Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment

Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells and/or biomaterials as major modulators of the spinal cord injury microenvironment.Here,we aimed to investigate the role of microenvironment modulation by cell graft on functional recovery after spinal cord injury.Induced neural stem cells reprogrammed from human peripheral blood mononuclear cells,and/or thrombin plus fibrinogen,were transplanted into the lesion site of an immunosuppressed rat spinal cord injury model.Basso,Beattie and Bresnahan score,electrophysiological function,and immunofluorescence/histological analyses showed that transplantation facilitates motor and electrophysiological function,reduces lesion volume,and promotes axonal neurofilament expression at the lesion core.Examination of the graft and niche components revealed that although the graft only survived for a relatively short period(up to 15 days),it still had a crucial impact on the microenvironment.Altogether,induced neural stem cells and human fibrin reduced the number of infiltrated immune cells,biased microglia towards a regenerative M2 phenotype,and changed the cytokine expression profile at the lesion site.Graft-induced changes of the microenvironment during the acute and subacute stages might have disrupted the inflammatory cascade chain reactions,which may have exerted a long-term impact on the functional recovery of spinal cord injury rats.

Application of principal component-radial basis function neural networks (PC-RBFNN) for the detection of water-adulterated bayberry juice by near-infrared spectroscopy

Near-infrared (NIR) spectroscopy combined with chemometrics techniques was used to classify the pure bayberry juice and the one adulterated with 10% (w/w) and 20% (w/w) water. Principal component analysis (PCA) was applied to reduce the dimensions of spectral data, give information regarding a potential capability of separation of objects, and provide principal component (PC) scores for radial basis function neural networks (RBFNN). RBFNN was used to detect bayberry juice adulterant. Multiplicative scatter correction (MSC) and standard normal variate (SNV) transformation were used to preprocess spectra. The results demonstrate that PC-RBFNN with optimum parameters can separate pure bayberry juice samples from water-adulterated bayberry at a recognition rate of 97.62%, but cannot clearly detect water levels in the adulterated bayberry juice. We conclude that NIR technology can be successfully applied to detect water-adulterated bayberry juice.

Artificial Neural Network Modeling for Predicting Thermal Conductivity of EG/Water-Based CNC Nanofluid for Engine Cooling Using Different Activation Functions

A vehicle engine cooling system is of utmost importance to ensure that the engine operates in a safe temperature range.In most radiators that are used to cool an engine,water serves as a cooling fluid.The performance of a radiator in terms of heat transmission is significantly influenced by the incorporation of nanoparticles into the cooling water.Concentration and uniformity of nanoparticle distribution are the two major factors for the practical use of nanofluids.The shape and size of nanoparticles also have a great impact on the performance of heat transfer.Many researchers are investigating the impact of nanoparticles on heat transfer.This study aims to develop an artificial neural network(ANN)model for predicting the thermal conductivity of an ethylene glycol(EG)/waterbased crystalline nanocellulose(CNC)nanofluid for cooling internal combustion engine.The implementation of an artificial neural network considering different activation functions in the hidden layer is made to find the bestmodel for the cooling of an engine using the nanofluid.Accuracies of the model with different activation functions in artificial neural networks are analyzed for different nanofluid concentrations and temperatures.In artificial neural networks,Levenberg–Marquardt is an optimization approach used with activation functions,including Tansig and Logsig functions in the training phase.The findings of each training,testing,and validation phase are presented to demonstrate the network that provides the highest level of accuracy.The best result was obtained with Tansig,which has a correlation of 0.99903 and an error of 3.7959×10^(–8).It has also been noticed that the Logsig function can also be a good model due to its correlation of 0.99890 and an error of 4.9218×10^(–8).Thus ourANNwith Tansig and Logsig functions demonstrates a high correlation between the actual output and the predicted output.

