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基于改进Cascade R-CNN的安全帽检测算法 被引量:1
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作者 冯佩云 钱育蓉 +3 位作者 范迎迎 魏宏杨 秦雨刚 莫王昊 《微电子学与计算机》 2024年第1期63-73,共11页
针对安全帽检测中,目标形状、尺度变化大,易出现漏检、误检等问题,提出了一种基于改进级联基于区域的卷积神经网络(Cascade R-CNN)的安全帽检测算法。首先,对ResNet50进行改进形成D-ResNet50,利用可变形卷积仅增加少量参数就可增大感受... 针对安全帽检测中,目标形状、尺度变化大,易出现漏检、误检等问题,提出了一种基于改进级联基于区域的卷积神经网络(Cascade R-CNN)的安全帽检测算法。首先,对ResNet50进行改进形成D-ResNet50,利用可变形卷积仅增加少量参数就可增大感受野的特性,对特征提取网络的C2~C5卷积层进行重塑,提高网络对目标几何变换的适应能力和特征提取能力。其次,将D-ResNet50作为主干网络引入Cascade R-CNN,形成级联目标检测器,在每个阶段对正负样本重采样,抑制误检问题。再次,对递归特征金字塔进行改进,更高效地进行多尺度特征融合,并且基于反馈信息对特征进行二次处理,增强特征表达,提高网络的分类和定位能力。最后,使用Soft-非极大值抑制(Soft-NMS)进行后处理,进一步解决漏检问题。提出的方法在Hard hat workers数据集上的AP值相比检测基线提高了3.5%,与Sparse R-CNN、TridentNet、VFnet等先进算法相比分别提升了4.7%、5.9%、2.3%等。 展开更多
关键词 安全帽检测 多尺度特征融合 反馈连接 可变形卷积 cascade R-CNN CARAFE
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Pluggable multitask diffractive neural networks based on cascaded metasurfaces 被引量:4
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作者 Cong He Dan Zhao +8 位作者 Fei Fan Hongqiang Zhou Xin Li Yao Li Junjie Li Fei Dong Yin-Xiao Miao Yongtian Wang Lingling Huang 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第2期23-31,共9页
Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been c... Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been considered as one of the powerful tools in promoting the fields of imaging processing and object recognition.However,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems simultaneously.To push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal plug-ins.As the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared regimes.Encouragingly,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems. 展开更多
关键词 optical neural networks diffractive deep neural networks cascaded metasurfaces
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Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms 被引量:3
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作者 Keyao Li Yiming Wang +6 位作者 Dapu Pi Baoli Li Haitao Luan Xinyuan Fang Peng Chen Yanqing Lu Min Gu 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第1期28-35,共8页
Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since... Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display. 展开更多
关键词 holographic encryption optical secret sharing cascaded liquid crystal hologram multi-dimensional multiplexing
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基于改进Cascade R-CNN算法的船舶目标检测方法
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作者 杨镇宇 石刘 《舰船科学技术》 北大核心 2024年第6期144-149,共6页
为了解决实际场景下船舶目标检测精度低的问题,本文在Cascade R-CNN算法的基础上,提出一种船舶目标检测方法 Boat R-CNN。Boat R-CNN使用带自注意力机制的Swin-Transformer Tiny网络提取图像特征,使用Soft-NMS非极大值抑制方法提升候选... 为了解决实际场景下船舶目标检测精度低的问题,本文在Cascade R-CNN算法的基础上,提出一种船舶目标检测方法 Boat R-CNN。Boat R-CNN使用带自注意力机制的Swin-Transformer Tiny网络提取图像特征,使用Soft-NMS非极大值抑制方法提升候选框过滤精度,使用Smooth_L1损失函数加速模型收敛并减少梯度爆炸情况,使用CIOU边界框回归损失提高候选框回归质量,并针对船舶目标的形状特征优化锚框的长宽比,提高锚框的生成质量。实验结果表明,Boat R-CNN算法的精度相比原版Cascade R-CNN算法提高了21.8%,相比主流Faster R-CNN算法提高了30.3%,有效提升了实际场景下的船舶目标检测精度。 展开更多
关键词 船舶 目标检测 深度学习 cascade R-CNN Swin Transformer
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基于Cascade R-CNN的乳腺钼靶肿块检测算法研究
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作者 王立圣 李汉林 《计算机与数字工程》 2024年第4期966-972,共7页
乳腺癌生物学特性复杂,恶性程度极高,位于女性恶性肿瘤发病率首位。乳腺钼靶肿块的X射线检查是早期确诊乳腺癌的重要方式。但乳腺钼靶肿块的检测尚处于早期阶段,现有的计算机辅助检测检测精度较低。针对这一问题,论文提出了一种基于Casc... 乳腺癌生物学特性复杂,恶性程度极高,位于女性恶性肿瘤发病率首位。乳腺钼靶肿块的X射线检查是早期确诊乳腺癌的重要方式。但乳腺钼靶肿块的检测尚处于早期阶段,现有的计算机辅助检测检测精度较低。针对这一问题,论文提出了一种基于Cascade R-CNN的乳腺钼靶肿块检测方法。实验使用南佛罗里达大学的乳房X光检查数据集,将乳腺钼靶肿块分为良性和恶性两类。通过在特征网络中加入注意力模块,提取了较为丰富的乳腺钼靶肿块特征。此外,论文提出了一种新的FPN网络FA-FPN,进一步提高了乳腺钼靶肿块病灶特征的提取,解决了深层网络在下采样中特征出现稀释的问题,提高了乳腺钼靶肿块的检测准确率。经实验验证,该模型在南佛罗里达大学的乳房X光检查数据集上的mAP值达到82.9%,在AP75下表现尤为突出。该方法在乳腺钼靶肿块的检测中具有良好的性能,可以提高乳腺钼靶肿块的检测精度,并在一定程度上避免了误检和漏检。 展开更多
