BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as...Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as“Da Xia”and“Da Wu”.展开更多
“[ã44 kã44 paʔ5 lã44 tã53]”(Chinese characters transcription“昂更八冷打”)is an colloquial expression in Tongxiang dialect of Suzhou-Jiaxing-Huzhou Sub-branch,Taihu Branch,Wu.It describes an awkward state with ...“[ã44 kã44 paʔ5 lã44 tã53]”(Chinese characters transcription“昂更八冷打”)is an colloquial expression in Tongxiang dialect of Suzhou-Jiaxing-Huzhou Sub-branch,Taihu Branch,Wu.It describes an awkward state with unfinished tasks.Its similar expressions can be found in other regions of Taihu Branch,including Yixing,Changzhou,Shaoxing and Ningbo,usually serving as“all”,while the expression“[hÃɲ33 paʔ3 lÃɲ33 tÃɲ31]”(“亨八冷打”)in Shanghai Sub-branch indicates“the remaining parts”when used alone.“[hÃɲ33 paʔ3 lÃɲ33 tÃɲ31]”stands for“all”only when followed by a word with meaning of“adding together”.In this paper,it is concluded and deduced from other similar morphemes that the contradictory connotations are related to an“inner split”process of an original word.Considering similar morphemes in other Chinese dialects(including Cantonese,Hakka,Jianghuai and Min),the following analysis proposes three possible original expressions and correlating trajectories of this inner phonetic-semantic split process,and selects a most credible way based on the rhyming dictionary and previous reconstructive models of ancient Chinese phonology.This presumptive analysis indicates that a broader“split and derivate”process generating new morphemes exists widely in Sinitic dialects as a natural company of phonetic features in Chinese language flow.展开更多
In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological a...In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.展开更多
The paper focuses on Wu Zetian,the only empress in China’s history,and her relationship with Buddhism.This study focuses on the book Zizhi Tongjian and compares the differences in the portrayal of Wu Zetian’s connec...The paper focuses on Wu Zetian,the only empress in China’s history,and her relationship with Buddhism.This study focuses on the book Zizhi Tongjian and compares the differences in the portrayal of Wu Zetian’s connection with Buddhism with the ancient texts of the Old Tang Book and the New Tang Book.It uses historical contextualism to analyze the epochal implications of these differences in the Northern Song Dynasty.Additionally,the paper discusses how historians downplayed or marginalized Wu Zetian’s achievements while emphasizing the negative aspects of her reign.Notably,historian Sima Guang,who was influenced by Confucianism and his own political situation,produced a biased description of Wu Zetian and the Buddhism which she promoted during her reign.展开更多
WU polyomavirus,which was firstly discovered in 2007,is a new human polyomavirus belonging to Polyomaviridae and containing circular double-stranded genomic DNA.In this study,the 278 clinical sputum specimens from chi...WU polyomavirus,which was firstly discovered in 2007,is a new human polyomavirus belonging to Polyomaviridae and containing circular double-stranded genomic DNA.In this study,the 278 clinical sputum specimens from children under 5 years old were collected from Wenzhou Medical College affiliated Wenling First Hospital,Zhejiang Province.Based on identification assay of WU polyomavirus previously reported,a WU polyomavirus was identified from clinical samples successfully,the positive rate was 0.4%.The sequences of PCR products were identical to that of VP2 gene and large T antigen gene derived from WU polyomavirus reported.The above results strongly suggested that the WU polyomavirus isolated was firstly found in Chinese children with acute lower respiratory tract infections.This study provides a firm basis for further research of WU polyomavirus.展开更多
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
基金Research Center for the Protection and Development of Tangible Cultural Heritage in East Sichuan in 2022 (Project No.2022YB17)2018 Sichuan University of Arts and Sciences Ba Culture Research Special Project“Ba Culture Literature Compilation and Research” (Project Number:2018BWH001Z).
文摘Dachuan Baijie Muddymen Dance is a kind of dance with local characteristics.From its dance movements and prop usage,it should be related to ancient Ba people’s war dance,as well as to recorded ancient dances such as“Da Xia”and“Da Wu”.
文摘“[ã44 kã44 paʔ5 lã44 tã53]”(Chinese characters transcription“昂更八冷打”)is an colloquial expression in Tongxiang dialect of Suzhou-Jiaxing-Huzhou Sub-branch,Taihu Branch,Wu.It describes an awkward state with unfinished tasks.Its similar expressions can be found in other regions of Taihu Branch,including Yixing,Changzhou,Shaoxing and Ningbo,usually serving as“all”,while the expression“[hÃɲ33 paʔ3 lÃɲ33 tÃɲ31]”(“亨八冷打”)in Shanghai Sub-branch indicates“the remaining parts”when used alone.“[hÃɲ33 paʔ3 lÃɲ33 tÃɲ31]”stands for“all”only when followed by a word with meaning of“adding together”.In this paper,it is concluded and deduced from other similar morphemes that the contradictory connotations are related to an“inner split”process of an original word.Considering similar morphemes in other Chinese dialects(including Cantonese,Hakka,Jianghuai and Min),the following analysis proposes three possible original expressions and correlating trajectories of this inner phonetic-semantic split process,and selects a most credible way based on the rhyming dictionary and previous reconstructive models of ancient Chinese phonology.This presumptive analysis indicates that a broader“split and derivate”process generating new morphemes exists widely in Sinitic dialects as a natural company of phonetic features in Chinese language flow.
基金supported by the National Natural Science Foundation of China(81660649),and Innovative Scientific Research Project for Postgraduates of Hainan Medical University(HYYS2020-05)。
文摘In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.
文摘The paper focuses on Wu Zetian,the only empress in China’s history,and her relationship with Buddhism.This study focuses on the book Zizhi Tongjian and compares the differences in the portrayal of Wu Zetian’s connection with Buddhism with the ancient texts of the Old Tang Book and the New Tang Book.It uses historical contextualism to analyze the epochal implications of these differences in the Northern Song Dynasty.Additionally,the paper discusses how historians downplayed or marginalized Wu Zetian’s achievements while emphasizing the negative aspects of her reign.Notably,historian Sima Guang,who was influenced by Confucianism and his own political situation,produced a biased description of Wu Zetian and the Buddhism which she promoted during her reign.
文摘WU polyomavirus,which was firstly discovered in 2007,is a new human polyomavirus belonging to Polyomaviridae and containing circular double-stranded genomic DNA.In this study,the 278 clinical sputum specimens from children under 5 years old were collected from Wenzhou Medical College affiliated Wenling First Hospital,Zhejiang Province.Based on identification assay of WU polyomavirus previously reported,a WU polyomavirus was identified from clinical samples successfully,the positive rate was 0.4%.The sequences of PCR products were identical to that of VP2 gene and large T antigen gene derived from WU polyomavirus reported.The above results strongly suggested that the WU polyomavirus isolated was firstly found in Chinese children with acute lower respiratory tract infections.This study provides a firm basis for further research of WU polyomavirus.
