Gao-Yong湍流方程基于侧偏统计平均方法保留了湍流脉动量的一阶统计信息,并引入加权漂移速度对称性及正交各向异性,导出漂移流连续方程、动量方程和机械能方程,最后依据湍流物理的唯象论,使用动量传输链概念模化封闭了整个方程组.大量...Gao-Yong湍流方程基于侧偏统计平均方法保留了湍流脉动量的一阶统计信息,并引入加权漂移速度对称性及正交各向异性,导出漂移流连续方程、动量方程和机械能方程,最后依据湍流物理的唯象论,使用动量传输链概念模化封闭了整个方程组.大量算例验证了此方程对广泛范围的复杂湍流问题的适定性.为了进一步的工程应用,将其加入开源计算流体力学软件OpenFOAM(Open Field Operation and Manipulation)中,并就翼体角偶流动进行了数值模拟.翼体角偶流动具有三维分离、马蹄涡等十分复杂的流动特征,通过与实验测量结果的对比研究表明,Gao-Yong湍流方程不论在定性还是定量上,都成功捕捉到这类复杂流动现象的主要特征,得到了令人满意的结果.展开更多
Objective:To predict the effective components,potential targets and pathways of Simiao Yong’an Decoction in the treatment of lower extremity arteriosclerosis obliterans(ASO)based on the method of network pharmacology...Objective:To predict the effective components,potential targets and pathways of Simiao Yong’an Decoction in the treatment of lower extremity arteriosclerosis obliterans(ASO)based on the method of network pharmacology,and to explore the mechanism of Simiao Yong’an Decoction in treating ASO combined with cell experiment.Methods:TCMSP database was used to screen the active components and targets of Simiao Yong’an decoction,and Genecards and OMIM databases were used to obtain ASO related proteins;PPI network of drug disease target proteins was constructed by string platform;go function and KEGG pathway enrichment of Simiao Yong’an Decoction ASO target were analyzed by David database.The drug target pathway with high correlation with ASO was selected.The model of vascular smooth muscle cell injury(VSMCs)induced by ox LDL was used,and Simiao Yong’an decoction containing pharmaceutical Qing was given to verify the therapeutic effect of Simiao Yong’an Decoction on ox LDL induced VSMCs and its regulation on highly correlated target pathway.Results:A total of 126 active components of Simiao Yong'an Decoction were screened,40 targets of Simiao Yong’an Decoction ASO were selected,99 go biological processes and 48 related signal pathways were related to ASO;the experimental results showed that with the passage of time,Simiao Yongan decoction could significantly inhibit the proliferation of VSMCs(P<0.05);compared with the model group,the percentage of BrdU positive cells in each dose group of Simiao Yong’an decoction was significantly higher than that in the model group In addition,Simiao Yong’an decoction could significantly inhibit the proliferation of VSMCs(P<0.05);in addition,Simiao Yongan decoction could inhibit the levels of IL-6 and IL-1β(P<0.05);significantly inhibit the expression of PCNA,JAK2 and STAT3 mRNA(P<0.05);Conclusions:Simiao Yong’an decoction has the effect of"multi-component,multi-target and multi-channel"in the treatment of ASO.It can inhibit the activation of JAK/STAT signaling pathway,play an anti-inflammatory role and inhibit the proliferation of vascular smooth muscle cells.展开更多
In the eyes of history,the separation,especially separation between lovers is an eternal theme in literature works.In this paper,through comparisons and contrasts between Liu Yong’s Bells in the Ringing in the Rain a...In the eyes of history,the separation,especially separation between lovers is an eternal theme in literature works.In this paper,through comparisons and contrasts between Liu Yong’s Bells in the Ringing in the Rain and John Donne’s A Valediction:Forbidding Mourning from various perspectives and different backgrounds,the similarities as well as differences between these two Chinese and English poems can be perceived.A comprehensive and better understanding of the theme of separation can be obtained as well.展开更多
文摘Gao-Yong湍流方程基于侧偏统计平均方法保留了湍流脉动量的一阶统计信息,并引入加权漂移速度对称性及正交各向异性,导出漂移流连续方程、动量方程和机械能方程,最后依据湍流物理的唯象论,使用动量传输链概念模化封闭了整个方程组.大量算例验证了此方程对广泛范围的复杂湍流问题的适定性.为了进一步的工程应用,将其加入开源计算流体力学软件OpenFOAM(Open Field Operation and Manipulation)中,并就翼体角偶流动进行了数值模拟.翼体角偶流动具有三维分离、马蹄涡等十分复杂的流动特征,通过与实验测量结果的对比研究表明,Gao-Yong湍流方程不论在定性还是定量上,都成功捕捉到这类复杂流动现象的主要特征,得到了令人满意的结果.
基金Harbin Science and Technology Bureau Youth reserve talent project(No.2016RAQXJj209,2016RAQXJ157)"Double-First-Class"discipline development support fund of integrated traditional Chinese and Western Medicine(No.HIJSYL004)。
文摘Objective:To predict the effective components,potential targets and pathways of Simiao Yong’an Decoction in the treatment of lower extremity arteriosclerosis obliterans(ASO)based on the method of network pharmacology,and to explore the mechanism of Simiao Yong’an Decoction in treating ASO combined with cell experiment.Methods:TCMSP database was used to screen the active components and targets of Simiao Yong’an decoction,and Genecards and OMIM databases were used to obtain ASO related proteins;PPI network of drug disease target proteins was constructed by string platform;go function and KEGG pathway enrichment of Simiao Yong’an Decoction ASO target were analyzed by David database.The drug target pathway with high correlation with ASO was selected.The model of vascular smooth muscle cell injury(VSMCs)induced by ox LDL was used,and Simiao Yong’an decoction containing pharmaceutical Qing was given to verify the therapeutic effect of Simiao Yong’an Decoction on ox LDL induced VSMCs and its regulation on highly correlated target pathway.Results:A total of 126 active components of Simiao Yong'an Decoction were screened,40 targets of Simiao Yong’an Decoction ASO were selected,99 go biological processes and 48 related signal pathways were related to ASO;the experimental results showed that with the passage of time,Simiao Yongan decoction could significantly inhibit the proliferation of VSMCs(P<0.05);compared with the model group,the percentage of BrdU positive cells in each dose group of Simiao Yong’an decoction was significantly higher than that in the model group In addition,Simiao Yong’an decoction could significantly inhibit the proliferation of VSMCs(P<0.05);in addition,Simiao Yongan decoction could inhibit the levels of IL-6 and IL-1β(P<0.05);significantly inhibit the expression of PCNA,JAK2 and STAT3 mRNA(P<0.05);Conclusions:Simiao Yong’an decoction has the effect of"multi-component,multi-target and multi-channel"in the treatment of ASO.It can inhibit the activation of JAK/STAT signaling pathway,play an anti-inflammatory role and inhibit the proliferation of vascular smooth muscle cells.
文摘In the eyes of history,the separation,especially separation between lovers is an eternal theme in literature works.In this paper,through comparisons and contrasts between Liu Yong’s Bells in the Ringing in the Rain and John Donne’s A Valediction:Forbidding Mourning from various perspectives and different backgrounds,the similarities as well as differences between these two Chinese and English poems can be perceived.A comprehensive and better understanding of the theme of separation can be obtained as well.
