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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease
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作者 Hao Ding Yuan-Yuan Fang +5 位作者 Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei 《World Journal of Gastroenterology》 SCIE CAS 2025年第3期62-72,共11页
BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD patients.Yet,it poses a significan... BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD patients.Yet,it poses a significant challenge due to its limited accessibility through conventional endoscopic methods.AIM To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD patients.METHODS Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic model.Patient demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic features.The diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),respectively.RESULTS Of the 73 patients enrolled,25 patients achieved MH.The radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by DCA.CONCLUSION These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients. 展开更多
关键词 Crohn’s disease Computed tomography enterography Mucosal healing NOMOGRAM Radiomics
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Retrieval-balloon-assisted enterography for ERCP after Billroth Ⅱ gastroenterostomy and Braun anastomosis 被引量:8
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作者 Wen-Guang Wu Wen-Jie Zhang +5 位作者 Jun Gu Ming-Ning Zhao Ming Zhuang Yi-Jing Tao Ying-Bin Liu Xue-Feng Wang 《World Journal of Gastroenterology》 SCIE CAS 2014年第31期10921-10926,共6页
AIM: To describe an optimal route to the Braun anastomosis including the use of retrieval-balloon-assisted enterography.METHODS: Patients who received a Billroth Ⅱ gastroenterostomy(n = 109) and a Billroth Ⅱ gastroe... AIM: To describe an optimal route to the Braun anastomosis including the use of retrieval-balloon-assisted enterography.METHODS: Patients who received a Billroth Ⅱ gastroenterostomy(n = 109) and a Billroth Ⅱ gastroenterostomy with Braun anastomosis(n = 20) between January 2009 and May 2013 were analyzed in this study. Endoscopic ret-rograde cholangiopancreatography(ERCP) was performed under fluoroscopic control using a total length of 120 cm oblique-viewing duodenoscope with a 3.7-mm diameter working channel. For this procedure, we used a triplelumen retrieval balloon catheter in which a 0.035-inch guidewire could be inserted into the "open-channel" guidewire lumen while the balloon could be simultaneously injected and inflated through the other 2 lumens.RESULTS: For the patients with Billroth Ⅱ gastroenterostomy and Braun anastomosis, successful access to the papilla was gained in 17 patients(85%) and there was therapeutic success in 16 patients(80%). One patient had afferent loop perforation, but postoperative bleeding did not occur. For Billroth Ⅱ gastroenterostomy, there was failure in accessing the papilla in 15 patients(13.8%). ERCP was unsuccessful because of tumor infiltration(6 patients), a long afferent loop(9 patients), and cannulation failure(4 patients). The papilla was successfully accessed in 94 patients(86.2%), and there was therapeutic success in 90 patients(82.6%). Afferent loop perforation did not occur in any of these patients. One patient had hemorrhage 2 h after ERCP, which was successfully managed with conservative treatment.CONCLUSION: Retrieval-balloon-assisted enterography along an optimal route may improve the ERCP success rate after Billroth Ⅱ gastroenterostomy and Braun anastomosis. 展开更多
关键词 Retrieval-balloon-assisted enterography Billroth gastroenterostomy Braun anastomosis Optimal enterography route Gastrojejunal anastomosis Efferent loop Endoscopic retrograde cholangiopancreatography Duodenoscope enterography success rate Therapeutic success rate
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Small intestinal lipomas:Diagnostic value of multi-slice CT enterography 被引量:7
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作者 Fang, Song-Hua Dong, Dan-Jun +2 位作者 Chen, Fang-Hong Jin, Mei Zhong, Bai-Shu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第21期2677-2681,共5页
