Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landsli...Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas.展开更多
The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechani...The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 bar.Noteworthy seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe earthquake.Areas of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang faults.Additionally,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings.展开更多
Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in...Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related nIOD.However,the characteristics and triggering mechanisms of early nIOD are unclear.Our results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six decades.These two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal cycles.The early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related nIOD.The spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian Ocean.Opposite to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon onset.The results of this study are helpful for improving the prediction skill of IOD and its climate impacts.展开更多
Mechanisms have been proposed to explain the triggering,development,and persistence of soil liquefaction.The mechanism explaining the horizontal failure plane(triggering)and its depth below the phreatic surface is gov...Mechanisms have been proposed to explain the triggering,development,and persistence of soil liquefaction.The mechanism explaining the horizontal failure plane(triggering)and its depth below the phreatic surface is governed by the flux properties and effective stress at that plane.At the failure plane,the pore water pressure was higher than the effective stress,and the volume change was the highest.The pore water pressure is a function of the soil profile features(particularly the phreatic zone width)and bedrock motion(horizontal acceleration).The volume change at the failure plane is a function of the intrinsic permeability of the soil and bedrock displacement.The failure plane was predicted to occur during the oscillation with the highest amplitude,disregarding further bedrock motion,which was consistent with low seismic energy densities.Two mechanisms were proposed to explain the persistence of soil liquefaction.The first is the existence of low-permeability layers in the depth range in which the failure planes are predicted to occur.The other allows for the persistence and development of soil liquefaction;it is consistent with homogeneous soils and requires water inflow from bedrock water springs.The latter explains many of the features of soil liquefaction observed during earthquakes,namely,surficial effects,“instant”liquefaction,and the occurrence of short-and long-term changes in the level of the phreatic surfaces.This model(hypothesis),the relationship between the flux characteristics and loss of soil shear strength,provides self-consistent constraints on the depth below the phreatic surfaces where the failure planes are observed(expected to occur).It requires further experimental and observational evidence.Similar reasoning can be used to explain other saturated soil phenomena.展开更多
Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown t...Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown that earthquakes are positively correlated with tides,and thus,tides provide a potential tool for earthquake prediction,especially for imminent earthquakes.In this study,publications concerning the tidal triggering of earthquakes were compiled and analyzed with regard to global earthquakes,which were classified into three main types:tectonic,volcanic,and slow earthquakes.The results reveal a high correlation between tectonic earthquakes and tides(mainly for semidiurnal and diurnal tides;14-day tides) before and after the occurrence of significant earthquakes.For volcanic earthquakes,observations of volcanoes on the seafloor and land indicate that volcanic earthquakes in near-shore volcanic areas and mid-ocean ridges have a strong correlation with tidal forces,mostly those with semidiurnal and diurnal periods.For slow earthquakes,the periodicity of the tremor duration is highly correlated with semidiurnal and diurnal tides.In conclusion,the tidal triggering of these three types of earthquakes makes a positive contribution to earthquake preparation and understanding the triggering mechanism,and thus,the prediction of these types of earthquakes should be investigated.However,there are still several inadequacies on this topic that need to be resolved to gain a definitiveanswer regarding the tidal triggering of all earthquakes.The main inadequacies are discussed in this paper from our point of view.展开更多
This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial te...This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial tests,we examined the relation between the seismicity(time density of seismic events)and tidal potential arising from the Moon and Sun,using all tidal components simultaneously and focusing on the estimation of specific terms.The results show significant correlations between the seismicity and tidal potential for S2(0.5 d)and O1(1.075 d)tidal components in the case of solely isolated earthquake events,particularly for shallow earthquakes.Meanwhile,there is a strong relationship between aftershocks and tidal components larger than the Mf period(13.661 d).Finally,the analysis of the temporal variation of the earthquake-tide relation reveals an optimal correlation for about six years before the 2018 great Palu earthquake.The correlation becomes insignificant afterwards.展开更多
Triggering,locking,clicking,and crepitus of the fingers are common symptoms patients present with.Even though crepitus and triggering can occur as part of the same underlying diagnosis,it is important to differentiate...Triggering,locking,clicking,and crepitus of the fingers are common symptoms patients present with.Even though crepitus and triggering can occur as part of the same underlying diagnosis,it is important to differentiate between them,as they usually indicate different possible diagnoses.The differential diagnoses that should be considered include trigger finger,metacarpophalangeal joint(MCPJ)arthritis,fractures or dislocations,extensor digitorum communis subluxation or dislocation,locked MCPJ,avascular necrosis of the metacarpal head,and Dupuytren’s disease.A thorough clinical examination with appropriate special investigations can permit the clinician to make the correct diagnosis.Appropriate management of a confirmed diagnosis is successful in providing symptomatic improvement.展开更多
