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基于药物毒性反应等级的up-and-down自适应设计
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作者 王雪丽 张忠占 《生物数学学报》 CSCD 北大核心 2008年第3期549-556,共8页
Ⅰ期临床试验主要关心药物的毒性,目的是在给定的剂量水平中寻找最大耐受剂量(MTD).本文提出了基于药物毒性反应等级的up-and—down自适应设计,调查了该设计在各种变化的剂量-毒性关系下的运作特征.结果表明:该设计方法对提高建议MTD的... Ⅰ期临床试验主要关心药物的毒性,目的是在给定的剂量水平中寻找最大耐受剂量(MTD).本文提出了基于药物毒性反应等级的up-and—down自适应设计,调查了该设计在各种变化的剂量-毒性关系下的运作特征.结果表明:该设计方法对提高建议MTD的精确度,以及保护病人,防止病人暴露在较高毒性剂量下方面,对Ⅰ期临床试验的设计实现了有意义的改善. 展开更多
关键词 Ⅰ期临床试验 毒性研究 up-and-down设计 自适应设计
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Ocean surface current retrieval and imaging with a new shore-based X-band radar based on time-shifted up-and-down linear frequency modulated signal
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作者 Yijun He Xin Song +2 位作者 Baochang Liu Na Yi Xiuzhong Li 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2021年第3期112-121,共10页
This paper proposes a multifunction radar that can not only measure sea currents but also perform sea-surface imaging.The fundamental aspect of the proposed radar comprises transmitting time-shifted up-and-down contin... This paper proposes a multifunction radar that can not only measure sea currents but also perform sea-surface imaging.The fundamental aspect of the proposed radar comprises transmitting time-shifted up-and-down continuous wave linear frequency modulated signals that allow for the offset of two one-dimensional range images of the sea surface that respectively correspond to the upward linear frequency modulated(LFM)signal and the downward LFM signal.Owing to the Doppler frequency shift from the sea surface,a range offset,which is proportional to the radial velocity of the sea surface,occurs between the upward and downward LFM signals.By using the least-squares linear fitting method in the transformed domain,the range offset can be measured and the current velocity can be retrieved.Finally,we verify the accuracy of current measurement with simulation results. 展开更多
关键词 shore-based radars signal processing ocean surface currents up-and-down CWLFM
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竞争失效模式下成功反应的探讨
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作者 刘瑞银 张子选 巴桑卓玛 《沈阳师范大学学报(自然科学版)》 CAS 2006年第2期144-146,共3页
在phaseⅠ/Ⅱ剂量反应问题中,当一个受试者既不中毒又有良好的治疗效果时,我们称这种反应为成功反应.本文我们给出了成功曲线的一个简单的定义,并且通过模拟证明了这种定义是非常有效的.
关键词 up-and-down 定向游动 最有效剂量 成功曲线
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阶段Ⅰ/Ⅱ试验中成功曲线的探讨
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作者 刘瑞银 《长春大学学报》 2006年第6期31-34,共4页
在阶段Ⅰ/Ⅱ剂量反应问题中,我们的目的是通过成功曲线决定最优剂量。不同的成功曲线会得到不同的最优剂量,本文根据实际中的毒性和有效性来确定了适当的成功曲线。
关键词 up-and-down 定向游动 最有效剂量 成功曲线
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Experimental study of rotating wind turbine breakdown characteristics in large scale air gaps 被引量:1
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作者 Yu WANG Lu OU +3 位作者 Tianjun SI Yang NI Jianwei XU Xishan WEN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2017年第6期108-115,共8页
When a wind turbine is struck by lightning,its blades are usually rotating.The effect of blade rotation on a turbine's ability to trigger a lightning strike is unclear.Therefore,an arching electrode was used in a win... When a wind turbine is struck by lightning,its blades are usually rotating.The effect of blade rotation on a turbine's ability to trigger a lightning strike is unclear.Therefore,an arching electrode was used in a wind turbine lightning discharge test to investigate the difference in lightning triggering ability when blades are rotating and stationary.A negative polarity switching waveform of 250/2500 μs was applied to the arching electrode and the up-and-down method was used to calculate the 50%discharge voltage.Lightning discharge tests of a 1:30 scale wind turbine model with 2,4,and 6 m air gaps were performed and the discharge process was observed.The experimental results demonstrated that when a 2 m air gap was used,the breakdown voltage increased as the blade speed was increased,but when the gap length was 4 m or longer,the trend was reversed and the breakdown voltage decreased.The analysis revealed that the rotation of the blades changes the charge distribution in the blade-tip region,promotes upward leader development on the blade tip,and decreases the breakdown voltage.Thus,the blade rotation of a wind turbine increases its ability to trigger lightning strikes. 展开更多
关键词 wind turbine ROTATION up-and-down method breakdown characteristic large-scale air gap
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Confidence limit calculation for antidotal potency ratio derived from lethal dose 50
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作者 Ananda Manage Ilona Petrikovics 《World Journal of Methodology》 2013年第1期7-10,共4页
AIM:To describe confidence interval calculation for antidotal potency ratios using bootstrap method.METHODS:We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence in... AIM:To describe confidence interval calculation for antidotal potency ratios using bootstrap method.METHODS:We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence intervals in such situations like this.The bootstrap method is a resampling method in which the bootstrap samples are obtained by resampling from the original sample.RESULTS:The described confidence interval calculation using bootstrap method does not require the sampling distribution antidotal potency ratio.This can serve as a substantial help for toxicologists,who are directed to employ the Dixon up-and-down method with the application of lower number of animals to determine lethal dose 50 values for characterizing the investigated toxic molecules and eventually for characterizing the antidotal protections by the test antidotal systems.CONCLUSION:The described method can serve as a useful tool in various other applications.Simplicity ofthe method makes it easier to do the calculation using most of the programming software packages. 展开更多
关键词 up-and-down method Confidence limit Potency ratio Bootstrapping
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A three-parameter logistic regression model
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作者 Xiaoli Yu Shaoting Li Jiahua Chen 《Statistical Theory and Related Fields》 2021年第3期265-274,共10页
Dose–response experiments and data analyses are often carried out according to an optimal design under a model assumption.A two-parameter logistic model is often used because of its nice mathematical properties and p... Dose–response experiments and data analyses are often carried out according to an optimal design under a model assumption.A two-parameter logistic model is often used because of its nice mathematical properties and plausible stochastic response mechanisms.There is an extensive literature on its optimal designs and data analysis strategies.However,a model is at best a good approximation in a real-world application,and researchers must be aware of the risk of model mis-specification.In this paper,we investigate the effectiveness of the sequential EDdesign,the D-optimal design,and the up-and-down design under the three-parameter logistic regression model,and we develop a numerical method for the parameter estimation.Simulations show that the combination of the proposed model and the data analysis strategy performs well.When the logistic model is correct,this more complex model has hardly any efficiency loss.The three-parameter logistic model works better than the two-parameter logistic model in the presence of model mis-specification. 展开更多
关键词 effective dose level optimal design sequential ED-design up-and-down design vertex direction method
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