A piece of equipment designed under a multi-disciplinary project in Shandong University of Science and Technology is described.The purpose is to indicate speech-time status to speakers in debates by presenting a three...A piece of equipment designed under a multi-disciplinary project in Shandong University of Science and Technology is described.The purpose is to indicate speech-time status to speakers in debates by presenting a three-light output The speech length may be programmed by the user with a combination of buttons and LCD display.The system is portable and microcontroller-based,using on-chip timers for accurate measurement of durations.展开更多
Putonghua, more commonly known as Mandarin in English, is China's official standard language. Efforts to popularize it across the country began as early as 1955. Today, the necessity of further popularizing it is bei...Putonghua, more commonly known as Mandarin in English, is China's official standard language. Efforts to popularize it across the country began as early as 1955. Today, the necessity of further popularizing it is being stressed once more. Recently, China's media watchdog, the State General Administration of Press, Publication, Radio, Film and Television, issued a notification, requesting all TV and radio presenters to speak standard putonghua and refrain from using any dialectica vocabulary, slang, or foreign languages during programs, except for special cases where it is necessary. The administration said that presenters should take the lead in promoting the use of standard putonghua.展开更多
viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent w...viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent weeks.In the realm of social media,where trends emerge and vanish like fleeting sparks,the dance craze is currently at the zenith of popularity.展开更多
With the advancement of globalization,university students need not only to master English language skills but also to develop critical thinking and logical expression skills,both of which are crucial for academic and ...With the advancement of globalization,university students need not only to master English language skills but also to develop critical thinking and logical expression skills,both of which are crucial for academic and professional success.As an interactive and structured learning activity,English debates provide an effective platform for enhancing these cognitive and linguistic skills.This study investigates the impact of English debates on students’critical thinking and logical expression skills by analyzing pre-and post-debate assessments,survey data,and in-depth interviews with debate participants.The results indicate significant improvements in critical thinking skills,including argumentation logic,rebuttal techniques,and problem awareness.Students also demonstrated notable progress in organizing and expressing complex ideas logically in English.These findings offer valuable insights for English teaching in higher education,suggesting that debates can serve as an effective pedagogical tool for fostering both language and cognitive development in university students.展开更多
More than 200 scholars,researchers,former government o!cials and party leaders from over 50 countries gathered in the sprawling building of the Chinese Academy of History in Beijing on 20 March for the third Internati...More than 200 scholars,researchers,former government o!cials and party leaders from over 50 countries gathered in the sprawling building of the Chinese Academy of History in Beijing on 20 March for the third International Forum on Democracy:The Shared Human Values.The forum debated the concept of democracy,its trajectories and prospects,and,more importantly,how it can be made to work and deliver tangible results for di"erent countries.展开更多
Scholars resort to "the Way" to strike a balance between man and nature A forum on how to integrate Taoist philosophy with social reality, and how to build a harmonious world for humanity, was held at the He...Scholars resort to "the Way" to strike a balance between man and nature A forum on how to integrate Taoist philosophy with social reality, and how to build a harmonious world for humanity, was held at the Hengshan Mountain, a scenic site renowned for Taoist culture展开更多
Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this concept.The principal hallmarks of PD are the loss of dopaminergic neurons in the...Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this concept.The principal hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta and the aggregation of misfolded alpha-synuclein(α-syn).展开更多
BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously...BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics platform.The study was managed by six teams in six countries that promoted the study on social media.The questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff points.RESULTS The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and gender.This supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered individuals.The prevalence of the 4 psychiatric symptoms combination was significantly greater than that of 5 and 6 symptoms,when adding cognitive deficits and fatigue,respectively.MANCOVA showed a significant three-way interaction(age×gender×continent).Further analyses showed that the sources of this three-way interaction were threefold relating to two sub-populations at-risk:(1)Individuals that self-identified as non-binary gender scored significantly higher on all 4 psychiatric symptoms of the CSRS,Type A at young age groups(<50 years old)in North America compared to(self-identified)women and men located in the 4 continents studied,and to other ages across the adult life span;and(2)This pattern of results(CSRS,Type A)was found also in women at young ages(<40 years old)in North America who scored higher compared to men and women in other continents and other ages.Linear regression analyses confirmed the MANCOVA results.CONCLUSION These results show a combined mental health risk factor related to stress reactivity,suggesting that the CSRS is sensitive to populations at risk and may be applied to future identification of other vulnerable sub-populations.It also supports the transdiagnostic approach for more accurate prevention and treatment.Time will tell if such transdiagnostic syndromes will be part of the discussions on the next revisions of the traditional classification systems or whether the crisis in psychiatry further evolves.展开更多
Anti-hegemonic movements in Japan had occurred frequently since the early 20th century,and democratic revolution debate in the 1920s was the first significant domestic debate on future development strategy.Various dis...Anti-hegemonic movements in Japan had occurred frequently since the early 20th century,and democratic revolution debate in the 1920s was the first significant domestic debate on future development strategy.Various discussions on it from Japanese academia involved state power,absolutism,agrarian revolution,and revolutionary strategy,etc.An analysis of early Japanese scholars’perspectives on the democratic revolution helps to know about the social milieu in Japan at that time,and is of positive significance to comprehend the development process of the current Japanese democratic revolution.展开更多
This paper explores Mao Zedong’s early views on physical education and practice,focusing on the“Six-Section Exercise”he created.The exercise,which integrates elements from traditional health-preserving techniques,g...This paper explores Mao Zedong’s early views on physical education and practice,focusing on the“Six-Section Exercise”he created.The exercise,which integrates elements from traditional health-preserving techniques,gymnastics,boxing,and military training,was designed to promote balanced physical development,be practical and effective,and require less time per session.The paper argues that Mao Zedong’s views on physical education were grounded in the belief that it could effectively transform individuals and contribute to the creation of a strong sports nation.The paper also discusses the historical context and social trends behind the creation of the“Six-Section Exercise”,including the New Culture Movement and debates between Chinese and Western,static and dynamic,and new and old approaches to physical education.The paper concludes by suggesting that Mao Zedong’s early sports thinking has significant academic value and can provide guidance for the construction of a healthy China today.展开更多
Through our newly-developed "chemical vapor deposition integrated process (ISVD-IP)'" using carbon OlOXlae (t..u2) as me raw matenal and only carbon source introduced, CO2 could be catalytically activated and c...Through our newly-developed "chemical vapor deposition integrated process (ISVD-IP)'" using carbon OlOXlae (t..u2) as me raw matenal and only carbon source introduced, CO2 could be catalytically activated and converted to a new solid-form product, i.e., carbon nanotubes (CO2-derived) at a quite high yield (the single-pass carbon yield in the solid-form carbon-product produced from CO2 catalytic capture and conversion was more than 30% at a single-pass carbon-base). For comparison, when only pure carbon dioxide was introduced using the conventional CVD method without integrated process, no solid-form carbon-material product could be formed. In the addition of saturated steam at room temperature in the feed for CVD, there were much more end-opening carbon nano-tubes produced, at a slightly higher carbon yield. These inspiring works opened a remarkable and alternative new approach for carbon dioxide catalytic capture to solid-form product, comparing with that of CO2 sequestration (CCS) or CO2 mineralization (solidification), etc. As a result, there was much less body volume and almost no greenhouse effect for this solid-form carbon-material than those of primitive carbon dioxide.展开更多
The koala^1 is a cutie,but does it steal^2 too much of the limelight^3?A new study adds quantitative detail to an ongoing debate over whether such"conservation mascots^4"receive publicity and funding to the detrime...The koala^1 is a cutie,but does it steal^2 too much of the limelight^3?A new study adds quantitative detail to an ongoing debate over whether such"conservation mascots^4"receive publicity and funding to the detriment of^5 animals typically deemed less attractive.展开更多
Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a mu...Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study.展开更多
Gaming disorder has become a significant issue in mental healthcare. While gaming is an important form of entertainment, excessive gaming may cause serious consequences for players. At present, there are still controv...Gaming disorder has become a significant issue in mental healthcare. While gaming is an important form of entertainment, excessive gaming may cause serious consequences for players. At present, there are still controversies in the academic community concerning the public health problems related to gaming disorder. This article attempts to expound the definition, epidemiology, aetiology, diagnosis, treatment and prevention of gaming disorder, in order to contribute to future conceptualization of gaming disorder.展开更多
Following publication of NASCIS Ⅱ, methylprednisolone sodium succinate(MPSS) was hailed as a breakthrough for patients with acute spinal cord injury(SCI). MPSS use for SCI has since become very controversial and ...Following publication of NASCIS Ⅱ, methylprednisolone sodium succinate(MPSS) was hailed as a breakthrough for patients with acute spinal cord injury(SCI). MPSS use for SCI has since become very controversial and it is our opinion that additional evidence is unlikely to break the stalemate amongst clinicians. Patient opinion has the potential to break this stalemate and we review our recent findings which reported that spinal cord injured patients informed of the risks and benefits of MPSS reported a preference for MPSS administration. We discuss the implications of the current MPSS debate on translational research and seek to address some misconceptions which have evolved. As science has failed to resolve the MPSS debate we argue that the debate is an increasingly philosophical one. We question whether SCI might be viewed as a serious condition like cancer where serious side effects of therapeutics are tolerated even when benefits may be small. We also draw attention to the similarity between the side effects of MPSS and isotretinoin which is prescribed for the cosmetic disorder acne vulgaris. Ultimately we question how patient autonomy should be weighed in the context of current SCI guidelines and MPSS's status as a historical standard of care.展开更多
Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear wa...Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear was first invented during the last 40,000 years (no doubt at different times and in different places),shoes were by necessity minimal-essentially sandals and moccasins-designed to protect the sole of the foot but lacking any of the sophisticated features and materials present in modem running shoes such as elevated cushioned heels,arch supports,and toe springs.Most of these features were invented in the 1970s,and they quickly became more popular and sophisticated as running underwent a worldwide boom.Today,the vast majority of runners think it is normal to wear cushioned running shoes,and would never dream of running without them.展开更多
The recent and ongoing debate about the character of(not only)ancient economies reveals that the traditional rivalry between‘primitivist-substantivist’and‘modernist-formalist’views has defi nitely come to an end a...The recent and ongoing debate about the character of(not only)ancient economies reveals that the traditional rivalry between‘primitivist-substantivist’and‘modernist-formalist’views has defi nitely come to an end although a more or less conscious afterlife and shaping of minds still exists.1As such。展开更多
文摘A piece of equipment designed under a multi-disciplinary project in Shandong University of Science and Technology is described.The purpose is to indicate speech-time status to speakers in debates by presenting a three-light output The speech length may be programmed by the user with a combination of buttons and LCD display.The system is portable and microcontroller-based,using on-chip timers for accurate measurement of durations.
文摘Putonghua, more commonly known as Mandarin in English, is China's official standard language. Efforts to popularize it across the country began as early as 1955. Today, the necessity of further popularizing it is being stressed once more. Recently, China's media watchdog, the State General Administration of Press, Publication, Radio, Film and Television, issued a notification, requesting all TV and radio presenters to speak standard putonghua and refrain from using any dialectica vocabulary, slang, or foreign languages during programs, except for special cases where it is necessary. The administration said that presenters should take the lead in promoting the use of standard putonghua.
文摘viral dance sensation and the debate it sparks.EMERGING f rom a festive wedding ceremony,a dance colloquially known as Kemusan or Subject Three has achieved a meteoric rise to fame across digital platforms in recent weeks.In the realm of social media,where trends emerge and vanish like fleeting sparks,the dance craze is currently at the zenith of popularity.