Philippine archipelago (PA) has strong background seismicity,but there is no systematic study of earthquake triggering in this region. There are six earthquakes (M_(w) > 6) occurred between 2018/12/29 and 2019/09/2...Philippine archipelago (PA) has strong background seismicity,but there is no systematic study of earthquake triggering in this region. There are six earthquakes (M_(w) > 6) occurred between 2018/12/29 and 2019/09/29 in PA,which provides an excellent opportunity to investigate the triggering relationship among these events. We calculate the static Coulomb stress changes of the first five events,and find that the local seismicity after the 2018/12/29 M_(w) 7.0 earthquake is mostly associated with positive Coulomb stress changes,including the 2019/05/31 M_(w) 6.1 event,suggesting a possible triggering relationship. However,we cannot rule out the dynamic triggering mechanism,due to increased microseismicity in both positive and negative stress change regions,and an incomplete local catalog,especially right after the first M_(w) 7.0 mainshock. The dynamic stresses from these M_(w) > 6 events are large enough (from 5 kPa to 3532 kPa) to trigger subsequent events,but a lack of seismicity and waveform evidence does not support delayed dynamic triggering among these events,even the shortest time interval is less than 24 hours. In the past 45 years,the released seismic energy shows certain peaks every 5–10 years. However,earthquakes with M_(w) > 6.0 were relatively infrequent between 2004 and 2018 at PA. Hence,it is possible that several regions are relatively late in their earthquake cycles,which would enhance their susceptibility of being triggered by earthquakes at nearby and regional distances.展开更多
This paper briefly reviews basic theory of seismic stress triggering. Recent development on seismic stress triggering has been reviewed in the views of seismic static and dynamic stress triggering, application of visc...This paper briefly reviews basic theory of seismic stress triggering. Recent development on seismic stress triggering has been reviewed in the views of seismic static and dynamic stress triggering, application of viscoelastic model in seismic stress triggering, the relation between earthquake triggering and volcanic eruption or explosion, other explanation of earthquake triggering, etc. And some suggestions for further study on seismic stress triggering in near future are given.展开更多
AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2...AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2017 for histologically-proven AIH were retrospectively analyzed. However, 52 patients(9.2%) fulfilled the criteria for ALF defined by the "American Association for the Study of the Liver(AASLD)". According to this definition, patients with "acute-on-chronic" or "acute-on-cirrhosis" liver failure were excluded. Following parameters with focus on potential triggering factors were evaluated: Patients' demographics, causation of liver failure, laboratory data(liver enzymes, MELD-score, autoimmune markers, virus serology), liver histology, immunosuppressive regime, and finally, outcome of our patients.RESULTS The majority of patients with ALF were female(84.6%) and mean age was 43.6 ± 14.9 years. Interestingly, none of the patients with ALF was positive for antiliver kidney microsomal antibody(LKM). We could identify potential triggering factors in 26/52(50.0%) of previously healthy patients presenting ALF as their first manifestation of AIH. These were drug-induced ALF(57.7%), virus-induced ALF(30.8%), and preceding surgery in general anesthesia(11.5%), respectively. Unfortunately, 6 out of 52 patients(11.5%) did not survive ALF and 3 patients(5.7%) underwent liver transplantation(LT). Comparing data of survivors and patients with non-recovery following treatment, MELDscore(P < 0.001), age(P < 0.05), creatinine(P < 0.01), and finally, ALT-values(P < 0.05) reached statistical significance. CONCLUSION Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome.展开更多
Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the...Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the characteristics of triggering factors for avalanche activity in this region to improve road safety and the management of natural hazards. Based on the observation of avalanche activity along the national road G218 in the western Tianshan Mountains, avalanche event data in combination with meteorological, snowpack and earthquake data were collected and analyzed. The snow climate of the mountain range was examined using a recently developed snow climate classification scheme, and triggering conditions of snow avalanche in different snow climate regions were compared. The results show that snowfall is the most common triggering factor for a natural avalanche and there is high probability of avalanche release with snowfall exceeding 20.4 mm during a snowfall period. Consecutive rise in temperature within three days and daily mean temperature reaching 0.5℃ in the following day imply a high probability of temperaturerise-triggered avalanche release. Earthquakes have a significant impact on the formation of large size avalanches in the area. For the period 2011-2017, five cases were identified as a consequence of earthquake with magnitudes of 3.3≤M_L≤5.1 and source-to-site distances of 19~139 km. The Tianshan Mountains are characterized by a continental snow climate with lower snow density, lower snow shear strength and high proportion depth hoar, which explains that both the snowfall and temperature for triggering avalanche release in the continental snow climate of the Tianshan Mountains are lower than that in maritime snow climate and transitional snow climate regions. The findings help forecast avalanche release for mitigating avalanche disaster and assessing the risk of avalanche disaster.展开更多
