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Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury 被引量:6
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作者 Donia Tabka Mohamed Bejaoui +3 位作者 James Javellaud Joan Roselló-Catafau Jean-Michel Achard Hassen Ben Abdennebi 《World Journal of Gastroenterology》 SCIE CAS 2015年第14期4159-4168,共10页
AIM: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).METHODS: Two experimental models were used.In the fir... AIM: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).METHODS: Two experimental models were used.In the first one, acetylcholine-induced endotheliumdependent relaxation(EDR) was measured in isolated ring preparations of rat hepatic arteries preserved or not in IGL-1 or Celsior solutions(24 h at 4 ℃).To determine nitric oxide(NO) and cyclooxygenase EDR, hepatic arteries were incubated with L-NG-nitroarginine methyl ester(L-NAME), an inhibitor of endothelium nitric oxide synthase(e NOS), or with L-NAME plus indomethacin, an inhibitor of cyclooxygenase.In the second experiment, rat livers were cold-stored in IGL-1 or Celsior solutions for 24 h at 4 ℃ and then perfused "ex vivo " for 2 h at 37 ℃.Liver injury was assessed by transaminase measurements, liver function by bile production and bromosulfophthalein clearance, oxidative stress by malondialdehyde levels and catalase activity and alterations in cell signaling pathways by pA kt, pA MPK, eN OS and MAPKs proteins level.RESULTS: After cold storage for 24 h with either Celsior or IGL-1, EDR was only slightly altered.Infreshly isolated arteries, EDR was exclusively mediated by NO.However, cold-stored arteries showed NOand COX-dependent relaxation.The decrease in NO-dependent relaxation after cold storage was significantly more marked with Celsior.The second study indicated that IGL-1 solution obtained better liver preservation and protection against IRI than Celsior.Liver injury was reduced, function was improved and there was less oxidative stress.IGL-1 solution activated Akt and AMPK, which was concomitant with increased eN OS expression and nitrite/nitrate levels.Furthermore, MAPKs kinases were regulated in livers preserved with IGL-1 solution since reductions in p-p38, p-ERK and p-JNK protein levels were observed.CONCLUSION: IGL-1 solution preserved NO-dependent relaxation better than Celsior storage solution and enhanced liver graft preservation. 展开更多
关键词 ORGAN PRESERVATION SOLUTIONS Institut georges Lope
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Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal 被引量:3
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作者 Mohamed Amine Zaouali Arnau Panisello-Roselló +6 位作者 Alexandre Lopez Carlos Castro Benítez Emma Folch-Puy Agustín García-Gil Teresa Carbonell RenéAdam Joan Roselló-Catafau 《World Journal of Gastroenterology》 SCIE CAS 2017年第23期4211-4221,共11页
