The aim of this study was to compare mandibular form （i.e., size and shape） between patients with agenesis of the lower second premolar （P2） and a control group with no agenesis. Three hypotheses were tested： （H...The aim of this study was to compare mandibular form （i.e., size and shape） between patients with agenesis of the lower second premolar （P2） and a control group with no agenesis. Three hypotheses were tested： （H1） agenesis causes a change in mandibular morphology because of inadequate alveolar ridge development in the area of the missing tooth （mandibular plasticity）; （H2） agenesis is caused by spatial limitations within the mandible （dental plasticity）; and （H3） common genetic/ epigenetic factors cause agenesis and affect mandibular form （pleiotropy）. A geometric morphometric analysis was applied to cross-sectional images of computed tomography （CT） scans of three matched groups （n= 50 each）： （1） regularly erupted P2; （2） agenesis of P2 and the primary second molar in situ; and （3） agenesis of P2 and the primary second molar missing for 〉3 months. Cross-sections of the three areas of interest （first premolar, P2, first molar） were digitized with 23 landmarks and superimposed by a generalized Procrustes analysis. On average, the mandibular cross-sections were narrower and shorter in patients with P2 agenesis compared with that in the control group. Both agenesis groups featured a pronounced submandibular fossa. These differences extended at least one tooth beyond the agenesis-affected region. Taken together with the large interindividual variation that resulted in massively overlapping group distributions, these findings support genetic and/or epigenetic pleiotropy （H3） as the most likely origin of the observed covariation between mandibular form and odontogenesis. Clinically, reduced dimensions and greater variability of mandibular form, as well as a pronounced submandibular fossa, should be expected during the treatment planning of patients with P2 agenesis.展开更多
Analyzing the mass of behind-armor debris (BAD) generated by Rolled Homogeneous Armor (RHA) subjected to normal penetration of variable cross-section Explosively Formed Projectile (EFP) is the purpose of this paper. S...Analyzing the mass of behind-armor debris (BAD) generated by Rolled Homogeneous Armor (RHA) subjected to normal penetration of variable cross-section Explosively Formed Projectile (EFP) is the purpose of this paper. So theoretical analysis, numerical simulation and experimental data are combined to analyze the influence of variable cross-section characteristic on the time history of crater radius. Moreover the relationships between time history of crater radius (as well as mass of BAD) and the thickness of RHA (from 30mm to 70 mm) and the impact velocity of EFP (1650 m/s to 1860 m/s) are also investigated. The results indicate that: 1) being compared to the variable cross-section characteristic is ignored, the theoretical time history of crater radius is in better agreement with the simulation results when the variable cross-section characteristic is considered;2) being compared to the other three conditions of plug, the theoretical mass of BAD is in the best agreement with the simulation results when the shape of plug is frustum of a cone and the angle between generatrix and bottom is 45- and the axial length of mushroom is considered.展开更多
文摘The aim of this study was to compare mandibular form （i.e., size and shape） between patients with agenesis of the lower second premolar （P2） and a control group with no agenesis. Three hypotheses were tested： （H1） agenesis causes a change in mandibular morphology because of inadequate alveolar ridge development in the area of the missing tooth （mandibular plasticity）; （H2） agenesis is caused by spatial limitations within the mandible （dental plasticity）; and （H3） common genetic/ epigenetic factors cause agenesis and affect mandibular form （pleiotropy）. A geometric morphometric analysis was applied to cross-sectional images of computed tomography （CT） scans of three matched groups （n= 50 each）： （1） regularly erupted P2; （2） agenesis of P2 and the primary second molar in situ; and （3） agenesis of P2 and the primary second molar missing for 〉3 months. Cross-sections of the three areas of interest （first premolar, P2, first molar） were digitized with 23 landmarks and superimposed by a generalized Procrustes analysis. On average, the mandibular cross-sections were narrower and shorter in patients with P2 agenesis compared with that in the control group. Both agenesis groups featured a pronounced submandibular fossa. These differences extended at least one tooth beyond the agenesis-affected region. Taken together with the large interindividual variation that resulted in massively overlapping group distributions, these findings support genetic and/or epigenetic pleiotropy （H3） as the most likely origin of the observed covariation between mandibular form and odontogenesis. Clinically, reduced dimensions and greater variability of mandibular form, as well as a pronounced submandibular fossa, should be expected during the treatment planning of patients with P2 agenesis.
基金financially supported by the National Natural Science Foundation of China(Grant No.11372136)
文摘Analyzing the mass of behind-armor debris (BAD) generated by Rolled Homogeneous Armor (RHA) subjected to normal penetration of variable cross-section Explosively Formed Projectile (EFP) is the purpose of this paper. So theoretical analysis, numerical simulation and experimental data are combined to analyze the influence of variable cross-section characteristic on the time history of crater radius. Moreover the relationships between time history of crater radius (as well as mass of BAD) and the thickness of RHA (from 30mm to 70 mm) and the impact velocity of EFP (1650 m/s to 1860 m/s) are also investigated. The results indicate that: 1) being compared to the variable cross-section characteristic is ignored, the theoretical time history of crater radius is in better agreement with the simulation results when the variable cross-section characteristic is considered;2) being compared to the other three conditions of plug, the theoretical mass of BAD is in the best agreement with the simulation results when the shape of plug is frustum of a cone and the angle between generatrix and bottom is 45- and the axial length of mushroom is considered.
