The Five Plague Gods(五瘟神) in the Shuilu(水陆) murals from the Ming and Qing dynasties exemplify a distinctive manifestation of plague gods image developed under the pedigree of Taoist gods.As a significant system f...The Five Plague Gods(五瘟神) in the Shuilu(水陆) murals from the Ming and Qing dynasties exemplify a distinctive manifestation of plague gods image developed under the pedigree of Taoist gods.As a significant system for expelling disasters in Shuilu,the depiction of the Five Plague Gods prominently merges human beings and livestock.This shape form to a large extent,draws on the image of Nuo(傩),a figure reflecting an imagination of the host of plague pathogens.In terms of the numbers of gods,it aligns with the conceptual framework of Wu Xing(五行 the five elements),a foundational principle in traditional Chinese medicine.The internal cultural connection highlights the means of plague prevention and control in China,as well as the external reflection of plague culture.Through multi-dimensional interpretations with the double proof method,this article dissects the formation,core elements,and cultural characteristics of the beliefs in the Five Plague Gods reflected in the Shuilu murals,and transcends mere visual semantics,offering a deeper understanding of these complex cultural symbols.展开更多
目的探讨水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效。方法83例患者随机分为对照组(42例)和观察组(41例),对照组给予厄贝沙坦片,观察组在对照组基础上加用水陆二仙丹联合抵挡汤加减方,疗程12周。检测临床疗效、中医...目的探讨水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效。方法83例患者随机分为对照组(42例)和观察组(41例),对照组给予厄贝沙坦片,观察组在对照组基础上加用水陆二仙丹联合抵挡汤加减方,疗程12周。检测临床疗效、中医证候评分、血糖指标(FBG、HbA1c)、血脂指标(TC、TG)、肾功能指标(BUN、Scr、24 h UTP、eGFR)、炎症因子(IL-1β、hs-CRP、IL-6、TNF-α、IL-18、TGF-β1)、免疫功能指标(淋巴细胞、中性粒细胞、CD8^(+)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,观察组中医证候评分、血糖指标、血脂指标、BUN、Scr、24 h UTP、炎症因子、CD8^(+)降低(P<0.05),淋巴细胞、中性粒细胞减少(P<0.05),eGFR、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)升高(P<0.05),并比对照组更明显(HbA1c、TG、SCr、24 h UTP、淋巴细胞、中性粒细胞除外)(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论水陆二仙丹联合抵挡汤加减方可安全有效地改善早中期糖尿病肾病患者临床症状,其机制可能与降低炎症水平、改善机体免疫功能有关。展开更多
目的:评价水陆二仙丹合抵挡汤加减治疗早期糖尿病肾病(diabetic nephropathy,DN)的疗效。方法:将早期DN患者102例根据随访期间的暴露因素(是否服用水陆二仙丹合抵挡汤加减治疗)分为无暴露组和暴露组,无暴露组服用水陆二仙丹合抵挡汤加...目的:评价水陆二仙丹合抵挡汤加减治疗早期糖尿病肾病(diabetic nephropathy,DN)的疗效。方法:将早期DN患者102例根据随访期间的暴露因素(是否服用水陆二仙丹合抵挡汤加减治疗)分为无暴露组和暴露组,无暴露组服用水陆二仙丹合抵挡汤加减治疗时间<4周,低暴露组为4~8周,高暴露组为8~16周。观察水陆二仙丹合抵挡汤加减治疗与终点事件(DNⅢ期进展到临床蛋白尿期)及次要结局指标[临床症状、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2-hour postprandial blood glucose,2 h PG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipopro-tein cholesterol,LDL-C)、尿微量白蛋白排泄率(urinary albumin excretion rate,UAER)、24 h尿蛋白定量(24-hour urinary protein quantity,24 h UPQ)、血肌酐(serum creatinine,SCr)、尿素氮(blood urea nitrogen,BUN)]的关系。结果:不同暴露水平终点事件发生率比较差异无统计学意义(P>0.05);低、高暴露组患者腰膝酸软、倦怠乏力、口干、夜尿多症状较无暴露组改善明显(P<0.05);低、高暴露组FBG、TG、UAER、24 h UPQ、SCr均降低(P<0.05),且高暴露组FBG、TG、UAER、SCr降低更明显(P<0.05),而PPG、LDL、BUN低、高暴露组比较差异无统计学意义(P>0.05)。结论:在综合治疗基础上服用水陆二仙丹合抵挡汤加减4~16周可明显缓解早期DN患者临床症状,降低FBG、TG、UAER、SCr水平。展开更多
