Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardiovascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal diseas...Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardiovascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal disease, Porphyromonas gingivalis （P. gingivalis） has not yet been studied in the malignant gingival tissues. The objective of this study was to investigate the presence of R gingivalis in specimens from squamous cell carcinoma patients. We have performed immunohistochemical staining to investigate the presence of R gingivafis and Streptococcus gordonii （S. gordonii）, a non invasive oral bacteria, in paraffin embedded samples of gingival squamous cell carcinoma （n=10） and normal gingiva （n=5）. Staining for R gingivalis revealed the presence of the bacteria in normal gingival tissues and gingival carcinoma, with higher levels （more than 33%, P〈0.05） detected in the carcinoma samples. The staining intensity was also significantly enhanced in the malignant tissue by 2 folds （P〈0.023） compared to specimens stained for the non-invasive S. gordonii. R gingivalis is abundantly present in malignant oral epithelium suggesting a potential association of the bacteria with gingival squamous cell carcinoma.展开更多
Objective： In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 （PBX2） expression in gingival squamous cell carcinoma （GSCC）. Meth...Objective： In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 （PBX2） expression in gingival squamous cell carcinoma （GSCC）. Methods： Expression level of PBX2 was immunohistochemically examined in 66 GSCC subjects （30 men and 36 women） with ages ranging from 42 to 85 （median 64.5） years, in which staining intensity in tumor cells was categorized as either weaker （level 1 ） or equal to/stronger （level 2） than that in the endothelial cells. Results： PBX2 expression is correlated with valosin-containing protein （VCP） expression. Univariate and multivariate analyses revealed a high level of PBX2 expression to be a poor prognosticator for disease-free survival （DFS） and overall survival （OS）, and PBX2 expression was an independent prognostic factor for both DFS and OS in GSCC. Conclusions： PBX2 expression level in GSCC is proqnostic. PBX2 may be a useful marker to identify the potential for progression in GSCC.展开更多
基金supported by National Institute of Health/National Institute of Dental and Craniofacial Research training grant T32DE007200
文摘Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardiovascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal disease, Porphyromonas gingivalis （P. gingivalis） has not yet been studied in the malignant gingival tissues. The objective of this study was to investigate the presence of R gingivalis in specimens from squamous cell carcinoma patients. We have performed immunohistochemical staining to investigate the presence of R gingivafis and Streptococcus gordonii （S. gordonii）, a non invasive oral bacteria, in paraffin embedded samples of gingival squamous cell carcinoma （n=10） and normal gingiva （n=5）. Staining for R gingivalis revealed the presence of the bacteria in normal gingival tissues and gingival carcinoma, with higher levels （more than 33%, P〈0.05） detected in the carcinoma samples. The staining intensity was also significantly enhanced in the malignant tissue by 2 folds （P〈0.023） compared to specimens stained for the non-invasive S. gordonii. R gingivalis is abundantly present in malignant oral epithelium suggesting a potential association of the bacteria with gingival squamous cell carcinoma.
基金Project (No. 30801382) supported by the National Natural Science Foundation of China
文摘Objective： In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 （PBX2） expression in gingival squamous cell carcinoma （GSCC）. Methods： Expression level of PBX2 was immunohistochemically examined in 66 GSCC subjects （30 men and 36 women） with ages ranging from 42 to 85 （median 64.5） years, in which staining intensity in tumor cells was categorized as either weaker （level 1 ） or equal to/stronger （level 2） than that in the endothelial cells. Results： PBX2 expression is correlated with valosin-containing protein （VCP） expression. Univariate and multivariate analyses revealed a high level of PBX2 expression to be a poor prognosticator for disease-free survival （DFS） and overall survival （OS）, and PBX2 expression was an independent prognostic factor for both DFS and OS in GSCC. Conclusions： PBX2 expression level in GSCC is proqnostic. PBX2 may be a useful marker to identify the potential for progression in GSCC.
