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肺癌组织中Atonal homolog 1与Disabled-2的表达及其临床意义
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作者 刘洋 杨连赫 +2 位作者 徐洪涛 李庆昌 王恩华 《现代肿瘤医学》 CAS 2013年第1期57-62,共6页
目的:分析Atonal homolog 1(Atoh1)和Disabled-2(Dab2)在肺癌组织中的表达及其与临床病理因素间的关系。方法:采用免疫组化方法检测Atoh1和Dab2在100例非小细胞肺癌中的表达情况。结果:在100例非小细胞肺癌中,Atoh1的细胞质和细胞核的... 目的:分析Atonal homolog 1(Atoh1)和Disabled-2(Dab2)在肺癌组织中的表达及其与临床病理因素间的关系。方法:采用免疫组化方法检测Atoh1和Dab2在100例非小细胞肺癌中的表达情况。结果:在100例非小细胞肺癌中,Atoh1的细胞质和细胞核的平均阳性表达率分别为82.70%±19.06%和43.10%±27.16%,明显高于Atoh1在癌旁正常组织中的细胞质和细胞核的平均阳性表达率(71.80%±19.14%,18.77%±10.54%)。Atoh1在细胞核内的表达与肺癌的低分化(P=0.026)负相关,并且在肺腺癌(P=0.002)和女性患者(P=0.042)中阳性率较高。Dab2在细胞核内的表达与肺癌的原发灶T分期负相关(P=0.025),并且与肺癌的TNM分期相关(P=0.002)。Atoh1在肺癌中的细胞质表达与Dab2的细胞质表达显著相关(P<0.001)。结论:Atoh1在细胞核内的表达与肺癌的低分化负相关,Dab2在细胞核内的表达与肺癌患者TNM分期负相关。Atoh1和Dab2在肺癌组织中可能具有协同表达的现象。 展开更多
关键词 肺癌 atonal HOMOLOG 1 Disabled-2 免疫组织化学
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转录因子Atonal家族的研究进展 被引量:1
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作者 胡平 冯凡 陈克平 《生物学杂志》 CAS CSCD 2013年第5期81-84,100,共5页
转录因子atonal因其具有一个碱性螺旋-环-螺旋(bHLH)结构而被归属于bHLH转录因子家族,在调节真核生物生长发育过程中起着重要作用。目前的实验研究已经证明它与视觉、听觉、嗅觉的形成有关,同时在不同时期还能够决定细胞的分化命运和抑... 转录因子atonal因其具有一个碱性螺旋-环-螺旋(bHLH)结构而被归属于bHLH转录因子家族,在调节真核生物生长发育过程中起着重要作用。目前的实验研究已经证明它与视觉、听觉、嗅觉的形成有关,同时在不同时期还能够决定细胞的分化命运和抑制肿瘤的扩散。主要从模式生物果蝇和小鼠中的基因结构、组织分布、功能特征等方面研究概述,为进一步了解其他物种atonal转录因子的功能和作用机制奠定基础。 展开更多
关键词 bHLH转录因子 atonal家族 结构 功能
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Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development
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作者 Misako Okumura Takahiro Chihara 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1394-1395,共2页
Basic helix-loop-helix (bHLH) transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the fo... Basic helix-loop-helix (bHLH) transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila (larman et al., 1993, 1994). Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs (Jar- man et al., 1993). Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors (R1-R7) directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells (Jarman et al., 1994). 展开更多
关键词 ORN Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development
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Thirty-gauge needle-guided purse-string suture pupilloplasty:a new technique
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作者 Chun-Ming Chen Hong Zhong +4 位作者 Yan Shao Cheng-Yao Qin Ze-Hao Liu Wen-Xiu Sun Min Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第12期2327-2332,共6页
AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string p... AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string pupilloplasty were retrospectively analyzed.Preoperative data and at least 6mo of postoperative data were collected from all the patients.RESULTS:The corrected distance visual acuity(CDVA)before and after surgery was 0.58±0.22 and 0.20±0.10 logMAR,respectively(P=0.002).The pre-and postoperative pupil size was 7.38±0.88 and 3.09±0.71 mm(P=0.000),respectively.The corneal endothelial cell count was 2841±176/mm^(2) before and 2692±143/mm^(2) after surgery(P=0.000).No intraoperative or postoperative complications were reported.During the follow-up period of at least 6mo,all treated pupils were centered and generally or nearly round.Furthermore,the patients did not exhibit photophobia,glare,or diplopia.CONCLUSION:This technique is a simple and effective method for pupil reduction. 展开更多
关键词 purse-string suture iris reconstruction iris cerclage atonic pupil needle-guided suture
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Some Inequalities for L_p-mixed Affine Surface Area 被引量:1
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作者 朱先阳 《Chinese Quarterly Journal of Mathematics》 CSCD 2012年第4期572-581,共10页
In this paper, the concepts of the ith L;-mixed affine surface area and Lp-polar curvature images are introduced, some new inequalities connecting these new notions with Lρ-centroid bodies and ρ-Blaschke bodies are ... In this paper, the concepts of the ith L;-mixed affine surface area and Lp-polar curvature images are introduced, some new inequalities connecting these new notions with Lρ-centroid bodies and ρ-Blaschke bodies are showed. Moreover, a Blaschke-Santalo type inequality for Lρ-mixed affine surface area is established. Our results also imply the similar to the inequalities for Marcus-Lopes, Bergstrom and Ky Fan. 展开更多
关键词 Lρ-mixed atone surface area Lρ-polar curvature images ρ-Blaschke linearcombination Lρ-centroid body
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The“Conscious Absence”and“Virtuoso Presence”of Hegemonic Masculinity——Deciphering Ian McEwan's Atonement
