Rockfall软件进行落石轨迹模拟计算,通过对比分析计算成果与观测到的落石落点位置与威胁区域分布情况,反分析确定了两处落石源。在此基础上,根据落石源的落石运动特征,复核分析了原防护能力不足的原因,发现原防护网的能级和高度不足是导致落石灾害发生的主要原因。通过提高防护网的能级和高度,提出了原位修复和增高加固两种方案。研究结果表明:两种方案均能有效减小落石威胁区域面积、降低落石率、改善运动特征参数。其中增高加固方案的防护效果更加显著,落石被全部拦截,落石弹跳高度和动能的最大值分别降低了69.64%、66.02%。对被动防护网破损部位的修复加固,综合考虑现场实际情况与落石模拟计算成果进行修复方案设计更为科学合理。研究成果可为该工程的落石防护方案提供科学依据,为类似工程设计与落石分析提供参考。

股前外侧穿支皮瓣游离移植修复四肢皮肤缺损的临床疗效

目的:探究股前外侧穿支皮瓣游离移植修复四肢皮肤缺损的临床疗效。方法:选取2018年6月-2023年9月笔者医院收治的98例四肢皮肤缺损患者进行研究,患者皮肤软组织缺损面积为6.12 cm×9.34 cm~15.23 cm×32.74 cm,均行股前外侧穿支皮瓣游离移植修复,皮瓣切取面积为7.35 cm×10.34 cm~17.63 cm×34.49 cm。观察手术疗效、术后损伤部位功能、感觉恢复情况及术后并发症发生情况。结果:术后随访6个月,皮瓣全部成活,通过皮瓣供血优良度判断,术后优86例,良12例;DASH评分为18~24分,平均(21.46±1.27)分,下肢功能LEFS量表评分为36~52分,平均(43.97±5.57)分。79例患者感觉功能恢复至S3,其余恢复保护性感觉,两点辨别觉为5.3~8.2 mm。供区皮肤饱满红润,无感觉功能障碍。出现并发症共4例(4.08%),其中,感染3例,经抗感染治疗后得到控制;皮瓣边缘坏死1例,经换药或皮瓣移植后愈合,未发生血管危象、感觉障碍等情况。结论:股前外侧穿支皮瓣游离移植修复四肢皮肤缺损疗效显著,能够改善缺损部位的外观和功能,恢复损伤肢体感觉,并发症少,是一种较为理想的选择。

局部皮下蒂皮瓣修复非黑色素瘤皮肤癌一期切除术后缺损的效果及安全性

目的探究局部皮下蒂皮瓣对非黑色素瘤皮肤癌一期切除术后缺损的修复效果及安全性。方法选取2016年10月至2023年10月我院非黑色素瘤皮肤癌患者80例。对照组实施传统缝合(n=40),观察组采用皮下蒂皮瓣修复(n=40)。对比两组患者修复疗效、治疗后满意程度及不良反应。结果观察组患者修复疗效总有效率为95.00%大于对照组的75.00%(P<0.05);观察组患者治疗后总满意度为97.50%大于对照组的80.00%(P<0.05);术后两组患者各项创面评分均升高,且观察组更高,均有差异(P<0.05);观察组患者术后总不良反应发生率为7.50%低于对照组的27.50%(P<0.05)。结论对非黑色素瘤皮肤癌,于一期切除术后采用皮下蒂皮瓣修复的治疗方法,不仅可以提升患者术后愈合情况,还可以提高术后满意度,降低不良反应的发生,提高安全性。

Primer-Like Inhibitors for DNA Repair Enzymes of the AML-HL60 and WERI-1A/Y79 Malignant Cells

A conventionally synthesized thio- and cyano-modified single-stranded poly(dNTP) sequences of different molecular sizes (20n - 200n) and the same lengths routine poly(dNTP) and poly(NTP) species were obtained through the good services provided by the Russian Federal Bioorganic Products Group and by the ThermoFischer, Inc., and then tested for their impact on catalytic activities of β-like DNA polymerases from chromatin of HL-60, WERI-1A and Y-79 cells as well as for the affinity patterns in DNApolβ-poly(dNTP)/ (NTP) pairs, respectively. An essential link between the lengths of ultrashort (50n - 100n) single-stranded poly(dNTP) sequences of different structures and their inhibitory effects towards the cancer-specific DNA polymerases β has been found. A possible significance of this phenomenon for both DNA repair suppression in tumors and a consequent anti-cancer activity of the DNA repair related short poly(dNTP) fragments has been for the first time emphasized with a respect to their pharmacophore revealing potential. Thus, this work presents an experimental attempt to upgrade a contemporary attitude towards the DNA derived products applied for anti-cancer agenda, particularly, for acute myeloid leukemia and retinoblastoma cell DNA repair machinery breakdown. In this study, tumor specific DNA polymerases β were found of being the targets for attack promoted with the primer-like single-stranded DNA fragments followed by consequent cytostatic phenomena. A novel concept of the DNA related anti-cancer medicines is under discussion.