Fusion of Activation Functions: An Alternative to Improving Prediction Accuracy in Artificial Neural Networks

The purpose of this study was to address the challenges in predicting and classifying accuracy in modeling Container Dwell Time (CDT) using Artificial Neural Networks (ANN). This objective was driven by the suboptimal outcomes reported in previous studies and sought to apply an innovative approach to improve these results. To achieve this, the study applied the Fusion of Activation Functions (FAFs) to a substantial dataset. This dataset included 307,594 container records from the Port of Tema from 2014 to 2022, encompassing both import and transit containers. The RandomizedSearchCV algorithm from Python’s Scikit-learn library was utilized in the methodological approach to yield the optimal activation function for prediction accuracy. The results indicated that “ajaLT”, a fusion of the Logistic and Hyperbolic Tangent Activation Functions, provided the best prediction accuracy, reaching a high of 82%. Despite these encouraging findings, it’s crucial to recognize the study’s limitations. While Fusion of Activation Functions is a promising method, further evaluation is necessary across different container types and port operations to ascertain the broader applicability and generalizability of these findings. The original value of this study lies in its innovative application of FAFs to CDT. Unlike previous studies, this research evaluates the method based on prediction accuracy rather than training time. It opens new avenues for machine learning engineers and researchers in applying FAFs to enhance prediction accuracy in CDT modeling, contributing to a previously underexplored area.

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

Neural function rebuilding on different bodies using microelectronic neural bridge technique

A microelectronic circuit is used to regenerate the neural signals between the proximal end and the distal end of an injured nerve.An experimental scheme is designed and carried out to verify the feasibility of the so-called microelectronic neural bridge（MNB）.The sciatic signals of the source spinal toad which are evoked by chemical stimuli are used as source signals to stimulate the sciatic of the controlled spinal toad.The sciatic nerve signals of the source spinal toad,the regenerated sciatic signals in the controlled spinal toad,and the resulting electromyography（EMG）signals associated with the gastrocnemius muscle movements of the controlled spinal toad are displayed and recorded by an oscilloscope.By analyzing the coherence between the source sciatic nerve signals and the regenerated sciatic nerve signals and the coherence between the regenerated nerve signals and the EMG signals,it is proved that the regenerated sciatic nerve signals have a relationship with the source sciatic nerve signals and control shrinkage of the leg of the controlled toad.

INTERNET TRAFFIC DATA FLOW FORECAST BY RBF NEURAL NETWORK BASED ON PHASE SPACE RECONSTRUCTION

Characteristics of the Internet traffic data flow are studied based on the chaos theory. A phase space that is isometric with the network dynamic system is reconstructed by using the single variable time series of a network flow. Some parameters, such as the correlative dimension and the Lyapunov exponent are calculated, and the chaos characteristic is proved to exist in Internet traffic data flows. A neural network model is construct- ed based on radial basis function （RBF） to forecast actual Internet traffic data flow. Simulation results show that, compared with other forecasts of the forward-feedback neural network, the forecast of the RBF neural network based on the chaos theory has faster learning capacity and higher forecasting accuracy.

RBF neural network regression model based on fuzzy observations

A fuzzy observations-based radial basis function neural network （FORBFNN） is presented for modeling nonlinear systems in which the observations of response are imprecise but can be represented as fuzzy membership functions. In the FORBFNN model, the weight coefficients of nodes in the hidden layer are identified by using the fuzzy expectation-maximization （ EM ） algorithm, whereas the optimal number of these nodes as well as the centers and widths of radial basis functions are automatically constructed by using a data-driven method. Namely, the method starts with an initial node, and then a new node is added in a hidden layer according to some rules. This procedure is not terminated until the model meets the preset requirements. The method considers both the accuracy and complexity of the model. Numerical simulation results show that the modeling method is effective, and the established model has high prediction accuracy.

基于RBF神经网络的光伏并网系统自适应等效建模方法

针对广义负荷建模中的光伏并网系统模型难以适应不同逆变器控制和频率扰动的动态响应问题,提出了一种基于径向基函数(radialbasisfunction,RBF)神经网络的光伏并网系统自适应等效建模方法。首先,建立了光伏并网逆变器不同控制策略响应波形的检测判据。然后,构建了以电压-频率扰动为输入,有功功率和无功功率为输出的光伏并网系统RBF神经网络模型。最后,在Matlab/Simulink中搭建了光伏并网系统模型,并将其接入IEEE14节点配电网进行仿真验证。结果表明,构建的光伏并网自适应等效模型能够有效辨识电压频率给定控制、有功无功给定控制、下垂控制策略类型,能够准确反映光伏并网系统在不同电压、频率扰动下的有功功率、无功功率的动态响应特性。

Model Identification of Water Purification Systems Using RBF Neural Network

Aim The RFB (radial hats function) netal network was studied for the model indentificaiton of an ozonation/BAC system. Methods The optimal ozone's dosage and the remain time in carbon tower were analyzed to build the neural network model by which the expected outflow CODM can be acquired under the inflow CODM condition. Results The improved self-organized learning algorithm can assign the centers into appropriate places , and the RBF network's outputs at the sample points fit the experimental data very well. Conclusion The model of ozonation /BAC system based on the RBF network am describe the relationshipamong various factors correctly, a new prouding approach tO the wate purification process is provided.