BACKGROUND:Triggering receptor expressed on myeloid cells-1 (TREM-1) in the intestine was upregulated and correlated with disease activity in inflammatory bowel diseases. Membrane- bound TREM-1 protein is increased...BACKGROUND:Triggering receptor expressed on myeloid cells-1 (TREM-1) in the intestine was upregulated and correlated with disease activity in inflammatory bowel diseases. Membrane- bound TREM-1 protein is increased in the pancreas, liver and kidneys of patients with severe acute pancreatitis (SAP), suggesting that TREM-1 may act as an important mediator of inflammation and subsequent extra-pancreatic organ injury. This study aimed to investigate the relationship between the expression of TREM-1 in intestinal tissue and intestinal barrier dysfunction in SAP. METHODS: Sixty-four male Wistar rats were randomly divided into a sham operation group (SO group, n=32) and a SAP group (n=32). A SAP model was established by retrograde injection of 5% sodium deoxycholate into the bile-pancreatic duct. Specimens were taken from blood and intestinal tissue 2, 6, 12, and 48 hours after operation respectively. The levels of D-lactate, diamine oxidase (DAO) and endotoxin in serum were measured using an improved spectro-photometric method. The expression levels of TREM-1, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) mRNA in terminal ileum were detected by real-time reverse transcription-polymerase chain reaction (RT-PCR). Specimens of the distal ileum were taken to determine pathological changes by a validated histology score. The serum levels of D-lactate, DAO and endotoxin were significantly increased in each subgroup of SAP compared with the SO group (P〈0.01, P〈0.05). The expression levels of TREM-1, IL-1β and TNF-a mRNA in the terminal ileum in each subgroup of SAP were significantly higher than those in the SO group (P〈0.01, P〈0.05). The expression level of TREM-lmRNA was positively correlated with IL-1βand TNF-α mRNA (r=0.956, P=0.044; r=0.986, P=0.015), but the correlation was not found between IL-1β mRNA and TNF-a mRNA (P=0.133). Compared to the SO group, the pathological changes were aggravated significantly in the SAP group. CONCLUSIONS: The expression level of TREM-1 in intestinal tissue of rats with SAP was elevated, leading to the release of inflammatory mediators and intestinal mucosal injury. This finding indicates that TREM-I might play an important role in the development of intestinal barrier dysfunction in rats with SAP.展开更多
The triggering mechanisms of debris flows were explored in the field using artificial rainfall experiments in two gullies, Dawazi Gully and Aizi Gully, in Yunnan and Sichuan Provinces, China,respectively. The soils at...The triggering mechanisms of debris flows were explored in the field using artificial rainfall experiments in two gullies, Dawazi Gully and Aizi Gully, in Yunnan and Sichuan Provinces, China,respectively. The soils at both sites are bare, loose and cohesive gravel-dominated. The results of a direct shear test, rheological test and back-analysis using soil mass stability calculations indicate that the mechanisms responsible for triggering debris flows involved the decreases in static and dynamic resistance of the soil. The triggering processes can be divided into 7 stages: rainfall infiltration, generation of excess runoff, high pore water pressure, surface erosion, soil creep, soil slipping, debris flow triggering and debris flow increment. In addition, two critical steps are evident:(i) During the process of the soil mass changing from a static to a mobile state, its cohesion decreased sharply(e.g., the cohesion of the soil mass in Dawazi Gully decreased from 0.520 to0.090 k Pa, a decrease of 83%). This would have reduced the soil strength and the kinetic energy during slipping, eventually triggered the debris flow.(ii) When the soil mass began to slip, the velocity and the volume increment of the debris flow fluctuated as a result of the interaction of soil resistance and the sliding force. The displaced soil mass from the source area of the slope resulted in the deposition of a volume of soil more than 7-8 times greater than that in the source area.展开更多
A study of the Kunlunshan earthquake of MS = 8.1 based on observed coseismic strain steps from the borehole strain monitoring network over China has been carried out with some interesting results. Firstly, many record...A study of the Kunlunshan earthquake of MS = 8.1 based on observed coseismic strain steps from the borehole strain monitoring network over China has been carried out with some interesting results. Firstly, many recordings disagree with theoretic calculation using static dislocation model. Secondly, abnormally large strain steps are ob-served at quite a few stations in the tectonically active east-northern China, while in the relatively inactive east-southern China no obvious steps are recorded. It is inferred that seismic stress triggering may significantly affect remote seismic strain field. In other words, whether remote faulting be seismically triggered or not may de-termine the pattern of local seismic strain changes. Further comparison study results of March 11, 1999 Zhangbei earthquake and November 1, 1999 Datong earthquake show that the specific pattern of seismic zones has obvious influence on seismic strain changes in the region. This supports the idea that observed abnormal strain steps might be produced by coseismicly stress-triggered local faulting.展开更多
The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the We...The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the Wenchuan Ms8.0 earthquake, we calculated the coulomb failure stress change. The inverted coulomb stress changes based on the Nishimura and Chenji models both show that the Lushan MT. 0 earth- quake occurred in the increased area of coulomb failure stress induced by the Wenchuan Ms8. 0 earthquake. The coulomb failure stress increased by approximately 0. 135 - 0. 152 bar in the source of the Lushan M7.0 earthquake, which is far more than the stress triggering threshold. Therefore, the Lushan M7.0 earthquake was most likely triggered by the coulomb failure stress change.展开更多
Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mi...Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mine of China was investigated by combining field investigation, meteorological and hydrological survey with numerical simulation to understand its triggering mechanism and dynamic process. The field data shows that the short-term high-intensity rainfall is the most direct inducement to trigger water-rock flow in the waste dump. The loose shallow gravel soil and the V-shaped valley with a certain slope provide the necessary conditions of the occurrence of water-rock flow in the waste dump. Moreover, the possibility criterion of water-rock flow is presented by analyzing the historical rainfall data. In addition, the smoothed particle hydrodynamics(SPH) method was employed to simulate the waterrock flow under the conditions of Newtonian fluid with uniform distribution of water and coarse-grained materials. The simulating results show that the flow distance, velocity, shape, and deposition profile of water-rock flow are in good agreement with the field observation. The present work is beneficial to the risk assessment and mitigation design of water-rock flow disaster in the waste dump.展开更多
