The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],vario...The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],various morphology[6,7],easy sloughing and seeding[8],and having unique risk factors[2,9-11].We have previously proposed a morphologic classification[6]and a progression model of IPNB[12].展开更多
The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and...The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and Technology (NIST). Then many excellent properties were developed and they have a variety of applications such as aerospace, aircraft and automobile industries [1]. Example application for RoboCrane in the field of aircraft mainte- nance is equipped with a quick-change mechanism to remove the robot arm remotely.展开更多
The risk assessment of contract conclusion is the primary and key part of equipment purchase contract risk management. In this paper, based on the fuzzy characteristics of contract risks, and overcoming the traditiona...The risk assessment of contract conclusion is the primary and key part of equipment purchase contract risk management. In this paper, based on the fuzzy characteristics of contract risks, and overcoming the traditional disadvantages of analytic hierarchy process (AHP), the fuzzy analytic hierarchy process (FAHP) of contract conclusion is proposed for meeting the actual need of equipment procurement contract risk assessment, and implementing the risk factors qualitative and quantitative assessments of different working nodes in contract conclusion. Thus, a scientific and reliable important basis is provided for the risk management of equipment procurement contract.展开更多
Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for t...Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for the rest of the day.In general,the average consum ption varies from 2 to6 cups per day.What are the health implications?Given this consum ption,the benefits are actually greater than the risks.This is the conclusion of a careful study published in the New England Journal of Medicine(van Dam et al.,2020).展开更多
Dear Editor,We have read with interest the article by Li et al[1].In the response to this article[1]which is a well thought out and written paper,I would like to draw attention to some critical points in this study an...Dear Editor,We have read with interest the article by Li et al[1].In the response to this article[1]which is a well thought out and written paper,I would like to draw attention to some critical points in this study and add some comments to the results and the conclusion of the study which authors have detected.In the Li et al’s[1]study,it is detected that,choroidal thickness is significantly negatively correlated with body mass index(BMI)and choroidal thickness is decreased in people with overweight or obesity.展开更多
There has been an increasing interest in studying thesis writing genre in the past two decades, however, the study on how social science doctoral students construct their academic identity in 12 thesis writing still r...There has been an increasing interest in studying thesis writing genre in the past two decades, however, the study on how social science doctoral students construct their academic identity in 12 thesis writing still remains underexplored to date. This paper attempts to fill the gap by examining the ways in which a cohort of Chinese social science doctoral students constructed their academic identity in the process of drafting, revising, and shaping the Discussion & Conclusion section of their L2 theses. The study adopted multi-case approaches and in-depth interviews. It found that the process of the students' academic identity construction was fluid and dynamic. These students gradually evolved from novice student writers at the initial stage to more skilled academic writers at the later stage. The findings generated from this study offer significant implications for L2 writing pedagogy in China.展开更多
Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past C...Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past Chinese sages and philosophers reached this conclusion in their study of state governance amid the rise and fall of dynasties over thousands of years.Based on the belief that the people's support of state power is vital for its success,this precept has inspired policies and practices aimed at nurturing,benefiting and enriching the people throughout Chinese history.展开更多
There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusio...There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusion of this article.We apologize for the errors and for any resulting confusion.展开更多
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the scleroti...Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.展开更多
The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors si...The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors sincerely apologize for the mistake and confirm the change does not affect the scientific conclusion of the published work.展开更多
In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data f...In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data from the 2023 moulting season,during which we obtained 139 moult records from 98 individuals.The final sample size used for plotting these results are shown in the caption below.This amendment corroborates the conclusion already stated:body moult does not seem to be under physiological constraints,although primary moult appears to be tightly controlled to reduce aerodynamic losses.展开更多
Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from t...Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from their independent observations in the extremely low waveband of nanohertz.Consistent with each other,the results arrive at a common conclusion:our planet is immersed in a wavy spacetime ruffled by overlapping low-tone ripples.FAST,the Five-hundred-meter Aperture Spherical radio Telescope of China,is among the many giant telescopes that have played a key role in the search for this low-pitch voice.They are not the real detectors,though.展开更多
