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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain
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作者 Xiaoyu Zhang Yuqi Liu +6 位作者 Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu 《Neural Regeneration Research》 SCIE CAS 2025年第9期2682-2696,共15页
Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ... Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this effect.In this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic analysis.The results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer pain.In addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain hypersensitivity.Furthermore,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 expression.Moreover,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was enhanced.Mechanistically,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ribonucleoprotein-F.Additionally,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 methylation.These findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain. 展开更多
关键词 dorsal root ganglion heterogeneous nuclear ribonucleoprotein f neuropathic pain protein arginine methyltransferase-6 sensory neurons
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I-Fuzzy拓扑空间中的可数性 被引量:3
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作者 李清华 方进明 《模糊系统与数学》 CSCD 北大核心 2005年第3期71-75,共5页
引入I-fuzzy拓扑空间中的I-fuzzy第一可数性,I-fuzzy第二可数性,I-fuzzy稠密性,I-fuzzy可分性,I-fuzzyLindelo¨f性等概念。界定了它们的本质性质,并讨论了它们之间的关系,还给出了第一可数I-fuzzy拓扑空间中的映射连续性的序列刻画。
关键词 I-fuzzy 拓扑空间 I—fuzzy第一可数性 I—fuzzy第二可数性 I—fuzzy稠密性 I—fuzzy可分性 I—fuzzy Lindelof
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基于FasterNet和YOLOv5改进的玻璃绝缘子自爆缺陷快速检测方法 被引量:4
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作者 邬开俊 徐泽浩 单宏全 《高电压技术》 EI CAS CSCD 北大核心 2024年第5期1865-1876,共12页
为了实现对电力输电线路中绝缘子缺陷实时快速的巡检需求,提出了一种结合FasterNet-tiny和YOLOv5-s-v6.1网络模型改进的缺陷快速检测算法FasterNet-YOLOv5。首先引入参数量小推理速度更快的FasterNet网络替换原先的CSPDarkNet53主干网络... 为了实现对电力输电线路中绝缘子缺陷实时快速的巡检需求,提出了一种结合FasterNet-tiny和YOLOv5-s-v6.1网络模型改进的缺陷快速检测算法FasterNet-YOLOv5。首先引入参数量小推理速度更快的FasterNet网络替换原先的CSPDarkNet53主干网络,加快网络的检测速度。然后结合由GhostNetv2网络提出的解耦全连接注意力机制(decoupled fully connected,DFC),在主干特征提取网络中设计了DFC-FasterNet模块,模块中的DFC Attention机制可以在特征提取过程中增大感受野,提升网络的检测精度。最后针对玻璃绝缘子自爆缺陷目标较小和背景较复杂的情况,重新设计Neck模块,提出BiFPN-F特征融合模块,使网络更精确地定位绝缘子缺陷区域。实验结果表明:改进后的算法可以快速精准定位,其均值平均精度(mean average precision,mAP)达到93.3%,相较于改进前提升5.67%,检测速度达到45.7 Hz,较改进前提升近1倍。同时与最新的YOLOv8n和YOLOv7-tiny相比,改进后的FasterNet-YOLOv5在自爆缺陷上的检测精度和速度更具优势,该文所提算法能够更快速地对绝缘子及其自爆缺陷实时定位识别。 展开更多
关键词 缺陷检测 BifPN-f fasterNet YOLOv5s DfC Attention PConv
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族F-遍历与F-混合 被引量:2
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作者 刘桂仙 杨润生 《南京师大学报(自然科学版)》 CAS CSCD 北大核心 2006年第3期14-19,共6页
本文给出族F-遍历,族F-强混合,族F-弱混合,族F-2混合,族F-一致混合和族F-Césaro一致混合的概念,研究了它们的性质、判定及相互关系,并且讨论了对于连续变换的不变测度的族F-遍历和族F-混合的刻划.
