Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,China.We aimed to explore the frequencies of nasal symptoms in patients with COVID-19,includi...Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,China.We aimed to explore the frequencies of nasal symptoms in patients with COVID-19,including loss of smell and taste,as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19.In this retrospective study,1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital,Wuhan.Demographic data,laboratory values,comorbidities,symptoms,and numerical rating scale scores(0–10)of nasal symptoms were extracted from the hospital medical records,and confirmed or reevaluated by the telephone follow-up.From patients(n=1172)completing follow-up,199(17%)subjects had severe COVID-19 and 342(29.2%)reported nasal symptoms.20.6%COVID-19 patients had loss of taste(median score=6),while 11.4%had loss of smell(median score=5).Loss of taste scores,but not loss of smell scores,were significantly increased in severe vs.nonsevere COVID-19 patients.Interleukin(IL)-6 and lactose dehydrogenase(LDH)serum levels were positively correlated with loss of taste scores.About 80%of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks.In this cohort,only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19.Most patients recovered smell and taste dysfunctions in 2 weeks.展开更多
Human Action Recognition(HAR)in uncontrolled environments targets to recognition of different actions froma video.An effective HAR model can be employed for an application like human-computer interaction,health care,p...Human Action Recognition(HAR)in uncontrolled environments targets to recognition of different actions froma video.An effective HAR model can be employed for an application like human-computer interaction,health care,person tracking,and video surveillance.Machine Learning(ML)approaches,specifically,Convolutional Neural Network(CNN)models had beenwidely used and achieved impressive results through feature fusion.The accuracy and effectiveness of these models continue to be the biggest challenge in this field.In this article,a novel feature optimization algorithm,called improved Shark Smell Optimization(iSSO)is proposed to reduce the redundancy of extracted features.This proposed technique is inspired by the behavior ofwhite sharks,and howthey find the best prey in thewhole search space.The proposed iSSOalgorithmdivides the FeatureVector(FV)into subparts,where a search is conducted to find optimal local features fromeach subpart of FV.Once local optimal features are selected,a global search is conducted to further optimize these features.The proposed iSSO algorithm is employed on nine(9)selected CNN models.These CNN models are selected based on their top-1 and top-5 accuracy in ImageNet competition.To evaluate the model,two publicly available datasets UCF-Sports and Hollywood2 are selected.展开更多
Odors that induce psychological orbehavioral changes in the same species——fright in a catfish^2,sexual arousal in abull—are called pheromones^3.And nowheredo such odors have more profound aneffect than among the be...Odors that induce psychological orbehavioral changes in the same species——fright in a catfish^2,sexual arousal in abull—are called pheromones^3.And nowheredo such odors have more profound aneffect than among the bees,wasps,ants,and termites^4:Pheromones are the chemicalmessages that these insects use to organizetheir complex societies.The queen honeybee preserves hermonarchy^5 by exuding^6 an odor thatnhibits worker bees from laying eggs展开更多
Software systems have been employed in many fields as a means to reduce human efforts;consequently,stakeholders are interested in more updates of their capabilities.Code smells arise as one of the obstacles in the sof...Software systems have been employed in many fields as a means to reduce human efforts;consequently,stakeholders are interested in more updates of their capabilities.Code smells arise as one of the obstacles in the software industry.They are characteristics of software source code that indicate a deeper problem in design.These smells appear not only in the design but also in software implementation.Code smells introduce bugs,affect software maintainability,and lead to higher maintenance costs.Uncovering code smells can be formulated as an optimization problem of finding the best detection rules.Although researchers have recommended different techniques to improve the accuracy of code smell detection,these methods are still unstable and need to be improved.Previous research has sought only to discover a few at a time(three or five types)and did not set rules for detecting their types.Our research improves code smell detection by applying a search-based technique;we use the Whale Optimization Algorithm as a classifier to find ideal detection rules.Applying this algorithm,the Fisher criterion is utilized as a fitness function