Effects of Personalized Ultra-early Limb Function Rehabilitation on Neurological Impairment and Satisfaction of Inpatients with Hemiplegia after Ischemic Stroke

[Objectives]To investigate the effects of personalized ultra-early limb function rehabilitation on neurological impairment and satisfaction of inpatients with hemiplegia after ischemic stroke.[Methods]From November 2020 to November 2021,66 ischemic stroke patients with hemiplegia in the Neurology Department of a Grade A hospital were randomly divided into experimental group and control group,with 33 cases in each group.The experimental group received personalized ultra-early limb function rehabilitation,and the control group adopted routine rehabilitation nursing.The neurological function defect and nursing service satisfaction of inpatients were compared between the two groups at discharge.[Results]After intervention,the neurological impairment in the experimental group was lighter than that in the control group(P<0.05),and the nursing service satisfaction of the inpatients in the experimental group was higher than that in the control group(P<0.05).[Conclusions]Personalized ultra-early limb function rehabilitation can improve the neurological deficit of inpatients with hemiplegia after ischemic stroke and improve the satisfaction of inpatients.

Safety and feasibility of ultra-early lumbar puncture in patients with aneurysmal subarachnoid hemorrhage

Objective:to evaluate the clinical efficacy and safety of ultra-early lumbar puncture drainage of cerebrospinal fluid(CSF)in patients with aneurysmal subarachnoid hemorrhage(SAH).Methods:patients(n=140)with aneurysmal SAH were randomly divided into observation group(n=70)and control group(n=70).After admission,CSF was drained by ultra-early lumbar puncture in the observation group and intermittent lumbar puncture after aneurysm operation in the control group.The incidences of early aneurysm rupture,acute hydrocephalus and delayed hydrocephalus were compared between the two groups.Results:there was no significant diflerence in the incidence of early-ruptured aneurysm and acute hydrocephalus between the two groups,but the incidence of delayed hydrocephalus in the observation group was significantly lower than that in the control group.Conclusion:ultra-early lumbar puncture drainage of CSF in anexirysmal SAH can effectively reduce the incidence of long-term delayed hydrocephalus and it is a safe and effective treatment.

The Effects of Ultra-early Hyperbaric Oxygen Intervention in the Treatment of Diffuse Axonal Injury

Objective:To investigate the efficacy and mechanism of ultra-early hyperbaric oxygen intervention in the treatment of diffuse axonal injury(DAI).Methods:Eighty-six patients with diffuse axonal injury were selected and then divided into an ultra-early hyperbaric oxygen treatment group and a conventional treatment group with 43 patients in each group.The Glasgow Coma Scale(GCS)on the 10h day(10d),20h day(20d),and 30h day(30d)after treatment and the Glasgow Outcome Score(GOS)6 months later were observed and compared between both the groups.Results:The average score of the GCS at 10d,20d,and 30d as welll as the GOS 6 months later in the ultra-early hyperbaric oxygen treatment group were higher than those in the conventional treatment group(P<0.05).Conclusion:Hyperbaric oxygen therapy is one of the unique and effective methods in clinical treatment especially for the treatment of DAI patients and it is worthy of promotion.

Paraneoplastic cerebellar degeneration associated with somatic mutations in ultra-early diagnosis of small cell lung cancer: a case report

Paraneoplastic cerebellar degeneration(PCD)can occur in patients with underlying cancer,such as small cell lung cancer(SCLC).Anti-CV2/CRMP5 antibodies are well-established biomarkers of PCD associated with SCLC,but cannot be detected in most situations.Recently,next-generation sequencing has been a promising technology to discover cancer-driven mutations,which provide an alternative strategy to accomplish ultra-early diagnosis of those patients.Here,we report the case of a 75-year-old man diagnosed with SCLC,who primarily presented with anti-CV2/CRMP5 antibodies positive PCD.Eight high-frequency gene mutations(TSC2,DNMT1,CIC,FGF6,NSD1,TSHR,CRLF2,and EPPK1)were detected 7 months before diagnosis with no abnormalities of imaging or cerebrospinal fluid examination found initially.Therefore,this case suggests the possibility of detecting certain somatic mutations for the ultra-early diagnosis of patients presenting with PCD associated with SCLC.