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Transient Experiments on a Prototype Pump with an Atypical Open Impeller for Different Discharge Valve Openings
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作者 Xiao Sun Huifan Huang +4 位作者 Yuliang Zhang Lianghuai Tong Xiaowei Xu Xiaoqi Jia Litao Ou 《Fluid Dynamics & Materials Processing》 EI 2024年第10期2251-2264,共14页
In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pe... In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pearson correlation coefficient was used to reveal the linear correlation between variables.According to the results,the stable rotational speed decreases with increasing valve opening(rotational speed decreases from approximately 1472 to 1453 r/min),while the stable shaft power exhibits an increasing trend(shaft power increases from approximately 0.242 to 0.390 kW).The stable time and zeroing time of each parameter during start-up and shutdown processes vary,with the flow zeroing time significantly increasing with the relative flow,reaching up to 10.468 s,while the shaft power zeroing time is roughly between 1.219 and 1.375 s.The results demonstrate that with increasing valve opening,the stable and zeroing time of flow significantly increase(|r|greater than 0.95),while the stable and zeroing time of rotational speed,power,and head display a smaller sensitivity on the valve opening(|r|less than 0.6). 展开更多
关键词 Centrifugal pump STARTUP SHUTDOWN external characteristics zeroing time
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Neural Dynamics for Cooperative Motion Control of Omnidirectional Mobile Manipulators in the Presence of Noises: A Distributed Approach
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作者 Yufeng Lian Xingtian Xiao +3 位作者 Jiliang Zhang Long Jin Junzhi Yu Zhongbo Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第7期1605-1620,共16页
This paper presents a distributed scheme with limited communications, aiming to achieve cooperative motion control for multiple omnidirectional mobile manipulators(MOMMs).The proposed scheme extends the existing singl... This paper presents a distributed scheme with limited communications, aiming to achieve cooperative motion control for multiple omnidirectional mobile manipulators(MOMMs).The proposed scheme extends the existing single-agent motion control to cater to scenarios involving the cooperative operation of MOMMs. Specifically, squeeze-free cooperative load transportation is achieved for the end-effectors of MOMMs by incorporating cooperative repetitive motion planning(CRMP), while guiding each individual to desired poses. Then, the distributed scheme is formulated as a time-varying quadratic programming(QP) and solved online utilizing a noise-tolerant zeroing neural network(NTZNN). Theoretical analysis shows that the NTZNN model converges globally to the optimal solution of QP in the presence of noise. Finally, the effectiveness of the control design is demonstrated by numerical simulations and physical platform experiments. 展开更多
关键词 Cooperative motion control noise-tolerant zeroing neural network(NTZNN) omnidirectional mobile manipulator(OMM) repetitive motion planning
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Penguins, Climate, Electricity, Horses
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作者 Michael Bank 《Engineering(科研)》 2024年第1期24-31,共8页
When it was proposed to use one wire instead of two or three, there were many objections. The most serious objection was this. 1) The entire globe is covered with three phase (three wires) lines. They work and transmi... When it was proposed to use one wire instead of two or three, there were many objections. The most serious objection was this. 1) The entire globe is covered with three phase (three wires) lines. They work and transmit energy. Nobody will remake them [1]. 2) Yes it is logically. Therefore in this work we will not speak detailed about one wire method. About this method there are patents, books, articles [2]. Maybe will be better to speak about penguins and horses. 展开更多
关键词 THREE-PHASE One-Wire System zeroing Nullifier
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MPZL2基因突变致耳聋1例
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作者 杨静静 曹俊彪 +2 位作者 郭玲 孙磊 臧珍 《中华耳科学杂志》 CSCD 北大核心 2024年第4期703-704,共2页
1临床资料患儿男,6岁,无耳聋家族史,母亲怀孕期间未感染病毒,出生3 d听力筛查双耳未通过,出生42 d复筛双耳仍未通过,于2017年7月4日来我院进行听力诊断。体检:营养中等,发育正常。耳科检查:双耳廓无畸形,外耳道畅洁,鼓膜完整,标志清楚。
关键词 Myelin Protein Zero Like 2(MPZL2) 基因突变 耳聋
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“Buckets effect”in the kinetics of electrocatalytic reactions 被引量:2
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作者 Haowen Cui Yan-Xia Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期388-396,I0010,共10页
