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Text Simplification Using Transformer and BERT 被引量:1
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作者 Sarah Alissa Mike Wald 《Computers, Materials & Continua》 SCIE EI 2023年第5期3479-3495,共17页
Reading and writing are the main interaction methods with web content.Text simplification tools are helpful for people with cognitive impairments,new language learners,and children as they might find difficulties in u... Reading and writing are the main interaction methods with web content.Text simplification tools are helpful for people with cognitive impairments,new language learners,and children as they might find difficulties in understanding the complex web content.Text simplification is the process of changing complex text intomore readable and understandable text.The recent approaches to text simplification adopted the machine translation concept to learn simplification rules from a parallel corpus of complex and simple sentences.In this paper,we propose two models based on the transformer which is an encoder-decoder structure that achieves state-of-the-art(SOTA)results in machine translation.The training process for our model includes three steps:preprocessing the data using a subword tokenizer,training the model and optimizing it using the Adam optimizer,then using the model to decode the output.The first model uses the transformer only and the second model uses and integrates the Bidirectional Encoder Representations from Transformer(BERT)as encoder to enhance the training time and results.The performance of the proposed model using the transformerwas evaluated using the Bilingual Evaluation Understudy score(BLEU)and recorded(53.78)on the WikiSmall dataset.On the other hand,the experiment on the second model which is integrated with BERT shows that the validation loss decreased very fast compared with the model without the BERT.However,the BLEU score was small(44.54),which could be due to the size of the dataset so the model was overfitting and unable to generalize well.Therefore,in the future,the second model could involve experimenting with a larger dataset such as the WikiLarge.In addition,more analysis has been done on the model’s results and the used dataset using different evaluation metrics to understand their performance. 展开更多
关键词 Text simplification neural machine translation TRANSFORMER
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Analysis of a simplification strategy in a nonhydrostatic model for surface and internal wave problems
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作者 Jinghua Zhang Wensheng Jiang Xueqing Zhang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第2期29-43,共15页
This paper examines the simplification strategy of retaining only the nonhydrostatic effect of local acceleration in a three-dimensional fully nonhydrostatic model regarding the submesoscale wave phenomenon in the oce... This paper examines the simplification strategy of retaining only the nonhydrostatic effect of local acceleration in a three-dimensional fully nonhydrostatic model regarding the submesoscale wave phenomenon in the ocean.Elaborate scale analysis of the vertical component of the Reynold-averaged Navier-Stokes(RANS)equation was performed,confirming the rationalization of this simplification.Then,the simplification was implemented in a RANS equation-based nonhydrostatic model NHWAVE(nonhydrostatic WAVE)to make a simplified nonhydrostatic model.Numerical examples were taken to test its performance,including surface sinusoidal waves propagating on an idealized East China Sea topography,tidally induced internal lee waves and small-scale solitary waves.The results show that in a considerably wide range of nonlinear strengths,the simplified nonhydrostatic model can obtain similar results as those in the fully nonhydrostatic model,even for smaller-scale solitary waves.Nonlinearity influences the applicability of the simplification.The stronger the nonlinearity is,the worse the simplified model describes the nonhydrostatic phenomenon.In general,the simplified nonhydrostatic model can simulate surface waves better than internal waves.Improvement of computational efficiency in the simplified nonhydrostatic model is reasonable,reducing the central processing unit time duration in the fully nonhydrostatic model by 16.4%–20.6%.The specially designed algorithm based on the simplified nonhydrostatic equation can remarkably reduce the computational time. 展开更多
关键词 simplification of nonhydrostatic model submesoscale wave internal lee wave
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A Collaborative Simplification Method for Multiple Coastlines Based on the Hierarchical Triangulation Network Partition 被引量:6
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作者 Lihua ZHANG Lulu TANG +1 位作者 Shuaidong JIA Zeyuan DAI 《Journal of Geodesy and Geoinformation Science》 2020年第2期93-104,共12页