关键词 f-遍历 f-强混合 f-弱混合 f-2混合 f-一致混合 f-Césaro一致混合
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Fuzzy泛代数的理论框架 被引量:1
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作者 王家德 《纯粹数学与应用数学》 CSCD 1999年第3期1-7,共7页
通过一系列抽象概念的引入,建立了 Fuzzy 泛代数的理论框架,获得了若干有意义的结果.特别,本文可用来统一处理现行的有关各种具体的 Fuzzy 代数结构的孤立研究。
关键词 fΩ-代数 f-同余 f-缩商 f-理想 f-Birkhoff性质 f-根
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Facile identification of fluorosurfactant category in aqueous film-forming foam concentrates via optimized^(19)F NMR
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作者 Peiyao Chen Shuang Zhuang +5 位作者 Weiguang Chen Zhijian Chen Rongzhen Li Fangyu Chen Tingting Jiang Xiaobin Fu 《Magnetic Resonance Letters》 2024年第3期42-51,共10页
Aqueous film-forming foams(AFFFs)are the primary source of toxic perfluoroalkyl and polyfluoroalkyl substances(PFAS)in wastewater.Thus,it is urgent to develop a facile and fast method for identifying fluorosurfactants... Aqueous film-forming foams(AFFFs)are the primary source of toxic perfluoroalkyl and polyfluoroalkyl substances(PFAS)in wastewater.Thus,it is urgent to develop a facile and fast method for identifying fluorosurfactants in commercially available AFFFs.In this work,fluorine nuclear magnetic resonance(^(19)F NMR)spectroscopy was optimized to measure AFFFs directly with the extra addition of 5%D_(2)O as the locking reagent,and high-quality spectra could be acquired within 4 min(0.1%fluorosurfactant content).Recovery experiments demonstrated that the use of different AFFFs had no marked influence on the quantitative analysis of fluorosurfactants.Such method works with low-field NMR spectroscopy(1.4 T)as well.Two-dimensional(2D)^(19)F COSY NMR was used to make signal assignments for different fluorosurfactant derivatives.The optimized ^(19)F NMR could quantify the commercially available fluorosurfactants in different AFFFs,identify them being in either the perfluorooctane sulfonate(PFOS)or fluorotelomer sulfonic acid(FTS)categories,and distinguish the head-group of PFOS and FTS derivatives,which exhibits great potentials in the developments of relevant commercial detections. 展开更多
关键词 Aqueous film-forming foams fLUOROSURfACTANTS 19f NMR Perfluorooctane sulfonate
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Quintessence anisotropic stellar models in quadratic and Born-Infeld modified teleparallel Rastall gravity
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作者 Allah Ditta 夏铁成 +1 位作者 Irfan Mahmood Asif Mahmood 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期179-189,共11页
This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of gravity.To achieve this g... This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of gravity.To achieve this goal,the Krori and Barua arrangement for spherically symmetric components of the line element is incorporated.We explore the field equations by selecting appropriate off-diagonal tetrad fields.Born-Infeld function of torsion f(T)=β√λT+1-1 and power law form h(T)=δTn are used.The Born-Infeld gravity was the first modified teleparallel gravity to discuss inflation.We use the linear equation of state pr=ξρto separate the quintessence density.After obtaining the field equations,we investigate different physical parameters that demonstrate the stability and physical acceptability of the stellar models.We use observational data,such as the mass and radius of the compact star candidates PSRJ 1416-2230,Cen X-3,&4U 1820-30,to ensure the physical plausibility of our findings. 展开更多