关键词 乳腺钼靶肿块检测 cascade R-CNN 特征提取 FPN
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基于Local Cascade Ensemble方法的胎儿健康自动分类
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作者 黄梅佳 李宗辉 郑博伟 《信息技术与信息化》 2024年第4期122-125,共4页
为更好地自动评估胎儿宫内状态,提出一种基于local cascade ensemble(LCE)方法的胎儿健康状态分类模型。选用UCI数据集,使用ADASYN方法对不平衡数据集进行填充平衡,接着结合随机森林算法对数据特征进行选择,最后使用LCE方法对胎儿状态... 为更好地自动评估胎儿宫内状态,提出一种基于local cascade ensemble(LCE)方法的胎儿健康状态分类模型。选用UCI数据集,使用ADASYN方法对不平衡数据集进行填充平衡,接着结合随机森林算法对数据特征进行选择,最后使用LCE方法对胎儿状态进行自动分类。实验结果表明,所提出模型使用的方法平均准确率、精确率、召回率和F1分数分别达到了0.9554、0.9054、0.9557和0.9290,对比传统的机器学习算法能得到更好的分类效果,有效降低了误判率。 展开更多
关键词 机器学习 胎儿监护 自动分类 Local cascade Ensemble
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OFDM with Generalized Cascade Index Modulation for Secure Communications
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作者 Hu Zeng Jin Xiaopin +3 位作者 Yao Yudong Chen Fangjiong Wan Dehuan Liu Yun 《China Communications》 SCIE CSCD 2024年第10期210-225,共16页
Cascade index modulation(CIM) is a recently proposed improvement of orthogonal frequency division multiplexing with index modulation(OFDM-IM) and achieves better error performance.In CIM, at least two different IM ope... Cascade index modulation(CIM) is a recently proposed improvement of orthogonal frequency division multiplexing with index modulation(OFDM-IM) and achieves better error performance.In CIM, at least two different IM operations construct a super IM operation or achieve new functionality. First, we propose a OFDM with generalized CIM(OFDM-GCIM) scheme to achieve a joint IM of subcarrier selection and multiple-mode(MM)permutations by using a multilevel digital algorithm.Then, two schemes, called double CIM(D-CIM) and multiple-layer CIM(M-CIM), are proposed for secure communication, which combine new IM operation for disrupting the original order of bits and symbols with conventional OFDM-IM, to protect the legitimate users from eavesdropping in the wireless communications. A subcarrier-wise maximum likelihood(ML) detector and a low complexity log-likelihood ratio(LLR) detector are proposed for the legitimate users. A tight upper bound on the bit error rate(BER) of the proposed OFDM-GCIM, D-CIM and MCIM at the legitimate users are derived in closed form by employing the ML criteria detection. Computer simulations and numerical results show that the proposed OFDM-GCIM achieves superior error performance than OFDM-IM, and the error performance at the eavesdroppers demonstrates the security of D-CIM and M-CIM. 展开更多
关键词 cascade index modulation low-complexity detector maximum likelihood OFDM physical layer security
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Conjugated microporous polymers-scaffolded enzyme cascade systems with enhanced catalytic activity
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作者 Zhenhua Wu Jiafu Shi +6 位作者 Boyu Zhang Yushuai Jiao Xiangxuan Meng Ziyi Chu Yu Chen Yiran Cheng Zhongyi Jiang 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第8期213-223,共11页