For the current automatic coastline generalization method,only one-line element is considered separately,but the relationship between the nearby elements is not effectively considered.A synergistic simplification meth... For the current automatic coastline generalization method,only one-line element is considered separately,but the relationship between the nearby elements is not effectively considered.A synergistic simplification method for multiple coastlines based on the hierarchical triangulation network partition(HTNP)is proposed in this paper.Firstly,the constrained Delaunay triangulation is constructed to partition the regions that can be simplified.Then,a hierarchical binary tree model to structure the morphological characteristics of the above several coastlines and the spatial proximity between different coastlines is constructed.Finally,the small curved and curved invisible parts of the coastline are deleted according to the visual constraints,and the narrow part between the coastline itself or the different coastlines is exaggerated appropriately,and the automatic simplification of the coastline is realized.The experimental results show that:①Relationships between the different coastlines are considered,and the shortcomings of considering the coastline separately are overcome;②Under the condition of the multiple coastlines in complex sea areas,the problem of collaborative simplification is solved,the quality of the coastlines are improved obviously,and the proposed method can be applied into more types of coastlines. 展开更多
关键词 cartographic generalization coastline simplification hierarchy relationship synergistic simplification
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A Progressive Line Simplification Algorithm 被引量:2
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作者 Christoph Brandenberger Lorenz Hurni 《Geo-Spatial Information Science》 2002年第3期41-45,75,共6页
An application of line simplification considering spatial knowledge is described.A method for identifying potential conflict regions,in order to avoid the self_intersection of generalized lines,is also discussed.Furth... An application of line simplification considering spatial knowledge is described.A method for identifying potential conflict regions,in order to avoid the self_intersection of generalized lines,is also discussed.Furthermore,a new progressive line simplification algorithm is presented.From the view point of spatial cognition,a spatial hierarchical structure is proposed,and its application to construction of spatial knowledge related to a line is explained. 展开更多
关键词 PROGRESSIVE LINE simplification map GENERALIZATION SPATIAL knowledge SPATIAL cognitive SPATIAL hierarchical structure potential CONFLICT region selfintersection of a LINE
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Simplification and Experimental Verification for Temperature and Humidity Field Coupling Model of Conservatory Soil 被引量:1
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作者 曹滨斌 李惟毅 李兆力 《Transactions of Tianjin University》 EI CAS 2011年第1期33-38,共6页
Based on the surface energy balance model which is widely used abroad, a temperature and humidity field coupling model of conservatory soil without crop vegetation in full illumination was established. Considering the... Based on the surface energy balance model which is widely used abroad, a temperature and humidity field coupling model of conservatory soil without crop vegetation in full illumination was established. Considering the relatively closed environment in conservatory, weak solar radiation and little surface evaporation of soil, the daily variation of water content in different soil layers may be neglected, then the temperature and humidity field coupling model was simplified to a one-dimensional thermal diffusion model. The simplified model and the temperature and humidity field coupling model adopted the same computational method of soil physical parameters and discrete format of heat diffusion differential equations, and were applied to the continuous simulation of temperature field in conservatory soil without crop vegetation in full illumination. Through the comparison between simulation results and experimental data, the precision of the simplified model was verified. The typical rule of soil heat flux variation in a 24 h cycle was also obtained. 展开更多
关键词 conservatory SOIL TEMPERATURE humidity coupling model simplification
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An Adaptive SVP Simplification Based on Area Difference 被引量:5
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作者 Gen ZHENG Jianhu ZHAO Hongmei ZHANG 《Journal of Geodesy and Geoinformation Science》 2019年第4期53-63,共11页
Sound velocity profile(SVP)data is indispensable in the multi-beam data processing.The sampling density is of great importance for SVP to represent the vertical variation of sound velocity accurately and guarantee the... Sound velocity profile(SVP)data is indispensable in the multi-beam data processing.The sampling density is of great importance for SVP to represent the vertical variation of sound velocity accurately and guarantee the accuracy of sound ray tracing(SRT).However,the SVP also affects the SRT efficiency significantly,especially in deep-sea multi-beam sounding data processing.To improve SRT efficiency and ensure SRT accuracy,an adaptive SVP simplification method based on area difference is proposed in this article.Firstly,the relationship between the area difference of the raw SVP and the simplified one and SRT bias is studied,and the relationship model of them is built.Then,by considering the constraint of SRT accuracy,the SVP simplification method and the simplifying SVP procedure SVP are given.Finally,a deep water experiment is conducted to verify the proposed method.Compared to the existing method,the proposed method improves the robustness,feasibility of SVP simplification as well as the accuracy and efficiency of SRT. 展开更多
