Domain-domain interactions are important clues to inferring protein-protein interactions. Although about 8 000 domain-domain interactions are discovered so far,they are just the tip of the iceberg. Because domains are...Domain-domain interactions are important clues to inferring protein-protein interactions. Although about 8 000 domain-domain interactions are discovered so far,they are just the tip of the iceberg. Because domains are conservative and commonplace in proteins,domain-domain interactions are discovered based on pairs of domains which significantly co-exist in proteins. Meanwhile,it is realized that:( 1) domain-domain interactions may exist within the same proteins or across different proteins;( 2) only the domain-domain interactions across different proteins can mediate interactions between proteins;( 3) domains have biases to interact with other domains. And then,a novel method is put forward to construct protein-protein interaction network by using domain-domain interactions. The method is validated by experiments and compared with the state- of-art methods in the field. The experimental results suggest that the method is reasonable and effectiveness on constructing Protein-protein interactions network.展开更多
Smart environment is being used in many areas to deliver more services to individuals in a physical space, such as a hospital. In the UK, the National Health Service(NHS) provides free and high quality healthcare serv...Smart environment is being used in many areas to deliver more services to individuals in a physical space, such as a hospital. In the UK, the National Health Service(NHS) provides free and high quality healthcare service for all residents. Smart hospital environment is able to support NHS and provide more convenience. Patient flow scheduling is a crucial section in a smart hospital environment. Smart hospital environment aims to provide a smart environment in the hospital to facilitate individual experience and improve the quality of healthcare service.First of all, this paper investigates a real world patient flow scenario of a hospital in the UK and models a general scheduling scheme based on the scenario using a compositional formal approach, i.e. performance evaluation process algebra(PEPA). This scheduling scheme uses an easy-implemented solution(the grouping scheme) to reduce the waiting queue in the hospital. Secondly, fluid flow analysis is used for the performance analysis by generating a set of ordinary differential equations(ODEs) in terms of the PEPA model.展开更多
基金Sponsored by the National Natural Science Foundation of China(Grant No.61271346,61571163,61532014,91335112 and 61402132)the Fundamental Research Funds for the Central Universities(Grant No.DB13AB02)
文摘Domain-domain interactions are important clues to inferring protein-protein interactions. Although about 8 000 domain-domain interactions are discovered so far,they are just the tip of the iceberg. Because domains are conservative and commonplace in proteins,domain-domain interactions are discovered based on pairs of domains which significantly co-exist in proteins. Meanwhile,it is realized that:( 1) domain-domain interactions may exist within the same proteins or across different proteins;( 2) only the domain-domain interactions across different proteins can mediate interactions between proteins;( 3) domains have biases to interact with other domains. And then,a novel method is put forward to construct protein-protein interaction network by using domain-domain interactions. The method is validated by experiments and compared with the state- of-art methods in the field. The experimental results suggest that the method is reasonable and effectiveness on constructing Protein-protein interactions network.
基金the National Natural Science Foundation of China(Nos.61502206 and 61472343)the Natural Science Foundation of Jiangsu Province(Nos.BK20160543 and BK20150523)the Open Project of Key Laboratory of Jiangsu Province(No.BM20082061507)
文摘Smart environment is being used in many areas to deliver more services to individuals in a physical space, such as a hospital. In the UK, the National Health Service(NHS) provides free and high quality healthcare service for all residents. Smart hospital environment is able to support NHS and provide more convenience. Patient flow scheduling is a crucial section in a smart hospital environment. Smart hospital environment aims to provide a smart environment in the hospital to facilitate individual experience and improve the quality of healthcare service.First of all, this paper investigates a real world patient flow scenario of a hospital in the UK and models a general scheduling scheme based on the scenario using a compositional formal approach, i.e. performance evaluation process algebra(PEPA). This scheduling scheme uses an easy-implemented solution(the grouping scheme) to reduce the waiting queue in the hospital. Secondly, fluid flow analysis is used for the performance analysis by generating a set of ordinary differential equations(ODEs) in terms of the PEPA model.