to maximize the between-class distance over the withinclass variance.The proposed framework adopts if-then detection rules during the software development life cycle.Those rules identify the types for both medium and large projects.Experiments are conducted on five open-source software projects to discover nine smell types that mostly appear in codes.The proposed detection framework has an average of 94.24%precision and 93.4%recall.These accurate values are better than other search-based algorithms of the same field.The proposed framework improves code smell detection,which increases software quality while minimizing maintenance effort,time,and cost.Additionally,the resulting classification rules are analyzed to find the software metrics that differentiate the nine code smells.展开更多
Somerset Maugham<sup>2</sup> inquired of one of H·G·Wells’s<sup>3</sup> mistresses<sup>4</sup> why such a paunchy<sup>5</sup>, homely<sup>6</sup> ...Somerset Maugham<sup>2</sup> inquired of one of H·G·Wells’s<sup>3</sup> mistresses<sup>4</sup> why such a paunchy<sup>5</sup>, homely<sup>6</sup> writer had such success with women.He smells of honey, she said. Body odors are the smell of acids produced by bacteria metabolizing skin secretions.<sup>7</sup> The most repellent<sup>8</sup> odors result from the apocrine glands<sup>9</sup>, associated with underarm and genital hair<sup>10</sup> and activated<sup>11</sup> when we’re frightened, excited, or aroused. Men have more and larger apocrine glands than women, blacks more than Caucasians,<sup>12</sup> Caucasians more than Orientals.<sup>13</sup> Varying skin acidity controls the size of展开更多
Once there was a stingy(小气的)baker.He was angry at a poor man who would standoutside the bakery(面包房)every day,savoring(品尝)the scent of baking bread.The bakerfelt that anyone who smelled his delicious products s...Once there was a stingy(小气的)baker.He was angry at a poor man who would standoutside the bakery(面包房)every day,savoring(品尝)the scent of baking bread.The bakerfelt that anyone who smelled his delicious products should have to pay for the privilege.So展开更多
BACKGROUND There are numerous conflicting discussions about the outbreak of the new coronavirus 2019(COVID-19).AIM To present some anatomical and physiological considerations about two of the symptoms reported by pati...BACKGROUND There are numerous conflicting discussions about the outbreak of the new coronavirus 2019(COVID-19).AIM To present some anatomical and physiological considerations about two of the symptoms reported by patients:The loss or reduction of smell and taste.METHODS The loss or reduction of smell and taste is presented in a peculiar way,with some cases of persistence even after COVID-19.For this,it was searched in three databases,PubMed/MEDLINE,Web of Science,and Scopus,using the following keywords:"Smell","Taste","Smell AND COVID-19","Taste AND COVID-19",with no publication time restriction,only in English with full text available,excluding also brief communications,letters to the editor,editorials,reviews,comments,and conference abstracts.RESULTS The search found 776 articles in the PubMed/MEDLINE database,1018 in the Web of Science database,and 552 in the Scopus database,from which duplicates were removed(104 articles).Finally,17 studies were selected for detailed analysis within the eligibility criteria,with titles and abstracts related to central nervous system lesions responsible for smell and taste.This review suggests that viral mechanisms of action may be related to lesions both at the local level and at the level of the central nervous system,lasting up to 3 to 4 wk.It is considered persistent if it exceeds this period,as reported in one case in this review.There are still few studies about the treatment,and among those addressed in this review,only two studies reported possible treatments and emphasized the scarcity of data,with the best option being treatments that do not cause harm,such as gustatory and olfactory physiotherapy CONCLUSION Given the scarcity of data,this review emphasizes the importance of prevention,through the correct use of personal protective equipment by health professionals and respect for local behavioral indications.It is also emphasized,through five studies,that there is a predominance of such symptoms in patients with COVID-19,which can be a tool to control dissemination,through the early isolation of patients until the results are ready.展开更多