Enhancing catalytic activity of multi-enzyme in vitro through substrate channeling effect is promis-ing yet challenging.Herein,conjugated microporous polymers(CMPs)-scaffolded integrated en-zyme cascade systems(I-ECSs... Enhancing catalytic activity of multi-enzyme in vitro through substrate channeling effect is promis-ing yet challenging.Herein,conjugated microporous polymers(CMPs)-scaffolded integrated en-zyme cascade systems(I-ECSs)are constructed through co-entrapping glucose oxidase(GOx)and horseradish peroxidase(HRP),in which hydrogen peroxide(H_(2)O_(2)) is the intermediate product.The interplay of low-resistance mass transfer pathway and appropriate pore wall-H_(2)O_(2) interactions facilitates the directed transfer of H_(2)O_(2),resulting in 2.4-fold and 5.0-fold elevation in catalytic activ-ity compared to free ECSs and separated ECSs,respectively.The substrate channeling effect could be regulated by altering the mass ratio of GOx to HRP.Besides,I-ECSs demonstrate excellent stabili-ties in harsh environments and multiple recycling. 展开更多
关键词 BIOCATALYSIS IMMOBILIZATION Enzyme cascade system Substrate channeling effect Conjugated microporous polymers
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Enhanced picosecond terahertz wave generation based on cascade effects in a terahertz parametric generator
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作者 张敬喜 王与烨 +5 位作者 徐炳烽 陈锴 刘紫鲲 马鸿儒 徐德刚 姚建铨 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期271-275,共5页
Enhanced terahertz wave generation via a Stokes cascade process has been demonstrated using picosecond pulse pumped terahertz parametric generation at 1 kHz repetition rate.Clear cascade saturation of terahertz output... Enhanced terahertz wave generation via a Stokes cascade process has been demonstrated using picosecond pulse pumped terahertz parametric generation at 1 kHz repetition rate.Clear cascade saturation of terahertz output was observed,and the corresponding cascade-Stokes spectra were analyzed.The maximum terahertz wave average power was 22μW under a pump power of 30 W,whereas the maximum power conversion efficiency was 8×10^(-7)under a pump power of 21 W.The THz power fluctuation was measured to be about 1%in 20 min.This THz parametric source with a relatively stable output is suitable for a variety of practical applications. 展开更多
关键词 terahertz parametric generation stimulated polariton cascade effect CLN crystal
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Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade Structure Tuning for Highly Stable Biomass Upgrading
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作者 Xiaoli Jiang Xianhui Ma +7 位作者 Yuanteng Yang Yang Liu Yanxia Liu Lin Zhao Penglei Wang Yagang Zhang Yue Lin Yen Wei 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第12期449-467,共19页
Electrocatalytic 5-hydroxymethylfurfural oxidation reaction(HMFOR)provides a promising strategy to convert biomass derivative to highvalue-added chemicals.Herein,a cascade strategy is proposed to construct Pd-NiCo_(2)... Electrocatalytic 5-hydroxymethylfurfural oxidation reaction(HMFOR)provides a promising strategy to convert biomass derivative to highvalue-added chemicals.Herein,a cascade strategy is proposed to construct Pd-NiCo_(2)O_(4)electrocatalyst by Pd loading on Ni-doped Co3O4 and for highly active and stable synergistic HMF oxidation.An elevated current density of 800 mA cm^(-2)can be achieved at 1.5 V,and both Faradaic efficiency and yield of 2,5-furandicarboxylic acid remained close to 100%over 10 consecutive electrolysis.Experimental and theoretical results unveil that the introduction of Pd atoms can modulate the local electronic structure of Ni/Co,which not only balances the competitive adsorption of HMF and OH-species,but also promote the active Ni^(3+)species formation,inducing high indirect oxidation activity.We have also discovered that Ni incorporation facilitates the Co2+pre-oxidation and electrophilic OH*generation to contribute direct oxidation process.This work provides a new approach to design advanced electrocatalyst for biomass upgrading. 展开更多
