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Hydroxyapatite Coatings on Titanium Prepared by Electrodeposition in a Modified Simulated Body Fluid 被引量:5
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作者 赵旭辉 杨灵芳 +1 位作者 左禹 熊金平 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2009年第4期667-671,共5页
Hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body fluid.The configuration,structure and bioactivity of the coating were investigated with sca... Hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body fluid.The configuration,structure and bioactivity of the coating were investigated with scanning electron microscopy(SEM),X-ray diffraction analyzer(XRD)and Fourier transform infrared spectros-copy(FTIR)techniques.The results demonstrated that pure and homogeneous hydroxyapatite coating can be obtained without any post-treatment.The prepared coating showed good bioactivity in simulated body fluid(SBF).The time required for a fully covered dense hydroxyapatite coatings was 4 days immersion in SBF. 展开更多
关键词 hydroxyapatite coating ELECTRO-DEPOSITION modified simulated body fluid TITANIUM anodization
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Corrosion fatigue of the extruded Mg-Zn-Y-Nd alloy in simulated body fluid 被引量:5
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作者 Mengyao Liu Jianfeng Wang +4 位作者 Shijie Zhu Yabo Zhang Yufeng Sun Liguo Wang Shaokang Guan 《Journal of Magnesium and Alloys》 SCIE 2020年第1期231-240,共10页
Magnesium alloys were considered to be used as biodegradable implants due to their biocompatibility,biodegradability and nontoxicity.However,under the simultaneous action of corrosive environment and mechanical loadin... Magnesium alloys were considered to be used as biodegradable implants due to their biocompatibility,biodegradability and nontoxicity.However,under the simultaneous action of corrosive environment and mechanical loading in human body,magnesium alloys are easy to be affected by corrosion fatigue and stress corrosion cracking.In this work,the fatigue behavior of the extruded Mg-Zn-Y-Nd alloy used for vascular stents was studied both in air and in simulated body fluid(SBF).It was revealed that the fatigue limit of as-extruded Mg-Zn-Y-Nd alloy in air is about 65 MPa at 10^7 cycles,while there is no limit in SBF and shows a linear relationship between the fatigue life and stress amplitudes.The fatigue crack source in air was formed by the inclusions and defects.However,the stress corrosion and hydrogen embrittlement are the main reasons for the formation of the fatigue initial crack source in SBF. 展开更多
关键词 Biodegradable magnesium alloy Corrosion fatigue simulated body fluid Fatigue crack source
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Calcium phosphate deposition on surface of porous and dense TiNi alloys in simulated body fluid 被引量:1
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作者 刘珏 刘超 +2 位作者 李婧 刘敏 阮建明 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第1期1-9,共9页