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作者 谢淑芬 《海外英语》 2016年第10期137-140,144,共5页
Wittingly concealing the father images in his novel Atonement(2001), McEwan creates the"absence"of traditional hegemonic masculinity, which is a conscious activity in a combined consideration of the figural ... Wittingly concealing the father images in his novel Atonement(2001), McEwan creates the"absence"of traditional hegemonic masculinity, which is a conscious activity in a combined consideration of the figural and thematic progress, the grim social context, as well as his anxiety of influence and identity. Although this manliness is effaced on the surface, regarding the powerful images within, male authority still keeps running through the whole work. Hegemonic masculinity"presents"in manifold transformed and metaphorical forms, invisibly dictating the development of the protagonists and plots. This paper, giving a masculine reading through R.W. Connell's lens, aims to analyze and crystallize McEwan's such male writing, and finally to reach his real concerns: to deconstruct patriarchal culture, to defy dominant discourse, and to build a new order that opens up a real equality and coexistence for both the two sexes. 展开更多
关键词 Ian McEwan ATONEMENT hegemonic MASCULINITY PATRIARCHAL CULTURE R.W.Connell
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Super resolution reconstruction of moving objects from low resolution surveillance video
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作者 王素玉 Shen Lansun +1 位作者 David Daganfeng Li Xiaoguang 《High Technology Letters》 EI CAS 2008年第2期123-128,共6页
Construction of high resolution images from low resolution sequences having rigid or semi-rigid ob-jects with unified motions is often important in surveillance and other applications.In this paper a novelobject-based... Construction of high resolution images from low resolution sequences having rigid or semi-rigid ob-jects with unified motions is often important in surveillance and other applications.In this paper a novelobject-based super resolution reconstruction scheme was proposed,in which a six-parameter affine model-based object tracking and registration method was first used to segment and match objects among a se-quence of low resolution frames.The motion model was then further extended to the traditional maximuma posterior(MAP)super resolution algorithm.The proposed object tracking and registration method wasevaluated by both simulated and real acquired sequences.The results have demonstrated the high accura-cy of the proposed object based method and the enhanced reconstruction performance of the extended ap-proach. 展开更多
关键词 super resolution reconstruction visual surveillance maximum a posterior (MAP) atone model motion estimation
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Merck收购Aton增强抗癌药地位
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作者 景新 《国外药讯》 2004年第5期19-20,共2页
关键词 Merck公司 抗癌药 Aton Pharma公司 多发性骨髓瘤
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词汇衔接的重构与英汉语篇翻译质量——以小说Atonement的翻译为例 被引量:3
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作者 施秋蕾 《外语教学理论与实践》 CSSCI 北大核心 2014年第1期77-81,57,共6页
英语词汇衔接的两大模式,即复现和搭配,不仅可形成近程纽带,也可构成远程纽带,其成功识别与重构对提高英汉语篇翻译质量有重要意义。小说Atonement的中译本为分析英汉翻译过程中词汇衔接重构存在的问题及对语篇翻译质量的影响提供了原材... 英语词汇衔接的两大模式,即复现和搭配,不仅可形成近程纽带,也可构成远程纽带,其成功识别与重构对提高英汉语篇翻译质量有重要意义。小说Atonement的中译本为分析英汉翻译过程中词汇衔接重构存在的问题及对语篇翻译质量的影响提供了原材料,本文从中总结出形式对应的词汇衔接翻译策略。 展开更多
关键词 词汇衔接 翻译质量 形式对应 ATONEMENT
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Irreducible A1(1)-modules from modules over two-dimensional non-abelian Lie algebra 被引量:1
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作者 Genqiang LIU Yueqiang ZHAO 《Frontiers of Mathematics in China》 SCIE CSCD 2016年第2期353-363,共11页
For any module V over the two-dimensional non-abelian Lie algebra b and scalar a ∈C, we define a class of weight modules Fα(V) with zero central charge over the affine Lie algebra A(1). These weight modules have... For any module V over the two-dimensional non-abelian Lie algebra b and scalar a ∈C, we define a class of weight modules Fα(V) with zero central charge over the affine Lie algebra A(1). These weight modules have infinite- dimensional weight spaces if and only if V is infinite dimensional. In this paper, we will determine necessary and sufficient conditions for these modules Fα(V) to be irreducible. In this way, we obtain a lot of irreducible weight A1(1)-modules with infinite-dimensional weight spaces. 展开更多
关键词 Atone Lie algebras irreducible modules weight modules
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