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Semi-enclosed experimental system for coal spontaneous combustion for determining regional distribution of high-temperature zone of coal fire 被引量:3
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作者 Jingyu Zhao Hanqi Ming +5 位作者 Tao Guo Yuxuan Zhang Jun Deng Jiajia Song Qiang Zeng Chi‑Min Shu 《International Journal of Coal Science & Technology》 EI CAS CSCD 2022年第5期124-137,共14页
Temperature variation and gas generation at diferent depths and positions in the coal combustion process were studied to determine the propagation and evolution of high temperature regions in the process of coal spont... Temperature variation and gas generation at diferent depths and positions in the coal combustion process were studied to determine the propagation and evolution of high temperature regions in the process of coal spontaneous combustion.This study selected coal samples from Mengcun,Shaanxi Province,People’s Republic of China,and developed a semi-enclosed experimental system(furnace)for simulating coal combustion.The thermal mass loss of coal samples under various heating rates(5,10,and 15℃/min)was analyzed through thermogravimetric analysis,and the dynamic characteristics of the coal samples were analyzed;the reliability of the semi-enclosed experimental system was verifed through the equal proportional method of fuzzy response.The results reveal that the high-temperature zone is distributed nonlinearly from the middle to the front end of the furnace,and the temperatures of points in this zone decreased gradually as the layer depth increased.The apparent activation energy of the coal samples during combustion frst increased and then decreased as the conversion degree increased.Furthermore,the proportion of mass loss and the mass loss rate in the coal samples observed in the thermogravimetric experiment is consistent with that observed in the frst and second stages of the experiment conducted using the semi-enclosed system.The research fndings can provide a theoretical basis for the prevention and control of hightemperature zones in coal combustion. 展开更多
关键词 Coalfeld fre area Fuzzy migration path Semi-enclosed experimental system Thermogravimetric analysis Dynamic characteristics
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Study on the Gas Detonation Experimental System of Human Body Electrostatic Discharge
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作者 Xiu-jie Dong,Qiang Guo,Xu Chen,Jing-chang Zhang (School of Electronic and Information,Zhongyuan University of Technology China,Zhengzhou 450007) 《Journal of Measurement Science and Instrumentation》 CAS 2010年第S1期173-177,共5页
The modeling system of the gas detonation by the human body electrostatic discharge(ESD)in coal mine is developed successfully,and the body’s dynamic ESD model is established.To obtain a gas concentration causes by t... The modeling system of the gas detonation by the human body electrostatic discharge(ESD)in coal mine is developed successfully,and the body’s dynamic ESD model is established.To obtain a gas concentration causes by the explosions most easily in coal mine environment.The results provide an academic and experimental evidence for the safe electrostatic production and management in coal mine.The system adopts 77E58 as control core and the circuit optimized design,to take dual protection to the gas path and circuit of the system,systematic operation is safe and reliable.The experimental results show that the system can be carried out series of experiments of the human body ESD model detonating mixed gas,the measuring accuracy of gas concentration is 0.1%.And draws a conclusion that the gas concentration which causes the explosions most easily is 8.7%,but not the higher gas concentration is,the more explosive is. 展开更多
关键词 MICROCONTROLLER experimental system design hardware design software ESD model
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Large-scale Experimental System for Multiphase Fuel/Air Explosions
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作者 刘庆明 宫广东 +2 位作者 白春华 陈亚红 牛国涛 《Journal of Measurement Science and Instrumentation》 CAS 2011年第2期195-200,共6页
A large-scale experimental for multiphase combustion and explosion study was developed and manufactured. The explosion tank consists of a 2 m diameter, 3.5 m long tube and ellipsoidai dames on both ends. The volume of... A large-scale experimental for multiphase combustion and explosion study was developed and manufactured. The explosion tank consists of a 2 m diameter, 3.5 m long tube and ellipsoidai dames on both ends. The volume of the experimental tank is 10 ma. Pressure histories of the explosion pressure can be measured at different locations in the tank. High pressure glass windows of 200~300 mm were used to have access to the visualization of the explosion process. The explosion process of methane/air mixture and methane/coal dust/air mixture initiated by a 40 J electric spark at the center of the tank was studied in the large^scale experimental system. Five pressure sonsars were arranged in the tank with different distances from the ignition point. Ton dust dispersion traits were equipped to eject dust into the tank. A high-speed camera system was used to visualize the flame propagation during the explosion process. The characteristics of the pressure wave and flame propagated in methane/air mixtures and methane/coal dust/air mixtures have been 展开更多
关键词 a large-sale experimental system explosion COMBUSTION FLAME
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Vehicle Off-road Experimental System Development and Verification Based on the Labview