关键词 anisotropic spheres quintessence field modified Rastall teleparallel gravity equation of state(EoS) f(T)gravity
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F-干扰规律生成与它的特征识别 被引量:6
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作者 邱锦明 夏佳荣 史开泉 《山东大学学报(理学版)》 CAS CSCD 北大核心 2007年第8期36-41,共6页
利用单向S-粗集概念给出了知识的f-干扰生成与f-干扰规律生成,单向S-粗集的F-干扰生成与F-干扰规律生成的概念.提出了F-干扰损失与F-干扰度关系定理,F-干扰损失规律与F-干扰度规律关系定理,F-干扰分辨定理,干扰规律分辨定理,给出了F-干... 利用单向S-粗集概念给出了知识的f-干扰生成与f-干扰规律生成,单向S-粗集的F-干扰生成与F-干扰规律生成的概念.提出了F-干扰损失与F-干扰度关系定理,F-干扰损失规律与F-干扰度规律关系定理,F-干扰分辨定理,干扰规律分辨定理,给出了F-干扰规律识别准则与应用. 展开更多
关键词 单向S-粗集 f-干扰 f-干扰规律 f-干扰分辨 f-干扰规律分辨 f-干扰规律识别
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基于FPGA+ARM的异构列车数据交互系统
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作者 陈晓崎 张丽艳 +1 位作者 刘洋 李常贤 《集成电路与嵌入式系统》 2024年第5期60-64,共5页
本文设计并实现了基于FPGA的主机与ARM端的数据通信接口。其中,FPGA实现了与主机交互的PCIe接口功能以及与ARM交互的FMC接口功能。本文完成了PCIe接口和FMC接口传输性能测试,同时也进行了主机与ARM的数据回环测试。测试结果表明,本文设... 本文设计并实现了基于FPGA的主机与ARM端的数据通信接口。其中,FPGA实现了与主机交互的PCIe接口功能以及与ARM交互的FMC接口功能。本文完成了PCIe接口和FMC接口传输性能测试,同时也进行了主机与ARM的数据回环测试。测试结果表明,本文设计满足了整体的系统设计指标要求,其中PCIe1.0接口速率可达820 MB/s。 展开更多
关键词 fPGA ARM PCIe接口 fMC接口 STM32f7
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Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α 被引量:2
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作者 KUO-SHYANG JENG PO-YU CHENG +5 位作者 YUEH-HSIEN LIN PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU 《Oncology Research》 SCIE 2024年第1期163-174,共12页
Hepatocellular carcinoma(HCC)is a leading cause of death worldwide.Current therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to chem... Hepatocellular carcinoma(HCC)is a leading cause of death worldwide.Current therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to chemotherapy.Therefore,new therapeutic targets are needed.We analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly different.The analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC patients.In vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell lines.Knockdown of AKR1C3 in Huh7 cells reduced tumor growth in vivo.To explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target genes.Suppression of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 cells.Knockdown of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC growth.We showed that indomethacin potentiated the sensitivity of Huh7 cells to sorafenib.In summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC growth.Therefore,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC. 展开更多
关键词 Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin f2 alpha Prostaglandin f receptor
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基于F-DFCC融合特征的语音情感识别方法 被引量:1
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作者 何朝霞 朱嵘涛 罗辉 《现代电子技术》 北大核心 2024年第6期131-136,共6页
结合神经网络、并行多特征向量和注意力机制,有助于提高语音情感识别的性能。基于此,从前期已经提取的DFCC参数入手,提取I-DFCC和Mid-DFCC特征参数,利用Fisher比选取特征参数构成F-DFCC;再将F-DFCC特征参数与LPCC、MFCC特征参数进行对... 结合神经网络、并行多特征向量和注意力机制,有助于提高语音情感识别的性能。基于此,从前期已经提取的DFCC参数入手,提取I-DFCC和Mid-DFCC特征参数,利用Fisher比选取特征参数构成F-DFCC;再将F-DFCC特征参数与LPCC、MFCC特征参数进行对比并融合,输入到含双向LSTM网络及注意力机制的ECAPA-TDNN模型中;最后,在CASIA和RAVDESS数据集上验证F-DFCC融合特征参数的有效性。实验结果表明:与单一的F-DFCC特征参数相比,F-DFCC融合特征的准确率WA、召回率UA、F1-score在CASIA数据集上分别提高0.035 1、0.031 1、0.031 3;在RAVDESS数据集上分别提高0.024 5、0.035 8、0.033 2。在两个数据集中,surprised情感的识别准确率最高,为0.94;F-DFCC融合特征参数的6种和8种情感识别率与其他特征参数相比均有所提升。 展开更多