In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic solutions.Experimental results demonstrate a rectangular hyperbo... In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic solutions.Experimental results demonstrate a rectangular hyperbolic relationship,i.e.,the ORR current excluding the effect of other variables increases with proton concentration and then tends to a constant value.We consider that this is caused by the limitation of ORR kinetics by the trace oxygen concentration in the solution,which determines the upper limit of ORR kinetics.A model of effective concentration is further proposed for rectangular hyperbolic relationships:when the reactant concentration is high enough to reach a critical saturation concentration,the effective reactant concentration will become a constant value.This could be due to the limited concentration of a certain reactant for reactions involving more than one reactant or the limited number of active sites available on the catalyst.Our study provides new insights into the kinetics of electrocatalytic reactions,and it is important for the proper evaluation of catalyst activity and the study of structureperformance relationships. 展开更多
关键词 Oxygen reduction reaction KINETICS Zero order Rectangular hyperbolic relationship pH effect
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IRS Assisted UAV Communications against Proactive Eavesdropping in Mobile Edge Computing Networks 被引量:1
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作者 Ying Zhang Weiming Niu Leibing Yan 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期885-902,共18页
In this paper,we consider mobile edge computing(MEC)networks against proactive eavesdropping.To maximize the transmission rate,IRS assisted UAV communications are applied.We take the joint design of the trajectory of ... In this paper,we consider mobile edge computing(MEC)networks against proactive eavesdropping.To maximize the transmission rate,IRS assisted UAV communications are applied.We take the joint design of the trajectory of UAV,the transmitting beamforming of users,and the phase shift matrix of IRS.The original problem is strong non-convex and difficult to solve.We first propose two basic modes of the proactive eavesdropper,and obtain the closed-form solution for the boundary conditions of the two modes.Then we transform the original problem into an equivalent one and propose an alternating optimization(AO)based method to obtain a local optimal solution.The convergence of the algorithm is illustrated by numerical results.Further,we propose a zero forcing(ZF)based method as sub-optimal solution,and the simulation section shows that the proposed two schemes could obtain better performance compared with traditional schemes. 展开更多
关键词 Mobile edge computing(MEC) unmanned aerial vehicle(UAV) intelligent reflecting surface(IRS) zero forcing(ZF)
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Performance Analysis of ZF and RZF in Low-Resolution ADC/DAC Massive MIMO Systems
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作者 Talha Younas Shen Jin +4 位作者 Muluneh Mekonnen Gao Mingliang Saqib Saleem Sohaib Tahir Mahrukh Liaqat 《China Communications》 SCIE CSCD 2024年第8期115-126,共12页
Large number of antennas and higher bandwidth usage in massive multiple-input-multipleoutput(MIMO)systems create immense burden on receiver in terms of higher power consumption.The power consumption at the receiver ra... Large number of antennas and higher bandwidth usage in massive multiple-input-multipleoutput(MIMO)systems create immense burden on receiver in terms of higher power consumption.The power consumption at the receiver radio frequency(RF)circuits can be significantly reduced by the application of analog-to-digital converter(ADC)of low resolution.In this paper we investigate bandwidth efficiency(BE)of massive MIMO with perfect channel state information(CSI)by applying low resolution ADCs with Rician fadings.We start our analysis by deriving the additive quantization noise model,which helps to understand the effects of ADC resolution on BE by keeping the power constraint at the receiver in radar.We also investigate deeply the effects of using higher bit rates and the number of BS antennas on bandwidth efficiency(BE)of the system.We emphasize that good bandwidth efficiency can be achieved by even using low resolution ADC by using regularized zero-forcing(RZF)combining algorithm.We also provide a generic analysis of energy efficiency(EE)with different options of bits by calculating the energy efficiencies(EE)using the achievable rates.We emphasize that satisfactory BE can be achieved by even using low-resolution ADC/DAC in massive MIMO. 展开更多