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作者 XU Xi-meng ZHAO Wei +1 位作者 SU Bin XU Wan-li 《International Journal of Plant Engineering and Management》 2012年第4期230-237,共8页
The problems in the vehicle off-road experiment, such as various kinds of expensive instruments and diffi- culty in matching the input and the output signals of the vehicle status which cause useless data acquired. On... The problems in the vehicle off-road experiment, such as various kinds of expensive instruments and diffi- culty in matching the input and the output signals of the vehicle status which cause useless data acquired. On the basis of considering the test functions and experimental cost, this paper has developed a vehicle off-road experimental system basing on the Labview. This system can complete various kinds of signal acquisition in one experimental sys- tem and automatically restore the data by types. This solves the problem of real time matching between the input and the output signals, making sure that the data won't be confused as the experimental increase, so as to level the ex- perimental efficiency and data accuracy. This system has been used to the experiment of some armored vehicles. The analysis of the data has verified the reliability of the system. 展开更多
关键词 experimental system data acquisition LABVIEW experimental verification
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Laboratory core flooding experimental systems for CO_2 geosequestration: An updated review over the past decade 被引量:3
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作者 Yankun Sun Qi Li +1 位作者 Duoxing Yang Xuehao Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2016年第1期113-126,共14页
Carbon dioxide(CO2) geosequestration in deep saline aquifers has been currently deemed as a preferable and practicable mitigation means for reducing anthropogenic greenhouse gases(GHGs) emissions to the atmosphere, as... Carbon dioxide(CO2) geosequestration in deep saline aquifers has been currently deemed as a preferable and practicable mitigation means for reducing anthropogenic greenhouse gases(GHGs) emissions to the atmosphere, as deep saline aquifers can offer the greatest potential from a capacity point of view. Hence,research on core-scale CO2/brine multiphase migration processes is of great significance for precisely estimating storage efficiency, ensuring storage security, and predicting the long-term effects of the sequestered CO2in subsurface saline aquifers. This review article initially presents a brief description of the essential aspects of CO2subsurface transport and geological trapping mechanisms, and then outlines the state-of-the-art laboratory core flooding experimental apparatus that has been adopted for simulating CO2injection and migration processes in the literature over the past decade. Finally, a summary of the characteristics, components and applications of publicly reported core flooding equipment as well as major research gaps and areas in need of further study are given in relevance to laboratory-scale core flooding experiments in CO2geosequestration under reservoir conditions. 展开更多
关键词 Carbon capture and storage(CCS) Geosequestration Trapping mechanism Core flooding Saline aquifer experimental apparatus
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An intelligent navigation experimental system based on multi-mode fusion
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作者 Rui HAN Zhiquan FENG +3 位作者 Jinglan TIAN Xue FAN Xiaohui YANG Qingbei GUO 《Virtual Reality & Intelligent Hardware》 2020年第4期345-353,共9页
At present,most experimental teaching systems lack guidance of an operator,and thus users often do not know what to do during an experiment.The user load is therefore increased,and the learning efficiency of the stude... At present,most experimental teaching systems lack guidance of an operator,and thus users often do not know what to do during an experiment.The user load is therefore increased,and the learning efficiency of the students is decreased.To solve the problem of insufficient system interactivity and guidance,an experimental navigation system based on multi-mode fusion is proposed in this paper.The system first obtains user information by sensing the hardware devices,intelligently perceives the user intention and progress of the experiment according to the information acquired,and finally carries out a multi-modal intelligent navigation process for users.As an innovative aspect of this study,an intelligent multi-mode navigation system is used to guide users in conducting experiments,thereby reducing the user load and enabling the users to effectively complete their experiments.The results prove that this system can guide users in completing their experiments,and can effectively reduce the user load during the interaction process and improve the efficiency. 展开更多
关键词 Navigation interaction Chemical experiment system Multi-mode fusion
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Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation
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作者 Darui Lin Xiuye Wang +1 位作者 Yimin Wang Guolai Yang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期326-342,共17页
A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevaryin... A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain nonlinearity.First,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the system.Second,the dynamical equation in the form of state space is established by designing the angular tracking error.Third,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of uncertainty.Finally,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is proposed.The feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental platform.This paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time. 展开更多