关键词 语音情感识别 DfCC f-DfCC 融合特征 特征提取 fisher比 ECAPA-TDNN
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基于FGFR非对称二聚化模型的FGF19改构体的设计及活性评估
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作者 赵静 操宇 +1 位作者 周传仁 吴佳敏 《温州医科大学学报》 CAS 2024年第8期614-622,共9页
目的:探究以成纤维细胞生长因子受体(FGFR)非对称二聚化模型为结构基础设计成纤维细胞生长因子19(FGF19)的非促肿瘤型改构体,并对其增殖活性和代谢活性进行评估,使其成为治疗胆汁淤积症的候选药物之一。方法:利用pymol软件分析蛋白晶体... 目的:探究以成纤维细胞生长因子受体(FGFR)非对称二聚化模型为结构基础设计成纤维细胞生长因子19(FGF19)的非促肿瘤型改构体,并对其增殖活性和代谢活性进行评估,使其成为治疗胆汁淤积症的候选药物之一。方法:利用pymol软件分析蛋白晶体结构并设计FGF19改构体,将构建好的FGF19改构体(FGF19^(F159A))与FGF19野生型(FGF19^(WT))的质粒转化到大肠杆菌感受态细胞中,经过诱导表达、变性、复性获得正确构象的蛋白,经过镍柱亲和层析与分子排阻色谱方法纯化得到目的蛋白;通过蛋白邻位连接技术(PLA)对比FGF19^(WT)和FGF19^(F159A)诱导受体二聚化的程度;MTT实验检测细胞增殖活性;Western blot实验检测磷酸化成纤维细胞生长因子受体底物2(P-FRS2)、磷酸化细胞外调节蛋白激酶(P-ERK)、胆固醇7α-羟化酶(Cyp7A1)的蛋白表达水平;免疫组化法检测动物肝脏中促增殖指标Ki67和增殖细胞核抗原(PCNA)的蛋白表达水平;RT-qPCR法检测动物肝脏中肿瘤指标甲胎蛋白(AFP)、细胞周期蛋白A2(CCNA2)、表皮生长因子受体(EGFR)的相对mRNA水平;质谱法测定肝脏中胆酸(CA)、脱氧胆酸(DCA)、熊去氧胆酸(UDCA)、鹅去氧胆酸(CDCA)的含量;以db/db小鼠为模型,连续给药1个月,监测药物的慢性降糖效果,糖耐量实验检测其对糖耐量的改善能力。结果:以蛋白结构为基础成功构建了FGF19^(F159A),经过表达纯化得到了高纯度的目的蛋白;PLA结果显示,与FGF19^(WT)组相比,FGF19^(F159A)诱导受体二聚化的能力明显减弱(P<0.01);MTT实验显示,与FGF19^(WT)组相比,FGF19^(F159A)的促增殖活性明显减弱(P<0.05);Western blot实验表明,与FGF19^(WT)组相比,FGF19^(F159A)明显下调P-FRS2和P-ERK的蛋白表达水平(P<0.05);免疫组化结果显示,与FGF19^(WT)组相比,FGF19^(F159A)组Ki67和PCNA的蛋白表达水平显著降低(P<0.01);与FGF19^(WT)组相比,FGF19^(F159A)组AFP、CCNA2、EGFR的mRNA水平明显降低(P<0.01);与FGF19^(WT)组相比,FGF19^(F159A)组肝脏中Cyp7A1的蛋白表达水平,胆汁酸CA、DCA、UDCA、CDCA的含量差异无统计学意义(P>0.05);与FGF19^(WT)组相比,FGF19^(F159A)组的降糖能力和改善糖耐量的能力差异无统计学意义(P>0.05)。结论:基于FGFR非对称二聚化模型设计的FGF19改构体FGF19^(F159A)能够在极大减弱细胞增殖活性的同时保留其代谢活性,有望成为治疗胆汁淤积症的候选药物。 展开更多
关键词 fGf19^(f159A) fGf19^(WT) 非对称二聚化模型 胆汁酸 肿瘤活性
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加味升降散对急性胃黏膜损伤大鼠6-keto-PGF_(1α),TXB_2,TNF-α和EGF含量的影响 被引量:9
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作者 牛栋 侯菲 李士懋 《武警医学》 CAS 2005年第6期417-419,共3页
目的研究中药加味升降散对胃黏膜攻击因子、保护因子的调节作用。方法随机对照吲哚美辛所致胃黏膜急性损伤大鼠,对比加味升降散、丽珠得乐以及模型和空白组在血栓素B2(TXB2)、血小板活化因子(PAF)、6-酮-前列腺素F1α(6ketoPGF1α)、表... 目的研究中药加味升降散对胃黏膜攻击因子、保护因子的调节作用。方法随机对照吲哚美辛所致胃黏膜急性损伤大鼠,对比加味升降散、丽珠得乐以及模型和空白组在血栓素B2(TXB2)、血小板活化因子(PAF)、6-酮-前列腺素F1α(6ketoPGF1α)、表皮生长因子(EGF)的含量的差别。结果加味升降散能够降低实验性胃黏膜急性损伤大鼠血浆的TXB2,PAF含量,升高6ketoPGF1α,EGF的含量。结论加味升降散可通过削弱攻击因子和增强保护因子两个环节发挥细胞保护作用,从而保护胃黏膜免遭损伤。 展开更多
关键词 6-KETO-PGf 加味升降散 急性胃黏膜损伤 TNf 含量 血小板活化因子(PAf) 血栓素B2(TXB2) 6-酮-前列腺素f 表皮生长因子(EGf) 细胞保护作用 攻击因子 保护因子 急性损伤 调节作用 吲哚美辛 随机对照 丽珠得乐 大鼠血浆
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基于Flyback电源驱动功放拾音灯的设计与制作
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作者 何玲 孙志文 +2 位作者 许艳洪 洪祺韵 张淑雯 《电子制作》 2024年第16期94-99,共6页
本文设计并制作了一款基于Flyback电源驱动的功放拾音灯。该拾音灯采用了24V/2A反激式开关电源方案,其核心控制芯片为KP201CSGA,蓝牙功放模块则搭载了高性能TPA3116功放芯片。该模块配置了一系列丰富全面的功能按键,包括曲目前进/后退... 本文设计并制作了一款基于Flyback电源驱动的功放拾音灯。该拾音灯采用了24V/2A反激式开关电源方案,其核心控制芯片为KP201CSGA,蓝牙功放模块则搭载了高性能TPA3116功放芯片。该模块配置了一系列丰富全面的功能按键,包括曲目前进/后退、音量调节、模式切换以及播放/暂停等多元操控功能。在音频输入接口方面,本产品兼容多种格式源接入,还特别集成了前沿的拾音氛围灯电路,通过智能化感应音乐节奏与强度,实时变幻灯光效果。 展开更多
关键词 flyback开关电源 TPA3116-D类功放 AC6955蓝牙 STM32f103
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CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease
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作者 Xiang Chen Yuwan Lin +14 位作者 Zhiling Zhang Yuting Tang Panghai Ye Wei Dai Wenlong Zhang Hanqun Liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期196-204,共9页
Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucia... Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function. 展开更多
关键词 ATP synthase(f1f0-ATPase) coiled-coil helix coiled-coil helix domain containing 2 dopaminergic neuron mitochondrial dysfunction NEURODEGENERATION oligomycin sensitivity-conferring protein Parkinson's disease T61I mutation tyrosine hydroxylase
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Interface defect induced upgrade of K-storage properties in KFeSO4Fcathode: From lowered Fe-3d orbital energy level to advancedpotassium-ion batteries
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作者 Yan Liu Zhen-Yi Gu +7 位作者 Yong-Li Heng Jin-Zhi Guo Miao Du Hao-Jie Liang Jia-Lin Yang Kai-Yang Zhang Kai Li Xing-Long Wu 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第11期1724-1733,共10页
KFeSO_(4)F(KFSF)is considered a potential cathode due to the large capacity and low cost.However,the inferior electronic conductivity leads to poor electrochemical performance.Defect engineering can facilitate the ele... KFeSO_(4)F(KFSF)is considered a potential cathode due to the large capacity and low cost.However,the inferior electronic conductivity leads to poor electrochemical performance.Defect engineering can facilitate the electron/ion transfer by tuning electronic structure,thus providing favorable electrochemical performance.Herein,through the regulation of surface defect engineering in reduced graphene oxide(rGO),the Fe–C bonds were formed between KFSF and rGO.The Fe–C bonds formed work in regulating the Fe-3d orbital as well as promoting the migration ability of K ions and increasing the electronic conductivity of KFSF.Thus,the KFSF@rGO delivers a high capacity of 119.6 mAh g^(-1).When matched with a graphite@pitch-derived S-doped carbon anode,the full cell delivers an energy density of 250.5 Wh kg^(-1) and a capacity retention of 81.5%after 400 cycles.This work offers a simple and valid method to develop high-performance cathodes by tuning defect sites. 展开更多
关键词 Potassium-ion batteries CATHODE Defect chemistry KfeSO4f fe–C bond
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A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F
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作者 Jing Xue Linwei Zhang +11 位作者 Jingxian Tao Xuexue Xie Xi Wang Linlin Wu Shuhu Du Ninghua Tan Yang Jin Jianming Ju Junting Fan Jun Wang Fei Huan Rong Gao 《Journal of Biomedical Research》 CAS CSCD 2024年第5期451-463,共13页
As a potential endocrine-disrupting chemical,bisphenol F(BPF)may cause nonalcoholic fatty liver disease(NAFLD)-like changes,but the mechanisms under its pathogenesis as well as the intervention strategies remain uncle... As a potential endocrine-disrupting chemical,bisphenol F(BPF)may cause nonalcoholic fatty liver disease(NAFLD)-like changes,but the mechanisms under its pathogenesis as well as the intervention strategies remain unclear.Using the electron microscopy technology,along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays,we observed that BPF treatment elicited a striking accumulation of lipid droplets in HepG2 cells,accompanied by an increased total level of triglycerides.At the molecular level,the lipogenesis-associated mRNAs and proteins,including