Porous and dense TiNi alloys were successfully fabricated by powder metallurgy(P/M) method, and to further improve their surface biocompatibility, surface modification techniques including grind using silicon-carbide(... Porous and dense TiNi alloys were successfully fabricated by powder metallurgy(P/M) method, and to further improve their surface biocompatibility, surface modification techniques including grind using silicon-carbide(SiC) paper, acid etching and alkali treatment were employed to produce either irregularly rough surface or micro-porous surface roughness. X-ray diffractometry(XRD), scanning electron microscopy(SEM) and energy dispersive X-ray spectroscopy(EDX) attached to SEM were used to characterize surface structure and the Ca-P coatings. Effects of the above surface treatments on the surface morphology, apatite forming ability were systematically investigated. Results indicate that all the above surface treatments increase the apatite forming ability of TiNi alloys in varying degrees when soaked in simulated body fluid(SBF). More apatite coatings formed on TiNi samples sintered at 1050℃ and 1100℃ due to their high porosity and pure TiNi phase that is beneficial to heterogeneous nucleation. Furthermore, more uniform apatite was fabricated on the sample sintered from the mixture of Ni and Ti powders. 展开更多
关键词 calcium phosphate TiNi alloy surface treatment MICROSTRUCTURE simulated body fluid sbf
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Understanding the effects of excimer laser treatment on corrosion behavior of biodegradable Mg-1Ca alloy in simulated body fluid 被引量:1
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作者 Yuxiang Liu Michele Curioni +1 位作者 Shiyun Dong Zhu Liu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第4期1004-1023,共20页
In this study,a KrF excimer laser was used to modify the biodegradable Mg-1Ca alloy and the time-evolution degradation behavior of the alloy before and after laser treatment was investigated in simulated body fluid(SB... In this study,a KrF excimer laser was used to modify the biodegradable Mg-1Ca alloy and the time-evolution degradation behavior of the alloy before and after laser treatment was investigated in simulated body fluid(SBF)solution using immersion tests and electrochemical impedance spectroscopy(EIS).A 5μm melted layer with a homogeneous microstructure and an MgO film on the surface were achieved by laser radiation.Corrosion observations(hydrogen evolution,morphology and corrosion products)and EIS results revealed an improvement of corrosion resistance after laser treatment for 48 h.It was found a two-layer structure developed after 2 h immersion on both the untreated and laser-treated alloys,but the sequence of forming the two layers was opposite and greatly influenced by the laser-treated layer.The time-evolution corrosion processes on the untreated and laser-treated alloys were discussed,providing a better understanding of corrosion behavior of biodegradable Mg alloys modified by excimer laser. 展开更多
关键词 MAGNESIUM Biodegradable implant Excimer laser simulated body fluid Corrosion EIS
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Characterization and wear resistance of macro-arc oxidation coating on magnesium alloy AZ91 in simulated body fluids 被引量:7