关键词 Adaptive robust servo control experimental validation Nonlinearity compensation system uncertainty Vertical electric stabilization system
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Unexpected Diversity in Ecosystem Nutrient Responses to Experimental Drought in Temperate Grasslands
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作者 Biying Qiu Niwu Te +8 位作者 Lin Song Yuan Shi Chuan Qiu Xiaoan Zuo Qiang Yu Jianqiang Qian Zhengwen Wang Honghui Wu Wentao Luo 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第4期831-841,共11页
The responses of ecosystem nitrogen (N) and phosphorus (P) to drought are an important component of globalchange studies. However, previous studies were more often based on site-specific experiments, introducing a sig... The responses of ecosystem nitrogen (N) and phosphorus (P) to drought are an important component of globalchange studies. However, previous studies were more often based on site-specific experiments, introducing a significantuncertainty to synthesis and site comparisons. We investigated the responses of vegetation and soil nutrientsto drought using a network experiment of temperate grasslands in Northern China. Drought treatment (66%reduction in growing season precipitation) was imposed by erecting rainout shelters, respectively, at the driest,intermediate, and wettest sites. We found that vegetation nutrient concentrations increased but soil nutrient concentrationsdecreased along the aridity gradient. Differential responses were observed under experimentaldrought among the three grassland sites. Specifically, the experimental drought did not change vegetation andsoil nutrient status at the driest site, while strongly reduced vegetation but increased soil nutrient concentrationsat the site with intermediate precipitation. On the contrary, experimental drought increased vegetation N concentrationsbut did not change vegetation P and soil nutrient concentrations at the wettest site. In general, the differentialeffects of drought on ecosystem nutrients were observed between manipulative and observationalexperiments as well as between sites. Our research findings suggest that conducting large-scale, consistent, andcontrolled network experiments is essential to accurately evaluate the effects of global climate change on terrestrialecosystem bio-geochemistry. 展开更多
关键词 Climate change drought experiment PRECIPITATION nutrient cycles
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Experimental models of high-risk bowel anastomosis in rats:A systematic review
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作者 Georgios Ntampakis Manousos-Georgios Pramateftakis +8 位作者 Elissavet Anestiadou Stefanos Bitsianis Orestis Ioannidis Chryssa Bekiari George Koliakos Maria Karakota Anastasia Tsakona Angeliki Cheva Stamatios Angelopoulos Fourth 《World Journal of Experimental Medicine》 2024年第2期114-131,共18页
BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of life.Experimental studies play an imp... BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of life.Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation.Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features.Despite the advances in experimental protocols and techniques,designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.AIM To review current state of the art for experimental protocols in high-risk anastomosis in rats.METHODS This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.To identify eligible studies,a comprehensive literature search was performed in the electronic databases PubMed(MEDLINE)and Scopus,covering the period from conception until 18 October 2023.RESULTS From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis.Methods of assessing anastomotic healing were extracted and were individually appraised.CONCLUSION Anastomotic healing studies have evolved over the last decades,but the findings are yet to be translated into human studies.There is a need for high-quality,well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions. 展开更多
关键词 High-risk anastomosis RATS experimental models BOWEL COLON Anastomotic leak Colon resection Inflammatory bowel disease Intra-abdominal sepsis Bursting pressure
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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis 被引量:4
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作者 Jong Mi Park Masoud Rahmati +2 位作者 Sang Chul Lee Jae Il Shin Yong Wook Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1584-1592,共9页
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ... Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols. 展开更多
关键词 ANIMAL animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation
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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study 被引量:2
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作者 Shuo Han Tao Wei +6 位作者 Sijia Wang Yanlong Zhu Xingtong Guo Liang He Xiongzhuang Li Qing Huang Daifen Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第3期427-442,共16页
Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs s... Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas sealing.To solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output voltage.This work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical studies.Finally,the challenges and future development of tubular SIS-SOFCs are also discussed.The findings of this work can help guide the direction and inspire innovation of future development in this field. 展开更多
关键词 solid oxide fuel cell SEGMENTED-IN-SERIES TUBULAR experimental study numerical study
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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis 被引量:1