acetyl-CoA carboxylase,fatty acid synthase,stearoyl-CoA desaturase-1,peroxisome proliferator-activated receptor gamma,and CCAAT-enhancer-binding proteins,increased significantly via the AMP-activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)signaling regulation in both in vitro and in vivo studies.Furthermore,the immunofluorescence results also showed the robust lipogenesis induced by BPF,evident in its ability to promote the translocation of sterol regulatory element-binding protein-1c from the cytoplasm to the nuclei.To investigate the intervention strategies for BPF-induced NAFLD-like changes,we demonstrated that bellidifolin,isolated and purified from Swertia chirayita,significantly attenuated BPF-induced lipid droplet deposition in HepG2 cells and NAFLD-like changes in mice by blocking the expression of lipogenesis-associated proteins.Therefore,the present study elucidates the mechanisms underlying the BPF-induced lipid accumulation in HepG2 cells,while also highlighting the potential of bellidifolin to mitigate BPF-induced NAFLD-like changes. 展开更多
关键词 bisphenol f LIPOGENESIS non-alcoholic fatty liver disease bellidifolin
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Revealing Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles in oxygen/fluorine containing environments:A reactive molecular dynamics study meshing together experimental validation
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作者 Gang Li Chuande Zhao +2 位作者 Qian Yu Fang Yang Jie Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期313-327,共15页
Improving the energy conversion efficiency in metallic fuel(e.g.,Al)combustion is always desirable but challenging,which often involves redox reactions of aluminum(Al)with various mixed oxidizing environments.For inst... Improving the energy conversion efficiency in metallic fuel(e.g.,Al)combustion is always desirable but challenging,which often involves redox reactions of aluminum(Al)with various mixed oxidizing environments.For instance,Al-O reaction is the most common pathway to release limited energy while Al-F reaction has received much attentions to enhance Al combustion efficiency.However,microscopic understanding of the Al-O/Al-F reaction dynamics remains unsolved,which is fundamentally necessary to further improve Al combustion efficiency.In this work,for the first time,Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles(n-Al)in oxygen/fluorine containing environments have been revealed via reactive molecular dynamics(RMD)simulations meshing together combustion experiments.Three RMD simulation systems of Al core/O_(2)/HF,n-Al/O_(2)/HF,and n-Al/O_(2)/CF4 with oxygen percentage ranging from 0%to 100%have been performed.The n-Al combustion in mixed O_(2)/CF_4 environments have been conducted by constant volume combustion experiments.RMD results show that Al-O reaction exhibits kinetic benefits while Al-F reaction owns thermodynamic benefits for n-Al combustion.In n-Al/O_(2)/HF,Al-O reaction gives faster energy release rate than Al-F reaction(1.1 times).The optimal energy release efficiency can be achieved with suitable oxygen percentage of 10%and 50%for n-Al/O_(2)/HF and n-Al/O_(2)/CF_4,respectively.In combustion experiments,90%of oxygen percentage can optimally enhance the peak pressure,pressurization rate and combustion heat.Importantly,Al-O reaction prefers to occur on the surface regions while Al-F reaction prefers to proceed in the interior regions of n-Al,confirming the kinetic/thermodynamic benefits of Al-O/Al-F reactions.The synergistic effect of Al-O/Al-F reaction for greatly enhancing n-Al combustion efficiency is demonstrated at atomicscale,which is beneficial for optimizing the combustion performance of metallic fuel. 展开更多