关键词 5-Hydroxymethylfurfural oxidation reaction Competitive adsorption cascade strategy Elevated current density
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Phase-locked single-mode terahertz quantum cascade lasers array
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作者 Yunfei Xu Weijiang Li +9 位作者 Yu Ma Quanyong Lu Jinchuan Zhang Shenqiang Zhai Ning Zhuo Junqi Liu Shuman Liu Fengmin Cheng Lijun Wang Fengqi Liu 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期87-91,共5页
We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 K.The device utilizes a Talbot cavity to achieve phase locking among five ridge l... We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 K.The device utilizes a Talbot cavity to achieve phase locking among five ridge lasers with first-order buried distributed feedback(DFB)grating,resulting in nearly five times amplification of the single-mode power.Due to the optimum length of Talbot cavity depends on wavelength,the combination of Talbot cavity with the DFB grating leads to better power amplification than the combination with multimode Fabry-Perot(F-P)cavities.The Talbot cavity facet reflects light back to the ridge array direction and achieves self-imaging in the array,enabling phase-locked operation of ridges.We set the spacing between adjacent elements to be 220μm,much larger than the free-space wavelength,ensuring the operation of the fundamental supermode throughout the laser's dynamic range and obtaining a high-brightness far-field distribution.This scheme provides a new approach for enhancing the single-mode power of THz QCLs. 展开更多
关键词 quantum cascade lasers phase locking TERAHERTZ single mode
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基于CSS-Cascade Mask R-CNN的有遮挡多片烟叶部位识别
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作者 朱波 胡朋 +1 位作者 刘宇晨 张冀武 《农业工程学报》 EI CAS CSCD 北大核心 2024年第9期271-280,共10页
烟叶部位信息是进行烟叶分级的重要参考信息,准确识别烟叶部位对实现烟叶智能分级具有重要意义。在实际的烟叶智能分级应用中,为了提高分级效率,需要对多片烟叶等级进行同步识别。受现行上料方式的限制,同步识别的多片烟叶间往往存在局... 烟叶部位信息是进行烟叶分级的重要参考信息,准确识别烟叶部位对实现烟叶智能分级具有重要意义。在实际的烟叶智能分级应用中,为了提高分级效率,需要对多片烟叶等级进行同步识别。受现行上料方式的限制,同步识别的多片烟叶间往往存在局部遮挡的问题,给烟叶的目标检测和部位识别带来挑战。该研究提出一种基于改进Cascade Mask R-CNN,融合通道、非局部和空间注意力机制,并引入柔性极大值抑制检测框交并操作与斯库拉交并比损失函数(SIoU)的目标检测与识别模型(CSS-Cascade Mask R-CNN)。该模型对Cascade Mask R-CNN进行了三方面的改进:一是在其骨干网络Resent101上同时引入通道、非局部、空间3种注意力机制,使网络更加关注未被遮挡且部位特征明显区域的显著度;二是将Cascade Mask R-CNN中的损失函数SmoothL1Loss替换为SIoU损失函数,将预测框与真实框之间的方向差异引入到模型训练中提高模型检测精度;三是在筛选候选框时将常规的非极大抑制(non-max-suppression)替换为柔性非极大抑制,以避免删除候选框造成信息丢失。试验结果表明,利用提出的模型对有遮挡多片烟叶进行检测和部位识别,检测框平均准确率均值(bbox_mAP50)达到了80.2%,与改进前的Cascade Mask R-CNN模型相比提高了7.5个百分点。提出的模型与多个主流的目标检测模型(YOLOvX、YOLOv3、YOLOv5、Mask R-CNN、Cascade R-CNN)相比,分别高7.1、10.2、5.8、9.2、8.4个百分点,尤其是对较难区分的下部烟叶优势明显,因此研究结果可以为有遮挡多片烟叶部位的检测识别提供参考。 展开更多
关键词 机器视觉 烟叶部位识别 局部遮挡 cascade Mask R-CNN 非局部注意力机制
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Neutrophil-mimetic hybrid liposome with ROS cascade amplification for synergistic ferroptosis-photodynamic therapy of breast cancer
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作者 Jiaxin Li Jiaxin Li +8 位作者 Jiao He Xuan He Dong Chen Ziyan Dong Lin Xiong Wenjing Bai Man Li Rong Guo Qin He 《Nano Research》 SCIE EI CSCD 2024年第11期9932-9941,共10页