关键词 low-bit analog-digital converter massive(multiple-input-multiple-output)MIMO minimum mean square error(MMSE) regularized zero forcing zero forcing
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Reconfigurable mechanism-based metamaterials for ternary-coded elastic wave polarizers and programmable refraction control
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作者 Zhou HU Zhibo WEI +1 位作者 Yan CHEN Rui ZHU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第7期1225-1242,共18页
Elastic metamaterials with unusual elastic properties offer unprecedented ways to modulate the polarization and propagation of elastic waves.However,most of them rely on the resonant structural components,and thus are... Elastic metamaterials with unusual elastic properties offer unprecedented ways to modulate the polarization and propagation of elastic waves.However,most of them rely on the resonant structural components,and thus are frequency-dependent and unchangeable.Here,we present a reconfigurable 2D mechanism-based metamaterial which possesses transformable and frequency-independent elastic properties.Based on the proposed mechanism-based metamaterial,interesting functionalities,such as ternarycoded elastic wave polarizer and programmable refraction,are demonstrated.Particularly,unique ternary-coded polarizers,with 1-trit polarization filtering and 2-trit polarization separating of longitudinal and transverse waves,are first achieved.Then,the strong anisotropy of the proposed metamaterial is harnessed to realize positive-negative bi-refraction,only-positive refraction,and only-negative refraction.Finally,the wave functions with detailed microstructures are numerically verified. 展开更多
关键词 elastic metamaterial elastic wave reconfigurable design zero mode ternary code programmable refraction
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Influence of acceleration stage electrode voltage on the performance of double-stage Hall effect thruster with adjustable zero magnetic point
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作者 陈龙 高维富 +5 位作者 崔作君 段萍 许雪松 阚子晨 檀聪琦 陈俊宇 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第6期60-69,共10页
The configuration of electrode voltage and zero magnetic point position has a significant impact on the performance of the double-stage Hall effect thruster. A 2D-3V model is established based on the two-magnetic peak... The configuration of electrode voltage and zero magnetic point position has a significant impact on the performance of the double-stage Hall effect thruster. A 2D-3V model is established based on the two-magnetic peak type double-stage Hall thruster configuration, and a particle-in-cell simulation is carried out to investigate the influences of both acceleration electrode voltage value and zero magnetic point position on the thruster discharge characteristics and performances.The results indicate that increasing the acceleration voltage leads to a larger potential drop in the acceleration stage, allowing ions to gain higher energy, while electrons are easily absorbed by the intermediate electrode, resulting in a decrease in the anode current and ionization rate. When the acceleration voltage reaches 500 V, the thrust and efficiency are maximized, resulting in a 15%increase in efficiency. After the acceleration voltage exceeds 500 V, a potential barrier forms within the channel, leading to a decrease in thruster efficiency. Further study shows that as the second zero magnetic point moves towards the outlet of the channel, more electrons easily traverse the zero magnetic field region, participating in the ionization. The increase in the ionization rate leads to a gradual enhancement in both thrust and efficiency. 展开更多
关键词 Hall thruster particle-in-cell simulation intermediate electrode zero magnetic point
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Two innovative equivalent statements of the third law of thermodynamics
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作者 陈晓航 周颖慧 陈金灿 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期324-328,共5页