Recently published results of field and laboratory experiments on the seismic/acoustic response to injection of direct current (DC) pulses into the Earth crust or stressed rock samples raised a question on a possibi...Recently published results of field and laboratory experiments on the seismic/acoustic response to injection of direct current (DC) pulses into the Earth crust or stressed rock samples raised a question on a possibility of electrical earthquake triggering. A physical mechanism of the considered phenomenon is not clear yet in view of the very low current density (10-7-10-s A/m^2) generated by the pulsed power systems at the epicenter depth (5-10 km) of local earthquakes occurred just after the current injection. The paper describes results of laboratory "earthquake" triggering by DC pulses under conditions of a spring-block model simulated the seismogenic fault. It is experimentally shown that the electric triggering of the laboratory "earthquake" (sharp slip of a movable block of the spring-block system) is possible only within a range of subcritical state of the system, when the shear stress between the movable and fixed blocks obtains 0.98-0.99 of its critical value. The threshold of electric triggering action is about 20 A/m^2 that is 7-8 orders of magnitude higher than estimated electric current density for Bishkek test site (Northern Tien Shan, Kirghizia) where the seismic response to the man-made electric action was observed. In this connection, the electric triggering phenomena may be explained by contraction of electric current in the narrow conductive areas of the faults and the corresponding increase in current density or by involving the secondary triggering mechanisms like electromagnetic stimulation of conductive fluid migration into the fault area resulted in decrease in the fault strength properties.展开更多
BACKGROUND: Triggering receptor expressed on myeloid cells-1(TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify infl ammation and serves as a critical mediator of infl am...BACKGROUND: Triggering receptor expressed on myeloid cells-1(TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify infl ammation and serves as a critical mediator of infl ammatory response in the context of sepsis. To date, the predisposition of TREM-1 gene polymorphisms to septic shock has not been reported. This study was designed to investigate whether TREM-1 genomic variations are associated with the development of septic shock.METHODS: We genotyped two TREM-1 single nucleotide polymorphisms(SNPs, rs2234237 and rs2234246) and evaluated the relationships between these SNPs and septic shock on susceptibility and prognosis.RESULTS: TREM-1 rs2234246 A allele in the promoter region was signifi cantly associated with the susceptibility of septic shock in recessive model(AA, OR=3.10, 95%CI 1.15 to 8.32, P=0.02), and in codominant model(AG, OR=0.72, 95%CI 0.43–1.19, P=0.02; AA, OR=2.71, 95%CI 1.00–7.42; P=0.03). However, in three inherited models(dominant model, recessive model, and codominant model), none of the assayed loci was signif icantly associated with the prognosis of septic shock. The nonsurvivor group demonstrated higher plasma IL-6 levels(99.7±34.7 pg/mL vs. 61.2±26.5 pg/mL, P<0.01) than the survivor group. Plasma concentrations of IL-6 among the three genotypes of rs2234246 were AA 99.4±48.9 pg/m L, AG 85.4±43 pg/m L, and GG 65.3±30.7 pg/m L(P<0.01). The plasma concentrations of IL-6 in patients with AA genotypes were signifi cantly higher than those in patients with GG genotypes(P<0.01).CONCLUSION: TREM-1 genetic polymorphisms rs2234246 may be significantly correlated only with susceptibility to septic shock in the Chinese Han population.展开更多
Although new technologies have been deeply applied in manufacturing systems,manufacturing enterprises are still encountering difficulties in maintaining efficient and flexible production due to the random arrivals of ...Although new technologies have been deeply applied in manufacturing systems,manufacturing enterprises are still encountering difficulties in maintaining efficient and flexible production due to the random arrivals of diverse customer requirements.Fast order delivery and low inventory cost are fundamentally contradictory to each other.How to make a suitable production-triggering strategy is a critical issue for an enterprise to maintain a high level of competitiveness in a dynamic environment.In this paper,we focus on production-triggering strategies for manufacturing enterprises to satisfy randomly arriving orders and reduce inventory costs.Unified theoretical models and simulation models of different production strategies are proposed,including time-triggered strategies,event-triggered strategies,and hybrid-triggered strategies.In each model,both part-production-triggering strategies and product-assembly-triggering strategies are considered and implemented.The time-triggered models and hybrid-triggered models also consider the impact of the period on system performance.The results show that hybrid-triggered and time-triggered strategies yield faster order delivery and lower inventory costs than event-triggered strategies if the period is set appropriately.展开更多
With the recent development of digital Micro Electro Mechanical System (MEMS) sensors, the cost of monitoring and detecting seismic events in real time can be greatly reduced. Ability of MEMS accelerograph to record...With the recent development of digital Micro Electro Mechanical System (MEMS) sensors, the cost of monitoring and detecting seismic events in real time can be greatly reduced. Ability of MEMS accelerograph to record a seismic event depends upon the efficiency of triggering algorithm, apart from the sensor's sensitivity. There are several classic triggering algorithms developed to detect seismic events, ranging from basic amplitude threshold to more sophisticated pattern recognition. Algorithms based on STA/LTA are reported to be computationally efficient for real time monitoring. In this paper, we analyzed several STA/LTA algorithms to check their efficiency and suitability using data obtained from the Quake Catcher Network (network of MEMS accelerometer stations). We found that most of the STA/LTA algorithms are suitable for use with MEMS accelerometer data to accurately detect seismic events. However, the efficiency of any particular algorithm is found to be dependent on the parameter set used (i.e., window width of STA, LTA and threshold level).展开更多
基金supported by the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QD032)。
文摘Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas.
基金funded by the Youth Seismic Regime Tracking Project of CEA(2023010129)。
文摘The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 bar.Noteworthy seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe earthquake.Areas of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang faults.Additionally,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings.