AIM:To analyze the clinical and imaging features of the small intestinal lipomas and to evaluate the diagnostic value of multi-slice computed tomography(CT) enterography.METHODS:Fourteen cases(one had two intestinal l... AIM:To analyze the clinical and imaging features of the small intestinal lipomas and to evaluate the diagnostic value of multi-slice computed tomography(CT) enterography.METHODS:Fourteen cases(one had two intestinal lesions) of surgically confirmed lipomas of the small intestine were retrospectively analyzed.The location,size,clinical and radiological aspects were discussed.RESULTS:Twelve patients presented with abdominal pain,of whom three complained of paroxysmal colic.Melena or bloody stools was mentioned in five cases.One lesion was detected incidentally during routine physical examination.One lesion was found unexpectedly during the preoperational evaluation for cholecystitis.Examination of the abdomen revealed palpable masses in four cases.Precontrast CT scan showed round or oval well-defined hypo-intense intraluminal masses with the attenuation ranging from-130 HU to-60 HU.On contrast enhancement CT scan,no striking enhancement was seen.CONCLUSION:The small intestinal lipomas are rare and difficult to diagnose merely based on clinical manifestations,while the characteristic features at small intestinal CT enterography can help establish reliable prospective diagnoses. 展开更多
关键词 LIPOMA Small bowel Computed tomography X-RAY enterography
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Multi-detector CT enterography with iso-osmotic mannitol as oral contrast for detecting small bowel disease 被引量:9
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作者 Lian-HeZhang Shi-ZhengZhang +4 位作者 Hong-JieHu MinGao MingZhang QianCao Qiao-weiZhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第15期2324-2329,共6页
AIM: To assess the feasibility and usefulness of multi-detector CT enterography with orally administered iso-osmotic mannitol as negative contrast in demonstrating small bowel disease.METHODS: Thirteen volunteers and ... AIM: To assess the feasibility and usefulness of multi-detector CT enterography with orally administered iso-osmotic mannitol as negative contrast in demonstrating small bowel disease.METHODS: Thirteen volunteers and 38 patients with various kinds of small bowel disease were examined. We administered about 1 500 mL iso-osmotic mannitol as negative contrast agent and then proceeded with helical CT scanning on a Siemens Sensation 16 scanner. All volunteers and patients were interviewed about their tolerance of the procedure. Two radiologists postprocessed imaging data with MPR, thin MIP, VRT and INSPACE when necessary and then interpreted the scans,and adequacy of luminal distention was evaluated on a four-point scale. Demonstration of features of various kinds of small bowel disease was analyzed.RESULTS: The taste of iso-osmotic mannitol is good (slightly sweet) and acceptable by all. Small bowel distention was excellent and moderate in most volunteers and patients. CT features of many kinds of diseases such as tumors, Crohn's disease,and small bowel obstruction,etc. were clearly displayed.CONCLUSION: Multi-detector CT enterography with iso-osmotic mannitol as negative contrast to distend the small bowel is a simple, rapid, noninvasive and effective method of evaluating small bowel disease. 展开更多
关键词 Small bowel CONTRAST enterography
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Retrieval-balloon-assisted enterography in post-pancreaticoduodenectomy endoscopic retrograde cholangiopancreatography 被引量:6
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作者 Ming Zhuang Wen-Jie Zhang +2 位作者 Jun Gu Ying-Bin Liu XueFeng Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7109-7112,共4页
This case reports an application of conventional duodenoscope in a post pancreaticoduodenectomy patient with the help of retrieval balloon assisted enterography.The 56-year-old woman had pancreaticoduodenectomy with C... This case reports an application of conventional duodenoscope in a post pancreaticoduodenectomy patient with the help of retrieval balloon assisted enterography.The 56-year-old woman had pancreaticoduodenectomy with Child reconstruction 9 mo ago because of pancreatic adenocarcinoma and now there are recurrent enlarged lymph nodes in the anastomotic stoma of hepaticojejunostomy.Considering the patient's late-stage cancer,a plastic stent was then successfully placed there to drainage.The main challenge in this case was the extremely long afferent loop and blind cannulation through the anastomotic stoma of hepaticojejunostomy.Retrieval balloon assisted enterography is very helpful for duodenoscope going through the reconstructed intestinal tract and for the cannulation.After two weeks,the patient remained free of painful symptoms and free of fever.Liver function improved well.Four months after the placement of stent,the patient died of cachexia without jaundice,fever and abdominal pain according to her daughter's statement. 展开更多