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作者 陈君 曾荣昌 +3 位作者 黄伟九 郑自芹 王振林 王俊 《中国有色金属学会会刊:英文版》 CSCD 2008年第A01期361-364,共4页
The mechanical characteristics of the macro-arc oxidation(MAO) coating on Mg alloy AZ91 were examined by means of nano scratch tester.The corrosion and erosion corrosion behavior of AZ91 with and without MAO coating w... The mechanical characteristics of the macro-arc oxidation(MAO) coating on Mg alloy AZ91 were examined by means of nano scratch tester.The corrosion and erosion corrosion behavior of AZ91 with and without MAO coating were investigated by using potentiodynamic electrochemical technique and micro-abrasion tribometer in simulated body fluids,respectively.The influence of HCO_3^- ions on the erosion corrosion was discussed.The results show that the coating and its substrate are in a pronounced bond.The MAO coating increases 1-2 orders of magnitude of the corrosion resistance of AZ91 alloy.HCO_3^- ions enhance the corrosion rates of the AZ91 alloys more significantly than the alloys with MAO coating.However,there exists an obvious passivation process of AZ91 without coating in the HCO_3^- solutions.Moreover,an MgCO_3 film formed in HCO_3^- containing solutions leads to an enhancement in micro-wear resistance.MAO coating deteriorates the erosion corrosion resistance of AZ91 alloy due to the formation of oxidation debris resulted from the broken MAO coating. 展开更多
关键词 AZ91合金 镁合金 金属材料 热处理
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Bone-like apatite formation on HA/316L stainless steel composite surface in simulated body fluid 被引量:3
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作者 樊新 陈剑 +3 位作者 邹俭鹏 万千 周忠诚 阮建明 《中国有色金属学会会刊:英文版》 EI CSCD 2009年第2期347-352,共6页
HA/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,pla... HA/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,plasma emission spectrometer,scanning electron microscope(SEM) and energy dispersive X-ray energy spectrometer(EDX). The results indicate that the pH value in SBF varies slightly during the immersion. It is a dynamic process of dissolution-precipitation for the formation of apatite on the surface. With prolonging immersion time,Ca and P ion concentrations increase gradually,and then approach equilibrium. The bone-like apatite layer forms on the composites surface,which possesses benign bioactivity and favorable biocompatibility and achieves osseointegration,and can provide firm fixation between HA60/316L SS composite implants and human body bone. 展开更多
关键词 316L不锈钢 类骨磷灰石 模拟体液 复合材料 表面 HA 等离子发射光谱仪 扫描电子显微镜
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Reflections on the Mechanism of Calcium Phosphate Nucleation on Titanium in Simulated Body Fluids
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作者 F.T.ChengDepartment of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2005年第5期613-617,共5页
