The development of a new silane reagent derived from tetrachlorosilane (TCS) was applied in the present work. TCS-sodium nitrate (NaNO3) binary reagent and zinc chloride (ZnCl2) were reported here as a homogeneous nit...The development of a new silane reagent derived from tetrachlorosilane (TCS) was applied in the present work. TCS-sodium nitrate (NaNO3) binary reagent and zinc chloride (ZnCl2) were reported here as a homogeneous nitrating system. The later was used for the efficient mono nitration, in most cases, with high para-regioselectivity. The nitration proceeded smoothly under mild condition, fairly clean and in good yields. This readily available and inexpensive system is superior to other methods by avoidance of the use of corrosive nitrating reagents and therefore considered to be convenient in terms of risk reduction, economic advantages and environment protection. The present protocol was convenient and applicable to a variety of aromatic hydrocarbons and could be amenable to high throughput synthesis of combinatorial libraries for potential drug development, which needs to be studied as part of future investigations.展开更多
An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of...An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of tetrachlorosilane (TCS). A binary reagent from (TCS)/ZnCl2 was used upon applying benzonitrile.展开更多
A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosi...A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosilane（TCS） as catalyst under mild conditions.Reaction of the titled compounds with TCSNaN_3 to give novel functionalized pyrano[3,2-c]tetrazolo[1,5-a]azepine derivatives is also described.展开更多
A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield...A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.展开更多
An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide...An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate （TPP） riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.展开更多
文摘The development of a new silane reagent derived from tetrachlorosilane (TCS) was applied in the present work. TCS-sodium nitrate (NaNO3) binary reagent and zinc chloride (ZnCl2) were reported here as a homogeneous nitrating system. The later was used for the efficient mono nitration, in most cases, with high para-regioselectivity. The nitration proceeded smoothly under mild condition, fairly clean and in good yields. This readily available and inexpensive system is superior to other methods by avoidance of the use of corrosive nitrating reagents and therefore considered to be convenient in terms of risk reduction, economic advantages and environment protection. The present protocol was convenient and applicable to a variety of aromatic hydrocarbons and could be amenable to high throughput synthesis of combinatorial libraries for potential drug development, which needs to be studied as part of future investigations.
文摘An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of tetrachlorosilane (TCS). A binary reagent from (TCS)/ZnCl2 was used upon applying benzonitrile.
文摘A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosilane（TCS） as catalyst under mild conditions.Reaction of the titled compounds with TCSNaN_3 to give novel functionalized pyrano[3,2-c]tetrazolo[1,5-a]azepine derivatives is also described.
文摘A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.
文摘An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate （TPP） riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.