关键词 Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy Duodenoscope Retrieval-balloon-assisted enterography
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Video capsule endoscopy and CT enterography in diagnosing adult hypertrophic pyloric stenosis 被引量:3
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作者 Grigoriy E Gurvits Amy Tan Dmitri Volkov 《World Journal of Gastroenterology》 SCIE CAS 2013年第37期6292-6295,共4页
Primary adult hypertrophic pyloric stenosis is a rare but important cause of gastric outlet obstruction that may be misdiagnosed as idiopathic gastroparesis.Clinically,patients present with early satiety,abdominal ful... Primary adult hypertrophic pyloric stenosis is a rare but important cause of gastric outlet obstruction that may be misdiagnosed as idiopathic gastroparesis.Clinically,patients present with early satiety,abdominal fullness,nausea,epigastric discomfort and eructation.Permanent gastric retention of a video capsule endoscope is diagnostic in differentiating between the two diseases,in the absence of an organic gastric outlet obstruction.This case presents the longest video capsule retention in the medical literature to date.It is also the first case report of adult hypertrophic pyloric stenosis diagnosed with video capsule endoscopy or a computed tomography scan.Finally,an unusual"plugging"of the gastric outlet with free floating capsule has an augmented effect on disease physiology and on patient’s symptoms. 展开更多
关键词 Video capsule ENDOSCOPY HYPERTROPHIC pyloric STENOSIS GASTROPARESIS ENDOSCOPY COMPUTED tomography enterography
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Meckel's diverticulum bleeding diagnosed with magnetic resonance enterography:A case report 被引量:3
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作者 Fu-Run Zhou Liu-Ye Huang Hai-Zhu Xie 《World Journal of Gastroenterology》 SCIE CAS 2013年第17期2727-2730,共4页
Although the introduction of double-balloon enteroscopy has greatly improved the diagnostic rate, definite diagnosis of Meckel's diverticulum far from the ileocecal valve is still impossible in most cases. We expl... Although the introduction of double-balloon enteroscopy has greatly improved the diagnostic rate, definite diagnosis of Meckel's diverticulum far from the ileocecal valve is still impossible in most cases. We explored the role of magnetic resonance (MR) enterography in detecting bleeding from Meckel's diverticulum that can not be confirmed via double-balloon enteroscopy. This study describes a case of male patient with bleeding from Meckel's diverticulum diagnosed with MR enterography of the small intestine. No bleeding lesion was found via colonoscopy, anal enteroscopy, or oral colonoscopy. MR enterography of the small intestine revealed an occupying lesion of 3.0 cm in the lower segment of the ileum. The patient was transferred to the Department of Abdominal Surgery of our hospital for surgical treatment. During surgery, a mass of 3 cm × 2 cm was found 150 cm from the ileocecal valve, in conjunction with congestion and edema of the corresponding mesangium. Intraoperative diagnosis was small bowel diverticulum with bleeding. The patient underwent partial resection of the small intestine. Postopera-tive pathology showed Meckel's diverticulum containing pancreatic tissues. He was cured and discharged 7 d after operation. We conclude that MR enterography of the small intestine has greatly improved the diagnosis rate of Meckel's diverticulum, particularly in those patients with the disease which can not be confirmed via double-balloon enteroscopy. 展开更多
关键词 Meckel’s DIVERTICULUM Double-balloon ENTEROSCOPY Magnetic RESONANCE enterography
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Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease 被引量:3
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作者 Nadia Mazen Hijaz Thomas Mario Attard +2 位作者 Jennifer Marie Colombo Neil Joseph Mardis Craig Alan Friesen 《World Journal of Gastroenterology》 SCIE CAS 2019年第28期3808-3822,共15页
BACKGROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) a... BACKGROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIM To prospectively compare the findings of MRE and WCE and their agreement with PCDAI or histology in children with CD or IC. METHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent MRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (Attard TM and Colombo JM) blinded to each other's findings and to the findings on MRE (Mardis NJ). Agreement between WCE reviewers, WCE and MRE findings and concordance between positive PCDAI and SBI based on MRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good correlation between the two Lewis scores (r=0.875, P<0.001). Concordance between WCE and MRE was poor (69%). In CD patients, when both MRE and WCE were compared using PCDAI>10 as the standard reference reflecting active small intestinal CD, the sensitivity of MRE and WCE were 100% and 83% respectively and the specificity of MRE and WCE were 57.14% and 78.6%, respectively. If the histology in ileum or/and duodenum was used as the reference for active small bowel involvement, WCE had a higher specificity as compared to MRE (83.3% vs 50%). In patients with Crohn’s disease, those with a positive PCDAI (>10) were more likely to have a positive WCE as compared to those with a negative PCDAI (83% vs 21%;P=0.018). CONCLUSION We suggest that MRE and WCE have a complementary role in the assessment of SBI in CD. WCE detected SBI with a much higher specificity while MRE had a higher sensitivity. 展开更多
关键词 Crohn’s DISEASE Wireless capsule endoscopy Inflammatory BOWEL DISEASE Magnetic resonance enterography SMALL BOWEL involvement SMALL BOWEL DISEASE INDETERMINATE colitis Pediatric CHILDREN
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Magnetic resonance enterography in Crohn’s disease: Standard and advanced techniques 被引量:3
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作者 Arda Kayhan Jacob Oommen +1 位作者 Farid Dahi Aytekin Oto 《World Journal of Radiology》 CAS 2010年第4期113-121,共9页
Crohn's disease (CD) is a chronic autoimmune disorder that affects mainly young people. The clinical management is based on the Crohn's Disease Activity Index and especially on biologic parameters with or with... Crohn's disease (CD) is a chronic autoimmune disorder that affects mainly young people. The clinical management is based on the Crohn's Disease Activity Index and especially on biologic parameters with or without additional endoscopic and imaging procedures, such as barium and computed tomography examinations. Recently, magnetic resonance (MR) imaging has been a promising diagnostic radiologic technique with lack of ionizing radiation, enabling superior tissue contrast resolution due to new pulse-sequence developments. Therefore, MR enterography has the potential to become the modality of choice for imaging the small bowel in CD patients. 展开更多
关键词 Crohn’s disease Magnetic RESONANCE enterography Advantages PULSE SEQUENCES ADVANCED TECHNIQUES
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Comparative study between bowel ultrasound and magnetic resonance enterography among Egyptian inflammatory bowel disease patients 被引量:1
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作者 Shimaa Kamel Mohamed Sakr +5 位作者 Waleed Hamed Mohamed Eltabbakh Safaa Askar Ahmed Bassuny Rasha Hussein Ahmed Elbaz 《World Journal of Gastroenterology》 SCIE CAS 2020年第38期5884-5895,共12页
BACKGROUND Bowel ultrasound and magnetic resonance enterography(MRE)are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications.They assess the degree... BACKGROUND Bowel ultrasound and magnetic resonance enterography(MRE)are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications.They assess the degree of activity,help clinicians to identify patients in need of surgery,and can be used for patient follow-up.AIM To compare the role of MRE and bowel ultrasound in diagnosis and follow-up of inflammatory bowel disease(IBD)patients in Egypt.METHODS The study was conducted on 40 patients with IBD.All patients were subjected to clinical assessment,laboratory investigations,bowel ultrasound,MRE,and colonoscopy up to the terminal ileum with biopsies for histopathological examination.RESULTS This study was conducted on 14 patients(35%)with ulcerative colitis and 26 patients(65%)with Crohn's disease;34(85%)of these patients had active disease.Bowel ultrasound detected different bowel lesions with the following accuracies:ileum(85%),large bowel(70%),fistula(95%),stricture and proximal dilatation(95%)and abscesses(100%).Also,it showed that statistically significance of bowel ultrasound in differentiation between remission and activity of IBD in comparison to MRE and colonoscopy.CONCLUSION In comparison to MRE,bowel ultrasound is a useful,non-invasive,and feasible bedside imaging tool for the detection of inflammation,detection of complications,and follow-up of IBD patients when performed by the attending physician. 展开更多