Coronavirus disease 2019(COVID-19)is caused by SARS-CoV2 and is still not yet under complete control and no cure is available until this moment.It is still unpredictable to expect vaccination available worldwide in th...Coronavirus disease 2019(COVID-19)is caused by SARS-CoV2 and is still not yet under complete control and no cure is available until this moment.It is still unpredictable to expect vaccination available worldwide in the near future.Early diagnosis hence becomes extremely important.Various papers have proven that early identification of loss of smell and taste is of significance in the diagnosis of this disease.Some patients of COVID-19 may carry on suffering from loss of smell and taste even long after the other symptoms of the infection subside.The aetiology,pathology,and mechanism of loss of smell and taste are discussed in this article,pointing out that impairment of meridians,disturbed Brain-Shen and dysfunction of the Zang-Fu organs are the key pathology of loss of smell and taste by COVID-19.Traditional Chinese medicine resolution with acupuncture and Chinese herbs are therefore demonstrated accordingly,aiming to establish some practical and effective strategies to deal with loss of smell and taste.This unique presentation in the treatment illustrate that even though loss of smell and taste being a single symptom,it requires a profound understanding on the complicated and sophisticated background mechanism of the COVID-19,which is urgently in need of comprehensive treatment in time.Loss of smell and taste by COVID-19 is not only a minor suffering of the infection,but also a very critical part of a fully recovery of COVID-19,it shall not be left untreated.展开更多
Once an old couple stayed over night at a small hotel in the countryside. Their room wasvery hot in the night, so the husband got up in the dark to open the door. When he got back, hiswife asked him what kind of night...Once an old couple stayed over night at a small hotel in the countryside. Their room wasvery hot in the night, so the husband got up in the dark to open the door. When he got back, hiswife asked him what kind of night it was. "I don t think it s raining," he replied. "But it s pitch-dark(漆黑的), and there is a展开更多
Code smell detection is essential to improve software quality, enhancing software maintainability, and decrease the risk of faults and failures in the software system. In this paper, we proposed a code smell predictio...Code smell detection is essential to improve software quality, enhancing software maintainability, and decrease the risk of faults and failures in the software system. In this paper, we proposed a code smell prediction approach based on machine learning techniques and software metrics. The local interpretable model-agnostic explanations (LIME) algorithm was further used to explain the machine learning model's predictions and interpretability. The datasets obtained from Fontana et al. were reformed and used to build binary-label and multi-label datasets. The results of 10-fold cross-validation show that the performance of tree-based algorithms (mainly Random Forest) is higher compared with kernel-based and network-based algorithms. The genetic algorithm based feature selection methods enhance the accuracy of these machine learning algorithms by selecting the most relevant features in each dataset. Moreover, the parameter optimization techniques based on the grid search algorithm significantly enhance the accuracy of all these algorithms. Finally, machine learning techniques have high potential in predicting the code smells, which contribute to detect these smells and enhance the software's quality.展开更多
Medications frequently have chemosensory side effects that can adversely affect compliance with medical treatment regimens. Hundreds of drugs have been reported to induce unpleasant tastes and/or odors as well as alte...Medications frequently have chemosensory side effects that can adversely affect compliance with medical treatment regimens. Hundreds of drugs have been reported to induce unpleasant tastes and/or odors as well as altered chemosensations when administered alone or in combination with other medications. Some chemosensory complaints are due to the sensory properties of the drug itself such as aversive bitter and metallic tastes. However, most chemo-sensory side effects of drugs are due to alterations in the transduction pathways, biochemical targets, enzymes, and transporters by the offending medications. Studies of chemosensory perception in medicated older individuals have found that taste and smell loss is greatest for those consuming the largest number of prescription drugs. There are no standard treat-ments for drug-induced chemosensory disorders because each drug has unique biological ef-fects. However, there are a few treatment options to ameliorate chemosensory alterations including addition of simulated flavors to food to compensate for losses and to override offend-ing tastes and smells.展开更多