Photodynamic therapy (PDT) and ferroptosis therapy have received extensive attention in breast cancer treatment. PDT induced apoptosis of tumor cells by producing a large amount of reactive oxygen species (ROS) under ... Photodynamic therapy (PDT) and ferroptosis therapy have received extensive attention in breast cancer treatment. PDT induced apoptosis of tumor cells by producing a large amount of reactive oxygen species (ROS) under laser irradiation. Differently, ferroptosis therapy exerts its antitumor effect by inducing excessive accumulation of lipid peroxides on tumor cell membranes. Based on that, ROS produced by PDT may promote ferroptosis in tumor cells, and ferroptosis therapy is expected eliminate apoptosis-resistant tumor cells. Therefore, a synergistic ferroptosis-photodynamic therapy will be more effective and more potential in breast cancer treatment. Considering PDT has the characteristic of producing ROS, and neutrophil has a natural tendency to ROS, a neutrophil-mimetic hybrid liposome (CR-NML) was designed for co-delivery of the photosensitizer Ce6 and the ferroptosis inducer RSL3. CR-NML targeted tumor through the ROS tendency of neutrophil and the enhanced permeability and retention (EPR) effect of liposome, then induced both apoptosis and ferroptosis in tumor cells, which increased ROS level and finally realized ROS cascade amplification. The synergistic ferroptosis-photodynamic therapy demonstrated significant therapeutic efficacy in 4T1 tumor bearing mice, which provided a promising strategy for breast cancer treatment. 展开更多
关键词 neutrophil-mimetic hybrid liposome reactive oxygen species(ROS)cascade amplification photodynamic therapy ferroptosis therapy breast cancer
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Optical facet coatings for high-performance LWIR quantum cascade lasers atλ∼8.5μm
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作者 MA Yuan LIN Yu-Zhe +5 位作者 WAN Chen-Yang WANG Zi-Xian ZHOU Xu-Yan ZHANG Jin-Chuan LIU Feng-Qi ZHENG Wan-Hua 《红外与毫米波学报》 SCIE EI CAS CSCD 北大核心 2024年第4期497-502,共6页
We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet coating.Compared to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)A... We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet coating.Compared to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)AR coating exhibits higher catastrophic optical mirror damage(COMD)level,and the optical facet coatings of both material systems have no beam steering effect.A 3-mm-long,9.5-μm-wide buried-heterostruc⁃ture(BH)LWIR QCL ofλ~8.5μm with Y_(2)O_(3)metallic high-reflection(HR)and AR of~0.2%reflectivity coating demonstrates a maximum pulsed peak power of 2.19 W at 298 K,which is 149%higher than that of the uncoated device.For continuous-wave(CW)operation,by optimizing the reflectivity of the Y_(2)O_(3)AR coating,the maximum output power reaches 0.73 W,which is 91%higher than that of the uncoated device. 展开更多
关键词 quantum cascade lasers long-wave infrared optical facet coatings catastrophic optical mirror damage
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Industrial Fusion Cascade Detection of Solder Joint
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作者 Chunyuan Li Peng Zhang +2 位作者 Shuangming Wang Lie Liu Mingquan Shi 《Computers, Materials & Continua》 SCIE EI 2024年第10期1197-1214,共18页
With the remarkable advancements in machine vision research and its ever-expanding applications,scholars have increasingly focused on harnessing various vision methodologies within the industrial realm.Specifically,de... With the remarkable advancements in machine vision research and its ever-expanding applications,scholars have increasingly focused on harnessing various vision methodologies within the industrial realm.Specifically,detecting vehicle floor welding points poses unique challenges,including high operational costs and limited portability in practical