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作者 Chunyun Liu Shangde Guo +5 位作者 Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期671-679,共9页
Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pat... Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple sclerosis.This study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune encephalomyelitis.We found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6.Crucially,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified macrophages.In addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced inflammation.These findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for multiple sclerosis. 展开更多
关键词 ANTI-INFLAMMATORY experimental autoimmune encephalomyelitis FASUDIL macrophage multiple sclerosis PRO-INFLAMMATORY Rho kinase
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Experimental investigation on coal pore-fracture variation and fractal characteristics synergistically affected by solvents for improving clean gas extraction 被引量:1
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作者 Feilin Han Sheng Xue +3 位作者 Chunshan Zheng Zhongwei Chen Guofu Li Bingyou Jiang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期413-425,共13页
Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal... Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal synergistically affected by solvents have not been fully understood.Ultrasonic testing,nuclear magnetic resonance analysis,liquid phase mass spectrometry was adopted to comprehensively analyze pore-fracture change characteristics of lean coal treated by combined solvent(NMP and CS_(2)).Meanwhile,quantitative characterization of above changing properties was conducted using geometric fractal theory.Relationship model between permeability,fractal dimension and porosity were established.Results indicate that the end face fractures of coal are well developed after CS2and combined solvent treatments,of which,end face box-counting fractal dimensions range from 1.1227 to 1.4767.Maximum decreases in ultrasonic longitudinal wave velocity of coal affected by NMP,CS_(2)and combined solvent are 2.700%,20.521%,22.454%,respectively.Solvent treatments could lead to increasing amount of both mesopores and macropores.Decrease ratio of fractal dimension Dsis 0.259%–2.159%,while permeability increases ratio of NMR ranges from 0.1904 to 6.4486.Meanwhile,combined solvent could dissolve coal polar and non-polar small molecules and expand flow space.Results could provide reference for solvent selection and parameter optimization of permeability-enhancement technology. 展开更多
关键词 Clean gas extraction Chemical solvent experimental investigation Fractal characteristics Pore fracture
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Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer 被引量:1
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作者 Guo-Qing Chen Yi Nan +6 位作者 Na Ning Shi-Cong Huang Yu-Ting Bai Zi-Ying Zhou Gu Qian Wei-Qiang Li Ling Yuan 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第9期3932-3954,共23页
BACKGROUND Cancer is one of the most serious threats to human health worldwide.Conventional treatments such as surgery and chemotherapy are associated with some drawbacks.In recent years,traditional Chinese medicine t... BACKGROUND Cancer is one of the most serious threats to human health worldwide.Conventional treatments such as surgery and chemotherapy are associated with some drawbacks.In recent years,traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians,and has become an indispensable part of the comprehensive treatment for gastric cancer.AIM To investigate the mechanism of Xiaojianzhong decoction(XJZ)in the treatment of gastric cancer(GC)by utilizing network pharmacology and experimental validation,so as to provide a theoretical basis for later experimental research.METHODS We analyzed the mechanism and targets of XJZ in the treatment of GC through network pharmacology and bioinformatics.Subsequently,we verified the impact of XJZ treatment on the proliferative ability of GC cells through CCK-8,apoptosis,cell cycle,and clone formation assays.Additionally,we performed Western blot analysis and real-time quantitative PCR to assess the protein and mRNA expression of the core proteins.RESULTS XJZ mainly regulates IL6,PTGS2,CCL2,MMP9,MMP2,HMOX1,and other target genes and pathways in cancer to treat GC.The inhibition of cell viability,the increase of apoptosis,the blockage of the cell cycle at the G0/G1 phase,and the inhibition of the ability of cell clone formation were observed in AGS and HGC-27 cells after XJZ treatment.In addition,XJZ induced a decrease in the mRNA expression of IL6,PTGS2,MMP9,MMP2,and CCL2,and an increase in the mRNA expression of HOMX1.XJZ significantly inhibited the expression of IL6,PTGS2,MMP9,MMP2,and CCL2 proteins and promoted the expression of the heme oxygenase-1 protein.CONCLUSION XJZ exerts therapeutic effects against GC through multiple components,multiple targets,and multiple pathways.Our findings provide a new idea and scientific basis for further research on the molecular mechanisms underlying the therapeutic effects of XJZ in the treatment of GC. 展开更多
关键词 Xiaojianzhong decoction Gastric cancer Network pharmacology Molecular mechanism In vitro experiment
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Packed Bed Thermocline Thermal Energy Storage for Medium-Temperature Concentrating Solar Systems: Numerical and Experimental Study
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作者 Nikolaos Stathopoulos Nikolaos Papadimitriou +1 位作者 Vassilis Belessiotis Elias Papanicolaou 《Journal of Power and Energy Engineering》 2023年第5期1-23,共23页