Food selection plays a pivotal role in maintaining adequate nutrient intake, thus elucidating drivers of food choice is a meaningful strategy to maintain health and manage dis-ease. Taste and smell are key determinant...Food selection plays a pivotal role in maintaining adequate nutrient intake, thus elucidating drivers of food choice is a meaningful strategy to maintain health and manage dis-ease. Taste and smell are key determinants of food choice and warrant careful consideration. In this review, we first discuss how sensory stimulation influences food selection and meta-bolism. We then review the evidence regarding the relationship between taste and smell dysfunction and food preferences and selection, with attention given to contexts of certain chronic diseases. We conclude with brief recommendations for the management of chemosen-sory disorders. While sensory abilities influence food selection, the effect of taste and smell dysfunction on long-term consumption patterns and health status must be considered in light of environment, exposure, and culture.展开更多
Community smells are sub-optimal developer community structures that hinder productivity.Prior studies performed smell prediction and provided refactoring guidelines from a top-down aspect to help community shepherds....Community smells are sub-optimal developer community structures that hinder productivity.Prior studies performed smell prediction and provided refactoring guidelines from a top-down aspect to help community shepherds.Simultaneously,refactoring smells also requires bottom-up effort from every developer.However,supportive measures and guidelines for them are not available at a fine-grained level.Since recent work revealed developers'personalities and working states could influence community smells'emergence and variation,we build prediction models with experience,sentiment,and development process features of developers considering three smells including Organizational Silo,Lone Wolf,and Bottleneck,as well as two related classes including smelly developer and smelly quitter.We predict the five classes in the individual granularity,and we also generate forecasts for the number of smelly developers in the community granularity.The proposed models achieve F-measures ranging from 0.73 to 0.92 in individual-wide within-project,time-wise,and cross-project prediction,and mean R2 performance of 0.68 in community-wide Smelly Developer prediction.We also exploit SHAP(SHapley Additive exPlanations)to assess feature importance to explain our predictors.In conclusion,we suggest developers with heavy workload should foster more frequent communication in a straightforward and polite way to build healthier communities,and we recommend community shepherds to use the forecasting model for refactoring planning.展开更多
我们热情地向读者推荐这篇科普性和趣味性俱佳的短文。BBC English在原文前加了这样一句话: Humans might think they lead the rest of the animal world, but as Dilys Bressesreveals, when it comes to the five senses, many anima...我们热情地向读者推荐这篇科普性和趣味性俱佳的短文。BBC English在原文前加了这样一句话: Humans might think they lead the rest of the animal world, but as Dilys Bressesreveals, when it comes to the five senses, many animals leave us behind. 而读了此文,读者不仅会认识嗅觉的奇妙功能,而且不得不承认,就嗅觉言,在许多动物面前,人类只得自叹弗如。 嗅觉的产生主要依靠什么? In mammals, smells are detected by a thin layer of very sensitive cells in the nosecalled the olfactory epithelium (嗅觉上皮组织). 人类的嗅觉所以不如狗,原因就在于此: Humans only have about five square centimeters of thesc cells, while an Alsatian dog,for example, has 150 equare centimeters. 我们称smell为“气味”,其实并不科学。因为,smell也同样存在于水中。如: …but scents can be detected in water too. The hammerhead can detect blood at several hundred meters. 以下这句话,读者也许没有想到过,但言之有理: Sight and hearing provide information too, but in short lived messages. Theadvantage of scent is that it can remain for hours or days. 下面这一则信息真令人类叹?展开更多
基金the Natural Science Foundation of Hubei Province of China(No.2018CFB602)National Key R&D Program of China(No.2018YFC0116800)National Natural Science Foundation of China(Nos:81630024,81920108011,and 81900925)。
文摘Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,China.We aimed to explore the frequencies of nasal symptoms in patients with COVID-19,including loss of smell and taste,as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19.In this retrospective study,1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital,Wuhan.Demographic data,laboratory values,comorbidities,symptoms,and numerical rating scale scores(0–10)of nasal symptoms were extracted from the hospital medical records,and confirmed or reevaluated by the telephone follow-up.From patients(n=1172)completing follow-up,199(17%)subjects had severe COVID-19 and 342(29.2%)reported nasal symptoms.20.6%COVID-19 patients had loss of taste(median score=6),while 11.4%had loss of smell(median score=5).Loss of taste scores,but not loss of smell scores,were significantly increased in severe vs.nonsevere COVID-19 patients.Interleukin(IL)-6 and lactose dehydrogenase(LDH)serum levels were positively correlated with loss of taste scores.About 80%of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks.In this cohort,only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19.Most patients recovered smell and taste dysfunctions in 2 weeks.