To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions.METHODSFatty liver grafts from male obese Z... To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions.METHODSFatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to “ex vivo” normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system (UPS: measured as chymotryptic-like activity and 20S and 19S proteasome), the prevention of liver injury (transaminases), mitochondrial injury (confocal microscopy) and inflammation markers (TNF 1 alpha, high mobility group box-1 (HGMB-1) and PPAR gamma), and liver apoptosis (TUNEL assay, cytochrome c and caspase 3).RESULTSProfiles of free AA (alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW (P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity (measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury (AST/ALT) and mitochondrial damage (revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers (TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels.CONCLUSIONOur comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis. 展开更多
关键词 Liver proteolysis Proteasome activation Fatty liver preservation Institut georges Lopez-1 University of Wisconsin High mobility group box 1 Cold ischemia reperfusion injury
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Georges Braque-Father of Cubism’s First Exhibition in China
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作者 Xin Yuan 《China & The World Cultural Exchange》 2012年第11期20-22,共3页
正When it comes to Cubism, one thinks of Picasso. But he was not the only founding father of Cubism. Georges Braque was the other equally important one. Georges Braque (1882-1963) was a French artist, one of the great... 正When it comes to Cubism, one thinks of Picasso. But he was not the only founding father of Cubism. Georges Braque was the other equally important one. Georges Braque (1882-1963) was a French artist, one of the greatest in the 20th century. Perhaps for the Chinese, he is far less famous than Picasso, but his art style has a great influence on the successors. 展开更多
关键词 In georges Braque-Father of Cubism’s First Exhibition in China
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外滩三号Jean Georges——奢华彰显贵族气质
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作者 海山 《烹调知识》 2010年第3X期26-27,共2页
上海的历史虽然只有短短的百年,却是充满辉煌和传奇的百年。外滩优雅华贵的气质有着东西方美感交融的跨世纪魅力,代言着上海百年的辉煌和当下的繁荣。这个被当做上海滩形象的标志性地域,自然成为进驻上海的米其林厨师们首选之地。虽然... 上海的历史虽然只有短短的百年,却是充满辉煌和传奇的百年。外滩优雅华贵的气质有着东西方美感交融的跨世纪魅力,代言着上海百年的辉煌和当下的繁荣。这个被当做上海滩形象的标志性地域,自然成为进驻上海的米其林厨师们首选之地。虽然是中国接受外来文化的先行者,但上海骨子里却有着一丝挥之不去的排外,所以来到上海的米其林厨师们在自己的餐厅中,无不极力在细节上表达着对上海文化的敬意,生怕在浪奔浪流的上海滩被滚滚东逝的波涛冲刷掉。 展开更多
