Rare primary gastric peripheral T-cell lymphoma not otherwise specified:A case report

BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastric peripheral T-cell lymphoma-not otherwise specified(PTCL-NOS)is an extremely rare subtype.CASE SUMMARY We report a 63-year-old male presenting with epigastric pain.Esophagogastro-duodenoscopy revealed a large ulcerative lesion in the gastric cardia.Biopsy and immunohistochemical profiling confirmed PTCL-NOS.Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes.The patient is planned to undergo cyclophosphamide,doxorubicin,vincristine,and prednisone or cyclophosphamide,doxorubicin,vincristine,prednisone,and etoposide chemo-therapy.CONCLUSION This case highlights the necessity of considering PTCL-NOS in differential diag-noses of gastric lesions.Comprehensive histopathological and immunohistoche-mical analysis is crucial for accurate diagnosis and guiding treatment.

Tissue-specific transcriptomics reveals a central role of CcNST1 in regulating the fruit lignification pattern in Camellia chekiangoleosa,a woody oil-crop

Fruit lignification is of significant economic importance because it affects the quality of fruit and the production of seed oil.The specified lignification pattern in Camellia chekiangoleosa fruits plays critical roles in its seed oil yield,but little is known about how this lignification process is regulated.Here,we report on a comprehensive tissue-specific transcriptomics analysis conducted for C.chekiangoleosa fruit.By mining the differentially expressed genes,we found that lignin biosynthesis and transcriptional regulation pathways were significantly enriched in the lignified tissues.The homolog of NST-like transcription factor,CcNST1,was highly expressed in lignified seed coat and endocarp tissues;transgenic analyses of CcNST1 in Arabidopsis and hybrid poplar revealed the enhanced lignification levels of various tissues.Gene expression analysis of the transgenic lines uncovered potential downstream genes involved in the regulation of lignin biosynthesis.This work provides a valuable gene expression resource and identified the pivotal role of CcNST1 in regulating the lignin biosynthesis underlying fruit lignification.

Autoimmune pancreatitis not otherwise specified(NOS): Clinical features and outcomes of the forgotten type

Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these patients.The aim of this study was to investigate clinical and radiological features of AIP type NOS-patients.Methods:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were evaluated.Epidemiological,clinical data were collected and analyzed.Results:Forty-six patients were included in the study.The clinical onset was mainly characterized by weight loss,jaundice and acute pancreatitis.Eight patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.Seven patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent relapses.Conclusions:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.The risk of relapse is low but not irrelevant.

Theoretical Aspect of Suitable Spatial Boundary Condition Specified for Adjoint Model on Limited Area

Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary condition resulting from an adjoint model on a limited-area is no longer an issue, and yet preserve its well-poseness and optimal character in the boundary setting. The ill-poseness of over-specified spatial boundary condition is in a sense, inevitable from an adjoint model since data assimilation processes have to adapt prescribed observations that used to be over-specified at the spatial boundaries of the modeling domain. In the view of pragmatic implement, the theoretical framework of our proposed condition for spatial boundaries indeed can be reduced to the hybrid formulation of nudging filter, radiation condition taking account of ambient forcing, together with Dirichlet kind of compatible boundary condition to the observations prescribed in data assimilation procedure. All of these treatments, no doubt, are very familiar to mesoscale modelers. Key words Variational data assimilation - Adjoint model - Over-specified partial boundary condition This research work is sponsored by the National Key Programme for Developing Basic Sciences (G1998040907), the Project of Natural Science Foundation of Jiangsu Province (BK99020), the President Foundation of Nanjing University (985) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

Secure Order-Specified Multisignature Scheme Based on DSA

In multisignature schemes signers can sign either in a linear order or not in any specified order, but neither of them is adequate in some scenarios where require mixture using of orderless and ordered multisignature. Most order-specified multisignatures specified the orders as linear ones. In this paper, we proposed an order-specified multisignature scheme based on DSA secure against active insider attack. To our knowledge, it is the first order-specified multisignature scheme based on DSA signature scheme, in which signers can sign in flexible order represented by series-parallel graphs. In the multisignature scheme verification to both signers and signing order are available. The security of the scheme is proved by reduce to an identification scheme that is proved have some concrete security. The running time of verifying a signature is comparable to previous schemes while the running time of multisignature generation and the space needed is less than those schemes.

