Wereport a base-promoted catalyst-free protocol for the highly regioselective hydroacylation of styrenes with hydrazones derived from naturally abundant aldehydes.This protocolgeneratedlinearketoneswith goodfunctional...Wereport a base-promoted catalyst-free protocol for the highly regioselective hydroacylation of styrenes with hydrazones derived from naturally abundant aldehydes.This protocolgeneratedlinearketoneswith goodfunctional grouptolerance anda broadsubstrate scope under mild conditions.Mechanistic studies showed that the addition of hydrazone anion to a styrene double bond was the key step,different from previoushydroacylationpathways(viaorganometallic complexes or radical intermediates).展开更多
Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discove...Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in 2008.Diverse organic structures act as additives that assist these reactions.These additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain mechanisms.This review provides an overview of the initiation stages of these reactions.展开更多
t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell t...t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell tolerated under the optimal condition, making this reaction particularly attractive for expanding the scope of thepresent protocols that provides bis（1H-indol-3-yl）arylmethanes.展开更多
基金from the National Natural Science Foundation of China(grant no.21971093)the International Joint Research Centre for Green Catalysis and Synthesis(grant no.2016B01017),and the 111 project.
文摘Wereport a base-promoted catalyst-free protocol for the highly regioselective hydroacylation of styrenes with hydrazones derived from naturally abundant aldehydes.This protocolgeneratedlinearketoneswith goodfunctional grouptolerance anda broadsubstrate scope under mild conditions.Mechanistic studies showed that the addition of hydrazone anion to a styrene double bond was the key step,different from previoushydroacylationpathways(viaorganometallic complexes or radical intermediates).
基金EPSRCGSKthe University of Strathclyde for funding(AJS)
文摘Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in 2008.Diverse organic structures act as additives that assist these reactions.These additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain mechanisms.This review provides an overview of the initiation stages of these reactions.
文摘t-BuOK-promoted synthesis of bis（indolyl）arylmethunes from aromatic aldehydes and indoles wasachieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, arewell tolerated under the optimal condition, making this reaction particularly attractive for expanding the scope of thepresent protocols that provides bis（1H-indol-3-yl）arylmethanes.