关键词 贵族气质 Jean georges 上海文化 伏特加酒 吐司 棕褐 鹅肝酱 酒红色 桃木 香草冰淇淋
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A Set of Acupuncture Needles in the Late Qing Dynasty Collected by George Souliéde Morant
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作者 WANG Han PANG Yichao +1 位作者 ZENG Ruilin WU Kai 《Chinese Medicine and Culture》 2024年第3期233-240,共8页
In the early 20th century,French vice-consul George Souliéde Morant encountered acupuncture during his visit to China,and then brought it back to France.After more than a century,his collection was transported fr... In the early 20th century,French vice-consul George Souliéde Morant encountered acupuncture during his visit to China,and then brought it back to France.After more than a century,his collection was transported from Paris,France to Kunming,China,and later recognized as a Chinese national third-class precious cultural heritage.Currently housed in the Museum of Western Studies on Chinese Medicine at Yunnan University of Chinese Medicine,this set of instruments includes one needle holder converted from a fan-shaped holder,ten acupuncture needles,and eleven paper tags handwritten in English with names of diseases and body parts.This article attempts to present the foundational information and historical significance of this collection of this set of late Qing dynasty acupuncture instruments by reviewing the collection and related research on acupuncture instruments,consulting acupuncture professionals,measuring the detailed information of the set of instruments,and employing a method of translating and summarizing the content of the attached tags. 展开更多
关键词 George Souliéde Morant Qing dynasty Acupuncture needles Traditional Chinese medicine FRANCE Tags
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英国茶文化对维多利亚时代英国艺术的影响——以乔治·邓禄普·莱斯利的作品为例 被引量:1
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作者 王琳 刘涵 王心璐 《福建茶叶》 2023年第6期170-172,共3页
茶叶从17世纪开始由中国流入英国,维多利亚时代(1837年至1901年)英国工业革命进行的如火如荼,英国的经济文化也进入了全盛时期。文化的相互影响,在英国,茶元素作为维多利亚时代人们饮食文化中的重要一部分出现在了作家的小说和绘画艺术... 茶叶从17世纪开始由中国流入英国,维多利亚时代(1837年至1901年)英国工业革命进行的如火如荼,英国的经济文化也进入了全盛时期。文化的相互影响,在英国,茶元素作为维多利亚时代人们饮食文化中的重要一部分出现在了作家的小说和绘画艺术作品中。本文从英国维多利亚时代文学作品以及绘画作品中出现的茶元素,进一步论证英国茶文化对维多利亚时代艺术的影响。通过深刻剖析乔治·邓禄普·莱斯利的美术作品,总结其作品中茶元素的种类和表现手法。在文化自信的背景下,我们应当继续关注茶文化在艺术领域的体现,为后世艺术家和文化研究者提供丰富的启示。 展开更多
关键词 英国茶文化 维多利亚时代 乔治·邓禄普·莱斯利(George Dunlop Leslie)
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吸入布地奈德福莫特罗干粉剂对慢性阻塞性肺疾病患者的疗效分析 被引量:3
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作者 郑明星 方智野 +2 位作者 袁丽芬 张敏 王健 《临床和实验医学杂志》 2008年第3期21-23,共3页
