How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following concussion.Methods:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May 2022.Two reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)checklists.Additional information was sought my study authors where reporting was incomplete.Risk of bias(ROB)was assessed with the Cochrane ROB-2 Tool.RCTs examining non-pharmacological interventions following concussion.Results:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck cooling.Median scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified supervisor.Reporting completeness improved after TIDieR and CERT publication,but publication in highly cited journals and low ROB do not guarantee reporting completeness.

Active Fault Tolerant Nonsingular Terminal Sliding Mode Control for Electromechanical System Based on Support Vector Machine

Effective fault diagnosis and fault-tolerant control method for aeronautics electromechanical actuator is concerned in this paper.By borrowing the advantages of model-driven and data-driven methods,a fault tolerant nonsingular terminal sliding mode control method based on support vector machine(SVM)is proposed.A SVM is designed to estimate the fault by off-line learning from small sample data with solving convex quadratic programming method and is introduced into a high-gain observer,so as to improve the state estimation and fault detection accuracy when the fault occurs.The state estimation value of the observer is used for state reconfiguration.A novel nonsingular terminal sliding mode surface is designed,and Lyapunov theorem is used to derive a parameter adaptation law and a control law.It is guaranteed that the proposed controller can achieve asymptotical stability which is superior to many advanced fault-tolerant controllers.In addition,the parameter estimation also can help to diagnose the system faults because the faults can be reflected by the parameters variation.Extensive comparative simulation and experimental results illustrate the effectiveness and advancement of the proposed controller compared with several other main-stream controllers.

Base Pressure Control with Semi-Circular Ribs at Critical Mach Number

When better fuel-air mixing in the combustion chamber or a reduction in base drag are required in vehicles,rockets,and aeroplanes,the base pressure control is activated.Controlling the base pressure and drag is necessary in both scenarios.In this work,semi-circular ribs with varying diameters(2,4,and 6 mm)positioned at six distinct positions(0.5D,1D,1.5D,2D,3D,and 4D)inside a square duct with a side of 15 mm are proposed as an efficient way to apply the passive control technique.In-depth research is done on optimising rib size for various rib sites.According to this study,the base pressure rises as rib height increases.Furthermore,the optimal location for the semi-circular ribs with a diameter of 2 mm is at 0.5D.The 1D location appears to be optimal for the 4 mm size as well.For the 6 mm size,however,the 4D position fills this function.

Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control

Gentiana macrophylla Pall.(G.macrophylla),whose genus and family belong to the Gentianaceae and Gentiana.The main distribution centers of G.macrophylla resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in China.G.macrophylla,as a traditional medicine,has a long history and was used in different ethnic medicines.Its roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing swelling.From previous studies,it could be found that there were more than forty components isolated and identified from G.macrophylla.The main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and alkaloids.Iridoid terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of G.macrophylla,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract activities.The flower mainly contains isoorientin and isovitexin as the representative of flavonoids.They have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of melanin.It could be seen from previous studies that the research on G.macrophylla was mainly focused on the root,and the flower was rarely studied.It was reported that the experimental data of the anti-inflammatory and anti-tumor effects of G.macrophylla flowers show that its curative effect was very good.Therefore,the flowers of the flower of G.macrophylla can be used as potential medicinal parts for research.Given that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about G.macrophylla’s potential medical benefits.Based on botanical books,Chinese classic texts,medical monographs and academic search engines(Google,Google Scholar,Web of Science,SciFinder,Pubmed,CNKI,Sci-hub,Elsevier and Wanfang),the data and information on G.macrophylla in the past 20 years are inquired and summarized comprehensively.The basic source,traditional use,chemical composition,biological activity,pharmacodynamics and quality control of G.macrophylla was systematically reviewed,in order to provide reliable basis for the subsequent development and utilization of G.macrophylla.

Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.

一种移动感知的太赫兹无线局域网定向MAC协议

现有太赫兹无线局域网定向MAC(Medium Access Control)协议中,节点移动情况下PNC(PicoNet)发送beacon帧时存在部分控制字段浪费、CTAP(Channel Time Allocation Period)中PNC与DEV(Device)进行波束赋形开销偏大等问题。为此,提出了一种移动感知的太赫兹无线局域网定向MAC(Mobility-aware Directional MAC,MA-MAC)协议。该协议采用基于卡尔曼算法的节点扇区预测机制对移动节点的扇区范围进行迭代预测,采用基于DEV扇区预测的beacon帧内容填充机制对beacon帧中时隙分配字段进行填充,采用基于节点扇区预测的快速波束赋形机制使得PNC与DEV之间波束赋形操作简化。通过仿真验证,与基于IEEE 802.15.3c的太赫兹无线局域网定向MAC协议和现有协议进行对比,MA-MAC协议下网络吞吐量得到了提升,网络平均时延、网络整体控制开销得到了改善。