Super rice is an essendal part of China's rice production. Through survey on actual situation of 1568 households of rice growers in Heilongjiang, Hunan and Zhejiang provinces, this paper focused on influence of super...Super rice is an essendal part of China's rice production. Through survey on actual situation of 1568 households of rice growers in Heilongjiang, Hunan and Zhejiang provinces, this paper focused on influence of super rice development on increase of China's grain yield, influence on increase of rice growers' economic in- come, difference in production cost and profit between the North and the South, as well as profit percentage of super rice in production, processing, and sales. It obtained following results: rice price determines rice growers' income; expansion of super rice extension area plays a great role in increase of China's grain yield; by 2015 and 2020, keeping the yield of other crops not changed, merely the extension of super rice can increase grain for 5 million tons and 11 million tons separately; super rice significantly increases rice growers' economic income; for production cost of super rice, the South is higher than the North, and the profit ratio of cost is up to 35.54% on average; with respect of profit in production, processing, and sales, the ratio is 1:2:1.5; with the yield of other crops unchanged, every increase of 1% in area percentage of super rice to rice will additionally produce 1 million tons of grain for China, which is equivalent to saving the yield of 133 300 hm2 farmland and can additional feed 3.5 million people. In view of importance of super rice production, at the same time of strengthening research on super rice variety, it is required to accelerate expanding production area of super rice in suitable areas. Since the development of super rice can support China's ration demand of increasing population, China should make effort to realize "one yuan for one mu" financial subsidy for super rice of main grain production provinces and counties. Besides, China should establish special financial plan for extension of super rice.展开更多
The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'...The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'-30°40′ N. The ancient desert study is so little in China that there has not been a systematic report about it up to now. Based on the study in many ways on Cretaceous-Tertiary deserts in southwestern China, plentiful data have been obtained. Though it is still a bit rough, the study is a good beginning of the ancient desert study in China. The main ideas and conclusions are summarized as follows.展开更多
文摘The concept of intraductal papillary neoplasm of the bile duct(IPNB)has gained recognition as a discrete entity[1,2],possessing many features including multiplicity[3,4],mucin production[3],slow progression[3,5],various morphology[6,7],easy sloughing and seeding[8],and having unique risk factors[2,9-11].We have previously proposed a morphologic classification[6]and a progression model of IPNB[12].
基金Supported by National Natural Science Foundation of China(Grant No.51575150)
文摘The theoretical research of cable-driven mechanisms is developed with its broad applications. The first prototype of cable-driven mechanisms is RoboCrane, which was developed by the National Institute of Standards and Technology (NIST). Then many excellent properties were developed and they have a variety of applications such as aerospace, aircraft and automobile industries [1]. Example application for RoboCrane in the field of aircraft mainte- nance is equipped with a quick-change mechanism to remove the robot arm remotely.
文摘The risk assessment of contract conclusion is the primary and key part of equipment purchase contract risk management. In this paper, based on the fuzzy characteristics of contract risks, and overcoming the traditional disadvantages of analytic hierarchy process (AHP), the fuzzy analytic hierarchy process (FAHP) of contract conclusion is proposed for meeting the actual need of equipment procurement contract risk assessment, and implementing the risk factors qualitative and quantitative assessments of different working nodes in contract conclusion. Thus, a scientific and reliable important basis is provided for the risk management of equipment procurement contract.
文摘Coffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and tea.For many people,it is an indispensable habit before going to work and a socialization tool for the rest of the day.In general,the average consum ption varies from 2 to6 cups per day.What are the health implications?Given this consum ption,the benefits are actually greater than the risks.This is the conclusion of a careful study published in the New England Journal of Medicine(van Dam et al.,2020).
文摘Dear Editor,We have read with interest the article by Li et al[1].In the response to this article[1]which is a well thought out and written paper,I would like to draw attention to some critical points in this study and add some comments to the results and the conclusion of the study which authors have detected.In the Li et al’s[1]study,it is detected that,choroidal thickness is significantly negatively correlated with body mass index(BMI)and choroidal thickness is decreased in people with overweight or obesity.
基金part of the project entitled "Study of the Development of Chinese Students' Generic Competence",supported by the National Grant for Social Sciences (No: 10BYY088)supported by Wuhan University Teaching Research grant entitled "A Multi-model Construction of Curriculum System for English Speciality" (No: 2011303)
文摘There has been an increasing interest in studying thesis writing genre in the past two decades, however, the study on how social science doctoral students construct their academic identity in 12 thesis writing still remains underexplored to date. This paper attempts to fill the gap by examining the ways in which a cohort of Chinese social science doctoral students constructed their academic identity in the process of drafting, revising, and shaping the Discussion & Conclusion section of their L2 theses. The study adopted multi-case approaches and in-depth interviews. It found that the process of the students' academic identity construction was fluid and dynamic. These students gradually evolved from novice student writers at the initial stage to more skilled academic writers at the later stage. The findings generated from this study offer significant implications for L2 writing pedagogy in China.