基金supported by the Collabo R&D between Industry,Academy,and Research Institute(S3250534)funded by the Ministry of SMEs and Startups(MSS,Korea)the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00218176)the Soonchunhyang University Research Fund.
文摘Human Action Recognition(HAR)in uncontrolled environments targets to recognition of different actions froma video.An effective HAR model can be employed for an application like human-computer interaction,health care,person tracking,and video surveillance.Machine Learning(ML)approaches,specifically,Convolutional Neural Network(CNN)models had beenwidely used and achieved impressive results through feature fusion.The accuracy and effectiveness of these models continue to be the biggest challenge in this field.In this article,a novel feature optimization algorithm,called improved Shark Smell Optimization(iSSO)is proposed to reduce the redundancy of extracted features.This proposed technique is inspired by the behavior ofwhite sharks,and howthey find the best prey in thewhole search space.The proposed iSSOalgorithmdivides the FeatureVector(FV)into subparts,where a search is conducted to find optimal local features fromeach subpart of FV.Once local optimal features are selected,a global search is conducted to further optimize these features.The proposed iSSO algorithm is employed on nine(9)selected CNN models.These CNN models are selected based on their top-1 and top-5 accuracy in ImageNet competition.To evaluate the model,two publicly available datasets UCF-Sports and Hollywood2 are selected.
文摘Odors that induce psychological orbehavioral changes in the same species——fright in a catfish^2,sexual arousal in abull—are called pheromones^3.And nowheredo such odors have more profound aneffect than among the bees,wasps,ants,and termites^4:Pheromones are the chemicalmessages that these insects use to organizetheir complex societies.The queen honeybee preserves hermonarchy^5 by exuding^6 an odor thatnhibits worker bees from laying eggs
文摘Software systems have been employed in many fields as a means to reduce human efforts;consequently,stakeholders are interested in more updates of their capabilities.Code smells arise as one of the obstacles in the software industry.They are characteristics of software source code that indicate a deeper problem in design.These smells appear not only in the design but also in software implementation.Code smells introduce bugs,affect software maintainability,and lead to higher maintenance costs.Uncovering code smells can be formulated as an optimization problem of finding the best detection rules.Although researchers have recommended different techniques to improve the accuracy of code smell detection,these methods are still unstable and need to be improved.Previous research has sought only to discover a few at a time(three or five types)and did not set rules for detecting their types.Our research improves code smell detection by applying a search-based technique;we use the Whale Optimization Algorithm as a classifier to find ideal detection rules.Applying this algorithm,the Fisher criterion is utilized as a fitness function to maximize the between-class distance over the withinclass variance.The proposed framework adopts if-then detection rules during the software development life cycle.Those rules identify the types for both medium and large projects.Experiments are conducted on five open-source software projects to discover nine smell types that mostly appear in codes.The proposed detection framework has an average of 94.24%precision and 93.4%recall.These accurate values are better than other search-based algorithms of the same field.The proposed framework improves code smell detection,which increases software quality while minimizing maintenance effort,time,and cost.Additionally,the resulting classification rules are analyzed to find the software metrics that differentiate the nine code smells.