关键词 sound velocity profile(SVP)simplification area difference equivalent SVP sound ray tracing(SRT)bias maximum offset of sound velocity(MOV)
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Simplification of English Sentence Pattern Structure in the Teaching of Translation and Grammar
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作者 汤伟 YANG Ya-lan 《海外英语》 2014年第20期278-279,共2页
In the teaching of translation and grammar,it is essential that the English sentence structure is analyzed and transformation of sentence structures both in English and Chinese in class and after class. However,many k... In the teaching of translation and grammar,it is essential that the English sentence structure is analyzed and transformation of sentence structures both in English and Chinese in class and after class. However,many kinds of English sentences structures prevent the students who study English from getting the basic idea and concept of a sentence in translation or grammatical analysis. In this paper,the author submitted the basic mould of simplification of English sentence structure,and the students can learn and master the translating technique through the simplified English sentence structure. Thus it helps to improve students' competence of translation. 展开更多
关键词 ENGLISH SENTENCE STRUCTURE simplification SV SVO S
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The Solid-liquid Transformation of Low-grade Solid Potash Deposit in Dalangtan Basin and the Simplification of the Liquid Phase System
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作者 WANG Xiaohan ZHANG Chao +2 位作者 XIE Shaolei JIA Yongzhong YAO Ying 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2014年第S1期436-436,共1页
We studied the solid-liquid transformation of low-grade solid potash deposit in Dalangtan Basin and simplified the liquid phase system.We did experiments to optimize conditions of the solid-liquid transformation.The S... We studied the solid-liquid transformation of low-grade solid potash deposit in Dalangtan Basin and simplified the liquid phase system.We did experiments to optimize conditions of the solid-liquid transformation.The Suitable 展开更多
关键词 low-grade solid potash deposit solid-liquid transformation liquid phase system simplification
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The Spatial Characteristics of a Line and Their Application to Line Simplification
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作者 GUOQingsheng ChristophBrandenberger 《Geo-Spatial Information Science》 2002年第1期62-67,共6页
This paper discusses the spatial knowledge related to a line ,and the characteristic points of lines is detected.According to the requirements of line generalization,new algorithms for identifying characteristic line ... This paper discusses the spatial knowledge related to a line ,and the characteristic points of lines is detected.According to the requirements of line generalization,new algorithms for identifying characteristic line points are presented.These characteristic points are used to improve the algorithms of line generalization.An algorithm for identifying bends is shown.In this paper,improved algorithms based on those by Douglas_Peucker,Visvalingam and Whyatt are shown.In this test,the progressive process of line generalization is emphasized. 展开更多
关键词 spatial knowledge characteristic point BEND automated map generalization line simplification progressive map generalization
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Complex Model Simplification Algorithm with Improved Error Evaluation
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作者 JIANGHong-bo LUYan-sheng TANGBo 《Wuhan University Journal of Natural Sciences》 EI CAS 2005年第2期380-384,共5页
Given the framework of incremental mesh simplification based on edgecollapse, the paper proposes a mesh simplification algorithm using an improved approach formeasuring simplification error. The algorithm uses edge co... Given the framework of incremental mesh simplification based on edgecollapse, the paper proposes a mesh simplification algorithm using an improved approach formeasuring simplification error. The algorithm uses edge collapse to simplify the trianglemesh andmaintains surface error approximations using c-error for the faces which have changed after edgecollapse and d-crror for the faces which become degenerated after edge collapse. Also, we reportsome results using a variety of computer graphics models, which can show that the algorithm canachieve the desired simplification effect. 展开更多
关键词 mesh simplification c-crror d-error edge collapse
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THE METHOD OF GRAPHIC SIMPLIFICATION OF AREA FEATURE BOUNDARY WITH RIGHT ANGLES
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作者 GUO Qingsheng MAO Jianhua 《Geo-Spatial Information Science》 2000年第2期74-78,共5页
Some rules of simplification of area feature boundary and the method of acquiring spatial knowledge, such as maintaining area and shape of area feature, are discussed. This paper focuses on the progressive method of g... Some rules of simplification of area feature boundary and the method of acquiring spatial knowledge, such as maintaining area and shape of area feature, are discussed. This paper focuses on the progressive method of graphic simplification of area feature boundary with right angles based on its characteristics. 展开更多
