Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed.

Expression Profile Analysis of Genes Involved in Brassinosteroid Biosynthesis Pathway in Cotton Fiber Development

Cotton(Gossypium hirsutum L.) is the leading fiber crop and one of the mainstays of the economy in the world.Cotton fibers,as the main product of cotton plants,are unicellular,linear

SME： The Hungarian Experience Situation and Development in Hungary

This paper aims to present the development of the SME sector through the example of a country in East-Central Europe. This country was once a member of the so-called communist block until 1989, but had a market economy in 1989. Hungary joined the EU on May 1, 2004, and displaied numerous interesting features concerning small and medium sized enterprises ever since, complying with a variety of expectations. The research study investigated the East-Central European SME systems, and particularly the Hungarian SME practice. The main methods used in this paper are present European and Hungarian research findings of nternational relevance. Several data and figures from the European Union, the Central European area and of course from Hungary were used for the characterization of the SME systems. The main results of the research study is a set of characteristics of the SMEs＇ East-Central European pathway： （1） SMEs as a pillar of the nation in the world and in Hungary; （2） Hungary as the Paradise of small enterprises （numbers versus reality）; （3） Domestic small enterprises in an international （European） comparison; （4） How the crisis impacted the domestic SME sector; （5） Misconceptions and dead ends in small enterprises today： What should the state subsidise and how？

A review of the balance of regional development in China from the perspective of development geography

Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course of balanced regional development in China and summarizes its characteristics in each period. The results show that inter-regional development in China has undergone successive periods of balanced and unbalanced development. Each period has enhanced social development and contributed to a more balanced regional development. This paper discusses the scientific connotation of balanced regional development, and invokes sustainable development theory to argue that we should pay attention to the differences in resource endowments among regions, and solves the imbalance among the economy, humans, and nature to promote the spatial balance of regional development and green development for better coordination between economy and ecology. The balanced promotion of the well-being of people in each region is the ultimate goal of balanced regional development. We then use concepts from development geography to examine China’s path of balanced regional development from the three perspectives of society, the economy, and ecology. Suggestions are also provided for the balanced development of China’s regions and the improvement of public well-being.

Differential expression of Bmp2,Bmp4 and Bmp3 in embryonic development of mouse anterior and posterior palate

Background The palate is differently regulated and developed along the anterior-posterior axis. The Bmp signal pathway plays a crucial role in palatogenesis. Conditioned-inactivation of Bmp type I receptor Alk2 or Alk3 in the neural crest or craniofacial region leads to palatal cleft in mice. However, how different Bmp members are involved in palatogenesis remains to be elucidated. In the present study, mRNA expression patterns of Bmp2, Bmp3 and Bmp4 in the developing anterior and posterior palates were examined and compared, focusing on the fusion stage.Methods To detect the expression of Bmp mRNA, antisense riboprobes were synthesized by in vitro transcription. Radioactive in situ hybridization was performed on sagital and coronal sections of mice head from E13 to E18.Results The expression of these Bmps were developmentally regulated in the anterior and posterior palates prior to, during and after palatal fusion. During palatal fusion, Bmp4 expression shifted from the anterior to the process, pattern whereas in their palates regulatingConclusions Bmp signalling is involved in palatogenesis in muhiple stages and has muhiple roles in regulating anterior and posterior palatal development. Disturbances of Bmp signalling during palatogenesis might be a possible mechanism of cleft palate.