settings.To address these challenges,this paper innovatively integrates template matching and the Faster RCNN algorithm,presenting an industrial fusion cascaded solder joint detection algorithm that seamlessly blends template matching with deep learning techniques.This algorithm meticulously weights and fuses the optimized features of both methodologies,enhancing the overall detection capabilities.Furthermore,it introduces an optimized multi-scale and multi-template matching approach,leveraging a diverse array of templates and image pyramid algorithms to bolster the accuracy and resilience of object detection.By integrating deep learning algorithms with this multi-scale and multi-template matching strategy,the cascaded target matching algorithm effectively accurately identifies solder joint types and positions.A comprehensive welding point dataset,labeled by experts specifically for vehicle detection,was constructed based on images from authentic industrial environments to validate the algorithm’s performance.Experiments demonstrate the algorithm’s compelling performance in industrial scenarios,outperforming the single-template matching algorithm by 21.3%,the multi-scale and multitemplate matching algorithm by 3.4%,the Faster RCNN algorithm by 19.7%,and the YOLOv9 algorithm by 17.3%in terms of solder joint detection accuracy.This optimized algorithm exhibits remarkable robustness and portability,ideally suited for detecting solder joints across diverse vehicle workpieces.Notably,this study’s dataset and feature fusion approach can be a valuable resource for other algorithms seeking to enhance their solder joint detection capabilities.This work thus not only presents a novel and effective solution for industrial solder joint detection but lays the groundwork for future advancements in this critical area. 展开更多
关键词 cascade object detection deep learning feature fusion multi-scale and multi-template matching solder joint dataset
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Mito-specific cascade amplifier sniping metabolism homeostasis for multimodal imaging-guided antitumor bioenergetic therapy
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作者 Jingjing Yang Yuanlin Zhang +5 位作者 Maoquan Chu Jin Qian Jie Liu Manyu Wang Zhe Qiang Jie Ren 《Nano Research》 SCIE EI CSCD 2024年第11期9908-9919,共12页
Nicotinamide adenine dinucleotide (NAD+/NADH) pools homeostasis is recognized as an Achilles’ Heel in tumor metabolism reprogramming. However, mitochondria can enable cancer cells to overcome NADH exhaustion by provi... Nicotinamide adenine dinucleotide (NAD+/NADH) pools homeostasis is recognized as an Achilles’ Heel in tumor metabolism reprogramming. However, mitochondria can enable cancer cells to overcome NADH exhaustion by providing NAD+ precursors and/or intermediates, thus promoting their survival rate and potentially driving uncontrollable proliferation. Here, a synergistic intervention NAD+/NADH homeostasis and mitochondrial metabolism strategy with magnetic resonance imaging (MRI)/photoacoustic imaging (PAI) are developed to address grand challenge of metabolic reprogramming for antitumor bioenergetic therapy. A mitochondrial-targeted cascade amplification nanoplatform ([β-MQ]TRL), triggered by NAD(P)H: quinone oxidoreductase-1 (NQO1), can enable a continuous depletion of cytosol NADH until cell death. The end-product, hydrogen peroxide (H_(2)O_(2)), can be further catalytically converted to higher toxic ·OH in proximity to mitochondria based on [β-MQ]TRL mediated Fenton-like reaction, hijacking tumorigenic energy sources and leading to mitochondrial dysfunction. Additionally, the mild thermal ablation enabled by [β-MQ]TRL further amplifies this cascade reaction to effectively prevent tumor metastasis and recurrence. This synchronous intervention strategy with MRI/PAI establishes unprecedented efficiency in antitumor bioenergetic therapy in vivo, which shows excellent promise for clinical application. 展开更多