The results and main findings of studies reported in the literature in relation to the deposition of calcium phosphate on Ti in simulated body fluids are summarized. The effects of the surface hydroxyl groups and the ... The results and main findings of studies reported in the literature in relation to the deposition of calcium phosphate on Ti in simulated body fluids are summarized. The effects of the surface hydroxyl groups and the sign of surface charge on the nucleation of calcium phosphate are reviewed. One major controversy among the conclusions of different studies is the order of adsorption of the calcium ions and the phosphate ions in the initial stage of immersion. A simple model based on the amphoteric nature of the hydroxyl groups on Ti is proposed in an attempt to delineate the nucleation process for calcium phosphate on Ti in simulated body fluids. HPO4^2- ions interact with the hydroxyl groups via ion exchange and/or electrostatic attraction, and Ca^2+ ions, via electrostatic attraction only. There is no preferential order of adsorption. Seemingly inconsistent results in different studies possibly arise from different prior treatments of the samples, which affect the adsorption properties. 展开更多
关键词 TITANIUM Calcium phosphate simulated body fluid Hydroxyl group Point of zero charge Surface charge
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Evaluation of Bioactive Properties of α and β Wollastonite Bioceramics Soaked in a Simulated Body Fluid 被引量:1
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作者 Luis A.Nunez-Rodriguez Martin A.Encinas-Romero +2 位作者 Agustin Gomez-Alvarez Jesus L.Valenzuela-Garcia Guillermo C.Tiburcio-Munive 《Journal of Biomaterials and Nanobiotechnology》 2018年第3期263-276,共14页
Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical pro... Dense natural wollastonite bioceramics (CaSiO3) were prepared by a sintering method, varying the pressing load and sintering temperature, in order to obtain different phases of wollastonite, and different physical properties in the materials. The products were characterized by TGA-DTA, XRD, FT-IR, SEM-EDS, TEM and XPS techniques. The results indicate the presence of two polymorphic phases of wollastonite, the β-wollastonite and α-wollastonite with a transition temperature of the β phase to α phase at approximately 1250&#8451;. These materials were soaked in a simulated body fluid (SBF) during 1, 2 and 3 weeks, to study their solubility and bioactivity. The effect of different wollastonite phases on the solubility of Ca and Si, as well as the capacity of producing layers of “newly formed apatite” on the surfaces of these materials in SBF solution were analyzed. 展开更多
关键词 BIOCERAMICS WOLLASTONITE simulated body fluid Bioactivity
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Formation of Apatite in Simulated Body Fluid
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作者 樊东辉 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2002年第4期44-46,共3页
It is confirmed that the essential condition for glasses and glass-ceramics to bond to living bone is the formation of an apatite layer on their surfaces in the body.It is proposed that a hydrated silica formed on the... It is confirmed that the essential condition for glasses and glass-ceramics to bond to living bone is the formation of an apatite layer on their surfaces in the body.It is proposed that a hydrated silica formed on the surfaces of these materials in the body plays an important role in forming the surface apatite layer,which has not been proved yet.It is shown experimentally that a pure hydrated silica gel can induce the apatite formation on its surface in a simulated body fluid when its starting pH is increased from 7.2 to 7.4. 展开更多