A Review of Comprehensive River Regulation Specification

Comprehensive river regulation in the new era is a series of construction procedures from planning,scheme generation and engineering design to commercial pattern,construction and operation,etc.,which is a comprehensive project coordinated and managed by multiple departments.Different industry departments measure the feasibility of scheme design according to the standards of their own departments in the examination of river regulation,but due to the lack of understanding of other industry standards,some unnecessary scheme contradictions are often caused in the cross-industry cooperation.The study integrates and sorts out specifi cations of various departments involved in river regulation,and performs analogy study of standards of various contents in multi-industry cooperation with contents of comprehensive river regulation as the scale,so as to promote cross-industry communication of comprehensive river regulation and promote construction of integrated river regulation platform.

Backward Dijkstra Algorithms for Finding the Departure Time Based on the Specified Arrival Time for Real-Life Time-Dependent Networks

A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “Dynamic ” Networks is considered in this study. Although shortest path (SP) for dynamic networks have been studied/documented by various researchers, contributions from this present work consists of a sparse matrix storage scheme for efficiently storing large scale sparse network’s connectivity, a concept of Time Delay Factor (TDF) combining with a “general piece- wise linear function” to describe the link cost as a function of time for Non-FIFO links’ costs, and Backward Dijkstra SP Algorithm with simple heuristic rules for rejecting unwanted solutions during the backward search algorithm. Both small-scale (academic) networks as well as large- scale (real-life) networks are investigated in this work to explain and validate the proposed dynamic algorithms. Numerical results obtained from this research work have indicated that the newly proposed dynamic algorithm is reliable, and efficient. Based on the numerical results, the calculated departure time at the source node(s), for a given/specified arrival time at the destination node(s), can be non-unique, for some Non-FIFO networks’ connectivity.

Designing mixed <i>H</i>₂/<i>H</i>_&infin;structure specified controllers using Particle Swarm Optimization (PSO) algorithm

This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).

A Fatal Case of Chronic Eosinophilic Leukemia Not Otherwise Specified (CEL-NOS) in a 19-Year-Old Male with Acute Transformation into Blast Crisis

Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndrome (HES) by the presence of eosinophilic clonality. Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) diagnosis is made when no fusion genes are detected by most modern molecular testing, particularly the most common fusion gene FIP1L-1/PDGFRA (Factor Interacting with PAP like-1/Platelet-Derived Growth Factor Receptor Alpha). This disease is very rare, and its description in the literature is not well characterized. We report a fetal case of severe CEL-NOS in a 19-year-old male who presented with a plethora of clinical features consists of constitutional symptoms, pancytopenia, intravascular thrombosis, acute stroke and endomyocardial infiltrates. The course of his disease was aggressive and resistant to conventional treatment. After a short period of improvement, an acute transformation into blast crisis (BC) had occurred. The diagnosis was confirmed by morphology and immunophenotyping of bone marrow biopsy. The patient eventually died of heart failure and sepsis. To our knowledge this is the first case report of fatal CEL-NOS transforming into severe blast crisis.

International Standard for TCM Technology:Specification of Health Tai Chi(Heart-Lung Benefiting Tai Chi)

This specification is mainly drafted by Beijing Sport University(BSU),Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine in accordance with the drafting procedure specified in The General Rules for the Compilation of International Traditional Chinese Medicine(TCM)Technical Specifications and The Common Standards for the Compilation of International Standards for TCM Technology.