关键词 automated map generalization area feature spatial knowledge progressive graphic simplification
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Terrain Simplification Research in Augmented Scene Modeling
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作者 Ming Delie You Kefei Tian Jinwen Liu Jian State Key Laboratory for Image Processing and Intelligent Control, Institute for Pattern Recognition and Artificial Intelligence , Huazhong University of Science and Technology , Wuhan 430074 Wang Guangju 《Journal of China University of Geosciences》 SCIE CSCD 2001年第4期351-355,共5页
Augmented reality is the merging of synthetic sensory information into a user's perception of a real environment. As one of the most important tasks in augmented scene modeling, terrain simplification research has... Augmented reality is the merging of synthetic sensory information into a user's perception of a real environment. As one of the most important tasks in augmented scene modeling, terrain simplification research has gained more and more attention. In this paper, we mainly focus on point selection problem in terrain simplification using triangulated irregular network. Based on the analysis and comparison of traditional importance measures for each input point, we put forward a new importance measure based on local entropy. The results demonstrate that the local entropy criterion has a better performance than any traditional methods. In addition, it can effectively conquer the 'short-sight' problem associated with the traditional methods. 展开更多
关键词 augmented reality scene modeling terrain simplification triangulated irregular network importance measures local entropy.
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Application of equivalent resistance to simplification of Sutong Bridge piers in tidal river section modeling
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作者 Lei TANG WeiZHANG +1 位作者 Ming-xiao XIE Zhen YU 《Water Science and Engineering》 EI CAS 2012年第3期316-328,共13页
This paper describes some details and procedural steps in the equivalent resistance (E-R) method for simplifying the pier group of the Sutong Bridge, which is located on the tidal reach of the lower Yangtze River, i... This paper describes some details and procedural steps in the equivalent resistance (E-R) method for simplifying the pier group of the Sutong Bridge, which is located on the tidal reach of the lower Yangtze River, in Jiangsu Province. Using a two-dimensional tidal current numerical model, three different models were established: the non-bridge pier model, original bridge pier model, and simplified bridge pier model. The difference in hydrodynamic parameters, including water level, velocity, and diversion ratio, as well as time efficiency between these three models is discussed in detail. The results show that simplifying the pier group using the E-R method influences the water level and velocity near the piers, but has no influence on the diversion ratio of each cross-section of the Xuliujing reach located in the lower Yangtze River. Furthermore, the simplified bridge pier model takes half the calculation time that the original bridge pier model needs. Thus, it is concluded that the E-R method can be use to simplify bridge piers in tidal river section modeling reasonably and efficiently. 展开更多
关键词 E-R method tidal river section pier group simplification numerical modeling
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Unsupervised statistical text simplification using pre-trained language modeling for initialization 被引量:1
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作者 Jipeng QIANG Feng ZHANG +3 位作者 Yun LI Yunhao YUAN Yi ZHU Xindong WU 《Frontiers of Computer Science》 SCIE EI CSCD 2023年第1期81-90,共10页
Unsupervised text simplification has attracted much attention due to the scarcity of high-quality parallel text simplification corpora. Recent an unsupervised statistical text simplification based on phrase-based mach... Unsupervised text simplification has attracted much attention due to the scarcity of high-quality parallel text simplification corpora. Recent an unsupervised statistical text simplification based on phrase-based machine translation system (UnsupPBMT) achieved good performance, which initializes the phrase tables using the similar words obtained by word embedding modeling. Since word embedding modeling only considers the relevance between words, the phrase table in UnsupPBMT contains a lot of dissimilar words. In this paper, we propose an unsupervised statistical text simplification using pre-trained language modeling BERT for initialization. Specifically, we use BERT as a general linguistic knowledge base for predicting similar words. Experimental results show that our method outperforms the state-of-the-art unsupervised text simplification methods on three benchmarks, even outperforms some supervised baselines. 展开更多
关键词 text simplification pre-trained language modeling BERT word embeddings
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A distributed variable density path search and simplification method for industrial manipulators with end-effector's attitude constraints