基于RBF网络的新疆特重雪灾区最大积雪深度预测研究

基于建立的雪灾灾损指数,确定新疆特重雪灾区域;进一步聚焦特重雪灾区的8个县(市),包括阿勒泰市、福海县、青河县、塔城市、托里县、沙湾市、尼勒克县和伊宁县,分别建立县域RBF网络模型,预测2021—2050年年最大积雪深度。结果表明:该模型可用于新疆特重雪灾区最大积雪深度预测,但预测精度仍有待提升;塔城市、尼勒克县将于2025—2029年连续出现最大积雪深度偏高事件,2039年青河县将出现最大积雪深度的极大值,因此应关注可能发生雪灾的年份与县(市),积极做好雪灾的防御工作。

基于GA的RBF神经网络气液两相流持液率预测模型优化

为了提高气液两相流持液率预测精度,针对传统径向基函数(RBF)神经网络预测气液两相流持液率网络拓扑结构困难和收敛速度慢等问题,提出一种基于遗传算法(GA)优化径向基函数神经网络的气液两相流持液率预测模型。通过系统聚类算法和灰色关联度分析(GRA)对收集的实验数据进行处理,优选出最优模型特征,同时结合遗传算法确定了RBF神经网络结构参数。基于室内实验数据进行训练,并与常用于持液率预测的反向传播(BP)神经网络、GA-BP神经网络及RBF神经网络进行对比,评估了模型的准确性及可行性。结果表明:GA-RBF神经网络模型均方误差为0.0017,均方根误差为0.0416,平均绝对误差为0.0281,拟合度为0.9483。相较于其他神经网络模型,该预测模型表现出更高的计算精度和更强的泛化能力。

智能汽车轨迹跟踪MPC-RBF-SMC协同控制策略研究

针对自动驾驶车辆行驶过程中模型失配以及外部环境干扰导致车辆轨迹跟踪环节精确性不高的问题,提出了一种结合车辆运动学模型预测控制(MPC)、径向基(RBF)神经网络和滑模控制(SMC)的轨迹跟踪控制策略。通过建立车辆运动学MPC模型计算当前状态车辆期望横摆角速度,并将其与实际横摆角速度的偏差输入RBF-SMC控制器,利用RBF快速逼近非线性模型的特点,结合滑模控制输出前轮转角,实现车辆的横向轨迹跟踪控制。仿真结果表明,与传统的控制器相比,该方法轨迹跟踪精度显著提高,并在不同行驶工况下表现出较好的鲁棒性。

Calibration Method Based on RBF Neural Networks for Soil Moisture Content Sensor

Temporal and spatial variation of soil moisture content is significant for crop growth,climate change and the other fields.In order to overcome shortage of non-linear output voltage of TDR3 soil moisture content sensor and increase soil moisture content data collection and computational efficiency,this paper presents a RBF neural network calibration method of soil moisture content based on TDR3 soil moisture sensor and wireless sensor networks.Experiment results show that the calibration method is effective...

基于MI-PSO-RBF神经网络的铁路客货运量预测研究

准确地预测铁路客货运量对合理配置运输资源、提高铁路客货运组织工作效率有重要作用。为提高铁路客货运量的预测精度,提出一种基于MI-PSO-RBF神经网络的客货运量组合预测模型。本研究对铁路客货运量的影响因素及其内在关联进行分析,选取相关指标,利用互信息素法对指标进行筛选,构建影响因素指标体系。基于该指标体系,运用粒子群算法优化的RBF神经网络模型分别对铁路客货运量进行预测,并与传统的BP神经网络、RBF神经网络预测模型进行比较。结果显示,经过参数调整优化后的MI-PSO-RBF神经网络在铁路客运量及货运量的预测精度方面表现最佳,测试集R2分别达到了0.9481与0.9911,具有较高的精度及泛化能力,表明该组合预测模型能够进一步提升神经网络模型预测铁路客货运量精确度。