儿童过敏性鼻炎伴食物过敏原检测阳性的临床特征分析

目的总结过敏性鼻炎(AR)伴食物过敏原检测阳性患儿的临床特征,为制订AR儿童的饮食及营养方案提供依据。方法本研究为回顾性分析,选取2021年1月至2022年12月于首都医科大学附属北京同仁医院变态反应科就诊的330例AR伴食物过敏原检测阳性患儿为研究对象。收集患儿血清过敏原检测结果,包括血清总免疫球蛋白E(IgE)以及13种食物过敏原的血清特异性免疫球蛋白E(sIgE),分析其临床特征和食物过敏原分布特点。结果330例AR伴食物过敏原检测阳性患儿中男性209例(63.33%),女性121例(36.67%);中位就诊年龄5岁,按年龄进行分组,其中<3岁组17例,3~<6岁组155例和≥6岁组158例,年龄≥6岁患儿占比最高(47.88%)。血清总IgE为4~4674 kUA/L,中位数167 kUA/L,其中检测结果升高者(≥60 kUA/L)占78.18%。99例患儿吸入性过敏原筛查阴性,231例患儿吸入性过敏原筛查阳性,吸入性过敏原筛查阴性患儿的血清总IgE升高比例(51.52%)低于吸入性过敏原筛查阳性患儿(89.61%),差异有统计学意义(P<0.05);不同年龄患儿血清总IgE升高比例比较差异有统计学意义(P<0.05),≥6岁组血清总IgE升高比例最高(51.94%),其次是3~<6岁组(42.64%)。食物过敏原阳性检出率最高的3种食物分别是牛奶(72.42%)、蛋清/蛋白(22.42%)和水果类(13.94%);对不同年龄、性别患儿的食物过敏原分布进行比较,结果显示女性患儿的蛋清/蛋白阳性率高于男性,蛋清/蛋白阳性率在<3岁年龄患儿中最高,其次是3~<6岁,最低的是≥6岁,差异均有统计学意义(P<0.05)。结论儿童AR伴食物过敏原检测阳性以男性患儿更为多见,牛奶、蛋清/蛋白及水果类为主要食物过敏原,且女性患儿及年龄<3岁患儿的蛋清/蛋白阳性率最高。

光伏出力序列场景生成新方法

面向更精准的中长期电力电量平衡校验,提出横纵向融合及人为指定持续极端日的光伏出力场景生成新方法。首先,依据日辐照度特征指标及聚类把历史数据划分为多个极端日和多个典型日;然后,利用马氏链生成下一个月横向辐照度日类型序列及特征指标序列的基础上,提出基于日类型出现概率及日类型允许转换矩阵的辐照度日类型序列生成方法,生成下一个月纵向日类型序列及特征指标序列,并将横纵向数据进行融合;最后,基于优化方法及光电转化模型生成月度光伏出力场景,并在此基础上提出人为指定持续极端日光伏出力序列场景生成方法。算例表明所提算法能更好地为运行调度提供参考。

Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Background:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial.Whether the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was uncertain.Methods:In this phase 3,double-blind,placebo-controlled trial,we randomly assigned(in a 1:1 ratio)participants with clear-cell renal-cell carcinoma who had an increased risk of recurrence after surgery to receive pembrolizumab(at a dose of 200 mg)or placebo every 3 weeks for up to 17 cycles(approximately 1 year)or until recurrence,the occurrence of unacceptable toxic effects,or withdrawal of consent.A significant improvement in disease-free survival according to investigator assessment(the primary end point)was shown previously.Overall survival was the key secondary end point.Safety was a secondary end point.

论违约方申请合同解除中解除时间的确定——兼评《民法典合同编通则解释》第59条

最高人民法院在违约方申请合同解除中解除时间的规定上变化较大。整体而言,存在法院自由裁量说和确定日期说。从合同终止(解除)的功能目的、体系解释以及规则设计的内在逻辑看,确定日期说是能够实现效率、合乎规则体系以及任意性规则设计等更优的和理想的选择。自由裁量说虽然描述了法院的多数实际做法,但其原理内核仍然只能是确定日期说。这一分析能够为法院在违约方申请合同解除中解除时间点确定上的一般情况与例外情况提供更好的指引。

从动物防疫角度浅谈实验动物运输的法律规定

实验动物运输活动应按照相关法律规定做好动物防疫工作,以防止实验动物疫病远距离跨地区传播。本文从动物防疫的角度概括了国内机构通过道路运输实验动物,尤其是向无规定动物疫病区运输实验动物,在运输前、中、后不同环节应遵循的法律规定及相关要求,并指出运输环节易出现的违规问题及处罚规定,提出了动物防疫部门应加强运输实验动物的动物卫生监管及相关法律法规宣传,实验动物运输机构应加强动物防疫相关法规的学习,做到依法运输实验动物。本文为相关单位及人员做好实验动物卫生防疫工作提供参考。

Lock-in phenomenon of tip clearance flow and its influence on aerodynamic damping under specified vibration on an axial transonic compressor rotor

In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.