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作者 Jin WANG Shengjie LI +4 位作者 Haiyun ZHANG Guodong LU Yichang FENG Peng WANG Jituo LI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2023年第4期536-552,共17页
In many robot operation scenarios, the end-effector's attitude constraints of movement are indispensable for the task process, such as robotic welding, spraying, handling, and stacking. Meanwhile, the inverse kine... In many robot operation scenarios, the end-effector's attitude constraints of movement are indispensable for the task process, such as robotic welding, spraying, handling, and stacking. Meanwhile, the inverse kinematics, collision detection, and space search are involved in the path planning procedure under attitude constraints, making it difficult to achieve satisfactory efficiency and effectiveness in practice. To address these problems, we propose a distributed variable density path planning method with attitude constraints(DVDP-AC) for industrial robots. First, a position – attitude constraints reconstruction(PACR) approach is proposed in the inverse kinematic solution. Then, the distributed signed-distance-field(DSDF) model with single-step safety sphere(SSS) is designed to improve the efficiency of collision detection. Based on this, the variable density path search method is adopted in the Cartesian space. Furthermore, a novel forward sequential path simplification(FSPS) approach is proposed to adaptively eliminate redundant path points considering path accessibility. Finally, experimental results verify the performance and effectiveness of the proposed DVDP-AC method under end-effector's attitude constraints, and its characteristics and advantages are demonstrated by comparison with current mainstream path planning methods. 展开更多
关键词 Path planning Industrial robots Distributed signed-distance-field Attitude constraints Path simplification
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Numerical Simulation of the Settling Flux of Biodeposition in a Bay with Cage Culture Through Similarity Theory and a Simplified Pollution Source
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作者 LIU Yao CHEN Yifan GE Changzi 《Journal of Ocean University of China》 CAS CSCD 2024年第1期247-254,共8页
The settling flux of biodeposition affects the environmental quality of cage culture areas and determines their environmental carrying capacity.Simple and effective simulation of the settling flux of biodeposition is ... The settling flux of biodeposition affects the environmental quality of cage culture areas and determines their environmental carrying capacity.Simple and effective simulation of the settling flux of biodeposition is extremely important for determining the spatial distribution of biodeposition.Theoretically,biodeposition in cage culture areas without specific emission rules can be simplified as point source pollution.Fluent is a fluid simulation software that can simulate the dispersion of particulate matter simply and efficiently.Based on the simplification of pollution sources and bays,the settling flux of biodeposition can be easily and effectively simulated by Fluent fluid software.In the present work,the feasibility of this method was evaluated by simulation of the settling flux of biodeposition in Maniao Bay,Hainan Province,China,and 20 sampling sites were selected for determining the settling fluxes.At sampling sites P1,P2,P3,P4,P5,Z1,Z2,Z3,Z4,A1,A2,A3,A4,B1,B2,C1,C2,C3 and C4,the measured settling fluxes of biodeposition were 26.02,15.78,10.77,58.16,6.57,72.17,12.37,12.11,106.64,150.96,22.59,11.41,18.03,7.90,19.23,7.06,11.84,5.19 and 2.57 g d^(−1)m^(−2),respectively.The simulated settling fluxes of biodeposition at the corresponding sites were 16.03,23.98,8.87,46.90,4.52,104.77,16.03,8.35,180.83,213.06,39.10,17.47,20.98,9.78,23.25,7.84,15.90,6.06 and 1.65 g d^(−1)m^(−2),respectively.There was a positive correlation between the simulated settling fluxes and measured ones(R=0.94,P=2.22×10^(−9)<0.05),which implies that the spatial differentiation of biodeposition flux was well simulated.Moreover,the posterior difference ratio of the simulation was 0.38,and the small error probability was 0.94,which means that the simulated results reached an acceptable level from the perspective of relative error.Thus,if nonpoint source pollution is simplified to point source pollution and open waters are simplified based on similarity theory,the setting flux of biodeposition in the open waters can be simply and effectively simulated by the fluid simulation software Fluent. 展开更多
关键词 fluent fluid simulation software pollution source simplification posterior difference ratio similarity theory Spear-man correlation
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Motion and Special Relativity in Complex Spaces
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作者 Jerzy K. Filus 《Journal of Applied Mathematics and Physics》 2024年第1期330-361,共32页