创面组织再生修复材料的安全性和有效性评价技术研究进展

新型组织再生修复生物材料具有促进创面细胞增生和迁移,加速创面愈合速度和提高创面愈合质量的作用。随着这类新型材料的不断涌现,传统的评价方法和技术在一定程度上已经不完全适用,因此就新型创面再生修复材料的表征以及生物安全性和有效性评价的最新研究进展进行了总结。介绍了这类材料的化学性能、降解吸收、物理性能以及生物相容性评价要求,重点综述了新建立的有效评价技术,包括体外细胞增殖、细胞迁移、体外屏蔽保护、微血管形成试验,以及体内动物创伤模型的建立和创面愈合有效性评价方法。

放射影像设备的质控管理及维修分析

临床对放射影像设备进行质控管理的预期目标是在符合行业的标准要求下,采用适当的影像检查技术条件为临床提供优质的图像信息。我院1.5T MRI设备于2015年10月开始使用,虽然该设备已使用了8年,经过持续而严格的质控,使该设备的各项技术指标依然保持在较好状态,不但满足了正常的工作需求,而且保持了较低的故障率。设备的良好运转、医务人员准确的技术应用,以及患者的最佳配合才能得到优质的影像图像。对于放射影像设备的质量控制,其覆盖了设备的整个使用周期,且质量控制的过程也是设备在整个使用周期中的运行流程。只有通过科学的手段,强化和优化放射影像设备的质量控制,提升设备的使用效率,才能为临床诊断提供有效的技术支持。同时及时的维修和独立的解决问题既能保证诊疗的正常进行,还能给医院节省资金。因此,优秀的技术能力加上严格规范的质控管理是我院影像设备安全运行的最好保证。

Effect of Pulse Parameters on Deposition in Concrete Crack using Pulse Current Electro-deposition

To evaluate the effect of pulse parameters on the formation of electrodeposits in concrete cracks, five different types of pulse current were set up, and ZnSO_4 and MgSO_4 solutions were used as the electrolytes. The rate of weight gain, rate of surface coating, rate of crack closure and crack filling depth were measured. Scanning electron microscopy was used to assess the morphology of the electrodeposits, and energy dispersive spectroscopy was used to analyze the mineral composition of the electrodeposits in the cracks. The experimental results demonstrate that, among five different pulse parameters, when T_（on）/T_（off）=0.8 ms/0.8 ms, the healing effect of electro-deposition is the best. The pulse mode hardly affects the mineral composition of the electrodeposits but changes the micromorphology. In addition, for both ZnSO_4 and MgSO_4 solutions, when T_（on）/T_（off）=0.8 ms/0.8 ms, the crystal structure of the electrodeposits is the most uniform and the densest.

摄食细节管理结合舒适护理模式在口腔癌游离皮瓣移植术后患者康复中的应用

目的:探讨摄食细节管理结合舒适护理模式在口腔癌游离皮瓣移植术后患者康复中的应用效果.方法:选取2020年3月至2023年3月本院收治的122例口腔癌游离皮瓣移植术后患者为研究对象.采取随机数字表法将其分为观察组(n=62,采用摄食细节管理和舒适护理模式)和对照组(n=60,采用常规饮食干预模式).对两组患者吞咽功能、舒适度及并发症发生率进行统计学分析.结果:干预后,观察组患者洼田饮水试验(WST)评分低于对照组,改良曼恩吞咽能力评估量表(MMASA)、Kolcaba的舒适状况量表(CGQ)评分均高于对照组,差异均有统计学意义(P<0.05).观察组患者并发症发生率低于对照组,差异有统计学意义(P<0.05).结论:摄食细节管理结合舒适护理模式在口腔癌游离皮瓣移植术后患者康复中效果理想,可有效调整患者的吞咽功能障碍,改善舒适度,降低并发症发生率.

高压注浆法修复桩基断桩效果分析研究

文章以扶海-马塘220 kV线路改造工程中输电杆塔混凝土灌注桩基础为研究对象,通过有限元计算分析了采用高压注浆法修复混凝土灌注桩断桩的效果,并与断桩和正常桩的性能进行对比。通过有限元计算结果可知,高压注浆法修复断桩的抗压、抗拔承载力分别可达正常桩的93%和84%以上,证明了采用高压注浆法修复混凝土灌注桩断桩的可行性及有效性。同时,分析了断桩缺陷位置和缺陷厚度对高压注浆法修复断桩效果的影响规律。