基金financed by the grants from Shanxi Province Postgraduate Education Innovation Plan (No. 2023KY126)Humanities and Social Sciences Research Project of The Ministry of Ecuation (No. 23YJAZH182)。
文摘The Five Plague Gods(五瘟神) in the Shuilu(水陆) murals from the Ming and Qing dynasties exemplify a distinctive manifestation of plague gods image developed under the pedigree of Taoist gods.As a significant system for expelling disasters in Shuilu,the depiction of the Five Plague Gods prominently merges human beings and livestock.This shape form to a large extent,draws on the image of Nuo(傩),a figure reflecting an imagination of the host of plague pathogens.In terms of the numbers of gods,it aligns with the conceptual framework of Wu Xing(五行 the five elements),a foundational principle in traditional Chinese medicine.The internal cultural connection highlights the means of plague prevention and control in China,as well as the external reflection of plague culture.Through multi-dimensional interpretations with the double proof method,this article dissects the formation,core elements,and cultural characteristics of the beliefs in the Five Plague Gods reflected in the Shuilu murals,and transcends mere visual semantics,offering a deeper understanding of these complex cultural symbols.
文摘目的探讨水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效。方法83例患者随机分为对照组(42例)和观察组(41例),对照组给予厄贝沙坦片,观察组在对照组基础上加用水陆二仙丹联合抵挡汤加减方,疗程12周。检测临床疗效、中医证候评分、血糖指标(FBG、HbA1c)、血脂指标(TC、TG)、肾功能指标(BUN、Scr、24 h UTP、eGFR)、炎症因子(IL-1β、hs-CRP、IL-6、TNF-α、IL-18、TGF-β1)、免疫功能指标(淋巴细胞、中性粒细胞、CD8^(+)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,观察组中医证候评分、血糖指标、血脂指标、BUN、Scr、24 h UTP、炎症因子、CD8^(+)降低(P<0.05),淋巴细胞、中性粒细胞减少(P<0.05),eGFR、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)升高(P<0.05),并比对照组更明显(HbA1c、TG、SCr、24 h UTP、淋巴细胞、中性粒细胞除外)(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论水陆二仙丹联合抵挡汤加减方可安全有效地改善早中期糖尿病肾病患者临床症状,其机制可能与降低炎症水平、改善机体免疫功能有关。
文摘目的:评价水陆二仙丹合抵挡汤加减治疗早期糖尿病肾病(diabetic nephropathy,DN)的疗效。方法:将早期DN患者102例根据随访期间的暴露因素(是否服用水陆二仙丹合抵挡汤加减治疗)分为无暴露组和暴露组,无暴露组服用水陆二仙丹合抵挡汤加减治疗时间<4周,低暴露组为4~8周,高暴露组为8~16周。观察水陆二仙丹合抵挡汤加减治疗与终点事件(DNⅢ期进展到临床蛋白尿期)及次要结局指标[临床症状、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2-hour postprandial blood glucose,2 h PG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipopro-tein cholesterol,LDL-C)、尿微量白蛋白排泄率(urinary albumin excretion rate,UAER)、24 h尿蛋白定量(24-hour urinary protein quantity,24 h UPQ)、血肌酐(serum creatinine,SCr)、尿素氮(blood urea nitrogen,BUN)]的关系。结果:不同暴露水平终点事件发生率比较差异无统计学意义(P>0.05);低、高暴露组患者腰膝酸软、倦怠乏力、口干、夜尿多症状较无暴露组改善明显(P<0.05);低、高暴露组FBG、TG、UAER、24 h UPQ、SCr均降低(P<0.05),且高暴露组FBG、TG、UAER、SCr降低更明显(P<0.05),而PPG、LDL、BUN低、高暴露组比较差异无统计学意义(P>0.05)。结论:在综合治疗基础上服用水陆二仙丹合抵挡汤加减4~16周可明显缓解早期DN患者临床症状,降低FBG、TG、UAER、SCr水平。
