Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesqu...Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesquiterpenoid were isolated from the whole plants of Chloranthus elatior.Their structures and relative configurations were established on the basis of extensive spectroscopic analysis.展开更多
Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（E.elatior）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical ...Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（E.elatior）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the extract.The pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower extract.The antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal strains.Apart from that,the methanolic extract of E.elatior flower was further tested in vivo toxicity using the brine shrimp lethality test.Moreover,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） assay.Results:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/mL.The brine shrimp lethality test exhibited no significant toxicity(LC<sub>50</sub>= 2.52 mg/mL) against Artemia salina.The E.elatior flower extract with high LC<sub>50</sub> value signified that this plant is not toxic to humans.While the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were absent.The concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC<sub>50</sub>) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/mL.Conclusions:These findings indicate that the extract of E.elatior flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.展开更多
基金supported by National Natural Science Funding of China(No.81072543)the Key Project of Knowledge Innovation Project of CAS(No.KSCX2-EW-Q-10)funds(No.P2009-KF04)from the State Key Laboratory of Phytochemistry and Plant Resources in West China.
文摘Two new eudesmane-type sesquiterpenoid lactones,named chlorelactone A(1)and chlorelactone B(2),and one new labdane-type diterpenoid,named elatiorlabdane(3),along with seven known sesquiterpenoids and one known disesquiterpenoid were isolated from the whole plants of Chloranthus elatior.Their structures and relative configurations were established on the basis of extensive spectroscopic analysis.
基金supported by Universiti Sains Malaysia fellowship from Institute for Postgraduate Studies,Universiti Sains Malaysia
文摘Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（E.elatior）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the extract.The pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower extract.The antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal strains.Apart from that,the methanolic extract of E.elatior flower was further tested in vivo toxicity using the brine shrimp lethality test.Moreover,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） assay.Results:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/mL.The brine shrimp lethality test exhibited no significant toxicity(LC<sub>50</sub>= 2.52 mg/mL) against Artemia salina.The E.elatior flower extract with high LC<sub>50</sub> value signified that this plant is not toxic to humans.While the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were absent.The concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC<sub>50</sub>) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/mL.Conclusions:These findings indicate that the extract of E.elatior flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.