关键词 apatite formation silica gel simulated body fluid
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Effects of different simulated fluids on anticorrosion biometallic materials 被引量:2
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作者 梁成浩 牟战旗 《中国有色金属学会会刊:英文版》 CSCD 2001年第4期579-582,共4页
The corrosion behaviors of SUS316L stainless steel, Co Cr alloy and Ti 6Al 4V alloy in Ringer’s, PBS(-) and Hank’s solutions have been investigated. The results indicate that the corrosion of Ringer’s solution is t... The corrosion behaviors of SUS316L stainless steel, Co Cr alloy and Ti 6Al 4V alloy in Ringer’s, PBS(-) and Hank’s solutions have been investigated. The results indicate that the corrosion of Ringer’s solution is the strongest, then followed by PBS(-) and Hank’s solution. The presence of HPO 2- 4, H 2PO - 4, SO 2- 4 and glucose in the PBS(-)and Hank’s solution probably reduces the corrosion inhibitor and corrosion current. The decrease of the solution’s pH significantly increases the corrosion rate and susceptibility to localized corrosion of SUS316L SS and Co Cr alloy. However, Ti 6Al 4V alloy exhibits an exceptional stability and has only a slight increase of corrosion rate with decreasing pH. 展开更多
关键词 simulated body fluids biomedical material CORROSION corrosion inhibition
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SBF下镁锌钙合金耐蚀性能和耐磨性能研究
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作者 徐世伟 胡楠 +2 位作者 滕杰 胡镜宙 牛云飞 《湖南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2023年第12期138-146,共9页
面向生物医用镁合金,用Zn、Ca元素微合金化和大挤压比变形工艺制备了MgZn-Ca三元合金,通过金相分析,扫描电镜分析手段对材料的显微组织进行了表征;根据应用场景,在人体模拟体液(SBF)中通过常规电化学测试、微区电化学测试相结合综合评... 面向生物医用镁合金,用Zn、Ca元素微合金化和大挤压比变形工艺制备了MgZn-Ca三元合金,通过金相分析,扫描电镜分析手段对材料的显微组织进行了表征;根据应用场景,在人体模拟体液(SBF)中通过常规电化学测试、微区电化学测试相结合综合评估了该合金的耐蚀性能.同时,通过摩擦磨损测试对材料的滑动磨损性能进行了试验分析.结果表明:通过微合金化和热挤压加工,制备出的合金组织为单相固溶体,合金晶粒尺寸较为均匀,自腐蚀电流密度约为119.33μA/cm^(2),腐蚀机制表现为均匀腐蚀.相比于干摩擦,材料本身较好的耐蚀性能协同提高了材料在模拟体液环境下耐磨性能,同时配合模拟体液带来的润滑作用,材料的磨损率得到显著降低.此时,磨损机制以腐蚀磨损为主并伴有轻微的磨粒磨损. 展开更多
关键词 Mg-Zn-Ca合金 生物医用 微区电化学测试 人体模拟体液 摩擦磨损
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氧化石墨烯辅助仿生矿化原位合成羟基磷灰石
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作者 张彪 石淇铭 +5 位作者 白梓恒 刘泓宇 马涛 王芬 朱建锋 施佩 《硅酸盐通报》 CAS 北大核心 2024年第1期363-369,共7页
羟基磷灰石(HAp)是一种与人体骨骼成分类似的无机材料,具有良好的生物相容性。本文以氧化石墨烯(GO)为模板,通过模拟体液(SBF)仿生矿化原位合成了HAp纳米粒子。通过SEM、XRD、EDS和拉曼光谱等测试分析研究了矿化时间、SBF/GO体积比对矿... 羟基磷灰石(HAp)是一种与人体骨骼成分类似的无机材料,具有良好的生物相容性。本文以氧化石墨烯(GO)为模板,通过模拟体液(SBF)仿生矿化原位合成了HAp纳米粒子。通过SEM、XRD、EDS和拉曼光谱等测试分析研究了矿化时间、SBF/GO体积比对矿化产物物相组成、形貌和结构的影响。结果表明,矿化处理后的GO表面形成了大量均匀分布的类骨HAp。随着矿化时间延长和SBF体积占比增大,矿化产物的尺寸及数量增大,GO层间距逐渐扩大。本研究验证了GO辅助合成HAp的可行性,拓展了仿生矿化法的应用领域。 展开更多
关键词 仿生矿化 氧化石墨烯 羟基磷灰石 模拟体液 原位合成 粒径变化
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CaO-P_2O_5-SiO_2系统溶胶-凝胶生物活性多孔材料在SBF中的性能研究 被引量:6
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作者 张晓凯 陈晓峰 +1 位作者 王迎军 张梅梅 《化学学报》 SCIE CAS CSCD 北大核心 2005年第22期2077-2081,共5页