It is found from textbooks and literature that there are three different statements for the third law of thermodynamics,i.e., the Nernst theorem, the unattainability statement of absolute zero temperature, and the hea... It is found from textbooks and literature that there are three different statements for the third law of thermodynamics,i.e., the Nernst theorem, the unattainability statement of absolute zero temperature, and the heat capacity statement. It is pointed out that such three statements correspond to three thermodynamic parameters, which are, respectively, the entropy,temperature, and heat capacity, and can be obtained by extrapolating the experimental results of different parameters at ultralow temperatures to absolute zero. It is expounded that because there is no need for additional assumptions in the derivation of the Nernst equation, the Nernst theorem should be renamed as the Nernst statement. Moreover, it is proved that both the Nernst statement and the heat capacity statement are mutually deducible and equivalent, while the unattainability of absolute zero temperature is only a corollary of the Nernst statement or the heat capacity statement so that it is unsuitably referred to as one statement of the third law of thermodynamics. The conclusion is that the Nernst statement and the heat capacity statement are two equivalent statements of the third law of thermodynamics. 展开更多
关键词 Nernst statement heat capacity statement Nernst theorem absolute zero temperature the third law of thermodynamics
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RKDG Methods with Multi-resolution WENO Limiters for Solving Steady-State Problems on Triangular Meshes
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作者 Jun Zhu Chi-Wang Shu Jianxian Qiu 《Communications on Applied Mathematics and Computation》 EI 2024年第3期1575-1599,共25页
In this paper, we design high-order Runge-Kutta discontinuous Galerkin (RKDG) methods with multi-resolution weighted essentially non-oscillatory (multi-resolution WENO) limiters to compute compressible steady-state pr... In this paper, we design high-order Runge-Kutta discontinuous Galerkin (RKDG) methods with multi-resolution weighted essentially non-oscillatory (multi-resolution WENO) limiters to compute compressible steady-state problems on triangular meshes. A troubled cell indicator extended from structured meshes to unstructured meshes is constructed to identify triangular cells in which the application of the limiting procedures is required. In such troubled cells, the multi-resolution WENO limiting methods are used to the hierarchical L^(2) projection polynomial sequence of the DG solution. Through using the RKDG methods with multi-resolution WENO limiters, the optimal high-order accuracy can be gradually reduced to first-order in the triangular troubled cells, so that the shock wave oscillations can be well suppressed. In steady-state simulations on triangular meshes, the numerical residual converges to near machine zero. The proposed spatial reconstruction methods enhance the robustness of classical DG methods on triangular meshes. The good results of these RKDG methods with multi-resolution WENO limiters are verified by a series of two-dimensional steady-state problems. 展开更多
关键词 RKDG method Steady-state problem Multi-resolution WENO limiter Triangular mesh Machine zero
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Majorana noise model and its influence on the power spectrum
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作者 陈书梦 丁思凡 +1 位作者 张振涛 刘东 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期637-646,共10页
Majorana quantum computation offers a potential approach to securely manipulating and storing quantum data in a topological manner that may effectively resist the decoherence induced by local noise. However, actual Ma... Majorana quantum computation offers a potential approach to securely manipulating and storing quantum data in a topological manner that may effectively resist the decoherence induced by local noise. However, actual Majorana qubit setups are susceptible to noise. In this study, from a quantum dynamics perspective, we develop a noise model for Majorana qubits that accounts for quasi-particle poisoning and Majorana overlapping with fluctuation. Furthermore, we focus on Majorana parity readout methodologies, specifically those leveraging an ancillary quantum dot, and carry out an indepth exploration of continuous measurement techniques founded on the quantum jump model of a quantum point contact.Utilizing these methodologies, we proceed to analyze the influence of noise on the afore-mentioned noise model, employing numerical computation to evaluate the power spectrum and frequency curve. In the culmination of our study, we put forward a strategy to benchmark the presence and detailed properties of noise in Majorana qubits. 展开更多
关键词 Majorana zero mode topological quantum computation topological devices decoherence and noise in qubits
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Vector magnetometry in zero bias magnetic field using nitrogen-vacancy ensembles
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作者 Chunxing Li Fa-Zhan Shi +1 位作者 Jingwei Zhou Peng-Fei Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期21-29,共9页