关键词 Bowel ultrasound COLONOSCOPY Crohn's disease Magnetic resonance enterography Ulcerative colitis Inflammatory bowel disease
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Magnetic resonance enterography in Crohn's disease: How we do it and common imaging findings 被引量:1
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作者 Annalisa Mantarro Paola Scalise +1 位作者 Elisa Guidi Emanuele Neri 《World Journal of Radiology》 CAS 2017年第2期46-54,共9页
Crohn's disease(CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial an... Crohn's disease(CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial and is still not completely known; globally the westernization of lifestyle is causing an increasing incidence of CD, with peak age of 20-30 years. The diagnostic workup begins with the evaluation of the clinical history, physical examination and laboratory tests. However, the clinical assessment is subjected interobserver variability and, occasionally, the symptoms of acute and chronic inflammation may be indistinguishable. In this regards, the role of magnetic resonance(MR) enterography is crucial to determine the extension, the disease activity and the presence of any complications without ionizing radiations, making this method very suitable for young population affected by CD. The purpose of this review article is to illustrate the MR enterography technique and the most relevant imaging findings of CD, allowing the detection of small bowel involvement and the assessment of disease activity. 展开更多
关键词 Crohn’s disease Disease activity Magnetic resonance sequences Small bowel Magnetic resonance enterography
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Magnetic resonance enterography in refractory iron deficiency anemia:A pictorial overview
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作者 Ismet Cengic Derya Tureli +3 位作者 Hilal Aydin Onur Bugdayci Nese Imeryuz Davut Tuney 《World Journal of Gastroenterology》 SCIE CAS 2014年第38期14004-14009,共6页
AIM: To highlight magnetic resonance enterography (MRE) for diagnosis of patients with refractory iron deficiency anemia and normal endoscopy results.
关键词 ANEMIA Magnetic resonance enterography Double-balloon enteroscopy Small intestine Crohn’ s disease LYMPHOMA ADENOCARCINOMA GASTRITIS
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Motility index measured by magnetic resonance enterography is associated with sex and mural thickness
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作者 Sven Mansson Olle Ekberg Bodil Ohlsson 《World Journal of Gastroenterology》 SCIE CAS 2020年第36期5484-5497,共14页
BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel motility.The hypothesis was that assessment of the motility index(MI)should reflect diffe... BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel motility.The hypothesis was that assessment of the motility index(MI)should reflect differences in motility between clinical conditions.AIM To aim of the present observational,cross-sectional study was to evaluate the use of the MI in daily clinical practice.METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate.Healthy volunteers were included as controls.MRE was prepared and conducted in accordance with clinical routines.On the day of examination,all the participants had to complete the visual analog scale for irritable bowel syndrome(IBS)and IBS-symptom severity scale.Maps of MI were calculated from dynamic MR images.ANOVA was used to evaluate differences in MI between groups,classified as healthy,Crohn’s disease,ulcerative colitis,IBS,other assorted disorders and dysmotility.Logistic and linear regression were applied to the MI values.All medical records were scrutinized for medical history.RESULTS In all,224 examinations were included(inclusion prevalence 76.3%),with 22 controls and 202 patients.There was a significant difference in the MI of the jejunum(P=0.021)and terminal ileum(P=0.007)between the different groups.The MI was inversely associated with the mural thickness of the terminal ileum in men(P<0.001)and women(P=0.063)after adjustments,and tended to be lower in men than in women(P=0.056).Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men(P<0.001)and women(P=0.030).In women,diarrhea was inversely associated with the MI of the jejunum(P=0.029),and constipation was positively associated with the MI of the terminal ileum(P=0.039).CONCLUSION Although MIs differ across diseases,a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness.Symptoms are weakly associated with the MI. 展开更多