关键词 metabolism programming nicotinamide adenine dinucleotide(NAD+/NADH)pools homeostasis disruption mitochondrial-targeting cascade therapy magnetic resonance imaging(MRI)/photoacoustic imaging(PAI)
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Coordinated Capacitor Voltage Balancing Method for Cascaded H-bridge Inverter with Supercapacitor and DC-DC Stage
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作者 Ye Zhang Zixin Li +2 位作者 Fanqiang Gao Cong Zhao Yaohua Li 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第2期191-201,共11页
Cascaded H-bridge inverter(CHBI) with supercapacitors(SCs) and dc-dc stage shows significant promise for medium to high voltage energy storage applications. This paper investigates the voltage balance of capacitors wi... Cascaded H-bridge inverter(CHBI) with supercapacitors(SCs) and dc-dc stage shows significant promise for medium to high voltage energy storage applications. This paper investigates the voltage balance of capacitors within the CHBI, including both the dc-link capacitors and SCs. Balance control over the dc-link capacitor voltages is realized by the dcdc stage in each submodule(SM), while a hybrid modulation strategy(HMS) is implemented in the H-bridge to balance the SC voltages among the SMs. Meanwhile, the dc-link voltage fluctuations are analyzed under the HMS. A virtual voltage variable is introduced to coordinate the balancing of dc-link capacitor voltages and SC voltages. Compared to the balancing method that solely considers the SC voltages, the presented method reduces the dc-link voltage fluctuations without affecting the voltage balance of SCs. Finally, both simulation and experimental results verify the effectiveness of the presented method. 展开更多
关键词 cascaded H-bridge inverter(CHBI) Hybrid modulation strategy(HMS) Capacitor voltage balancing DClink voltage fluctuation Supercapacitor(SC)
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Human immunodeficiency virus cascade–continuum of care stages and outcomes in a hospital in southern Brazil
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作者 Manoela Badinelli Vaucher Patrícia Fisch Dimas Alexandre Kliemann 《World Journal of Virology》 2024年第3期65-75,共11页
BACKGROUND The human immunodeficiency virus(HIV)continuum of care cascade illustrates the 90-90-90 goals defined by the Joint United Nations Program on HIV/acquired immunodeficiency syndrome(UNAIDS).The care cascade i... BACKGROUND The human immunodeficiency virus(HIV)continuum of care cascade illustrates the 90-90-90 goals defined by the Joint United Nations Program on HIV/acquired immunodeficiency syndrome(UNAIDS).The care cascade includes the following five steps:Diagnosis,linkage to care,retention in care,adherence to antiretroviral therapy(ART),and viral suppression.AIM To elaborate the HIV cascade of patients diagnosed with HIV at the Nossa Senhora da Conceição Hospital(HNSC)and to determine possible local causes for the loss of patients between each step of the cascade.METHODS This retrospective cohort study included patients diagnosed with HIV infection from January 1,2015 to December 31,2016 and followed up until July 31,2019.The data were analyzed by IBM SPSS software version 25,and Poisson