Leader-following cooperative guidance law with specified impact time

The problem of guidance law is investigated for multiple interceptors to attack a target cooperatively.A leader-following cooperative guidance strategy is presented to render the leader and the followers reach the target at specified impact time.The guidance law of leader is given to meet the demand of specified impact time.The arrival time is synchronized by enforcing the ranges-to-go of followers keep consensus with that of leader.The convergence time bound is estimated without dependence on the initial states,since the proposed leader-following cooperative guidance law is fixed-time convergent.The simulation is developed to validate the availability of proposed cooperative guidance law.

Efficient processing of partially specified twig pattern queries

As huge volumes of data are organized or exported in tree-structured form, it is quite necessary to extract useful information from these data collections using effective and efficient query processing methods. A natural way of retrieving desired information from XML documents is using twig pattern （TP）, which is, actually, the core component of existing XML query languages. Twig pattern possesses the inherent feature that query nodes on the same path have concrete precedence relationships. It is this feature that makes it infeasible in many actual scenarios. This has driven the requirement of relaxing the complete specification of a twig pattern to express more flexible semantic constraints in a single query expression. In this paper, we focus on query evaluation of partially specified twig pattern （PSTP） queries, through which we can reap the most flexibility of specifying partial semantic constraints in a query expression. We propose an extension to XPath through introducing two Samepath axes to support partial semantic constraints in a concise but effective way. Then we propose a stack based algorithm, pTwigStack, to process a PSTP holistically without deriving the concrete twig patterns and then processing them one by one. Further, we propose two DTD schema based optimization methods to improve the performance of pTwigStack algorithm. Our experimental results on various datasets indicate that our method performs significantly better than existing ones when processing PSTPs.

Bivalirudin is superior to heparins alone with bailout GP Ⅱb / Ⅲa inhibitors in patients with ST-segment elevation myocardial infarction transported emergently for primary percutaneous coronary intervention: a pre-specified analysis from the EUROMAX tria

Aims In the HORIZONS trial, in-hospital treatment with bivalirudin reduced bleeding and mortality in primary percutaneous coronary intervention（PCI） compared with heparin and routine glycoprotein Ⅱb / Ⅲa inhibitors（GPI）. It is unknown whether this advantage of bivalirudin is observed in comparison with heparins only with GPI used as bailout. Methods and results In the EUROMAX study, 2198 patients with ST-segment elevation myocardial infarction（STEMI） were randomized during transport for primary PCI to bivalirudin or to heparins with optional GPI. Primary and principal outcome was the composites of death or nonCABG-related major bleeding at 30 days. This pre-specified analysis compared patients receiving bivalirudin（n = 1089） with those receiving heparins with routine upstream GPI（n = 649） and those receiving heparins only with GPI use restricted to bailout（n = 460）. The primary outcome death and major bleeding occurred in5.1% with bivalirudin, 7.6% with heparin plus routine GPI（HR 0.67 and 95% CI 0.46-0.97, P = 0.034）,and 9.8% with heparins plus bailout GPI（HR 0.52 and 95% CI 0.35-0.75, P = 0.006）. Following adjustment by logistic regression, bivalirudin was still associated with significantly lower rates of the primary outcome（odds ratio 0.53, 95% CI 0.33-0.87） and major bleeding（odds ratio 0.44, 95% CI 0.24 – 0.82） compared with heparins alone with bailout GPI. Rates of stent thrombosis were higher with bivalirudin（1.6 vs. 0.6 vs.0.4%, P = 0.09 and 0.09）. Conclusion Bivalirudin, started during transport for primary PCI, reduces major bleeding compared with both patients treated with heparin only plus bailout GPI and patients treated with heparin and routine GPI, but increased stent thrombosis.