基金The Basic Scientific Fund for National Public Research Institutes of China under contract No.2022S02the National Natural Science Foundation of China under contract No.41976021.
文摘Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related nIOD.However,the characteristics and triggering mechanisms of early nIOD are unclear.Our results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six decades.These two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal cycles.The early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related nIOD.The spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian Ocean.Opposite to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon onset.The results of this study are helpful for improving the prediction skill of IOD and its climate impacts.
文摘Mechanisms have been proposed to explain the triggering,development,and persistence of soil liquefaction.The mechanism explaining the horizontal failure plane(triggering)and its depth below the phreatic surface is governed by the flux properties and effective stress at that plane.At the failure plane,the pore water pressure was higher than the effective stress,and the volume change was the highest.The pore water pressure is a function of the soil profile features(particularly the phreatic zone width)and bedrock motion(horizontal acceleration).The volume change at the failure plane is a function of the intrinsic permeability of the soil and bedrock displacement.The failure plane was predicted to occur during the oscillation with the highest amplitude,disregarding further bedrock motion,which was consistent with low seismic energy densities.Two mechanisms were proposed to explain the persistence of soil liquefaction.The first is the existence of low-permeability layers in the depth range in which the failure planes are predicted to occur.The other allows for the persistence and development of soil liquefaction;it is consistent with homogeneous soils and requires water inflow from bedrock water springs.The latter explains many of the features of soil liquefaction observed during earthquakes,namely,surficial effects,“instant”liquefaction,and the occurrence of short-and long-term changes in the level of the phreatic surfaces.This model(hypothesis),the relationship between the flux characteristics and loss of soil shear strength,provides self-consistent constraints on the depth below the phreatic surfaces where the failure planes are observed(expected to occur).It requires further experimental and observational evidence.Similar reasoning can be used to explain other saturated soil phenomena.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB41 000000)the National Natural Science Foundation of China (Grant No. 42174101, 41974023, 41874094, 41874026)。
文摘Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown that earthquakes are positively correlated with tides,and thus,tides provide a potential tool for earthquake prediction,especially for imminent earthquakes.In this study,publications concerning the tidal triggering of earthquakes were compiled and analyzed with regard to global earthquakes,which were classified into three main types:tectonic,volcanic,and slow earthquakes.The results reveal a high correlation between tectonic earthquakes and tides(mainly for semidiurnal and diurnal tides;14-day tides) before and after the occurrence of significant earthquakes.For volcanic earthquakes,observations of volcanoes on the seafloor and land indicate that volcanic earthquakes in near-shore volcanic areas and mid-ocean ridges have a strong correlation with tidal forces,mostly those with semidiurnal and diurnal periods.For slow earthquakes,the periodicity of the tremor duration is highly correlated with semidiurnal and diurnal tides.In conclusion,the tidal triggering of these three types of earthquakes makes a positive contribution to earthquake preparation and understanding the triggering mechanism,and thus,the prediction of these types of earthquakes should be investigated.However,there are still several inadequacies on this topic that need to be resolved to gain a definitiveanswer regarding the tidal triggering of all earthquakes.The main inadequacies are discussed in this paper from our point of view.
文摘This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial tests,we examined the relation between the seismicity(time density of seismic events)and tidal potential arising from the Moon and Sun,using all tidal components simultaneously and focusing on the estimation of specific terms.The results show significant correlations between the seismicity and tidal potential for S2(0.5 d)and O1(1.075 d)tidal components in the case of solely isolated earthquake events,particularly for shallow earthquakes.Meanwhile,there is a strong relationship between aftershocks and tidal components larger than the Mf period(13.661 d).Finally,the analysis of the temporal variation of the earthquake-tide relation reveals an optimal correlation for about six years before the 2018 great Palu earthquake.The correlation becomes insignificant afterwards.
文摘Triggering,locking,clicking,and crepitus of the fingers are common symptoms patients present with.Even though crepitus and triggering can occur as part of the same underlying diagnosis,it is important to differentiate between them,as they usually indicate different possible diagnoses.The differential diagnoses that should be considered include trigger finger,metacarpophalangeal joint(MCPJ)arthritis,fractures or dislocations,extensor digitorum communis subluxation or dislocation,locked MCPJ,avascular necrosis of the metacarpal head,and Dupuytren’s disease.A thorough clinical examination with appropriate special investigations can permit the clinician to make the correct diagnosis.Appropriate management of a confirmed diagnosis is successful in providing symptomatic improvement.
基金The National Natural Science Foundation of China under contract Nos 41704049,41890813,91628301 and 41974068the Chinese Academy of Sciences under contract Nos QYZDY-SSW-DQC005 and 133244KYSB20180029+3 种基金the foundation of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)under contract No.GML2019ZD0205the foundation of Youth Innovation Promotion Association,Chinese Academy of Sciences under contract No.YIPA2018385the United States National Science Foundation under contract No.EAR-1736197the Foundation of Science Foundation for the Earthquake Resilience of China Earthquake Administration under contract No.XH20072.