文摘Only when the foundation is strong will the state be safe and stable.THE concept that"the people are the foundation of a state"is the best expression of the people-centered philosophy of ancient China.Past Chinese sages and philosophers reached this conclusion in their study of state governance amid the rise and fall of dynasties over thousands of years.Based on the belief that the people's support of state power is vital for its success,this precept has inspired policies and practices aimed at nurturing,benefiting and enriching the people throughout Chinese history.
文摘There are errors in Figure 1D1 on page 94.Specifically,RAB22A-induced autophagosomes were inadvertently marked in Figure 1D.We have revised Figure 1 to correct the errors.Of note,the errors do not impact the conclusion of this article.We apologize for the errors and for any resulting confusion.
基金funded by the F.R.S.-FNRS for the “EOS: The Excellence of Science-Join-t-against-Osteoarthritis”, grant number 30480119by a research grant from the Osteoarthritis Foundation and by the University of Liege (Fonds Léon Fredericq and Fonds Speciaux à la Recherche)funded by Versus Arthritis senior fellowship 21937。
文摘Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.
文摘The authors examined the original data of their work and noticed misuse of images in fig.1 and fig.3(as shown below on the upper panels,red box).The correct images are shown on the lower panels(red box).The authors sincerely apologize for the mistake and confirm the change does not affect the scientific conclusion of the published work.
文摘In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult progress.Here,we amended this problem adding data from the 2023 moulting season,during which we obtained 139 moult records from 98 individuals.The final sample size used for plotting these results are shown in the caption below.This amendment corroborates the conclusion already stated:body moult does not seem to be under physiological constraints,although primary moult appears to be tightly controlled to reduce aerodynamic losses.
文摘Gravitational waves propagating at nanohertz frequencies?Do they exist?Yes.Four observational networks,from China,Australia,Europe-India,and USA,respectively,simultaneously answered on June 29,releasing results from their independent observations in the extremely low waveband of nanohertz.Consistent with each other,the results arrive at a common conclusion:our planet is immersed in a wavy spacetime ruffled by overlapping low-tone ripples.FAST,the Five-hundred-meter Aperture Spherical radio Telescope of China,is among the many giant telescopes that have played a key role in the search for this low-pitch voice.They are not the real detectors,though.
基金Supported by Super Rice Program for Agricultural Scientific&Technological Innovation Project of Chinese Academy of Agricultural SciencesSpecial Project of Public Welfare Industry of Ministry of Agriculture(201203029)Special Project for Construction of Modern Agricultural Industrial Technology System(CARS-01-09B)~~
文摘Super rice is an essendal part of China's rice production. Through survey on actual situation of 1568 households of rice growers in Heilongjiang, Hunan and Zhejiang provinces, this paper focused on influence of super rice development on increase of China's grain yield, influence on increase of rice growers' economic in- come, difference in production cost and profit between the North and the South, as well as profit percentage of super rice in production, processing, and sales. It obtained following results: rice price determines rice growers' income; expansion of super rice extension area plays a great role in increase of China's grain yield; by 2015 and 2020, keeping the yield of other crops not changed, merely the extension of super rice can increase grain for 5 million tons and 11 million tons separately; super rice significantly increases rice growers' economic income; for production cost of super rice, the South is higher than the North, and the profit ratio of cost is up to 35.54% on average; with respect of profit in production, processing, and sales, the ratio is 1:2:1.5; with the yield of other crops unchanged, every increase of 1% in area percentage of super rice to rice will additionally produce 1 million tons of grain for China, which is equivalent to saving the yield of 133 300 hm2 farmland and can additional feed 3.5 million people. In view of importance of super rice production, at the same time of strengthening research on super rice variety, it is required to accelerate expanding production area of super rice in suitable areas. Since the development of super rice can support China's ration demand of increasing population, China should make effort to realize "one yuan for one mu" financial subsidy for super rice of main grain production provinces and counties. Besides, China should establish special financial plan for extension of super rice.
文摘The special issue deals with the Cretaceous-Tertiary deserts in southwestern China and relevant sedimentological problems about deserts. The study area is located between 101°10'- 107°00'E and 28°00'-30°40′ N. The ancient desert study is so little in China that there has not been a systematic report about it up to now. Based on the study in many ways on Cretaceous-Tertiary deserts in southwestern China, plentiful data have been obtained. Though it is still a bit rough, the study is a good beginning of the ancient desert study in China. The main ideas and conclusions are summarized as follows.