关键词 DYSMOTILITY Gastrointestinal symptoms Magnetic resonance enterography Motility index Mural thickness Small bowel
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Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn's disease
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作者 Gabriele Masselli Ilaria Mastroiacovo +4 位作者 Emidio De Marco Giulia Francione Emanuele Casciani Elisabetta Polettini Gianfranco Gualdi 《World Journal of Radiology》 CAS 2016年第7期668-682,共15页
Crohn&#x02019;s disease affects more than 500000 individuals in the United States, and about 25% of cases are diagnosed during the pediatric period. Imaging of the bowel has undergone dramatic changes in the past ... Crohn&#x02019;s disease affects more than 500000 individuals in the United States, and about 25% of cases are diagnosed during the pediatric period. Imaging of the bowel has undergone dramatic changes in the past two decades. The endoscopy with biopsy is generally considered the diagnostic reference standard, this combination can evaluates only the mucosa, not inflammation or fibrosis in the mucosa. Actually, the only modalities that can visualize submucosal tissues throughout the small bowel are the computed tomography (CT) enterography (CTE) with the magnetic resonance enterography (MRE). CT generally is highly utilized, but there is growing concern over ionizing radiation and cancer risk; it is a very important aspect to keep in consideration in pediatric patients. In contrast to CTE, MRE does not subject patients to ionizing radiation and can be used to detect detailed morphologic information and functional data of bowel disease, to monitor the effects of medical therapy more accurately, to detect residual active disease even in patients showing apparent clinical resolution and to guide treatment more accurately. 展开更多
关键词 Magnetic resonance imaging IMAGING PEDIATRIC enterography Crohn’ s disease
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Study on the role of magnetic resonance enterography in valuating infliximab therapy in small bowel crohn's disease
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作者 Li-Wei Dong Xiao-Ning Sun +5 位作者 Xiao-Zhao Zhuang Fei Wang Yi-Yao Chen Zhou-TaoHe Xiang-Yang Han Cheng Lan 《Journal of Hainan Medical University》 2019年第12期16-19,共4页
Objective:To investigate the role of magnetic resonance enterography (MRE) in valuating infliximab's (IFX)curative effect in active small bowel Crohn's Disease (CD).Methods:27 patients diagnosed as active CD w... Objective:To investigate the role of magnetic resonance enterography (MRE) in valuating infliximab's (IFX)curative effect in active small bowel Crohn's Disease (CD).Methods:27 patients diagnosed as active CD were treated with IFX. Before and after the treatment, the patients were scanned with 3.0 T MRE after small intestinal preparation. The imaging characteristic was analyzed and the relevance analysis between the imaging performance and the clinical score were investigated.Results: (1) Before IFX treatment, MRE could clearly detect the intestinal wall and extra luminal lesion in active CD, including intestinal wall multiple segmental thickening and abnormal enhancement, irregular signaling, comb sign, and intestinal stricture or dilation;(2) After IFX treatment, MRE show that intestinal wall thinning and the dilated bowel lumen were improved, and the comb sign disappeared;(3) During artery phase, the signal of the intestinal lesion was improved from high signal or equal signal before the IFX treatment to equal signal or low signal after treatment (P<0.05). During vein phase, there was no significant change of lesion signal before and after treatment (P>0.05).4. the changes of imaging performance were consistant with that of the clinical score (P>0.05). Conclusions: MRE possesses clinical value in evaluating the IFX curative effect in active small bowel CD. 展开更多
关键词 Magnetic RESONANCE enterography Crhon's disease Small BOWEL INFLIXIMAB CURATIVE effect
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Identification of the distinguishing features of Crohn’s disease and ischemic colitis using computed tomographic enterography 被引量:2
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作者 Min Chen Erick M.Remer +2 位作者 Xiuli Liu Rocio Lopez Bo Shen 《Gastroenterology Report》 SCIE EI 2017年第3期219-225,I0002,共8页