利用溶胶-凝胶生物活性材料粉末二次烧结工艺,制备了CaO-P_2O_5-SiO_2系统溶胶-凝胶生物活性多孔材料,并利用体外实验(in vitro)方法和XRD,SEM及FTIR技术研究了此烧结材料的显微形貌、晶相、生物活性和可降解性能.结果表明,经800℃烧结5... 利用溶胶-凝胶生物活性材料粉末二次烧结工艺,制备了CaO-P_2O_5-SiO_2系统溶胶-凝胶生物活性多孔材料,并利用体外实验(in vitro)方法和XRD,SEM及FTIR技术研究了此烧结材料的显微形貌、晶相、生物活性和可降解性能.结果表明,经800℃烧结5min后,有少量硅磷酸钙[Ca_5(PO_4)_2SiO_4,5CPS]析出,在模拟体液(SBF)中浸泡,随着时间的增长,材料表面最初形成的无定形钙磷化合物矿化成碳酸羟基磷灰石(HCA)纳米团簇,并逐渐相互融合形成HCA覆盖层;HCA只在烧结体的玻璃相(SG相)表面生成,在5CPS微晶相表面未发现HCA,该材料在37℃恒温的SBF溶液中具有较高的生物活性和可降解性能. 展开更多
关键词 CaO-P2O5-SiO2系统 溶胶-凝胶法 生物活性 多孔材料 粉末二次烧结工艺 可降解性能 显微形貌 晶相
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溶胶-凝胶生物活性玻璃在SBF中反应的形貌特征 被引量:8
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作者 张晓凯 刘玮 陈晓峰 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 北大核心 2004年第4期495-498,共4页
利用溶胶 凝胶生物活性玻璃粉末二次烧结工艺 ,制备了CaO P2 O5 SiO2 系统溶胶 凝胶生物玻璃 ,并以其为原料制备了用于骨修复及骨组织工程支架的块状多孔生物活性材料 .并应用体外实验 (invitro)方法和XRD、SEM、FTIR技术研究了此烧结... 利用溶胶 凝胶生物活性玻璃粉末二次烧结工艺 ,制备了CaO P2 O5 SiO2 系统溶胶 凝胶生物玻璃 ,并以其为原料制备了用于骨修复及骨组织工程支架的块状多孔生物活性材料 .并应用体外实验 (invitro)方法和XRD、SEM、FTIR技术研究了此烧结材料的显微形貌、晶相、和生物活性 .结果表明 ,经 80 0℃烧结 5min后 ,材料有硅磷酸钙 (Ca5(PO4 ) 2 SiO4 ,5CPS)析出 ,在模拟体液 (SBF)中浸泡 ,随着时间的增长 ,玻璃表面最初形成的无定形钙磷化合物矿化成碳酸羟基磷灰石 (HCA)纳米团簇 ,并逐渐相互融合形成HCA覆盖层 ;且HCA只在烧结体的玻璃相 (SG相 )表面生成 ,在 5CPS微晶相表面未发现HCA . 展开更多
关键词 溶胶-凝胶 生物活性玻璃 模拟体液(sbf) 碳酸羟基磷灰石(HCA)
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纳米羟基磷灰石/聚酰胺66复合材料在模拟体液(SBF)中的表面生物活性研究 被引量:15
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作者 彭雪林 李玉宝 +2 位作者 严永刚 张利 魏杰 《高技术通讯》 EI CAS CSCD 2003年第12期38-42,共5页
通过纳米羟基磷灰石 /聚酰胺 6 6 (n HA/PA6 6 )复合材料体外模拟体液 (SBF)浸泡实验 ,以聚酰胺 6 6 (PA6 6 )为对照 ,用IR、XRD、SEM和ICP等手段对材料的表面组成和形貌变化进行了分析 ,比较了PA6 6和n HA/PA6 6复合材料的表面生物活... 通过纳米羟基磷灰石 /聚酰胺 6 6 (n HA/PA6 6 )复合材料体外模拟体液 (SBF)浸泡实验 ,以聚酰胺 6 6 (PA6 6 )为对照 ,用IR、XRD、SEM和ICP等手段对材料的表面组成和形貌变化进行了分析 ,比较了PA6 6和n HA/PA6 6复合材料的表面生物活性。结果表明 ,n HA/PA6 6复合材料在SBF中其表面形成的HA沉积物为部分碳酸基团取代的磷灰石 ,而PA6 6在浸泡过程中Ca、P不在聚合物表面沉积 ;n HA/PA6 6复合材料具有良好的生物活性 ,作为骨组织修复或替代材料具有较高的研究和应用价值。 展开更多
关键词 纳米羟基磷灰石/聚酰胺66复合材料 模拟体液 sbf 生物活性 骨组织材料
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可降解医用Zn-3Al-1Mg合金的体外腐蚀行为和力学性能
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作者 刘晓倩 刘翠 +1 位作者 乔爱科 穆永亮 《材料与冶金学报》 CAS 北大核心 2024年第2期181-189,196,共10页
采用热挤压方法制备了管状Zn-3Al-1Mg合金,利用扫描电子显微镜(SEM)及拉伸、压缩测试等方法研究了铸态和挤压态管状Zn-3Al-1Mg合金的微观组织与力学性能同时,利用浸泡试验、电化学测试、X射线光电子能谱分析(XPS)研究了挤压态管状Zn-3Al... 采用热挤压方法制备了管状Zn-3Al-1Mg合金,利用扫描电子显微镜(SEM)及拉伸、压缩测试等方法研究了铸态和挤压态管状Zn-3Al-1Mg合金的微观组织与力学性能同时,利用浸泡试验、电化学测试、X射线光电子能谱分析(XPS)研究了挤压态管状Zn-3Al-1Mg合金在模拟体液(SBF)溶液中的腐蚀行为结果表明:铸态及挤压态合金均由η-Zn,α-Al及Mg2Zn11三相组成,挤压态合金的微观组织明显细化,且力学性能明显优于铸态合金的力学性能挤压态合金在模拟体液中的腐蚀速率为015~028 mm/a腐蚀形貌分析结果揭示了不同物相间的微电偶腐蚀机制,腐蚀产物包括Zn/Al/Mg的氧化物、氢氧化物,以及Ca,P和Zn/Al/Mg相结合产生的磷酸盐、碳酸盐结合电化学测试结果,对挤压态合金的腐蚀过程和腐蚀机理进行了分析. 展开更多
关键词 ZN合金 生物材料 力学性能 模拟体液 降解行为
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热处理和SBF浸泡对羟基磷灰石涂层力学性能的影响 被引量:5
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作者 肖桂勇 吕宇鹏 +2 位作者 朱瑞富 许文花 王爱娟 《材料热处理学报》 EI CAS CSCD 北大核心 2007年第B08期146-149,共4页
利用X射线衍射仪(XRD)、电子探针(EPMA)、扫描电镜(SEM)等检测手段,研究了等离子喷涂羟基磷灰石(HA)涂层热处理前后的显微组织变化,以及经热处理和模拟体液(SBF)浸泡处理对涂层力学性能的影响。结果表明:涂层内部衬度不一,存在化学非均... 利用X射线衍射仪(XRD)、电子探针(EPMA)、扫描电镜(SEM)等检测手段,研究了等离子喷涂羟基磷灰石(HA)涂层热处理前后的显微组织变化,以及经热处理和模拟体液(SBF)浸泡处理对涂层力学性能的影响。结果表明:涂层内部衬度不一,存在化学非均匀性。涂层中的裂纹、气孔、未熔颗粒界面是断裂的起源。热处理能使涂层中的不均匀性消失,成分趋于一致,结晶度提高。热处理后,粗颗粒涂层结合强度升高而细颗粒涂层则降低。0.5 SBF浸泡处理后,所有涂层的结合强度都降低,原始细颗粒涂层降低幅度最大,原始粗颗粒涂层次之,热处理细涂层降低幅度最小。 展开更多