regression with simple robust variance was used to analyze variables in relation to each step of the cascade.Variables with P<0.20 were included in multivariable analysis,and P<0.05 was considered significant.Pearson’sχ^(2) test was used to compare the groups of patients followed up at the HNSC and those followed up at other sites.RESULTS The results were lower than those expected by the UNAIDS,with 94%of patients linked,91%retained,81%adhering to ART,and 84%in viral suppression.Age and site of follow-up were the variables with the highest statistical significance.A comparison showed that the cascade of patients from the HNSC had superior results than outpatients,with a significant difference in the last step of the cascade.CONCLUSION The specialized and continued care provided at the HNSC was associated with better results and was closer to the goals set by the UNAIDS.The development of the HIV cascade using local data allowed for the stratification and evaluation of risk factors associated with the losses occurring between each step of the cascade. 展开更多
关键词 cascade Continuum care Human immunodeficiency virus Antiretroviral therapy ADHERENCE
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基于Open CASCADE的拱桥建模研究
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作者 黄飞 《铁路技术创新》 2024年第2期63-70,共8页
几何引擎是三维BIM建模软件中的核心组件,对软件的性能、准确性、互操作性和用户体验等方面有着重要影响。商业软件的几何引擎虽然经过了多年的发展和优化具有较好的性能和稳定性,但常受限于软件厂商提供的API接口和商业软件所需要的系... 几何引擎是三维BIM建模软件中的核心组件,对软件的性能、准确性、互操作性和用户体验等方面有着重要影响。商业软件的几何引擎虽然经过了多年的发展和优化具有较好的性能和稳定性,但常受限于软件厂商提供的API接口和商业软件所需要的系统环境,无法对底层数据进行访问或修改,灵活性较差,且不具备完全自主商业版权。基于开源几何引擎的应用在很多领域已有相关的研究成果,但在桥梁工程领域较少,基于开源几何引擎Open CASCADE对桥梁工程领域的模型构建技术进行探索,实现自主可控的桥梁工程三维建模平台,以拱桥为研究对象,结合几何引擎的模型构建技术,实现拱桥模型的创建。探索开源几何引擎在桥梁工程领域的建模实现能力,为实现更多桥型的三维建模以及基于模型更进一步的衍生应用积累经验,并为打造自主可控的桥梁工程建模软件提供参考。 展开更多
关键词 桥梁工程 BIM 开源几何引擎 Open cascade 拱桥建模 自主可控
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Numerical Study of Co-flow Jet Control on Corner Separation in Compressor Cascade
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作者 Rui-ling Xu Tong-xi Li +1 位作者 Zhi-heng Wang Guang Xi 《风机技术》 2024年第5期25-33,共9页
The design objectives of modern aircraft engines include high load capacity,efficiency,and stability.With increasing loads,the phenomenon of corner separation in compressors intensifies,affecting engine performance an... The design objectives of modern aircraft engines include high load capacity,efficiency,and stability.With increasing loads,the phenomenon of corner separation in compressors intensifies,affecting engine performance and stability.Therefore,the adoption of appropriate flow control technology holds significant academic and engineering significance.This study employs the Reynolds-averaged Navier-Stokes(RANS)method to investigate the effects and mechanisms of active/passive Co-flow Jet(CFJ)control,implemented by introducing full-height and partial height jet slots between the suction surface and end wall of a compressor cascade.The results indicate that passive CFJ control significantly reduces the impact of corner separation at small incidence,with partial-height control further enhancing the effectiveness.The introduction of active CFJ enables separation control at large incidence,improving blade performance under different operating conditions.Active control achieves this by reducing the scale of corner separation vortices,effectively reducing the size of the separation region and enhancing blade performance. 展开更多
关键词 Compressor cascade Co-flow Jet Control Corner Separation Loss Analysis Vortex Structure Analysi
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