Background and aims:The differential diagnosis between Crohn’s disease(CD)and ischemic colitis(ISC)is important as their clinical management is different.ISC can easily be misdiagnosed as CD,especially in elderly pop... Background and aims:The differential diagnosis between Crohn’s disease(CD)and ischemic colitis(ISC)is important as their clinical management is different.ISC can easily be misdiagnosed as CD,especially in elderly populations.The distinctive radiographic features of the two disease entities have not been investigated.The aim of this study is to assess the utility of computed tomographic enterography(CTE)in the differential diagnosis between CD and ISC.Methods:Patients with confirmed CD and ISC were identified through an electronic medical record search of the Cleveland Clinic Foundation.Patients who had undergone CTE,with or without concurrent colonoscopy and histopathological specimens,were included in this study.CTE images were blindly re-reviewed by an expert gastrointestinal radiologist.The sensitivities,specificities,accuracies and positive and negative predictive values for each of the CTE findings in differentiating CD from ISC were estimated.Kappa coefficients(j)were calculated tomeasure diagnosis agreement between CTE and the reference standard.Results:A total of 34 eligible patients were included in this study with 17 having CD and 17 having ISC.In differentiating CD from ISC,the presence ofmucosal hyperenhancement and absence of the“target sign”on CTE showed a sensitivity of 100% each for CD,while the two radiographic features yielded a low specificity of 35.3%and 76.5%,respectively.The presence of stricture had a lower sensitivity of 64.7% for the detection of CD but had a high specificity of 100%.In distinguishing CD fromISC,the accuracy of presence ofmucosal hyperenhancement,stricture and absence of target sign were 67.7%,82.4% and 88.2%,respectively.The combination of the presence ofmucosal hyperenhancement and the absence of the target sign achieved an accuracy of 100%for distinguishing CD from ISC.There was a good correlation between CTE and the reference standard for distinguishing CD fromISC(k=0.882).Conclusions:CTE appeared to be clinically useful in distinguishing CD from ISC. 展开更多
关键词 computed tomographic enterography Crohn’s disease ischemic colitis differential diagnosis
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Differentiating Crohn's disease from intestinal tuberculosis 被引量:25
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作者 Saurabh Kedia Prasenjit Das +5 位作者 Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja 《World Journal of Gastroenterology》 SCIE CAS 2019年第4期418-432,共15页
Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammato... Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. 展开更多
关键词 Crohn's disease INTESTINAL tuberculosis Endoscopy COMPUTED tomographic enterography GRANULOMA
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ERCP for patients who have undergone Billroth Ⅱ gastroenterostomy and Braun anastomosis 被引量:22
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作者 Wen-Guang Wu Jun Gu +5 位作者 Wen-Jie Zhang Ming-Ning Zhao Ming Zhuang Yi-Jing Tao Ying-Bin Liu Xue-Feng Wang 《World Journal of Gastroenterology》 SCIE CAS 2014年第2期607-610,共4页
Endoscopic retrograde cholangiopancreatography (ERCP) is efficacious in patients who have undergone Billroth II gastroenterostomies, but the success rate decreases in patients who also have experienced Braun anastomos... Endoscopic retrograde cholangiopancreatography (ERCP) is efficacious in patients who have undergone Billroth II gastroenterostomies, but the success rate decreases in patients who also have experienced Braun anastomoses. There are currently no reports describing the preferred enterography route for cannulation in these patients. We first review the patient&#x02019;s previous surgery records, which most often indicate that the efferent loop is at the greater curvature of the stomach. We recommend extending the duodenoscope along the greater curvature of the stomach and then advancing it through the &#x0201c;lower entrance&#x0201d; at the site of the gastrojejunal anastomosis, along the efferent loop, and through the &#x0201c;middle entrance&#x0201d; at the site of the Braun anastomosis to reach the papilla of Vater. Ten patients who had each undergone Billroth II gastroenterostomy and Braun anastomosis between January 2009 and December 2011 were included in our study. The overall success rate of enterography was 90% for the patients who had undergone Billroth II gastroenterostomy and Braun anastomosis, and the therapeutic success rate was 80%. We believe that this enterography route for ERCP is optimal for a patient who has had Billroth II gastroenterostomy and Braun anastomosis and helps to increase the success rate of the procedure. 展开更多
