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Base editing in plants: Current status and challenges 被引量:10
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作者 Sutar Suhas Bharat Shaoya Li +2 位作者 Jingying Li Lei Yan Lanqin Xia 《The Crop Journal》 SCIE CAS CSCD 2020年第3期384-395,共12页
Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improve... Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improvement. Although homology-directed repair(HDR)is a feasible approach to achieve precise gene replacement and base substitution in some plant species, the dominance of the non-homologous end joining pathway and low efficiency of HDR in plant cells have limited its application. Base editing has emerged as an alternative tool to HDR-mediated replacement, facilitating precise editing of plant genome by converting one single base to another in a programmable manner without a doublestranded break and a donor repair template. In this review, we summarize the latest developments in base-editing technologies as well as their underlying mechanisms. We review current applications of these technologies in plant species. Finally, we address the challenges and future perspectives of this emerging technology in plants. 展开更多
关键词 Base editing in plants current status and challenges
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The Current Status and Challenges Regarding Tuberculosis Infection Control in Health Care Facilities in China 被引量:3
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作者 ZHAO Fei CHENG Jun +9 位作者 CHENG Shi Ming ZHANG Hui ZHAO Yan Lin ZHANG Can You HU Dong Mei FAN Hai Ying HUANG Fei QU Yan HE Guang Xue WANG Li Xia 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第11期848-854,共7页
Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis (TB). The TB prevention and treatment staff in health care facilities are responsi... Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis (TB). The TB prevention and treatment staff in health care facilities are responsible for the identification, diagnosis, treatment, supervision, and management of TB patients . 展开更多
关键词 TB The current status and challenges Regarding Tuberculosis Infection Control in Health Care Facilities in China
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