文摘Philippine archipelago (PA) has strong background seismicity,but there is no systematic study of earthquake triggering in this region. There are six earthquakes (M_(w) > 6) occurred between 2018/12/29 and 2019/09/29 in PA,which provides an excellent opportunity to investigate the triggering relationship among these events. We calculate the static Coulomb stress changes of the first five events,and find that the local seismicity after the 2018/12/29 M_(w) 7.0 earthquake is mostly associated with positive Coulomb stress changes,including the 2019/05/31 M_(w) 6.1 event,suggesting a possible triggering relationship. However,we cannot rule out the dynamic triggering mechanism,due to increased microseismicity in both positive and negative stress change regions,and an incomplete local catalog,especially right after the first M_(w) 7.0 mainshock. The dynamic stresses from these M_(w) > 6 events are large enough (from 5 kPa to 3532 kPa) to trigger subsequent events,but a lack of seismicity and waveform evidence does not support delayed dynamic triggering among these events,even the shortest time interval is less than 24 hours. In the past 45 years,the released seismic energy shows certain peaks every 5–10 years. However,earthquakes with M_(w) > 6.0 were relatively infrequent between 2004 and 2018 at PA. Hence,it is possible that several regions are relatively late in their earthquake cycles,which would enhance their susceptibility of being triggered by earthquakes at nearby and regional distances.
基金Chinese Joint Seismological Science Foundation (602005).
文摘This paper briefly reviews basic theory of seismic stress triggering. Recent development on seismic stress triggering has been reviewed in the views of seismic static and dynamic stress triggering, application of viscoelastic model in seismic stress triggering, the relation between earthquake triggering and volcanic eruption or explosion, other explanation of earthquake triggering, etc. And some suggestions for further study on seismic stress triggering in near future are given.
文摘AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2017 for histologically-proven AIH were retrospectively analyzed. However, 52 patients(9.2%) fulfilled the criteria for ALF defined by the "American Association for the Study of the Liver(AASLD)". According to this definition, patients with "acute-on-chronic" or "acute-on-cirrhosis" liver failure were excluded. Following parameters with focus on potential triggering factors were evaluated: Patients' demographics, causation of liver failure, laboratory data(liver enzymes, MELD-score, autoimmune markers, virus serology), liver histology, immunosuppressive regime, and finally, outcome of our patients.RESULTS The majority of patients with ALF were female(84.6%) and mean age was 43.6 ± 14.9 years. Interestingly, none of the patients with ALF was positive for antiliver kidney microsomal antibody(LKM). We could identify potential triggering factors in 26/52(50.0%) of previously healthy patients presenting ALF as their first manifestation of AIH. These were drug-induced ALF(57.7%), virus-induced ALF(30.8%), and preceding surgery in general anesthesia(11.5%), respectively. Unfortunately, 6 out of 52 patients(11.5%) did not survive ALF and 3 patients(5.7%) underwent liver transplantation(LT). Comparing data of survivors and patients with non-recovery following treatment, MELDscore(P < 0.001), age(P < 0.05), creatinine(P < 0.01), and finally, ALT-values(P < 0.05) reached statistical significance. CONCLUSION Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome.
基金supported by the Science and Technology Service Network Initiative of the Chinese Academy of Science (Grant No.KFJSTSZDTP-015)the National Project of Investigation of Basic Resources for Science and Technology (Grant No.2017FY100501)the supports in field and laboratory work from the Tianshan Station for Snow cover and Avalanche Research,Chinese Academy of Sciences
文摘Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the characteristics of triggering factors for avalanche activity in this region to improve road safety and the management of natural hazards. Based on the observation of avalanche activity along the national road G218 in the western Tianshan Mountains, avalanche event data in combination with meteorological, snowpack and earthquake data were collected and analyzed. The snow climate of the mountain range was examined using a recently developed snow climate classification scheme, and triggering conditions of snow avalanche in different snow climate regions were compared. The results show that snowfall is the most common triggering factor for a natural avalanche and there is high probability of avalanche release with snowfall exceeding 20.4 mm during a snowfall period. Consecutive rise in temperature within three days and daily mean temperature reaching 0.5℃ in the following day imply a high probability of temperaturerise-triggered avalanche release. Earthquakes have a significant impact on the formation of large size avalanches in the area. For the period 2011-2017, five cases were identified as a consequence of earthquake with magnitudes of 3.3≤M_L≤5.1 and source-to-site distances of 19~139 km. The Tianshan Mountains are characterized by a continental snow climate with lower snow density, lower snow shear strength and high proportion depth hoar, which explains that both the snowfall and temperature for triggering avalanche release in the continental snow climate of the Tianshan Mountains are lower than that in maritime snow climate and transitional snow climate regions. The findings help forecast avalanche release for mitigating avalanche disaster and assessing the risk of avalanche disaster.
基金The study was supported by a grant from the National Natural Science Foundation of China (81070287).