基于自适应RBF神经网络具有模型不确定性的四旋翼无人机指定时间预设性能控制方法

四旋翼无人机具有强耦合和欠驱动的特点,在飞行过程中很容易受到外界干扰,进而影响整个无人机系统的稳定性和精度。为此,提出了一种基于RBF神经网络的指定时间预设性能约束控制策略。首先,针对四旋翼无人机的不确定数学模型难以精确建立,并且在执行任务过程中存在外部未知扰动问题,提出了一种基于指定时间预设性能控制方法,将四旋翼无人机的轨迹跟踪问题转换为对位置子系统和姿态子系统的期望指令跟踪问题;其次,在设计控制器过程中,为了解决“微分爆炸”问题产生的滤波器误差,引入一种新型滤波误差补偿方法,通过RBF神经网络逼近外部未知扰动,并将预测结果补偿给控制器以提高轨迹跟踪的鲁棒性。最后,应用仿真模拟方法验证无人机控制系统稳定性和性能优势,通过飞行试验验证,微风聚拢环境下实际飞行轨迹与仿真模拟结果趋于一致,自主轨迹跟踪起降位置偏差小于1 cm,证明了所提出算法的有效性。

基于IPSO-RBF神经网络的西北内陆河流域突发水污染风险评估

突发水污染事故会破坏环境、危害健康,开展西北内陆河流域突发水污染风险评估对于维护西部脆弱生态安全尤为重要。该文针对西北内陆河流域突发水污染问题,利用PSR模型遴选18个因素建立突发水污染风险评价指标体系,基于径向基神经网络模型(RBF)构建突发水污染风险评价模型。为进一步保证模型精度,采用改进惯性权重因子和学习因子的粒子群算法(IPSO)对神经网络模型参数进行优化,建立IPSO-RBF神经网络西北内陆河突发水污染风险评价模型,并运用该模型对石羊河流域武威段2017-2022年突发水污染进行风险等级评价。结果显示,石羊河流域武威段突发水污染2017-2019年风险等级为Ⅱ级,2020-2022年风险等级为Ⅲ级,结果与熵权-TOPSIS法一致,与流域治理情况相符。该研究成果有利于提升石羊河流域突发水污染的防控水平与应急处置能力,对于西北内陆河流域水资源管理以及祁连山生态保护具有重要意义。

Target maneuver trajectory prediction based on RBF neural network optimized by hybrid algorithm

Target maneuver trajectory prediction plays an important role in air combat situation awareness and threat assessment.To solve the problem of low prediction accuracy of the traditional prediction method and model,a target maneuver trajectory prediction model based on phase space reconstruction-radial basis function(PSR-RBF)neural network is established by combining the characteristics of trajectory with time continuity.In order to further improve the prediction performance of the model,the rival penalized competitive learning(RPCL)algorithm is introduced to determine the structure of RBF,the Levenberg-Marquardt(LM)and the hybrid algorithm of the improved particle swarm optimization(IPSO)algorithm and the k-means are introduced to optimize the parameter of RBF,and a PSR-RBF neural network is constructed.An independent method of 3D coordinates of the target maneuver trajectory is proposed,and the target manuver trajectory sample data is constructed by using the training data selected in the air combat maneuver instrument(ACMI),and the maneuver trajectory prediction model based on the PSR-RBF neural network is established.In order to verify the precision and real-time performance of the trajectory prediction model,the simulation experiment of target maneuver trajectory is performed.The results show that the prediction performance of the independent method is better,and the accuracy of the PSR-RBF prediction model proposed is better.The prediction confirms the effectiveness and applicability of the proposed method and model.

Global approximation based adaptive RBF neural network control for supercavitating vehicles

A global approximation based adaptive radial basis function（RBF） neural network control strategy is proposed for the trajectory tracking control of supercavitating vehicles（SV）.A nominal model is built firstly with the unknown disturbance.Next, the control scheme is established consisting of a computed torque controller（CTC） for the practical vehicle and an RBF neural network controller to estimate model error between the practical vehicle and the nominal model. The network weights are adapted by employing a Lyapunov-based design. Then it is shown by the Lyapunov theory that the trajectory tracking errors asymptotically converge to a small neighborhood of zero. The control performance of the proposed controller is illustrated by simulation.