OBJECTIVE: To investigate the efficacy and safety of Xinglouchengqi(XLCQ) decoction in treatment of acute ischemic stroke with constipation.METHODS: In this prospective, multicenter, assessor-blinded, randomized contr...OBJECTIVE: To investigate the efficacy and safety of Xinglouchengqi(XLCQ) decoction in treatment of acute ischemic stroke with constipation.METHODS: In this prospective, multicenter, assessor-blinded, randomized controlled trial, 360 eligible participants will be randomized to the XLCQ group or the control group. Participants in the XLCQ group will receive XLCQ decoction, while those in the control group will undergo clysis therapy using glycerin enemas or oral administration of lactulose solution. Both groups will undergo a treatment period of(5 ± 2) d and a 1-month follow-up.The primary outcome measure will be the Constipation Scale score. The secondary outcome measures will include scores on the National Institutes of Health Stroke Scale, the Traditional Chinese Medicine(TCM) Stroke Scale, the Diagnostic Scale for TCM Syndromes of Ischemic Stroke and TCM Scale for Syndrome of Phlegm-heat and Fu-organ Excess.Therapeutic mechanism outcomes and safety outcomes will also be assessed. Assessments will be conducted at baseline, at the end of the treatment period, and at the follow-up. Moreover, daily visits will be scheduled to grade the status of constipation during the treatment period.DISCUSSION: The results of this study will provide scientific and objective data with which to assess the efficacy and safety of XLCQ decoction for patients with acute ischemic stroke and constipation.展开更多
OBJECTIVE: To determine the effects of Taijiquan practice on knee proprioception in patients with knee osteoarthritis(OA).METHODS: We conducted a randomized controlled trial comparing Taijiquan with a control conditio...OBJECTIVE: To determine the effects of Taijiquan practice on knee proprioception in patients with knee osteoarthritis(OA).METHODS: We conducted a randomized controlled trial comparing Taijiquan with a control condition(wellness education) in patients with knee OA. The patients participated in either a 60-min Taijiquan session three times weekly or a 60-min weekly educational session, for 24 consecutive weeks. The primary outcomes were changes in knee proprioception. Secondary outcomes were changes in the Western Ontario and Mc Master University Osteoarthritis Index(WOMAC).RESULTS: After 24 weeks, compared with the control group, the Taijiquan group demonstrated better improvements in the joint position sense in knee flexion(left:-2.12°; right:-2.02°), and knee extension(left:-2.22°; right:-1.54°). In addition,the Taijiquan group showed significantly greater improvements in the WOMAC scores(P < 0.05) for knee pain(left:-3.17 points; right:-3.74 points),stiffness(left:-2.43 points; right:-2.13 points),and physical function(left:-10.99 points; right:-8.00 points), compared with the control group.CONCLUSION: A 24-week Taijiquan practice resulted in a significant improvement in knee proprioception in patients with knee OA. The present findings add increasing evidence regarding the clinical benefits of Taijiquan as a therapeutic modality for patients to improve the reflex protection of knee joints against potentially harmful forces.展开更多
This paper presents an asynchronous output-feed-back control strategy of semi-Markovian systems via sliding mode-based learning technique.Compared with most literature results that require exact prior knowledge of sys...This paper presents an asynchronous output-feed-back control strategy of semi-Markovian systems via sliding mode-based learning technique.Compared with most literature results that require exact prior knowledge of system state and mode information,an asynchronous output-feedback sliding sur-face is adopted in the case of incompletely available state and non-synchronization phenomenon.The holonomic dynamics of the sliding mode are characterized by a descriptor system in which the switching surface is regarded as the fast subsystem and the system dynamics are viewed as the slow subsystem.Based upon the co-occurrence of two subsystems,the sufficient stochastic admissibility criterion of the holonomic dynamics is derived by utilizing the characteristics of cumulative distribution functions.Furthermore,a recursive learning controller is formulated to guarantee the reachability of the sliding manifold and realize the chattering reduction of the asynchronous switching and sliding motion.Finally,the proposed theoretical method is substantia-ted through two numerical simulations with the practical contin-uous stirred tank reactor and F-404 aircraft engine model,respectively.展开更多
随着电力系统中可再生能源比重逐渐增加,电力系统频率波动的风险增大。飞轮和锂电池可以优势互补,作为混合储能应用于电网一次调频中,有效解决系统频率波动问题。为了充分发挥飞轮和锂电池各自的调频优势,提出基于自适应荷电状态(state ...随着电力系统中可再生能源比重逐渐增加,电力系统频率波动的风险增大。飞轮和锂电池可以优势互补,作为混合储能应用于电网一次调频中,有效解决系统频率波动问题。为了充分发挥飞轮和锂电池各自的调频优势,提出基于自适应荷电状态(state of charge,SOC)的电池-飞轮混合储能一次调频控制策略。首先,建立含正、负虚拟惯性控制和虚拟下垂控制的权重分配一次调频模型;然后,利用飞轮和锂电池SOC对一次调频模型参数进行修正,提高混合储能在SOC阈值附近的一次调频能力;最后,仿真对比各调频场景下文中控制策略与其他控制策略的调频能力及SOC恢复效果。研究结果表明,文中控制策略下储能系统SOC波动范围最小,电池不会发生过充过放,且系统频率波动不超过±0.2 Hz,可以提高电网频率稳定性。展开更多
基金Supported by the National Science and Technology Pillar Program during the 12th Five-year Plan Period of the People's Republic of China:Heritage Study on the Special Therapeutic Principles and Methods of Famous Experts in Traditional Chinese Medicine(No.2013BAI13B022)
文摘OBJECTIVE: To investigate the efficacy and safety of Xinglouchengqi(XLCQ) decoction in treatment of acute ischemic stroke with constipation.METHODS: In this prospective, multicenter, assessor-blinded, randomized controlled trial, 360 eligible participants will be randomized to the XLCQ group or the control group. Participants in the XLCQ group will receive XLCQ decoction, while those in the control group will undergo clysis therapy using glycerin enemas or oral administration of lactulose solution. Both groups will undergo a treatment period of(5 ± 2) d and a 1-month follow-up.The primary outcome measure will be the Constipation Scale score. The secondary outcome measures will include scores on the National Institutes of Health Stroke Scale, the Traditional Chinese Medicine(TCM) Stroke Scale, the Diagnostic Scale for TCM Syndromes of Ischemic Stroke and TCM Scale for Syndrome of Phlegm-heat and Fu-organ Excess.Therapeutic mechanism outcomes and safety outcomes will also be assessed. Assessments will be conducted at baseline, at the end of the treatment period, and at the follow-up. Moreover, daily visits will be scheduled to grade the status of constipation during the treatment period.DISCUSSION: The results of this study will provide scientific and objective data with which to assess the efficacy and safety of XLCQ decoction for patients with acute ischemic stroke and constipation.