Thermal Energy Storage is becoming a necessary component of sustainable energy production systems as it helps alleviate intrinsic limitations of Renewable Energy Sources, such as intermittent use and mismatch between ... Thermal Energy Storage is becoming a necessary component of sustainable energy production systems as it helps alleviate intrinsic limitations of Renewable Energy Sources, such as intermittent use and mismatch between power demand and supply. This paper discusses a packed bed thermocline tank as a thermal energy storage solution. Firstly, this paper presents the development of a numerical model calculating heat transfers within the tank, based on a discretization over several nodes and the nodal formulation of the heat balance equation. The model considers a filler material and a heat transferring fluid and uses the finite difference method to calculate the temperature evolution of the two media across the tank. The model was validated with two different packed bed systems from the literature during a discharging process, presenting a good fit with the experimental results. Secondly, the experimental packed bed is presented and characterized for a charging cycle from ambient temperature to approximately 180?C. The charging experiment was accurately reproduced with the numerical model requiring minimal computational time. Two additional charging modes were simulated with different inlet HTF conditions: constant temperature and varying temperature following the profile produced by a thermal solar collector field. The temperature profiles obtained from the three charging modes were analysed and compared to each other. The proposed numerical and experimental tools will be used in future studies for a better understanding of the design and operating conditions of packed bed thermal energy storage systems. 展开更多
关键词 Thermal Energy Storage Packed Bed NUMERICAL Model experimental
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Experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering boundary effect
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作者 Xuwei Wang Yeshuang Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期1072-1084,共13页
The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundar... The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundary effect is conducted,where the hydraulic head difference(DH)varies,and the boundary includes non-loss and soil-loss conditions.Soil samples are filled into seven soil storerooms connected in turn.After evaluation,the variation in content of fine sand(ΔR_(f))and the hydraulic conductivity of soils in each storeroom(C_(i))are analyzed.In the non-loss test,the soil sample filling area is divided into runoff,transited,and accumulated areas according to the negative or positive ΔR_(f) values.ΔR_(f) increases from negative to positive along the seepage path,and Ci decreases from runoff area to transited area and then rebounds in accumulated area.In the soil-loss test,all soil sample filling areas belong to the runoff area,where the gentle-loss,strengthened-loss,and alleviated-loss parts are further divided.ΔR_(f) decreases from the gentle-loss part to the strengthened-loss part and then rebounds in the alleviated-loss part,and C_(i) increases and then decreases along the seepage path.The relationship between ΔR_(f) and Ci is different with the boundary condition.Ci exponentially decreases with ΔR_(f) in the non-loss test and increases with ΔR_(f) generally in the soil-loss test. 展开更多
关键词 Suffusion PERMEABILITY experimental investigation Boundary effect Horizontal seepage
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A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations
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作者 Alex E.Mohr David B.Pyne +2 位作者 Geovana Silva Fogaça Leite Deborah Akins Jamie Pugh 《Journal of Sport and Health Science》 SCIE CSCD 2024年第1期61-71,共11页
Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public alike.There has also been an increased research focus within t... Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public alike.There has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut microbiota.However,compared to other ergogenic aids and dietary supplements,probiotics present unique study challenges.The objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active individuals.Methods:Four databases(MEDLINE,CINAHL,Cochrane CENTRAL,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active individuals.An intervention with probiotics and inclusion of a control and/or placebo group were essential.Only peer-reviewed articles in English were considered,and there were no date restrictions.Results were extracted and presented in tabular form to detail study protocols,characteristics,and outcomes.Bias in randomized controlled trials was determined with the RoB 2.0 tool.Results:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over design.Approximately half the studies used a single probiotic and the other half a multi-strain preparation.The probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 days.Fewer than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut microbiota.The sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated females.Low-level adverse events were reported in only 2 studies,although the methodology of reporting varied widely.The risk of bias was generally low,although details on randomization were lacking in some studies.Conclusion:There is a substantial body of research on the effects of prob iotic supplementation in healthy athletes and physically active individuals.Considerable heterogeneity in probiotic selection and dosage as well as outcome measures has made clinical and mechanistic interpretation challenging for both health care practitioners and researchers.Attention to issues of randomization of participants,treatments and interventions,selection of outcomes,demographics,and reporting of adverse events will facilitate more trustworthy interpretation of probiotic study results and inform evidence-based guidelines. 展开更多