文摘Somerset Maugham<sup>2</sup> inquired of one of H·G·Wells’s<sup>3</sup> mistresses<sup>4</sup> why such a paunchy<sup>5</sup>, homely<sup>6</sup> writer had such success with women.He smells of honey, she said. Body odors are the smell of acids produced by bacteria metabolizing skin secretions.<sup>7</sup> The most repellent<sup>8</sup> odors result from the apocrine glands<sup>9</sup>, associated with underarm and genital hair<sup>10</sup> and activated<sup>11</sup> when we’re frightened, excited, or aroused. Men have more and larger apocrine glands than women, blacks more than Caucasians,<sup>12</sup> Caucasians more than Orientals.<sup>13</sup> Varying skin acidity controls the size of
文摘Once there was a stingy(小气的)baker.He was angry at a poor man who would standoutside the bakery(面包房)every day,savoring(品尝)the scent of baking bread.The bakerfelt that anyone who smelled his delicious products should have to pay for the privilege.So
文摘BACKGROUND There are numerous conflicting discussions about the outbreak of the new coronavirus 2019(COVID-19).AIM To present some anatomical and physiological considerations about two of the symptoms reported by patients:The loss or reduction of smell and taste.METHODS The loss or reduction of smell and taste is presented in a peculiar way,with some cases of persistence even after COVID-19.For this,it was searched in three databases,PubMed/MEDLINE,Web of Science,and Scopus,using the following keywords:"Smell","Taste","Smell AND COVID-19","Taste AND COVID-19",with no publication time restriction,only in English with full text available,excluding also brief communications,letters to the editor,editorials,reviews,comments,and conference abstracts.RESULTS The search found 776 articles in the PubMed/MEDLINE database,1018 in the Web of Science database,and 552 in the Scopus database,from which duplicates were removed(104 articles).Finally,17 studies were selected for detailed analysis within the eligibility criteria,with titles and abstracts related to central nervous system lesions responsible for smell and taste.This review suggests that viral mechanisms of action may be related to lesions both at the local level and at the level of the central nervous system,lasting up to 3 to 4 wk.It is considered persistent if it exceeds this period,as reported in one case in this review.There are still few studies about the treatment,and among those addressed in this review,only two studies reported possible treatments and emphasized the scarcity of data,with the best option being treatments that do not cause harm,such as gustatory and olfactory physiotherapy CONCLUSION Given the scarcity of data,this review emphasizes the importance of prevention,through the correct use of personal protective equipment by health professionals and respect for local behavioral indications.It is also emphasized,through five studies,that there is a predominance of such symptoms in patients with COVID-19,which can be a tool to control dissemination,through the early isolation of patients until the results are ready.
文摘Coronavirus disease 2019(COVID-19)is caused by SARS-CoV2 and is still not yet under complete control and no cure is available until this moment.It is still unpredictable to expect vaccination available worldwide in the near future.Early diagnosis hence becomes extremely important.Various papers have proven that early identification of loss of smell and taste is of significance in the diagnosis of this disease.Some patients of COVID-19 may carry on suffering from loss of smell and taste even long after the other symptoms of the infection subside.The aetiology,pathology,and mechanism of loss of smell and taste are discussed in this article,pointing out that impairment of meridians,disturbed Brain-Shen and dysfunction of the Zang-Fu organs are the key pathology of loss of smell and taste by COVID-19.Traditional Chinese medicine resolution with acupuncture and Chinese herbs are therefore demonstrated accordingly,aiming to establish some practical and effective strategies to deal with loss of smell and taste.This unique presentation in the treatment illustrate that even though loss of smell and taste being a single symptom,it requires a profound understanding on the complicated and sophisticated background mechanism of the COVID-19,which is urgently in need of comprehensive treatment in time.Loss of smell and taste by COVID-19 is not only a minor suffering of the infection,but also a very critical part of a fully recovery of COVID-19,it shall not be left untreated.
文摘Once an old couple stayed over night at a small hotel in the countryside. Their room wasvery hot in the night, so the husband got up in the dark to open the door. When he got back, hiswife asked him what kind of night it was. "I don t think it s raining," he replied. "But it s pitch-dark(漆黑的), and there is a
文摘Code smell detection is essential to improve software quality, enhancing software maintainability, and decrease the risk of faults and failures in the software system. In this paper, we proposed a code smell prediction approach based on machine learning techniques and software metrics. The local interpretable model-agnostic explanations (LIME) algorithm was further used to explain the machine learning model's predictions and interpretability. The datasets obtained from Fontana et al. were reformed and used to build binary-label and multi-label datasets. The results of 10-fold cross-validation show that the performance of tree-based algorithms (mainly Random Forest) is higher compared with kernel-based and network-based algorithms. The genetic algorithm based feature selection methods enhance the accuracy of these machine learning algorithms by selecting the most relevant features in each dataset. Moreover, the parameter optimization techniques based on the grid search algorithm significantly enhance the accuracy of all these algorithms. Finally, machine learning techniques have high potential in predicting the code smells, which contribute to detect these smells and enhance the software's quality.