目的观察吸入布地奈德/福莫特罗干粉剂对稳定期、Ⅲ-Ⅳ级的慢性阻塞性肺疾病(COPD)患者的临床疗效。方法将明确诊断的78例COPD病人随机分为治疗组(42例)和对照组(36例),两组病人的基础治疗相同。在此基础上,治疗组给予吸入布... 目的观察吸入布地奈德/福莫特罗干粉剂对稳定期、Ⅲ-Ⅳ级的慢性阻塞性肺疾病(COPD)患者的临床疗效。方法将明确诊断的78例COPD病人随机分为治疗组(42例)和对照组(36例),两组病人的基础治疗相同。在此基础上,治疗组给予吸入布地奈德/福莫特罗干粉剂(160/4.5μg),每次1吸,每日2次;对照组给予茶碱缓释片0.2g口服,每日2次;疗程为6个月。观察前后进行肺功能指标测定和圣一齐治呼吸问卷(SGRQ)生活质量评分比较。结果在观察前,治疗组和对照组的一秒钟用力呼气容积(FEV1)/用力肺活量(FVC)和FEV1/预计值的差异无统计学意义(P〉0.05)。在观察结束时,治疗组FEV1/FVC和FEV1/预汁值较观察前均有不同程度的提高(P〈0,05);对照组FEV1/FVC和FEV1/预计值与试验前的差异无统计学意义(P均〉0.05);治疗组呼吸问卷生活质量评分比观察前明显减少(P〈0.05),对照组除呼吸症状得到改善外其他指标无明显变化(P〉0.05);两组因急性加重住院的比例治疗组明显低于对照组(P〈0.05)。结论布地奈德福莫特罗干粉剂能够改善稳定期Ⅲ-Ⅳ级COPD患者的肺功能和生活质量,降低住院率。 展开更多
关键词 布地奈德/福莫特罗干粉剂 慢性阻塞性肺疾病肺功能St georges呼吸问卷
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朋友间的烦恼
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作者 Garrett Hart 《空中英语教室(初级版.大家说英语)》 2023年第11期44-45,56,共3页
找找看George和Noah遇到了什么问题?George和Noah是好朋友。他们之间有个问题,但是他们还不知道。他们喜欢同一个女孩,她叫Veronica。今天,George决定告诉Noah,他无法再保持沉默了。他说:“Noah,我必须告诉你一件事,我真的很喜欢Veronic... 找找看George和Noah遇到了什么问题?George和Noah是好朋友。他们之间有个问题,但是他们还不知道。他们喜欢同一个女孩,她叫Veronica。今天,George决定告诉Noah,他无法再保持沉默了。他说:“Noah,我必须告诉你一件事,我真的很喜欢Veronica。”“她是个很棒的女孩。”Noah说。 展开更多
关键词 GEORGE VERONICA 朋友 女孩
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中药治疗对SARS恢复期患者肺功能、生存质量的影响 被引量:5
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作者 陈欣 林江涛 +7 位作者 俞红霞 李勇 赵秀梅 苏楠 杨萌 王志虹 贾玉萍 农英 《中国康复医学杂志》 CAS CSCD 北大核心 2006年第2期124-126,共3页
目的:评价SARS恢复期患者肺功能和生存质量变化以及中药治疗对两者的影响。方法:85例(男45例,女40例,平均年龄37.20±10.9岁)SARS恢复期患者被随机分为中药治疗组和对照组两组,所有患者进行肺功能测试,并选择St George′s呼吸问卷... 目的:评价SARS恢复期患者肺功能和生存质量变化以及中药治疗对两者的影响。方法:85例(男45例,女40例,平均年龄37.20±10.9岁)SARS恢复期患者被随机分为中药治疗组和对照组两组,所有患者进行肺功能测试,并选择St George′s呼吸问卷进行生存质量调查。结果:SARS恢复期患者出院时的肺功能损害以弥散障碍、限制性通气障碍为主,随出院时间的延长,肺功能各项损害指标均有好转趋势,其中,TLC%和DLCO%的变化差异具有显著性意义(P<0.05)。中药组SARS恢复期患者TLC%和DLCO%的变化值显著高于对照组(P<0.05);SARS恢复期患者出院后各项生存质量评分同正常相比均有轻度增高,出院8周时各项生存质量评分较出院4周时明显改善(P<0.05),中药组SARS恢复期患者和对照组患者在各个时间的生存质量评分差异无显著性意义(P>0.05)。直线相关分析发现活动、症状、影响和总分与DLCO%存在负线性相关关系(r=0.432—0.664,P<0.01),症状评分与TLC%存在负线性相关关系(r=0.298,P<0.01)。结论:SARS恢复期患者肺功能损害中的TLC%和DLCO%,随出院时间延长有显著的好转趋势,中药治疗可以增强这一趋势,但中药治疗SARS恢复期患者的生存质量评分似无明显作用。SARS恢复期患者各项生存质量评分与DLCO%存在显著的相关关系。 展开更多
关键词 严重急性呼吸综合征 肺功能 生存质量 St George’s呼吸问卷
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SARS患者康复期生活质量调查 被引量:3
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作者 柳涛 彭敏 +6 位作者 蔡柏蔷 许文兵 曹彬 马毅 李太生 王仲 金征宇 《中国医学科学院学报》 CAS CSCD 北大核心 2003年第5期516-519,共4页
摘要目的评估严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者康复期的生活质量。方法对2003年4月至2003年6月出院的119例SARS康复期患者进行生活质量调查,其中男性64例,女性55例,平均年龄(34.1±11.4)岁,平均出院时... 摘要目的评估严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者康复期的生活质量。方法对2003年4月至2003年6月出院的119例SARS康复期患者进行生活质量调查,其中男性64例,女性55例,平均年龄(34.1±11.4)岁,平均出院时间(28.0±12.8)d。选择StGeorge's呼吸问卷(StGeorge'srespiratoryquestionnaire,SGRQ)作为生活质量调查表,其中72例患者同时行肺功能检查。结果119例SARS康复期患者SGRQ症状、活动和影响以及总分的平均分轻度增高,72例肺功能检查提示34例患者肺一氧化碳弥散量(diffusecapacityofthelungforcarbonmonoxide,DLCO)和16例患者肺一氧化碳弥散常数(diffusecapacityofthelungforcarbonmonoxide/alveolarventilation,DLCO/VA)轻度下降;多元线性分析显示,SGRQ活动、影响和总分的变化均与DLCO占预计值的百分比(DLCO/pre,DLCO%)存在负线性回归关系(r=0.47~0.54,P<0.001),症状评分的变化与肺总量占预计值百分比(totallungcapacity/pre,TLC%)和DLCO/VA占预计值百分比(DLCO/VA%)呈负线性回归关系(r=0.54,P<0.001);SARS康复期患者的年龄和性别因素对SGRQ各分值影响显著,其中大于30岁的女性对生活质量影响较大,而出院时间只对SGRQ分值中症状分数有影响。结论SGRQ可以有效。 展开更多