高效低时延分级多PAN太赫兹无线网络MAC层优化协议

针对现有分级多PAN太赫兹无线网络MAC(Medium Access Control)协议中存在的子网形成方案不合理以及私有CTA(Channel Time Allocation)与子网内实际负载不匹配等问题,提出了一种高效低时延的MAC层优化协议.该协议采用基于泛听的按需形成子网机制避免了子网分布不均匀以及因子网形成后没有节点加入而造成的私有CTA资源浪费的问题.在子网形成后,子微微网协调器(Piconet Coordinator,PNC)根据子网内实际负载情况自适应选择私有CTA时隙资源优化机制,让有数据传输需求的节点及时将数据发出.仿真结果表明,所提出的方案能有效地降低数据帧平均接入时延,提高吞吐量以及数据帧的传输成功率.

基于MEC服务器优先服务的路侧单元MAC层调度策略

针对多接入边缘计算(MEC)服务器高可靠、低时延和大数据量的数据传输要求,基于无冲突接入、优先级架构和弹性服务技术,提出一种适用于车辆边缘计算场景下的媒体访问控制(MAC)调度策略。所提策略由车联网(IoV)路侧单元(RSU)集中协调信道接入权,优先确保车载网络中车载通信单元(OBU)与MEC服务器之间的链路传输质量,以及时传输车辆到网络(V2N)业务数据;同时,对本地OBU之间的业务采取弹性服务方式,增强密集车辆接入时应急消息传输的可靠性。首先,构建调度策略的排队分析模型;其次,根据各时刻系统状态变量的无后效性特点建立嵌入式马尔可夫链,并通过概率母函数的分析方法对系统进行理论分析,得到MEC服务器通信单元和OBU的平均排队队长、平均等待时延和RSU查询周期等关键指标的精确解析表达式。计算机仿真实验结果表明,统计分析结果与理论计算结果一致,所提调度策略在高负载情况下能够提高IoV的稳定性和灵活性。

Machine Learning Accelerated Real-Time Model Predictive Control for Power Systems

This paper presents a machine-learning-based speedup strategy for real-time implementation of model-predictive-control(MPC)in emergency voltage stabilization of power systems.Despite success in various applications,real-time implementation of MPC in power systems has not been successful due to the online control computation time required for large-sized complex systems,and in power systems,the computation time exceeds the available decision time used in practice by a large extent.This long-standing problem is addressed here by developing a novel MPC-based framework that i)computes an optimal strategy for nominal loads in an offline setting and adapts it for real-time scenarios by successive online control corrections at each control instant utilizing the latest measurements,and ii)employs a machine-learning based approach for the prediction of voltage trajectory and its sensitivity to control inputs,thereby accelerating the overall control computation by multiple times.Additionally,a realistic control coordination scheme among static var compensators(SVC),load-shedding(LS),and load tap-changers(LTC)is presented that incorporates the practical delayed actions of the LTCs.The performance of the proposed scheme is validated for IEEE 9-bus and 39-bus systems,with±20%variations in nominal loading conditions together with contingencies.We show that our proposed methodology speeds up the online computation by 20-fold,bringing it down to a practically feasible value(fraction of a second),making the MPC real-time and feasible for power system control for the first time.

Research trends in methods for controlling macro-micro motion platforms

With ongoing economic,scientific,and technological developments,the electronic devices used in daily lives are developing toward precision and miniaturization,and so the demand for high-precision manufacturing machinery is expanding.The most important piece of equipment in modern high-precision manufacturing is the macro-micro motion platform(M3P),which offers high speed,precision,and efficiency and has macro-micro motion coupling characteristics due to its mechanical design and composition of its driving components.Therefore,the design of the control system is crucial for the overall precision of the platform;conventional proportional–integral–derivative control cannot meet the system requirements,and so M3Ps are the subject of a growing range of modern control strategies.This paper begins by describing the development history of M3Ps,followed by their platform structure and motion control system components,and then in-depth assessments of the macro,micro,and macro-micro control systems.In addition to examining the advantages and disadvantages of current macro-micro motion control,recent technological breakthroughs are noted.Finally,based on existing problems,future directions for M3P control systems are given,and the present conclusions offer guidelines for future work on M3Ps.

