Based on the program developed to simulate the temperature field for ISM(Induction Skull Melting) process, the effects of power increasing rate and charge mass on the melting throughout time and the energy (consumptio...Based on the program developed to simulate the temperature field for ISM(Induction Skull Melting) process, the effects of power increasing rate and charge mass on the melting throughout time and the energy (consumption) for TiAl alloys were studied. The results show that the melting throughout time decreases (exponentially) with the increasing of the power increasing rate and it linearly increases with the increasing of the charge mass. There is a critical power increasing rate for different charge masses. At this critical power increasing rate, the charge can be molten when the melting power just reaches 300 kW. There exists an optimal power increasing rate, i.e. 1.3 kW/s. At the optimal power increasing rate, the energy consumption for melting the charge is the minimum. The charge mass has noticeable influence on the energy consumed by unit mass and the ratio of effective energy.展开更多
目的观察基于“互联网+”背景下的肿瘤化疗患者营养全程管理体系对胃癌化疗患者生活质量、营养状态的影响。方法选取2020年6月—2021年12月至厦门大学附属第一医院肿瘤内科化疗的100例胃癌化疗的患者。厦门大学附属第一医院肿瘤内科于2...目的观察基于“互联网+”背景下的肿瘤化疗患者营养全程管理体系对胃癌化疗患者生活质量、营养状态的影响。方法选取2020年6月—2021年12月至厦门大学附属第一医院肿瘤内科化疗的100例胃癌化疗的患者。厦门大学附属第一医院肿瘤内科于2021年3月联合多学科成立了营养支持专科小组,成员包括各级医生、护士,并且充分利用互联网的各种优势,对厦门大学附属第一医院肿瘤内科化疗患者实行全程营养支持管理。将2020年6月—2021年2月营养全程管理体系成立前的50例胃癌化疗患者设为对照组,实行常规的营养支持管理;将2021年3—12月营养全程管理体系成立后的50例胃癌化疗患者设为观察组,实行基于“互联网+”背景下的肿瘤化疗患者个性化的营养全程管理。比较2组患者营养状况、生活质量评分。结果干预后,2组患者的主观整体营养风险评估(subjective nutrition assessment for cancer patients,PG-SGA)评分均较干预前明显降低,且对照组PG-SGA明显低于观察组(P<0.05)。对照组患者的身体质量指数(body mass index,BMI)(18.59±2.60)kg/m^(2)、血清白蛋白(33.00±5.01)g/L、血红蛋白(110.00±18.02)g/L,均低于观察组BMI(20.65±1.51)kg/m^(2)、血清白蛋白(38.00±8.00)g/L、血红蛋白(135.00±20.01)g/L(P<0.05)。对照组的生活质量Karnofsky评分(75.77±7.01)分明显低于观察组(81.59±7.21)分(P<0.05)。结论基于“互联网+”背景下的肿瘤化疗患者营养全程管理体系应用于胃癌患者化疗过程中,可明显改善患者的营养状态,提高患者的生活质量。展开更多
Objective To develop a simple,cheap,quick,accurate and practical method for a high throughout genotypes assay of human papillomavirus (HPV) DNA. Methods Crude DNA was extracted by a simplified proteinase K digesting...Objective To develop a simple,cheap,quick,accurate and practical method for a high throughout genotypes assay of human papillomavirus (HPV) DNA. Methods Crude DNA was extracted by a simplified proteinase K digesting method. HPV common conservative primers: GP5+/6+ system was used to amplify HPV DNA in 127 samples of condylomata acuminatum (CA) and cervical scrapes by PCR,then the PCR product was assayed using a template directing terminator incorporation (TDI) and genotypes were detected with fluorescence polarization (FP). Major HPVs type-specific probes (HPV6,11,16,18,31,33,35 and 58) designed by us were hybridized with the specific PCR products and a special fluorescent ddNTP terminator was directly added to the end of the probe under direction of specific PCR products. The results were measured with FP and compared with the results of the DNA sequence. Results Compared with the results of DNA sequencing,the results detected with fluorescence polarization were all correct. The proposed method could detect more than one type of HPV infection,but DNA sequencing method could not. The positive rate of HPV was 100% in 78 CA biopsies. Among them,there were 14 HPV double infections [HPV6B and 11 (9 cases),HPV11 and 16 (4),HPV11 and 18 (1)],5 HPV triple infections [HPV6B,11 and 16 (4),HPV11,16 and 18 (1)],and one HPV quadruple infection (HPV6B,11,16 and 18). The positive rate of HPV was 77% in the 49 cervical scrapes. Six HPV double infections [HPV6B and 11 (2),HPV11 and 16 (1),HPV6B and 16 (1),HPV16 and 18 (1),HPV18 and 58 (1)], 3 HPV triple infections [HPV6B,11 and 16 (2),HPV11,16 and 18 (1)] and one HPV quadruple infection (HPV6B,11,16 and 18) were detected in cervical cancer scrapes.Conclusions The proposed method allowed a high throughout,special,simple,rapid,automatic and economical detection of HPV-DNA genotyping without a use of labeling probes. It can detect multiple HPV genotype infection and will be and useful tool in HPV genotype screening.展开更多
基金Project(50271020 50395102) supported by the National Natural Science Foundation of China Project(2002AA305209)supported by Hi tech Research and Development Program of China
文摘Based on the program developed to simulate the temperature field for ISM(Induction Skull Melting) process, the effects of power increasing rate and charge mass on the melting throughout time and the energy (consumption) for TiAl alloys were studied. The results show that the melting throughout time decreases (exponentially) with the increasing of the power increasing rate and it linearly increases with the increasing of the charge mass. There is a critical power increasing rate for different charge masses. At this critical power increasing rate, the charge can be molten when the melting power just reaches 300 kW. There exists an optimal power increasing rate, i.e. 1.3 kW/s. At the optimal power increasing rate, the energy consumption for melting the charge is the minimum. The charge mass has noticeable influence on the energy consumed by unit mass and the ratio of effective energy.