A natural extension of the Lorentz transformation to its complex version was constructed together with a parallel extension of the Minkowski M<sup>4</sup> model for special relativity (SR) to complex C<... A natural extension of the Lorentz transformation to its complex version was constructed together with a parallel extension of the Minkowski M<sup>4</sup> model for special relativity (SR) to complex C<sup>4</sup> space-time. As the [signed] absolute values of complex coordinates of the underlying motion’s characterization in C<sup>4</sup> one obtains a Newtonian-like type of motion whereas as the real parts of the complex motion’s description and of the complex Lorentz transformation, all the SR theory as modeled by M<sup>4</sup> real space-time can be recovered. This means all the SR theory is preserved in the real subspace M<sup>4</sup> of the space-time C<sup>4</sup> while becoming simpler and clearer in the new complex model’s framework. Since velocities in the complex model can be determined geometrically, with no primary use of time, time turns out to be definable within the equivalent theory of the reduced complex C<sup>4</sup> model to the C<sup>3</sup> “para-space” model. That procedure allows us to separate time from the (para)space and consider all the SR theory as a theory of C<sup>3</sup> alone. On the other hand, the complex time defined within the C<sup>3</sup> theory is interpreted and modeled by the single separate C<sup>1</sup> complex plane. The possibility for application of the C<sup>3</sup> model to quantum mechanics is suggested. As such, the model C<sup>3</sup> seems to have unifying abilities for application to different physical theories. 展开更多
关键词 Special Relativity Complex Space and Time Models and Dramatic SR simplification Complex Time and Space Separation Complex Time Interpretation
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A New Mesh Simplification Algorithm Based on Triangle Collapses 被引量:8
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作者 潘志庚 周昆 石教英 《Journal of Computer Science & Technology》 SCIE EI CSCD 2001年第1期57-63,共7页
In this paper a new mesh simplification algorithm based on triangle collapses is presented. The algorithm can provide efficient error management and simplify the original mesh greatly. Progressive meshes may be constr... In this paper a new mesh simplification algorithm based on triangle collapses is presented. The algorithm can provide efficient error management and simplify the original mesh greatly. Progressive meshes may be constructed with triangle collapsing operation. To make continuous transition between level of detail (LOD) models possible, a method for interpolating is also presented. Examples illustrate the efficiency of the algorithm. 展开更多
关键词 mesh simplification triangle mesh level of detail progressive mesh
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Feature Preserving Mesh Simplification Using Feature Sensitive Metric 被引量:7
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作者 魏瑨 楼宇 《Journal of Computer Science & Technology》 SCIE EI CSCD 2010年第3期595-605,共11页
We present a new method for feature preserving mesh simplification based on feature sensitive (FS) metric. Previous quadric error based approach is extended to a high-dimensional FS space so as to measure the geomet... We present a new method for feature preserving mesh simplification based on feature sensitive (FS) metric. Previous quadric error based approach is extended to a high-dimensional FS space so as to measure the geometric distance together with normal deviation. As the normal direction of a surface point is uniquely determined by the position in Euclidian space, we employ a two-step linear optimization scheme to efficiently derive the constrained optimal target point. We demonstrate that our algorithm can preserve features more precisely under the global geometric properties, and can naturally retain more triangular patches on the feature regions without special feature detection procedure during the simplification process. Taking the advantage of the blow-up phenomenon in FS space, we design an error weight that can produce more suitable results. We also show that Hausdorff distance is markedly reduced during FS simplification. 展开更多
关键词 mesh simplification feature preserving feature sensitive (FS) metric
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Structural simplification: an efficient strategy in lead optimization 被引量:2
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作者 Shengzheng Wang Guoqiang Dong Chunquan Sheng 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2019年第5期880-901,共22页
The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a power... The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the efficiency and success rate of drug design by avoiding 'molecular obesity'. The structural simplification of large or complex lead compounds by truncating unnecessary groups can not only improve their synthetic accessibility but also improve their pharmacokinetic profiles, reduce side effects and so on. This review will summarize the application of structural simplification in lead optimization. Numerous case studies, particularly those involving successful examples leading to marketed drugs or drug-like candidates, will be introduced and analyzed to illustrate the design strategies and guidelines for structural simplification. 展开更多
关键词 STRUCTURAL simplification Lead optimization DRUG discovery DRUG design REDUCING rings number REDUCING chiral centers STRUCTURE-BASED simplification Pharmacophore-based simplification
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