基金Supported by the Shanghai City Committee of Science and Technology Key Project,Evaluation of Nerve and Muscle Function after Taijiquan Practice for Patients with Knee Osteoarthritis(No.12490503200)Innovation Program of Shanghai Municipal Education Commission,Effect of exercise on the sub-health of physical inactivity adults(No.13ZS020)Shanghai University of Traditional Chinese Medicine,Evaluation of Taijiquan and Tuina Therapy on Knee Osteoarthritis(No.2014YSN48)
文摘OBJECTIVE: To determine the effects of Taijiquan practice on knee proprioception in patients with knee osteoarthritis(OA).METHODS: We conducted a randomized controlled trial comparing Taijiquan with a control condition(wellness education) in patients with knee OA. The patients participated in either a 60-min Taijiquan session three times weekly or a 60-min weekly educational session, for 24 consecutive weeks. The primary outcomes were changes in knee proprioception. Secondary outcomes were changes in the Western Ontario and Mc Master University Osteoarthritis Index(WOMAC).RESULTS: After 24 weeks, compared with the control group, the Taijiquan group demonstrated better improvements in the joint position sense in knee flexion(left:-2.12°; right:-2.02°), and knee extension(left:-2.22°; right:-1.54°). In addition,the Taijiquan group showed significantly greater improvements in the WOMAC scores(P < 0.05) for knee pain(left:-3.17 points; right:-3.74 points),stiffness(left:-2.43 points; right:-2.13 points),and physical function(left:-10.99 points; right:-8.00 points), compared with the control group.CONCLUSION: A 24-week Taijiquan practice resulted in a significant improvement in knee proprioception in patients with knee OA. The present findings add increasing evidence regarding the clinical benefits of Taijiquan as a therapeutic modality for patients to improve the reflex protection of knee joints against potentially harmful forces.
基金supported in part by the National Science Fund for Excellent Young Scholars of China(62222317)the National Science Foundation of China(62303492)+3 种基金the Major Science and Technology Projects in Hunan Province(2021GK1030)the Science and Technology Innovation Program of Hunan Province(2022WZ1001)the Key Research and Development Program of Hunan Province(2023GK2023)the Fundamental Research Funds for the Central Universities of Central South University(2024ZZTS0116)。
文摘This paper presents an asynchronous output-feed-back control strategy of semi-Markovian systems via sliding mode-based learning technique.Compared with most literature results that require exact prior knowledge of system state and mode information,an asynchronous output-feedback sliding sur-face is adopted in the case of incompletely available state and non-synchronization phenomenon.The holonomic dynamics of the sliding mode are characterized by a descriptor system in which the switching surface is regarded as the fast subsystem and the system dynamics are viewed as the slow subsystem.Based upon the co-occurrence of two subsystems,the sufficient stochastic admissibility criterion of the holonomic dynamics is derived by utilizing the characteristics of cumulative distribution functions.Furthermore,a recursive learning controller is formulated to guarantee the reachability of the sliding manifold and realize the chattering reduction of the asynchronous switching and sliding motion.Finally,the proposed theoretical method is substantia-ted through two numerical simulations with the practical contin-uous stirred tank reactor and F-404 aircraft engine model,respectively.
文摘随着电力系统中可再生能源比重逐渐增加,电力系统频率波动的风险增大。飞轮和锂电池可以优势互补,作为混合储能应用于电网一次调频中,有效解决系统频率波动问题。为了充分发挥飞轮和锂电池各自的调频优势,提出基于自适应荷电状态(state of charge,SOC)的电池-飞轮混合储能一次调频控制策略。首先,建立含正、负虚拟惯性控制和虚拟下垂控制的权重分配一次调频模型;然后,利用飞轮和锂电池SOC对一次调频模型参数进行修正,提高混合储能在SOC阈值附近的一次调频能力;最后,仿真对比各调频场景下文中控制策略与其他控制策略的调频能力及SOC恢复效果。研究结果表明,文中控制策略下储能系统SOC波动范围最小,电池不会发生过充过放,且系统频率波动不超过±0.2 Hz,可以提高电网频率稳定性。