关键词 EXERCISE experimental methodology Gastrointestinal symptoms Gut microbiota Probiotic supplementation
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Experimental investigation of dynamic characteristics of leaching tubing for solution mining of salt cavern carbon and energy storage
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作者 Yin-Ping Li Xin-Bo Ge +1 位作者 Xi-Lin Shi Hong-Ling Ma 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2703-2722,共20页
Salt caverns are extensively utilized for storing various substances such as fossil energy,hydrogen,compressed air,nuclear waste,and industrial solid waste.In China,when the salt cavern is leached through single-well ... Salt caverns are extensively utilized for storing various substances such as fossil energy,hydrogen,compressed air,nuclear waste,and industrial solid waste.In China,when the salt cavern is leached through single-well water solution mining with oil as a cushion,engineering challenges arise with the leaching tubing,leading to issues like damage and instability.These problems significantly hinder the progress of cavern construction and the control of cavern shape.The primary cause of this is the flowinduced vibration instability of leaching tubing within a confined space,which results in severe bending or damage to the tubing.This study presents a model experimental investigation on the dynamic characteristics of leaching tubing using a self-developed liquid-solid coupling physical model experiment apparatus.The experiment utilizes a silicone-rubber pipe(SRP)and a polycarbonate pipe(PCP)to examine the effects of various factors on the dynamic stability of cantilevered pipes conveying fluid.These factors include external space constraint,flexural rigidity,medium outside the pipe,overhanging length,and end conditions.The experiments reveal four dynamic response phenomena:water hammer,static buckling,chaotic motion,and flutter instability.The study further demonstrates that the length of the external space constraint has a direct impact on the flutter critical flow velocity of the cantilevered pipe conveying fluid.Additionally,the flutter critical flow velocity is influenced by the end conditions and different external media. 展开更多
关键词 Salt cavern storage Solution mining Leaching tubing experimental investigation Flutter instability
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Analytical and Experimental Research on Wave Scattering by an Open-Type Rectangular Breakwater with Horizontal Perforated Plates
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作者 HE Shuyue LIU Yong LI Huajun 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第5期1185-1201,共17页
This study proposes a novel open-type rectangular breakwater combined with horizontal perforated plates on both sides to enhance the sheltering effect of the rectangular box-type breakwaters against longer waves.The h... This study proposes a novel open-type rectangular breakwater combined with horizontal perforated plates on both sides to enhance the sheltering effect of the rectangular box-type breakwaters against longer waves.The hydrodynamic characteristics of this breakwater are analyzed through analytical potential solutions and experimental tests.The quadratic pressure drop conditions are exerted on the horizontal perforated plates to facilitate assessing the effect of wave height on the dissipated wave energy of breakwater through the analytical solution.The hydrodynamic quantities of the breakwater,including the reflection,transmission,and energyloss coefficients,together with vertical and horizontal wave forces,are calculated using the velocity potential decomposition method as well as an iterative algorithm.Furthermore,the reflection and transmission coefficients of the breakwater are measured by conducting experimental tests at various wave periods,wave heights,and both porosities and widths of the horizontal perforated plates.The analytical predicted results demonstrate good agreement with the iterative boundary element method solution and measured data.The influences of variable incident waves and structure parameters on the hydrodynamic characteristics of the breakwater are investigated through further calculations based on analytical solutions.Results indicate that horizontal perforated plates placed on the water surface for both sides of the rectangular breakwater can enhance the wave dissipation ability of the breakwater while effectively decreasing the transmission and reflection coefficients. 展开更多
关键词 rectangular breakwater horizontal perforated plates analytical solution experimental test hydrodynamic characteristics
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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation
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作者 Benfeng Gu Haiyuan Li Baoming Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期254-261,共8页
To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dime... To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried out.Various test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of rail.Combining the simulation results and experimental data,the damage condition of the contact surface is analyzed. 展开更多
关键词 Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling experimental validation PFN
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