文摘With the advancement of globalization,university students need not only to master English language skills but also to develop critical thinking and logical expression skills,both of which are crucial for academic and professional success.As an interactive and structured learning activity,English debates provide an effective platform for enhancing these cognitive and linguistic skills.This study investigates the impact of English debates on students’critical thinking and logical expression skills by analyzing pre-and post-debate assessments,survey data,and in-depth interviews with debate participants.The results indicate significant improvements in critical thinking skills,including argumentation logic,rebuttal techniques,and problem awareness.Students also demonstrated notable progress in organizing and expressing complex ideas logically in English.These findings offer valuable insights for English teaching in higher education,suggesting that debates can serve as an effective pedagogical tool for fostering both language and cognitive development in university students.
文摘More than 200 scholars,researchers,former government o!cials and party leaders from over 50 countries gathered in the sprawling building of the Chinese Academy of History in Beijing on 20 March for the third International Forum on Democracy:The Shared Human Values.The forum debated the concept of democracy,its trajectories and prospects,and,more importantly,how it can be made to work and deliver tangible results for di"erent countries.
文摘Scholars resort to "the Way" to strike a balance between man and nature A forum on how to integrate Taoist philosophy with social reality, and how to build a harmonious world for humanity, was held at the Hengshan Mountain, a scenic site renowned for Taoist culture
基金supported by a grant from NYU Grossman School of Medicine and The Marlene and Paolo Fresco Institute for Parkinson’s and Movement Disorders, which was made possible with support from Marlene and Paolo Fresco (to AC)
文摘Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this concept.The principal hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta and the aggregation of misfolded alpha-synuclein(α-syn).
文摘BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics platform.The study was managed by six teams in six countries that promoted the study on social media.The questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff points.RESULTS The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and gender.This supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered individuals.The prevalence of the 4 psychiatric symptoms combination was significantly greater than that of 5 and 6 symptoms,when adding cognitive deficits and fatigue,respectively.MANCOVA showed a significant three-way interaction(age×gender×continent).Further analyses showed that the sources of this three-way interaction were threefold relating to two sub-populations at-risk:(1)Individuals that self-identified as non-binary gender scored significantly higher on all 4 psychiatric symptoms of the CSRS,Type A at young age groups(<50 years old)in North America compared to(self-identified)women and men located in the 4 continents studied,and to other ages across the adult life span;and(2)This pattern of results(CSRS,Type A)was found also in women at young ages(<40 years old)in North America who scored higher compared to men and women in other continents and other ages.Linear regression analyses confirmed the MANCOVA results.CONCLUSION These results show a combined mental health risk factor related to stress reactivity,suggesting that the CSRS is sensitive to populations at risk and may be applied to future identification of other vulnerable sub-populations.It also supports the transdiagnostic approach for more accurate prevention and treatment.Time will tell if such transdiagnostic syndromes will be part of the discussions on the next revisions of the traditional classification systems or whether the crisis in psychiatry further evolves.
基金Youth Fund for Humanities and Social Sciences Research of the Ministry of Education“Research on the Translation,Sharing,and Evolution of Marxist Terminology in the Early Translation of the Communist Manifesto between China and Japan”(《共产党宣言》在中日两国早期译介过程中马克思主义术语的译出、共享与演变研究20YJC740035).
文摘Anti-hegemonic movements in Japan had occurred frequently since the early 20th century,and democratic revolution debate in the 1920s was the first significant domestic debate on future development strategy.Various discussions on it from Japanese academia involved state power,absolutism,agrarian revolution,and revolutionary strategy,etc.An analysis of early Japanese scholars’perspectives on the democratic revolution helps to know about the social milieu in Japan at that time,and is of positive significance to comprehend the development process of the current Japanese democratic revolution.
文摘This paper explores Mao Zedong’s early views on physical education and practice,focusing on the“Six-Section Exercise”he created.The exercise,which integrates elements from traditional health-preserving techniques,gymnastics,boxing,and military training,was designed to promote balanced physical development,be practical and effective,and require less time per session.The paper argues that Mao Zedong’s views on physical education were grounded in the belief that it could effectively transform individuals and contribute to the creation of a strong sports nation.The paper also discusses the historical context and social trends behind the creation of the“Six-Section Exercise”,including the New Culture Movement and debates between Chinese and Western,static and dynamic,and new and old approaches to physical education.The paper concludes by suggesting that Mao Zedong’s early sports thinking has significant academic value and can provide guidance for the construction of a healthy China today.