关键词 St George′s呼吸问卷 生活质量 严重急性呼吸综合征
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补肾中药复方联合舒利迭治疗慢性持续期支气管哮喘患者疗效观察 被引量:15
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作者 王国力 邓虎 徐艳玲 《世界中西医结合杂志》 2016年第10期1380-1382,1415,共4页
目的观察补肾中药复方联合舒利迭治疗慢性持续期支气管哮喘(简称哮喘)患者的临床疗效。方法将98例处于哮喘病情严重程度分级1~3级的患者随机随机分为两组,治疗组52例,对照组46例。两组均予常规基线治疗,予对照组沙美特罗替卡松粉吸入剂... 目的观察补肾中药复方联合舒利迭治疗慢性持续期支气管哮喘(简称哮喘)患者的临床疗效。方法将98例处于哮喘病情严重程度分级1~3级的患者随机随机分为两组,治疗组52例,对照组46例。两组均予常规基线治疗,予对照组沙美特罗替卡松粉吸入剂(50μg/250μg)吸入治疗,治疗组在对照组基础上予补肾中药复方煎剂口服,两组均治疗3个月。观察治疗前后肺功能指标、圣乔治呼吸问卷(ST.George’s respiratory questionnaire,SGRQ)评分,比较两组总体临床疗效。结果最终治疗组50例、对照组45例病例完成研究,两组均未发现明显不良反应。治疗结束后,两组第一秒用力呼气容积(FEV1)/预计值、呼气峰值流速(PEF)、PEF日变异率、SGRQ症状、活动、疾病影响及总分均有改善,组内比较,差异均有统计学意义(P<0.05,P<0.01)。治疗后组间比较,除症状、活动两项外,其他指标治疗组优于对照组,差异有统计学意义(P<0.05)。治疗组疾病总有效率优于对照组,差异有统计学意义(P<0.05)。结论以补肾为基础的中药复方联合舒利迭可显著改善哮喘患者肺功能与生活质量,优于单纯使用西药。 展开更多
关键词 支气管哮喘 舒利迭 补肾 第一秒用力呼气容积(FEV1) 呼气峰值流速(PEF) 圣乔治呼吸问卷(ST.George’s respiratory questionnaire SGRQ)
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慢性阻塞性肺病患者深吸气量和生活质量的相关性研究 被引量:20
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作者 张国清 金先桥 张鹏宇 《中国医师进修杂志(内科版)》 2006年第11期30-33,共4页
目的探讨深吸气量(IC)和慢性阻塞性肺病(COPD)患者生活质量的相关性。方法对65例COPD稳定期患者(Ⅱ、Ⅲ期)进行肺功能检查、StGeorge呼吸问卷(SGRQ)评分以及患者日记,并对结果进行多元相关性分析。结果SGRQ呼吸症状、活动受限、疾病影... 目的探讨深吸气量(IC)和慢性阻塞性肺病(COPD)患者生活质量的相关性。方法对65例COPD稳定期患者(Ⅱ、Ⅲ期)进行肺功能检查、StGeorge呼吸问卷(SGRQ)评分以及患者日记,并对结果进行多元相关性分析。结果SGRQ呼吸症状、活动受限、疾病影响三个能区分值与总分之间具有很好的相关性(相关系数分别为0.887、0.944和0.970,P<0.01),并且四者与患者症状积分间也有很好的相关性(相关系数分别为0.861、0.769、0.773和0.835,P<0.01)。第1秒钟用力呼气量(FEV1)占预计值百分比、肺总量(TLC)占预计值百分比、残气量(RV)占预计值百分比、IC占预计值百分比与SGRQ各能区分值及总分间具有相关性(P<0.05)。与FEV1占预计值百分比相比,IC占预计值百分比与SGRQ评分具有更高的相关性。结论肺功能检查结果与COPD患者的生活质量相关,与FEV1占预计值百分比相比,IC占预计值百分比对COPD患者的实际生活质量评价具有更高的价值,应当在临床上得到重视。 展开更多
关键词 慢性阻塞性肺病 生活质量 St George呼吸问卷 肺功能
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Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution 被引量:7
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作者 Mohamed Amine Zaouali Susagna Padrissa-Altés +5 位作者 Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第45期5693-5700,共8页
AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHO... AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1  solution supplemented with or without IGF-1 and then perfused "ex vivo " for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1  enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. 展开更多