文摘目的观察基于“互联网+”背景下的肿瘤化疗患者营养全程管理体系对胃癌化疗患者生活质量、营养状态的影响。方法选取2020年6月—2021年12月至厦门大学附属第一医院肿瘤内科化疗的100例胃癌化疗的患者。厦门大学附属第一医院肿瘤内科于2021年3月联合多学科成立了营养支持专科小组,成员包括各级医生、护士,并且充分利用互联网的各种优势,对厦门大学附属第一医院肿瘤内科化疗患者实行全程营养支持管理。将2020年6月—2021年2月营养全程管理体系成立前的50例胃癌化疗患者设为对照组,实行常规的营养支持管理;将2021年3—12月营养全程管理体系成立后的50例胃癌化疗患者设为观察组,实行基于“互联网+”背景下的肿瘤化疗患者个性化的营养全程管理。比较2组患者营养状况、生活质量评分。结果干预后,2组患者的主观整体营养风险评估(subjective nutrition assessment for cancer patients,PG-SGA)评分均较干预前明显降低,且对照组PG-SGA明显低于观察组(P<0.05)。对照组患者的身体质量指数(body mass index,BMI)(18.59±2.60)kg/m^(2)、血清白蛋白(33.00±5.01)g/L、血红蛋白(110.00±18.02)g/L,均低于观察组BMI(20.65±1.51)kg/m^(2)、血清白蛋白(38.00±8.00)g/L、血红蛋白(135.00±20.01)g/L(P<0.05)。对照组的生活质量Karnofsky评分(75.77±7.01)分明显低于观察组(81.59±7.21)分(P<0.05)。结论基于“互联网+”背景下的肿瘤化疗患者营养全程管理体系应用于胃癌患者化疗过程中,可明显改善患者的营养状态,提高患者的生活质量。
文摘Objective To develop a simple,cheap,quick,accurate and practical method for a high throughout genotypes assay of human papillomavirus (HPV) DNA. Methods Crude DNA was extracted by a simplified proteinase K digesting method. HPV common conservative primers: GP5+/6+ system was used to amplify HPV DNA in 127 samples of condylomata acuminatum (CA) and cervical scrapes by PCR,then the PCR product was assayed using a template directing terminator incorporation (TDI) and genotypes were detected with fluorescence polarization (FP). Major HPVs type-specific probes (HPV6,11,16,18,31,33,35 and 58) designed by us were hybridized with the specific PCR products and a special fluorescent ddNTP terminator was directly added to the end of the probe under direction of specific PCR products. The results were measured with FP and compared with the results of the DNA sequence. Results Compared with the results of DNA sequencing,the results detected with fluorescence polarization were all correct. The proposed method could detect more than one type of HPV infection,but DNA sequencing method could not. The positive rate of HPV was 100% in 78 CA biopsies. Among them,there were 14 HPV double infections [HPV6B and 11 (9 cases),HPV11 and 16 (4),HPV11 and 18 (1)],5 HPV triple infections [HPV6B,11 and 16 (4),HPV11,16 and 18 (1)],and one HPV quadruple infection (HPV6B,11,16 and 18). The positive rate of HPV was 77% in the 49 cervical scrapes. Six HPV double infections [HPV6B and 11 (2),HPV11 and 16 (1),HPV6B and 16 (1),HPV16 and 18 (1),HPV18 and 58 (1)], 3 HPV triple infections [HPV6B,11 and 16 (2),HPV11,16 and 18 (1)] and one HPV quadruple infection (HPV6B,11,16 and 18) were detected in cervical cancer scrapes.Conclusions The proposed method allowed a high throughout,special,simple,rapid,automatic and economical detection of HPV-DNA genotyping without a use of labeling probes. It can detect multiple HPV genotype infection and will be and useful tool in HPV genotype screening.