The application of the vector magnetometry based on nitrogen-vacancy(NV)ensembles has been widely investigatedin multiple areas.It has the superiority of high sensitivity and high stability in ambient conditions with ... The application of the vector magnetometry based on nitrogen-vacancy(NV)ensembles has been widely investigatedin multiple areas.It has the superiority of high sensitivity and high stability in ambient conditions with microscale spatialresolution.However,a bias magnetic field is necessary to fully separate the resonance lines of optically detected magneticresonance(ODMR)spectrum of NV ensembles.This brings disturbances in samples being detected and limits the rangeof application.Here,we demonstrate a method of vector magnetometry in zero bias magnetic field using NV ensembles.By utilizing the anisotropy property of fluorescence excited from NV centers,we analyzed the ODMR spectrum of NVensembles under various polarized angles of excitation laser in zero bias magnetic field with a quantitative numerical modeland reconstructed the magnetic field vector.The minimum magnetic field modulus that can be resolved accurately is downto~0.64 G theoretically depending on the ODMR spectral line width(1.8 MHz),and~2 G experimentally due to noisesin fluorescence signals and errors in calibration.By using 13C purified and low nitrogen concentration diamond combinedwith improving calibration of unknown parameters,the ODMR spectral line width can be further decreased below 0.5 MHz,corresponding to~0.18 G minimum resolvable magnetic field modulus. 展开更多
关键词 vector magnetometry NV ensembles optically detected magnetic resonance(ODMR) zero bias magnetic field
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Research on Data Tampering Prevention Method for ATC Network Based on Zero Trust
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作者 Xiaoyan Zhu Ruchun Jia +1 位作者 Tingrui Zhang Song Yao 《Computers, Materials & Continua》 SCIE EI 2024年第3期4363-4377,共15页
The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect,which is easy to leads to the problem that the data is usurped.Starting from the ... The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect,which is easy to leads to the problem that the data is usurped.Starting from the application of the ATC(automatic train control)network,this paper focuses on the zero trust and zero trust access strategy and the tamper-proof method of information-sharing network data.Through the improvement of ATC’s zero trust physical layer authentication and network data distributed feature differentiation calculation,this paper reconstructs the personal privacy scope authentication structure and designs a tamper-proof method of ATC’s information sharing on the Internet.From the single management authority to the unified management of data units,the systematic algorithm improvement of shared network data tamper prevention method is realized,and RDTP(Reliable Data Transfer Protocol)is selected in the network data of information sharing resources to realize the effectiveness of tamper prevention of air traffic control data during transmission.The results show that this method can reasonably avoid the tampering of information sharing on the Internet,maintain the security factors of air traffic control information sharing on the Internet,and the Central Processing Unit(CPU)utilization rate is only 4.64%,which effectively increases the performance of air traffic control data comprehensive security protection system. 展开更多
关键词 Zero trust access policy air traffic information sharing network privacy data tam-per-proof certification features
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Multi-source heterogeneous data access management framework and key technologies for electric power Internet of Things
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作者 Pengtian Guo Kai Xiao +1 位作者 Xiaohui Wang Daoxing Li 《Global Energy Interconnection》 EI CSCD 2024年第1期94-105,共12页