关键词 Al-O/Al—f reaction Kinetic benefits Thermodynamic benefits Molecular dynamics COMBUSTION
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Investigating the Genetic Bases of Growth Regulation by E2F3 in Dwarf Surf Clams Mulinia lateralis
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作者 YAO Ruixing WANG Chen +3 位作者 KONG Lingling WANG Yujue BAO Zhenmin HU Xiaoli 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第5期1347-1358,共12页
Bivalve aquaculture plays a crucial role in the aquaculture industry due to the economic value of many bivalve species.Understanding the underlying genetic basis of bivalve growth regulation is essential for enhancing... Bivalve aquaculture plays a crucial role in the aquaculture industry due to the economic value of many bivalve species.Understanding the underlying genetic basis of bivalve growth regulation is essential for enhancing germplasm innovation and ensuring sustainable development of the industry.Though numerous candidate genes have been identified,their functional validation remains challenging.Fortunately,the dwarf surf clam(Mulinia lateralis)serves as a promising model organism for investigating genetic mechanisms underlying growth regulation in bivalves.The GWAS study in the Yesso scallop(Patinopecten yessoensis)has pinpointed the E2F3 gene as a key regulator of growth-related traits.However,the specific role of E2F3 in bivalve growth remains unclear.This study aimed to further confirm the regulatory function of the E2F3 gene in the dwarf surf clam through RNA interference experiments.Our results revealed several genes are associated with individual growth and development,including CTS7,HSP70B2,and PGLYRP3,as well as genes involved in lipid metabolism such as FABP2 and FASN.Functional enrichment analysis indicated that E2F3 primarily modulates critical processes like amino acid and lipid metabolism.These findings suggest that E2F3 likely regulates growth in the dwarf surf clam by influencing amino acid and lipid metabolism.Overall,this study advances our understanding on the function of E2F3 gene in growth regulation in bivalves,providing valuable insights for future research in this field. 展开更多
关键词 growth regulation E2f3 RNA interference experiment transcriptomic analysis dwarf surf clam Mulinia lateralis BIVALVE
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基于STM32F4的集中润滑系统的设计
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作者 李长有 刘福乾 崔玉卓 《机械工程师》 2024年第10期9-12,共4页
针对传统的机械润滑设备耗能高、劳动强度大、结构复杂、智能化程度较低等问题,文中以STM32F407为控制核心、ESP8266无线WiFi为无线通信模块、KQ330为电力载波模块,设计了一款基于STM32F4+emWin+μC/OSIII的集中润滑系统。对润滑系统供... 针对传统的机械润滑设备耗能高、劳动强度大、结构复杂、智能化程度较低等问题,文中以STM32F407为控制核心、ESP8266无线WiFi为无线通信模块、KQ330为电力载波模块,设计了一款基于STM32F4+emWin+μC/OSIII的集中润滑系统。对润滑系统供电电路、人机交互界面、无线通信电路、通信协议及手机APP等进行了设计。实验结果表明,该润滑系统具有移动端APP监控、润滑可靠、润滑精确、操控简单等优点,能够满足现代机械的润滑需求。 展开更多
关键词 集中润滑系统 电力载波 STM32f4 WIfI
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