文摘BACKGROUND:Triggering receptor expressed on myeloid cells-1 (TREM-1) in the intestine was upregulated and correlated with disease activity in inflammatory bowel diseases. Membrane- bound TREM-1 protein is increased in the pancreas, liver and kidneys of patients with severe acute pancreatitis (SAP), suggesting that TREM-1 may act as an important mediator of inflammation and subsequent extra-pancreatic organ injury. This study aimed to investigate the relationship between the expression of TREM-1 in intestinal tissue and intestinal barrier dysfunction in SAP. METHODS: Sixty-four male Wistar rats were randomly divided into a sham operation group (SO group, n=32) and a SAP group (n=32). A SAP model was established by retrograde injection of 5% sodium deoxycholate into the bile-pancreatic duct. Specimens were taken from blood and intestinal tissue 2, 6, 12, and 48 hours after operation respectively. The levels of D-lactate, diamine oxidase (DAO) and endotoxin in serum were measured using an improved spectro-photometric method. The expression levels of TREM-1, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) mRNA in terminal ileum were detected by real-time reverse transcription-polymerase chain reaction (RT-PCR). Specimens of the distal ileum were taken to determine pathological changes by a validated histology score. The serum levels of D-lactate, DAO and endotoxin were significantly increased in each subgroup of SAP compared with the SO group (P〈0.01, P〈0.05). The expression levels of TREM-1, IL-1β and TNF-a mRNA in the terminal ileum in each subgroup of SAP were significantly higher than those in the SO group (P〈0.01, P〈0.05). The expression level of TREM-lmRNA was positively correlated with IL-1βand TNF-α mRNA (r=0.956, P=0.044; r=0.986, P=0.015), but the correlation was not found between IL-1β mRNA and TNF-a mRNA (P=0.133). Compared to the SO group, the pathological changes were aggravated significantly in the SAP group. CONCLUSIONS: The expression level of TREM-1 in intestinal tissue of rats with SAP was elevated, leading to the release of inflammatory mediators and intestinal mucosal injury. This finding indicates that TREM-I might play an important role in the development of intestinal barrier dysfunction in rats with SAP.
基金supported by the National Natural Science Foundation of China(Grant No.41190084Grant No.41671112+2 种基金Grant No.41661134012)the Technology Program of Housing and Urban-Rural Development of P.R.China(Grant No.2015-K6-016)the key projects of Education Department of Sichuan Province,China(Grant No.15ZA0053)
文摘The triggering mechanisms of debris flows were explored in the field using artificial rainfall experiments in two gullies, Dawazi Gully and Aizi Gully, in Yunnan and Sichuan Provinces, China,respectively. The soils at both sites are bare, loose and cohesive gravel-dominated. The results of a direct shear test, rheological test and back-analysis using soil mass stability calculations indicate that the mechanisms responsible for triggering debris flows involved the decreases in static and dynamic resistance of the soil. The triggering processes can be divided into 7 stages: rainfall infiltration, generation of excess runoff, high pore water pressure, surface erosion, soil creep, soil slipping, debris flow triggering and debris flow increment. In addition, two critical steps are evident:(i) During the process of the soil mass changing from a static to a mobile state, its cohesion decreased sharply(e.g., the cohesion of the soil mass in Dawazi Gully decreased from 0.520 to0.090 k Pa, a decrease of 83%). This would have reduced the soil strength and the kinetic energy during slipping, eventually triggered the debris flow.(ii) When the soil mass began to slip, the velocity and the volume increment of the debris flow fluctuated as a result of the interaction of soil resistance and the sliding force. The displaced soil mass from the source area of the slope resulted in the deposition of a volume of soil more than 7-8 times greater than that in the source area.
基金National Natural Science Foundation of China (40374011), Joint Seismological Foundation of China (1040037) and Investigating Active Faults in Major Cities Program.
文摘A study of the Kunlunshan earthquake of MS = 8.1 based on observed coseismic strain steps from the borehole strain monitoring network over China has been carried out with some interesting results. Firstly, many recordings disagree with theoretic calculation using static dislocation model. Secondly, abnormally large strain steps are ob-served at quite a few stations in the tectonically active east-northern China, while in the relatively inactive east-southern China no obvious steps are recorded. It is inferred that seismic stress triggering may significantly affect remote seismic strain field. In other words, whether remote faulting be seismically triggered or not may de-termine the pattern of local seismic strain changes. Further comparison study results of March 11, 1999 Zhangbei earthquake and November 1, 1999 Datong earthquake show that the specific pattern of seismic zones has obvious influence on seismic strain changes in the region. This supports the idea that observed abnormal strain steps might be produced by coseismicly stress-triggered local faulting.
基金supported by the Director Foundation of Institute of SeismologyChina Earthquake Administration(201056088)
文摘The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the Wenchuan Ms8.0 earthquake, we calculated the coulomb failure stress change. The inverted coulomb stress changes based on the Nishimura and Chenji models both show that the Lushan MT. 0 earth- quake occurred in the increased area of coulomb failure stress induced by the Wenchuan Ms8. 0 earthquake. The coulomb failure stress increased by approximately 0. 135 - 0. 152 bar in the source of the Lushan M7.0 earthquake, which is far more than the stress triggering threshold. Therefore, the Lushan M7.0 earthquake was most likely triggered by the coulomb failure stress change.
基金funded by the Fundamental Research Funds for the Central Universities,SCUT (No.2015QB02)the Special Fund for Yueqi Scholars (No.800015Z1207)。
文摘Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mine of China was investigated by combining field investigation, meteorological and hydrological survey with numerical simulation to understand its triggering mechanism and dynamic process. The field data shows that the short-term high-intensity rainfall is the most direct inducement to trigger water-rock flow in the waste dump. The loose shallow gravel soil and the V-shaped valley with a certain slope provide the necessary conditions of the occurrence of water-rock flow in the waste dump. Moreover, the possibility criterion of water-rock flow is presented by analyzing the historical rainfall data. In addition, the smoothed particle hydrodynamics(SPH) method was employed to simulate the waterrock flow under the conditions of Newtonian fluid with uniform distribution of water and coarse-grained materials. The simulating results show that the flow distance, velocity, shape, and deposition profile of water-rock flow are in good agreement with the field observation. The present work is beneficial to the risk assessment and mitigation design of water-rock flow disaster in the waste dump.