基金the National 973 Program of Ministry of Sciences and Technologies of China(2011CB201202)the National Natural Science Foundation of China(20776089)
文摘Through our newly-developed "chemical vapor deposition integrated process (ISVD-IP)'" using carbon OlOXlae (t..u2) as me raw matenal and only carbon source introduced, CO2 could be catalytically activated and converted to a new solid-form product, i.e., carbon nanotubes (CO2-derived) at a quite high yield (the single-pass carbon yield in the solid-form carbon-product produced from CO2 catalytic capture and conversion was more than 30% at a single-pass carbon-base). For comparison, when only pure carbon dioxide was introduced using the conventional CVD method without integrated process, no solid-form carbon-material product could be formed. In the addition of saturated steam at room temperature in the feed for CVD, there were much more end-opening carbon nano-tubes produced, at a slightly higher carbon yield. These inspiring works opened a remarkable and alternative new approach for carbon dioxide catalytic capture to solid-form product, comparing with that of CO2 sequestration (CCS) or CO2 mineralization (solidification), etc. As a result, there was much less body volume and almost no greenhouse effect for this solid-form carbon-material than those of primitive carbon dioxide.
文摘The koala^1 is a cutie,but does it steal^2 too much of the limelight^3?A new study adds quantitative detail to an ongoing debate over whether such"conservation mascots^4"receive publicity and funding to the detriment of^5 animals typically deemed less attractive.
文摘Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study.
基金grants from the National Key R&D Program of China(2017YFC1310400)the National Natural Science Foundation of China(81371465 and 81671324).
文摘Gaming disorder has become a significant issue in mental healthcare. While gaming is an important form of entertainment, excessive gaming may cause serious consequences for players. At present, there are still controversies in the academic community concerning the public health problems related to gaming disorder. This article attempts to expound the definition, epidemiology, aetiology, diagnosis, treatment and prevention of gaming disorder, in order to contribute to future conceptualization of gaming disorder.
文摘Following publication of NASCIS Ⅱ, methylprednisolone sodium succinate(MPSS) was hailed as a breakthrough for patients with acute spinal cord injury(SCI). MPSS use for SCI has since become very controversial and it is our opinion that additional evidence is unlikely to break the stalemate amongst clinicians. Patient opinion has the potential to break this stalemate and we review our recent findings which reported that spinal cord injured patients informed of the risks and benefits of MPSS reported a preference for MPSS administration. We discuss the implications of the current MPSS debate on translational research and seek to address some misconceptions which have evolved. As science has failed to resolve the MPSS debate we argue that the debate is an increasingly philosophical one. We question whether SCI might be viewed as a serious condition like cancer where serious side effects of therapeutics are tolerated even when benefits may be small. We also draw attention to the similarity between the side effects of MPSS and isotretinoin which is prescribed for the cosmetic disorder acne vulgaris. Ultimately we question how patient autonomy should be weighed in the context of current SCI guidelines and MPSS's status as a historical standard of care.
文摘Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear was first invented during the last 40,000 years (no doubt at different times and in different places),shoes were by necessity minimal-essentially sandals and moccasins-designed to protect the sole of the foot but lacking any of the sophisticated features and materials present in modem running shoes such as elevated cushioned heels,arch supports,and toe springs.Most of these features were invented in the 1970s,and they quickly became more popular and sophisticated as running underwent a worldwide boom.Today,the vast majority of runners think it is normal to wear cushioned running shoes,and would never dream of running without them.
文摘The recent and ongoing debate about the character of(not only)ancient economies reveals that the traditional rivalry between‘primitivist-substantivist’and‘modernist-formalist’views has defi nitely come to an end although a more or less conscious afterlife and shaping of minds still exists.1As such。