文摘Medications frequently have chemosensory side effects that can adversely affect compliance with medical treatment regimens. Hundreds of drugs have been reported to induce unpleasant tastes and/or odors as well as altered chemosensations when administered alone or in combination with other medications. Some chemosensory complaints are due to the sensory properties of the drug itself such as aversive bitter and metallic tastes. However, most chemo-sensory side effects of drugs are due to alterations in the transduction pathways, biochemical targets, enzymes, and transporters by the offending medications. Studies of chemosensory perception in medicated older individuals have found that taste and smell loss is greatest for those consuming the largest number of prescription drugs. There are no standard treat-ments for drug-induced chemosensory disorders because each drug has unique biological ef-fects. However, there are a few treatment options to ameliorate chemosensory alterations including addition of simulated flavors to food to compensate for losses and to override offend-ing tastes and smells.
文摘Food selection plays a pivotal role in maintaining adequate nutrient intake, thus elucidating drivers of food choice is a meaningful strategy to maintain health and manage dis-ease. Taste and smell are key determinants of food choice and warrant careful consideration. In this review, we first discuss how sensory stimulation influences food selection and meta-bolism. We then review the evidence regarding the relationship between taste and smell dysfunction and food preferences and selection, with attention given to contexts of certain chronic diseases. We conclude with brief recommendations for the management of chemosen-sory disorders. While sensory abilities influence food selection, the effect of taste and smell dysfunction on long-term consumption patterns and health status must be considered in light of environment, exposure, and culture.
基金supported by the National Natural Science Foundation of China under Grant No.61772200the Natural Science Foundation of Shanghai under Grant No.21ZR1416300.
文摘Community smells are sub-optimal developer community structures that hinder productivity.Prior studies performed smell prediction and provided refactoring guidelines from a top-down aspect to help community shepherds.Simultaneously,refactoring smells also requires bottom-up effort from every developer.However,supportive measures and guidelines for them are not available at a fine-grained level.Since recent work revealed developers'personalities and working states could influence community smells'emergence and variation,we build prediction models with experience,sentiment,and development process features of developers considering three smells including Organizational Silo,Lone Wolf,and Bottleneck,as well as two related classes including smelly developer and smelly quitter.We predict the five classes in the individual granularity,and we also generate forecasts for the number of smelly developers in the community granularity.The proposed models achieve F-measures ranging from 0.73 to 0.92 in individual-wide within-project,time-wise,and cross-project prediction,and mean R2 performance of 0.68 in community-wide Smelly Developer prediction.We also exploit SHAP(SHapley Additive exPlanations)to assess feature importance to explain our predictors.In conclusion,we suggest developers with heavy workload should foster more frequent communication in a straightforward and polite way to build healthier communities,and we recommend community shepherds to use the forecasting model for refactoring planning.
文摘我们热情地向读者推荐这篇科普性和趣味性俱佳的短文。BBC English在原文前加了这样一句话: Humans might think they lead the rest of the animal world, but as Dilys Bressesreveals, when it comes to the five senses, many animals leave us behind. 而读了此文,读者不仅会认识嗅觉的奇妙功能,而且不得不承认,就嗅觉言,在许多动物面前,人类只得自叹弗如。 嗅觉的产生主要依靠什么? In mammals, smells are detected by a thin layer of very sensitive cells in the nosecalled the olfactory epithelium (嗅觉上皮组织). 人类的嗅觉所以不如狗,原因就在于此: Humans only have about five square centimeters of thesc cells, while an Alsatian dog,for example, has 150 equare centimeters. 我们称smell为“气味”,其实并不科学。因为,smell也同样存在于水中。如: …but scents can be detected in water too. The hammerhead can detect blood at several hundred meters. 以下这句话,读者也许没有想到过,但言之有理: Sight and hearing provide information too, but in short lived messages. Theadvantage of scent is that it can remain for hours or days. 下面这一则信息真令人类叹?