基金funded by Russian Foundation for Basic Research according to research project No.15-55-53104National Natural Science Foundation of China according to International cooperation project No.41511130032
文摘Recently published results of field and laboratory experiments on the seismic/acoustic response to injection of direct current (DC) pulses into the Earth crust or stressed rock samples raised a question on a possibility of electrical earthquake triggering. A physical mechanism of the considered phenomenon is not clear yet in view of the very low current density (10-7-10-s A/m^2) generated by the pulsed power systems at the epicenter depth (5-10 km) of local earthquakes occurred just after the current injection. The paper describes results of laboratory "earthquake" triggering by DC pulses under conditions of a spring-block model simulated the seismogenic fault. It is experimentally shown that the electric triggering of the laboratory "earthquake" (sharp slip of a movable block of the spring-block system) is possible only within a range of subcritical state of the system, when the shear stress between the movable and fixed blocks obtains 0.98-0.99 of its critical value. The threshold of electric triggering action is about 20 A/m^2 that is 7-8 orders of magnitude higher than estimated electric current density for Bishkek test site (Northern Tien Shan, Kirghizia) where the seismic response to the man-made electric action was observed. In this connection, the electric triggering phenomena may be explained by contraction of electric current in the narrow conductive areas of the faults and the corresponding increase in current density or by involving the secondary triggering mechanisms like electromagnetic stimulation of conductive fluid migration into the fault area resulted in decrease in the fault strength properties.
基金supported by Science&Technology Pillar Program of Guangdong Province(2009BAI86B03)
文摘BACKGROUND: Triggering receptor expressed on myeloid cells-1(TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify infl ammation and serves as a critical mediator of infl ammatory response in the context of sepsis. To date, the predisposition of TREM-1 gene polymorphisms to septic shock has not been reported. This study was designed to investigate whether TREM-1 genomic variations are associated with the development of septic shock.METHODS: We genotyped two TREM-1 single nucleotide polymorphisms(SNPs, rs2234237 and rs2234246) and evaluated the relationships between these SNPs and septic shock on susceptibility and prognosis.RESULTS: TREM-1 rs2234246 A allele in the promoter region was signifi cantly associated with the susceptibility of septic shock in recessive model(AA, OR=3.10, 95%CI 1.15 to 8.32, P=0.02), and in codominant model(AG, OR=0.72, 95%CI 0.43–1.19, P=0.02; AA, OR=2.71, 95%CI 1.00–7.42; P=0.03). However, in three inherited models(dominant model, recessive model, and codominant model), none of the assayed loci was signif icantly associated with the prognosis of septic shock. The nonsurvivor group demonstrated higher plasma IL-6 levels(99.7±34.7 pg/mL vs. 61.2±26.5 pg/mL, P<0.01) than the survivor group. Plasma concentrations of IL-6 among the three genotypes of rs2234246 were AA 99.4±48.9 pg/m L, AG 85.4±43 pg/m L, and GG 65.3±30.7 pg/m L(P<0.01). The plasma concentrations of IL-6 in patients with AA genotypes were signifi cantly higher than those in patients with GG genotypes(P<0.01).CONCLUSION: TREM-1 genetic polymorphisms rs2234246 may be significantly correlated only with susceptibility to septic shock in the Chinese Han population.
基金supported by the National Key R&D Program of China(2018YFB1701600)the National Natural Science Foundation of China(61873014).
文摘Although new technologies have been deeply applied in manufacturing systems,manufacturing enterprises are still encountering difficulties in maintaining efficient and flexible production due to the random arrivals of diverse customer requirements.Fast order delivery and low inventory cost are fundamentally contradictory to each other.How to make a suitable production-triggering strategy is a critical issue for an enterprise to maintain a high level of competitiveness in a dynamic environment.In this paper,we focus on production-triggering strategies for manufacturing enterprises to satisfy randomly arriving orders and reduce inventory costs.Unified theoretical models and simulation models of different production strategies are proposed,including time-triggered strategies,event-triggered strategies,and hybrid-triggered strategies.In each model,both part-production-triggering strategies and product-assembly-triggering strategies are considered and implemented.The time-triggered models and hybrid-triggered models also consider the impact of the period on system performance.The results show that hybrid-triggered and time-triggered strategies yield faster order delivery and lower inventory costs than event-triggered strategies if the period is set appropriately.
基金IIT Roorkee under the Faculty Initiation Grant No.100556
文摘With the recent development of digital Micro Electro Mechanical System (MEMS) sensors, the cost of monitoring and detecting seismic events in real time can be greatly reduced. Ability of MEMS accelerograph to record a seismic event depends upon the efficiency of triggering algorithm, apart from the sensor's sensitivity. There are several classic triggering algorithms developed to detect seismic events, ranging from basic amplitude threshold to more sophisticated pattern recognition. Algorithms based on STA/LTA are reported to be computationally efficient for real time monitoring. In this paper, we analyzed several STA/LTA algorithms to check their efficiency and suitability using data obtained from the Quake Catcher Network (network of MEMS accelerometer stations). We found that most of the STA/LTA algorithms are suitable for use with MEMS accelerometer data to accurately detect seismic events. However, the efficiency of any particular algorithm is found to be dependent on the parameter set used (i.e., window width of STA, LTA and threshold level).