关键词 羟基磷灰石 涂层 热处理 模拟体液 结合强度
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多孔磷酸钙陶瓷在动态SBF中类骨磷灰石形成的研究 被引量:5
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作者 段友容 姚喆 +2 位作者 王朝元 陈继镛 张兴栋 《生物医学工程学杂志》 EI CAS CSCD 2002年第3期365-369,共5页
本实验在模拟体液 (SBF)以静止、等于或大于骨骼肌组织内体液正常生理流率 (2 m l/ 10 0 m l· min)的流动条件下 ,研究多孔磷酸钙陶瓷上类骨磷灰石的形成。结果表明 :SBF在生理流率 (2 m l/ 10 0 ml· m in)情况下 ,材料仅在... 本实验在模拟体液 (SBF)以静止、等于或大于骨骼肌组织内体液正常生理流率 (2 m l/ 10 0 m l· min)的流动条件下 ,研究多孔磷酸钙陶瓷上类骨磷灰石的形成。结果表明 :SBF在生理流率 (2 m l/ 10 0 ml· m in)情况下 ,材料仅在多孔磷酸钙陶瓷孔隙内部形成类骨磷灰石 ;静态 (0 ml/ 10 0 ml· m in)情况下 ,多孔磷酸钙陶瓷材料表面有类骨磷灰石形成 ;高于生理流率 (10 ml/ 10 0 m l· min)时 ,表面和断面均无类骨磷灰石形成 ,但如果增加 SBF中的 Ca2 +、HPO42 -的浓度 ,则在孔隙内部有类骨磷灰石形成。生理流速条件下的结果与多数肌肉内植入磷酸钙陶瓷试验的结果一致 :仅在多孔材料内部成骨。这个结果表明 ,比起通常使用的静态浸泡试验 ,SBF以生理流率流动的动态体外试验能够更好地模拟类骨磷灰石生长的体内环境。动态 SBF对了解类骨磷灰石形成 。 展开更多
关键词 多孔磷酸钙陶瓷 动态sbf 类骨磷灰石 骨诱导性 骨组织工程
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C/C复合材料表面等离子喷涂HA涂层在SBF中的试验 被引量:4
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作者 曹宁 隋金玲 +2 位作者 李木森 王峰 白允强 《生物骨科材料与临床研究》 CAS 2005年第1期5-8,11,共5页
目的 探讨不同模拟体液对HA涂层体外生物学行为的影响。方法采用等离子体喷涂法,在碳/碳复合材料表面制备HA涂层,并对涂层进行了热处理。利用X射线衍射仪(X-ray diffraction)、扫描电子显微镜(Scanning electron microscopy)等检测手段... 目的 探讨不同模拟体液对HA涂层体外生物学行为的影响。方法采用等离子体喷涂法,在碳/碳复合材料表面制备HA涂层,并对涂层进行了热处理。利用X射线衍射仪(X-ray diffraction)、扫描电子显微镜(Scanning electron microscopy)等检测手段,分析该涂层的物相和形貌,观察HA涂层在模拟体液中的影响。结果XRD检测结果表明,在模拟体液浸泡过程中,涂层的主要组成相的相对含量和结晶度不断发生变化。由SEM分析结果可知,在浸泡过程中,内送粉方式下制得的HA涂层的表面沉积物呈现近似网状的结构。同时,在Ringer溶液中,可以观察到HA涂层溶解痕迹。结论通过适当的热处理可以恢复HA的结构完整性,同时提高涂层的结晶度。 展开更多
关键词 羟基磷灰石 等离子体喷涂 模拟体液 碳复合材料
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Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,structure,in vitro and in vivo behavior of PEO coatings on Mg-alloy
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作者 D.V.Mashtalyar I.M.Imshinetskiy +7 位作者 V.V.Kashepa K.V.Nadaraia M.A.Piatkova A.I.Pleshkova K.A.Fomenko A.Yu.Ustinov S.L.Sinebryukhov S.V.Gnedenkov 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第6期2360-2379,共20页
The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on... The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on MA8 magnesium alloy.The obtained coatings demonstrate in vivo biocompatibility and in vitro bioactivity.Compared to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid,suggesting that the inclusion of nanoparticles improves bioactivity of the coatings.It was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in vivo.Based on in vivo studies,these coatings also provide favorable tissue response and minimal inflammatory reaction in comparison with the bare magnesium alloy due to protection of living tissues from deleterious corrosion events of magnesium implant such as local alkalization and intense hydrogen evolution.The results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protective layer for biodegradable magnesium implants. 展开更多
关键词 Plasma electrolytic oxidation Bioactive coatings Tantalum pentoxide simulated body fluid(sbf) Apatite formation HISTOLOGY
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