The power Internet of Things(IoT)is a significant trend in technology and a requirement for national strategic development.With the deepening digital transformation of the power grid,China’s power system has initiall... The power Internet of Things(IoT)is a significant trend in technology and a requirement for national strategic development.With the deepening digital transformation of the power grid,China’s power system has initially built a power IoT architecture comprising a perception,network,and platform application layer.However,owing to the structural complexity of the power system,the construction of the power IoT continues to face problems such as complex access management of massive heterogeneous equipment,diverse IoT protocol access methods,high concurrency of network communications,and weak data security protection.To address these issues,this study optimizes the existing architecture of the power IoT and designs an integrated management framework for the access of multi-source heterogeneous data in the power IoT,comprising cloud,pipe,edge,and terminal parts.It further reviews and analyzes the key technologies involved in the power IoT,such as the unified management of the physical model,high concurrent access,multi-protocol access,multi-source heterogeneous data storage management,and data security control,to provide a more flexible,efficient,secure,and easy-to-use solution for multi-source heterogeneous data access in the power IoT. 展开更多
关键词 Power Internet of Things Object model High concurrency access Zero trust mechanism Multi-source heterogeneous data
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Cloud edge integrated security architecture of new cloud manufacturing system
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作者 ZHAO Longbo LI Bohu YUAN Haitao 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第5期1177-1189,共13页
With the rapid development of cloud manufacturing technology and the new generation of artificial intelligence technology,the new cloud manufacturing system(NCMS)built on the connotation of cloud manufacturing 3.0 pre... With the rapid development of cloud manufacturing technology and the new generation of artificial intelligence technology,the new cloud manufacturing system(NCMS)built on the connotation of cloud manufacturing 3.0 presents a new business model of“Internet of everything,intelligent leading,data driving,shared services,cross-border integration,and universal innovation”.The network boundaries are becoming increasingly blurred,NCMS is facing security risks such as equipment unauthorized use,account theft,static and extensive access control policies,unauthorized access,supply chain attacks,sensitive data leaks,and industrial control vulnerability attacks.Traditional security architectures mainly use information security technology,which cannot meet the active security protection requirements of NCMS.In order to solve the above problems,this paper proposes an integrated cloud-edge-terminal security system architecture of NCMS.It adopts the zero trust concept and effectively integrates multiple security capabilities such as network,equipment,cloud computing environment,application,identity,and data.It adopts a new access control mode of“continuous verification+dynamic authorization”,classified access control mechanisms such as attribute-based access control,rolebased access control,policy-based access control,and a new data security protection system based on blockchain,achieving“trustworthy subject identity,controllable access behavior,and effective protection of subject and object resources”.This architecture provides an active security protection method for NCMS in the digital transformation of large enterprises,and can effectively enhance network security protection capabilities and cope with increasingly severe network security situations. 展开更多
关键词 new cloud manufacturing system(NCMS) integrated cloud-edge-terminal security system architecture zero trust
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NORMALITY AND THE NUMBER OF ZEROS
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作者 WANG Guang-sheng WEI Dong-mei XU Yan 《数学杂志》 2024年第5期377-382,共6页
In this paper,we study normal families of meromorphic functions.By using the idea in[11],we obtain some normality criteria for families of meromorphic functions that concern the number of zeros of the differential pol... In this paper,we study normal families of meromorphic functions.By using the idea in[11],we obtain some normality criteria for families of meromorphic functions that concern the number of zeros of the differential polynomial,which extends the related result of Li,and Chen et al..An example is given to show that the hypothesis on the zeros of a(z)is necessary. 展开更多
关键词 Meromorphic function normal family differential polynomial ZERO
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Novel Brick Technology for Carbon Reduction Footprint in Steel Shop Linings
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作者 Carlos PAGLIOSA Leandro ROCHA +1 位作者 Marcelo BORGES Celio CAVALCANTE 《China's Refractories》 CAS 2024年第2期16-21,共6页