四旋翼无人机滑模-CPCMAC联合控制半物理仿真系统

针对四旋翼无人机强耦合、欠驱动、非线性等特点,以及在实际飞行过程中极易受到干扰的问题,对四旋翼无人机动力学模型进行分析,提出了一种基于联合的四旋翼无人机姿态控制算法,并在此基础上设计了四旋翼无人机半物理仿真系统。首先,针对非线性系统设计滑模控制器,选择跟踪航迹和翻滚角设计位置控制率和姿态控制率。其次,滑模控制器在实际应用中易产生震荡,利用基于信用积分的小脑模型神经网络(CPCMAC)来学习滑模控制的方式。最后,搭建基于LabVIEW的控制站,同Matlab/Simulink进行数据收发控制。仿真结果表明,在跟踪目标相同时,提出的四旋翼无人机滑模-CPCMAC联合控制相比于传统的比例积分微分(PID)控制和积分反步法控制优势明显,能够抑制超调和余差,在快速性和鲁棒性方面都更加优越。同时,构建的四旋翼无人机半物理仿真平台能清晰反馈出无人机参数的变化,应用预留的参数接口和地面控制站,降低了无人机飞控算法的开发难度,提高了开发效率,具有明显的实用价值。

Recent Progress in Reinforcement Learning and Adaptive Dynamic Programming for Advanced Control Applications

Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, respectively.Then, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and RL frameworks,showing how they promote ADP formulation significantly.Finally, several typical control applications with respect to RL and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and RL for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence.

无线和电力线混合通信的MAC层接入算法设计和性能分析

电力线和无线混合通信可以优势互补提升电力物联网室内覆盖的综合性能。针对无线接入和电力线中继的混合通信场景,文章提出一种适用于两跳混合中继的通用MAC层算法。综合考虑物理层信道参数和MAC层的载波侦听多路访问(carrier sense multiple access,CSMA)退避流程,建立了该MAC层算法的跨层性能分析模型,推导了两跳传输系统归一化吞吐量以及系统时延等性能;最后仿真验证了算法有效性和模型准确性,分析了物理层和MAC层关键参数影响系统性能的机理。与Basic-RTS/CTS算法相比,所提算法可有效提升系统吞吐量和时延性能。

以太网MAC控制器GMII和RGMII接口转换IP设计

阐述RGMII接口是简化的GMII接口,解决GMII接口信号线过多造成的布线复杂和功耗大的问题。首先研究IEEE802.3千兆以太网MAC控制器的GMII接口协议和RGMII接口规范,分析在千兆以太网MAC控制器中两种接口转换的实现方案,包括RGMII正常和延迟模式的实现方案。用Verilog HDL完成代码实现,通过NC-SIM仿真和Quartus-II实现后下载到FPGA板验证,表明功能正确。最后将实现的RGMII应用到某以太网交换芯片。在交换芯片的功能板上两PC机通过RGMII接口和Marvell 88E1145等器件实现数据正确传输。通过这些流程,形成标准接口转换IP,可直接应用于其他产品。

认知传感网中基于Transformer网络的MAC协议识别方法

媒体接入控制(Media Access Control,MAC)识别有助于优化认知无线电系统的频谱管理并提高通信质量。已有的基于深度学习的MAC协议识别方法仍存在复杂信道环境的适应性不足、长期依赖关系捕捉能力有限的问题。因此,提出基于Transformer网络的MAC协议识别方法,利用自注意力机制有效捕捉长距离依赖,通过多头注意力机制同时关注输入序列中不同部分的相关性,提升对信号特征和行为的理解。针对认知传感网的特定需求,对传统的Transformer模型结构进行了优化,包括调整模型的深度和宽度以适应信号数据的特性。自注意力机制不仅增强了模型对时间序列数据的处理能力,还通过位置编码保留序列中的位置信息,结合前馈神经网络增强模型的非线性表达能力,并通过层归一化和残差连接机制提高模型的稳定性和训练效率。实验结果表明,所提方法在复杂无线通信环境中具有显著的性能优势,在识别4种主要MAC协议时展现出超过95%的高准确率。

Finite-time Prescribed Performance Time-Varying Formation Control for Second-Order Multi-Agent Systems With Non-Strict Feedback Based on a Neural Network Observer

This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

Control of highly pathogenic avian influenza through vaccination

The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to humans.In this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and effectiveness.In addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.

An Integrated Control Framework for Torque Vectoring and Active Suspension System

Four-wheel independently driven electric vehicles(FWID-EV)endow a flexible and scalable control framework to improve vehicle performance.This paper integrates the torque vectoring and active suspension system(ASS)to enhance the vehicle’s longitudinal and vertical motion control performance.While the nonlinear characteristic of the tire model leads to a relatively heavier computational burden.To facilitate the controller design and ease the load,a half-vehicle dynamics system is built and simplified to the linear-time-varying(LTV)model.Then a model predictive controller is developed by formulating the objective function by comprehensively considering the safety,energy-saving and comfort requirements.The in-wheel motor efficiency and the power loss of tire slip are treated as optimization indices in this work to reduce energy consumption.Finally,the effectiveness of the proposed controller is verified through the rapid-control-prototype(RCP)test.The results demonstrate the enhancement of the energy-saving as well as comfort on the basis of vehicle stability.

Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage

The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage.