"Endogenous wind " Theory theory in the prevention and treatment of anti-tumor treatment-related adverse reaction related research progress

The treatment of malignant tumor is mainly based on modern medical treatment,after treatment,there are many adverse reactions,such as dizziness,headache,fever,numbness of limbs,pruritus,rash,spasm,phalacrosis,elevated blood pressure,anemia,myelosuppression,impaired functions of liver and kidney."Endogenous wind"is a part of Traditional Chinese medicine,and the researches are mainly focused on tumor metastasis and treatment.The researches on the adverse reactions associated with the treatment of malignant tumors are less.This paper is built on the theory of"endogenous wind"of Chinese medicine,and initially analyzes the progress of the research on adverse reactions of malignant tumors after treatment by modern medical means.

An Isotopic(Sr,Nd and Pb) Tracer Study on the Xiaoxinancha Gold-rich Copper Deposit in Yanbian,China:Implication for the Geodynamic Model of Diagenesis and Metallogenesis

An isotopic study was systemically carried out on the granitic complex,diorite-porphyrite, ores and ore minerals of the 103 Ma Xiaoxinancha gold-rich copper deposit in Jilin province to determine the geodynamic model of diagenesis and metallogenesis.Results show that the initial Nd and Sr isotopic compositions of the granitic complex are in the range of 0.70425-0.70505 for（87Sr/86Sr）i, 0.51243-0.51264 for INd,and -1.31 to ＋2.64 forεNd（t）;those of the diorite-porphyrite are in the range from 0.70438-0.70448 for（87Sr/86Sr）,,0.51259-0.51261 for INd,and ＋1.56 to ＋2.09 forεNd（t）.For ores and sulfides,the（87Sr/86Sr）i,7Nd,andεNd（t） values are in the range from 0.70440-0.70805,0.51259- 0.51279 and ＋1.72 to ＋5.56,respectively.The Pb isotopic ratios of the granitic complex range from 18.2992-18.6636 for 206Pb/204Pb,from 15.5343-15.5660 for 207Pb/204Pb,and from 38.1640-38.5657 for 208Pb/204Pb For diorite-porphyrite,the isotopic ratios of 206Pb/204Pb,207Pb/204Pb and 208Pb/204Pb are 18.3919,15.5794 and 38.3566,respectively,whereas those of the ores and ore sulfides vary from 18.2275-18.3770 for 206Pb/204Pb,from 15.5555-15.5934 for 207Pb/204Pb and from 38.1318-38.3131 for 208Pb/204Pb.The results indicate that the mineralization was correlated to the formation and evolution of the granitic complex and the diorite-porphyrite.Combining with the reported data in petrologic characteristics,elemental geochemistry and chronology,conclusions can be drawn that the geodynamic settings of diagenesis and metallogenesis of this deposit were consistent with the subduction of the Izanagi oceanic plate during the Early Cretaceous.The diorite-porphyrite was formed by the emplacement of the adakitic magma triggered by partial melting of the enriched mantle,which originated from the derivative continental lithospheric mantle metasomatized by dehydration fluids from the subducting oceanic crust.The granitic complex was produced by fractional crystallization of the mixture between the adakitic magma and the high-K calc-alkaline acidic magma,which were generated by the remelting of the lower crust in the course of intraplate upwelling of the adakitic magma.The ore-bearing fluid reservoir convened in a late stage of the evolution of the mixed magma chamber.

The role of R&D and economic policy uncertainty in Sri Lanka’s economic growth

In this paper,we assess the role of investment in research and development(R&D)and economic policy uncertainty(EPU)in Sri Lanka’s economic growth experience.We do this by first determining which endogenous growth theories best explain the evolution of total factor productivity(TFP)in the country.Using historical time series data(1980–2018),we find that semi-endogenous growth theories best explain the evolution of TFP in Sri Lanka.This evidence suggests that R&D is critical to the country’s TFP expansion.We find that,through R&D,EPU has a crucial detrimental impact on TFP growth,although it is short-lived.Our findings are robust and have important implications for R&D investment and for moderating EPU.

Long noncoding RNA LINC01124 activates hepatocellular carcinoma cell proliferation, migration, and invasion by absorbing microRNA-1247-5p and overexpressing FOXO3

Long intergenic non-protein coding RNA 1124(LINC01124)has been identified as an important regulator of non-small-cell lung cancer.However,the expression and detailed role of LINC01124 in hepatocellular carcinoma(HCC)remain unestablished to date.Therefore,this study aimed to elucidate the role of LINC01124 in the aggressiveness of HCC cells and identify the underlying regulatory mechanism.Quantitative reverse transcriptase-polymerase chain reaction was performed to measure the expression of LINC01124 in HCC.Cell Counting Kit-8 assay,Transwell cell migration and invasion assays,and a xenograft tumor model were used to investigate the function of LINC01124 in HCC cells,and bioinformatics analysis,RNA immunoprecipitation,luciferase reporter assay,and rescue experiments were used to elucidate the underlying mechanisms.Herein,LINC01124 overexpression was confirmed in HCC tissues as well as cell lines.Further,the downregulation of LINC01124 decreased HCC cell proliferation,migration,and invasion in vitro,whereas the upregulation of LINC01124 triggered the opposite results.Additionally,LINC01124 ablation impaired tumor growth in vivo.Mechanistic analyses revealed that LINC01124 functions as a competing endogenous RNA to sponge microRNA-1247-5p(miR-1247-5p)in HCC cells.Moreover,forkhead box O3(FOXO3)was identified as a direct target of miR-1247-5p.FOXO3 was positively regulated by LINC01124 in HCC cells through the sequestration of miR-1247-5p.Finally,rescue assays revealed that the inhibition of miR-1247-5p or overexpression of FOXO3 reversed the effects of LINC01124 silencing on the HCC cell malignant phenotype.In summary,LINC01124 plays a tumor-promoting role in HCC by regulating the miR-1247-5p-FOXO3 axis.The LINC01124-miR-1247-5p-FOXO3 pathway may provide a foundation for the identification of alternative therapies for HCC.