关键词 AKT Institut georges lopez-1 SOLUTION Insulin like growth factor-1 Ischemia REPERFUSION injury NITRIC oxide Oxidative stress Steatotic GRAFT PRESERVATION
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中重度慢性阻塞性肺疾病患者6分钟步行试验及其相关因素分析 被引量:8
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作者 王虹 关向群 李兰英 《中国当代医药》 2009年第15期27-29,共3页
目的:探讨中重度COPD稳定期患者6min步行试验(6MWT)与肺功能、呼吸困难及生活质量的相关性。方法:选取中重度COPD患者63例,进行6min步行试验并测定肺功能、呼吸困难评分(MMRC)、生活质量(SGRQ)等指标。结果:FEV1%、MMRC、SGRQ总评分及... 目的:探讨中重度COPD稳定期患者6min步行试验(6MWT)与肺功能、呼吸困难及生活质量的相关性。方法:选取中重度COPD患者63例,进行6min步行试验并测定肺功能、呼吸困难评分(MMRC)、生活质量(SGRQ)等指标。结果:FEV1%、MMRC、SGRQ总评分及活动能力评分、社交心理影响评分与6min步行距离(6MWD)相关,多元逐步回归分析表明MMRC及活动能力评分与6MWD相关。结论:中重度COPD患者6MWD与MMRC、FEV1%及SGRQ相关。6min步行试验能反映中重度COPD患者的临床状况。 展开更多
关键词 6 MIN步行试验 慢性阻塞性肺疾病 肺功能 呼吸困难评分 St.George’s呼吸疾病问卷
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Bottom Factors Applied to the Zoning Study of the Risk Levels of Landslides in the Three Gorges Reservoir Area 被引量:12
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作者 QIAO Jianping ZHU Axing +1 位作者 WU Caiyan TIAN Hongling 《Wuhan University Journal of Natural Sciences》 EI CAS 2006年第4期761-766,共6页
Without taking inducing factors into consideration, this paper adopts a quantitative analysis of the bottom factors in the Three Gorges Reservoir area, studies the relationship between the bottom factors and the devel... Without taking inducing factors into consideration, this paper adopts a quantitative analysis of the bottom factors in the Three Gorges Reservoir area, studies the relationship between the bottom factors and the development of landslides, and then zones the area according to risk levels. The bottom factors adopted in this paper include lithological characters(U1 ), gradient(U2 ), slope form (U3), difference of helght(U4 ), and slope orientation(U5 ). In 4 650 km^2 of the studied area, the areas of the very high, high, medium and low hazard degree area respectively were 57. 94 km^2 , 2 305.15 km^2, 1 241.6 km^2, 1 045.31 km^2. The methodological steps are (1) inversion statistic analysis, (2) the analysis of contribution ratio and weighing, (3) getting results via fuzzy evaluation of risk levels. 展开更多
关键词 bottom factors Three georges area LANDSLIDE
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慢性进行性舞蹈病的临床特点及治疗进展 被引量:4
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作者 刘振国 王文安 《中国现代神经疾病杂志》 CAS 2007年第1期25-28,共4页
慢性进行性舞蹈病又称亨廷顿舞蹈病或亨廷顿病(Huntington disease,HD),是一种呈进行性发展的常染色体显性遗传性神经变性疾病,临床上较为少见。早在1872年George Huntington即对其进行了较为全面的描述,并阐述了它的遗传形式。... 慢性进行性舞蹈病又称亨廷顿舞蹈病或亨廷顿病(Huntington disease,HD),是一种呈进行性发展的常染色体显性遗传性神经变性疾病,临床上较为少见。早在1872年George Huntington即对其进行了较为全面的描述,并阐述了它的遗传形式。该病以慢性进行性舞蹈样异常运动、精神异常、认知障碍三联征为主要临床特征。1983年亨廷顿病的致病基因首次通过连锁分析定位于第4号染色体,近十年来随着分子克隆定位技术的发展, 展开更多