关键词 Optimal enterography route Endoscopic retrograde cholangiopancreatography Billroth II GASTROENTEROSTOMY Braun anastomosis
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Idiopathic mesenteric phlebosclerosis associated with long-term use of medical liquor:Two case reports and literature review 被引量:15
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作者 Fang Guo Yu-Fen Zhou +3 位作者 Fan Zhang Fei Yuan Yao-Zong Yuan Wei-Yan Yao 《World Journal of Gastroenterology》 SCIE CAS 2014年第18期5561-5566,共6页
A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the... A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the ileocolic vein and right colic vein,while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure.Based on the results of these tests,the patient was diagnosed with idiopathic mesenteric phlebosclerosis(IMP).She had a history of Chinese medical liquor intake for one and a half years and her symptoms subsided after conservative treatment.In 2013,a 63-year-old male patient who presented with recurrent lower right abdominal pain,bloating,melena and diarrhea for fifteen months was admitted to our institution.Colonoscopy and CTE led to the diagnosis of IMP.He also used Chinese medical liquor for approximately 12 years.The patient underwent total colectomy and the postoperative course was uneventful.We searched for previously published reports on similar cases and analyzed the clinical data of 50 cases identified in PubMed.As some of these patients admitted use of Chinese medicines,we hypothesize that Chinese medicines may play a role in the pathogenesis of IMP. 展开更多
关键词 Idiopathic mesenteric phlebosclerosis Chinese medical liquor ILEUS Colonoscopy Computed tomography enterography
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Potential model for differential diagnosis between Crohn's disease and primary intestinal lymphoma 被引量:8
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作者 Tian-Yu Zhang Yun Lin +7 位作者 Rong Fan Shu-Rong Hu Meng-Meng Cheng Mao-Chen Zhang Li-Wen Hong Xiao-Lin Zhou Zheng-Ting Wang Jie Zhong 《World Journal of Gastroenterology》 SCIE CAS 2016年第42期9411-9418,共8页
AIM To evaluate the usefulness of different parameters to differentiate Crohn's disease(CD) from primary intestinal lymphoma(PIL).METHODS The medical records of 85 patients with CD and 56 patients with PIL were re... AIM To evaluate the usefulness of different parameters to differentiate Crohn's disease(CD) from primary intestinal lymphoma(PIL).METHODS The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography(CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters. Diagnostic efficacy was analyzed, and a receiver operating characteristic(ROC) curve was plotted.RESULTS The demographic and clinical parameters that showed significant values for differentiating CD from PIL included age of onset, symptom duration, presence of diarrhea, abdominal mass, and perianal lesions(P < 0.05). Elevated lactate dehydrogenase and serum β2-microglobulin levels suggested a PIL diagnosis(P < 0.05). The endoscopic parameters that showed significant values for differentiating CD from PIL included multiple-site lesions, longitudinal ulcer, irregular ulcer,and intraluminal proliferative mass(P < 0.05). The CTE parameters that were useful in the identification of the two conditions included involvement of ≤ 3 segments, circular thickening of the bowel wall, wall thickness > 8 mm, aneurysmal dilation, stricture with proximal dilation, "comb sign", mass showing the "sandwich sign", and intussusceptions(P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the differentiation model were 91.8%, 96.4%, 93.6%, 97.5%, and 88.5%, respectively. The cutoff value was 0.5. The area under the ROC curve was 0.989.CONCLUSION The differentiation model that integrated the various parameters together may yield a high diagnostic efficacy in the differential diagnosis between CD and PIL. 展开更多
关键词 Primary intestinal lymphoma Crohn’s disease Differential diagnosis ENDOSCOPY CT enterography
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