Clean steel encompasses a multitude of concepts that are based on fulfilling customer requirements and can be produced in many ways depending on the existing equipment and detailed customer demands.A common feature of... Clean steel encompasses a multitude of concepts that are based on fulfilling customer requirements and can be produced in many ways depending on the existing equipment and detailed customer demands.A common feature of all clean steel production is tight process control along with continuous monitoring.To meet an increasing demand for cold-rolled(CR)steel sheets of improved mechanical properties,and to cope with the change of the annealing process from a batch-type to a continuous process,it is necessary to establish a technique for making ultralow carbon(ULC)steel with a C-concentration lower than 20 ppm for the steelmaking process associated with a major challenge to guarantee the competitiveness with observance of environmental requirements.Steel ladle lining plays an important role on the energy consumption during the production and the refractory lining design contributes to minimize thermal bath loss,carbon pick up and shell temperature.A new generation of unfired zero carbon refractories was developed with two specific approaches:(1)replacement of firing bricks reducing CO_(2) footprint and(2)replacement of carbon containing with performance increasing.Bricks can be used in working and safety linings with a unique microstructure with better heat scattering and similar thermomechanical properties.This work presents customers’performance compared to traditional products highlighting energy savings. 展开更多
关键词 steel ladle zero carbon energy saving
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A Cross-Sectional Study on the Impact of Operation Triple Zero (OTZ) Program on Viral Load Suppression amongst Members of the Adolescent Club in 68 Nigerian Army Reference Hospital Yaba Lagos, Nigeria
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作者 Nkechinyere Harrison Ismail Lawal +7 位作者 Yakubu Adamu Kehinde Aribisala Adegbenga Olarinoye Uzoamaka Agbaim Funmilayo Owolabi Dooshima Okonkwo Laura Chittenden Nathan Okeji 《World Journal of AIDS》 2024年第2期35-44,共10页
Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national ... Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAIDS 95-95-95 goals. It seeks to empower AYPLHIV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral load suppression in the AYP of the facility. 展开更多
关键词 Impact Operation Triple Zero ADOLESCENT Viral Load NIGERIA
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Comprehensive Assessment of Anxiolytic Properties in 4-HPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses
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作者 Kawthar Alhussieni Rami Ayoub +7 位作者 Jamal Jilani Qais Jarrar Othman Alhussinei Vetriselvan Subramaniyan Esra Nasraldin Khalil Sharafaldin Harshini Muruganantham Jureerat Kijsomporn Ling Shing Wong 《Open Journal of Medicinal Chemistry》 2024年第3期29-44,共16页
Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-Hydroxyphenyl acetic acid (4-HP... Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-Hydroxyphenyl acetic acid (4-HPAA) is identified in brain cells as a physiological byproduct of tyramine. This study hypothesizes that 4-HPAA may regulate anxiety due to its anxiolytic properties, acting as a modulator of the GABAergic system, which plays a crucial role in the pathophysiology of anxiety disorders. Our study aims to enhance the anxiolytic effects of 4-HPAA through chemical modification to improve its pharmacokinetic properties. Three derivatives, namely Isopropyl-4-hydroxy-[phenyl] acetate (IHPA), Isopropyl-4-hydroxy-[phenyl] acetate (MPAA), and 4-methoxyphenyl acetate (MPHA), have been synthesized from 4-HPAA. This assessment will use well-established animal models, specifically the Elevated Plus-Maze (EPM) and Zero Maze (EZM) tests, selected for their validity in replicating anxiety-like symptoms in animals. Chronic caffeine administration via drinking water (0.3 g/l for 14 days) was employed to induce an anxiety state for testing purposes. IHPA and MPAA demonstrated significant anxiolyticactivity when tested in the EPM and EZM experiments. Molecular docking simulations using AutoDock Vina indicated that 4-HPAA derivatives had docking scores ranging from −5.8 to −4.8 kcal/mol, compared to the standard anxiolytic medication Diazepam, which scored −7.1 kcal/mol. These scores suggest a potential for 4-HPAA derivatives to interact effectively with the Gamma-aminobutyric acid (GABA_A) receptor. In conclusion, our in vivo and in silico analyses indicate a promising anxiolytic potential for 4-HPAA derivatives. 展开更多
关键词 ANXIOLYTICS 4-HPAA Molecular Docking Elevated Plus-Maze Zero Maze Tests
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