关键词 慢性进行性舞蹈病 临床特点 常染色体显性遗传性 治疗 亨廷顿舞蹈病 神经变性疾病 GEORGE 亨廷顿病
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非典型完全型DiGeorge综合征1例临床及免疫学特征分析 被引量:1
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作者 李黎 周丽娜 +4 位作者 戴荣欣 秦涛 唐文静 丁媛 赵晓东 《免疫学杂志》 CAS CSCD 北大核心 2015年第8期682-686,共5页
目的探讨1例由22q11.2染色体微缺失导致非典型完全型Di George综合征的临床特征及免疫表型。方法收集2014年8月在重庆医科大学附属儿童医院就诊的1例非典型完全型Di George综合征患儿外周血标本,提取外周血单个核细胞(PBMC)及核酸,采用... 目的探讨1例由22q11.2染色体微缺失导致非典型完全型Di George综合征的临床特征及免疫表型。方法收集2014年8月在重庆医科大学附属儿童医院就诊的1例非典型完全型Di George综合征患儿外周血标本,提取外周血单个核细胞(PBMC)及核酸,采用流式细胞术进行T、B细胞亚群检测,羧基荧光双乙酸钠琥珀酰亚胺酯(CFSE)标记法分析T细胞增殖功能,CDR3扫描谱型技术分析T细胞受体(TCR)多样性,定量PCR检测T细胞受体重排剪切环(TREC)含量。结果 T、B细胞亚群分析显示T细胞明显降低,初始T细胞<50个/mm3,总B细胞数量正常,记忆B细胞稍减低;CFSE增殖法提示患儿T细胞无增殖反应;TCR-Vβ亚家族表现为单克隆或寡克隆峰;定量PCR未检测到TREC含量。结论通过临床及免疫学分析,确诊1例非典型完全型Di George综合征患儿。Di George综合征临床与免疫学表型多变,其分型及临床诊断存在困难,常导致漏诊与延迟诊断,因此提高临床工作者对本病的认识对于早期诊断至关重要。 展开更多
关键词 非典型完全型Di George综合征 原发性免疫缺陷病 免疫表型
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德国凯兴斯泰纳公民教育思想之研究 被引量:8
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作者 吴明海 《郑州大学学报(哲学社会科学版)》 CSSCI 北大核心 2004年第3期14-17,共4页
德国教育家乔治·凯兴斯泰教育思想体系核心是公民教育思想和劳作教育思想。公民教育的主要内 容是公民的权利与义务教育,集体观念的教育,权威感教育,民族感教育和劳作教育。劳作教育的实质是通过让学 生动手这种活动,培养学生的创... 德国教育家乔治·凯兴斯泰教育思想体系核心是公民教育思想和劳作教育思想。公民教育的主要内 容是公民的权利与义务教育,集体观念的教育,权威感教育,民族感教育和劳作教育。劳作教育的实质是通过让学 生动手这种活动,培养学生的创造精神。公民教育是劳作教育的目的与归宿,二者相互印证,相互实现。 展开更多
关键词 德国 乔治·凯兴斯泰纳(Georg Kerschenteiner) 公民教育 劳作教育
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Liver preservation prior to transplantation: Past, present, and future 被引量:4
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作者 Marcio F Chedid Marcelo A Pinto +2 位作者 Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2019年第3期122-125,共4页
Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's grou... Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. 展开更多
关键词 Liver TRANSPLANTATION University of WISCONSIN PRESERVATION SOLUTION Institute georges Lopez PRESERVATION SOLUTION Celsior PRESERVATION SOLUTION Histidine-tryptophanketoglutarate PRESERVATION SOLUTION Dymamic PRESERVATION Normothermic ISCHEMIA Normothermic PRESERVATION Hypotermic machine PRESERVATION Static cold prreservation
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胎儿畸形与22q11微缺失相关性的研究进展 被引量:3
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作者 杨文娟 吴青青 《中国妇产科临床杂志》 2011年第2期151-153,共3页
22q11微缺失综合征是由于22号染色体长臂近着丝粒端微片段22q11.21~q11.23缺失引起的遗传综合征,是常见的遗传学疾病,在新生活产儿中发病率为1/4000[1],其主要表现为Di George综合征(DGS):甲状旁腺发育不全、胸腺发育不全和锥干型心... 22q11微缺失综合征是由于22号染色体长臂近着丝粒端微片段22q11.21~q11.23缺失引起的遗传综合征,是常见的遗传学疾病,在新生活产儿中发病率为1/4000[1],其主要表现为Di George综合征(DGS):甲状旁腺发育不全、胸腺发育不全和锥干型心脏畸形(conotruncal defects,CTD); 展开更多
关键词 22Q11微缺失 胎儿畸形 相关性 胸腺发育不全 遗传综合征 GEORGE 主要表现 甲状旁腺
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