Human parvovirus B19-associated hematopathy in HIV disease:need for clinicopathological revisit

Persons living with HIV infection occasionally suffer from anemia due to varying causes.These include the use of zidovudine,malnutrition especially vitamin B12and iron deficiency,opportunistic infections by Mycobacterium tuberculosis,Pneumocystis jiroveci,and direct hematological effects of HIV infection itself within the marrow microenvironment.Persistent Parvovirus B19（B19V）infection is a clinically important and treatable etiology of anemia in HIV-infected persons.

Accuracy of glomerular filtration rate estimation equations in patients with hematopathy

Renal dysfunction is a common side-effect of chemotherapeutic agents in patients with hematopathy. Although broadly used, glomerular filtration rate(GFR) estimation equations were not fully validated in this specific population. Thus, this study was designed to further assess the accuracy of various GFR equations, including the newly 2012 CKD-EPI equations. Referring to ^(99m)Tc-DTPA clearance method, three Scr-based(MDRD, Peking, and CKD-EPI_(Scr)), three Scys C-based(Steven 1, Steven 2, and CKD-EPI_(Scys C)), and three Scr-Scys C combination based(Ma, Steven 3, and CKD-EPI_(Scr-Scys C)) equations were included. Bias, P_(30), and misclassification rate were applied to compare the applicability of the selected equations. A total of 180 Chinese hematological patients were enrolled.Mean bias, absolute mean bias, P_(30), misclassification rate and Bland-Altman plots of the CKD-EPI_(Scr-Scys C) equation were 7.90 mL/minute/1.73 m^2, 17.77 mL/minute/1.73 m^2, 73.3%, 38% and 79.7 mL/minute/1.73 m^2, respectively.CKD-EPI_(Scr-Scys C) predicted the most precise eGFR both in lymphoma and leukemia subgroups. Additionally, CKDEPI_(Scys C) equation in the rGFR■90 mL/minute/1.73 m^2 subgroup and Steven 2 equation in the rGFR<90 mL/minute/1.73 m^2 subgroup provided more accurate estimates in each subgroup. The CKD-EPI_(Scr-Scys C) equation could be recommended to monitor kidney function in hematopathy patients. The accuracy of GFR equations may be closely related with GFR level and kidney function markers, but not the primary cause of hematopathy.

Research and Development of New Chinese Materia Medica for Treatment of Refractory Hematopathy by Establishment and Application of Multiple Technique Platforms

Research Objective and Overview It is necessary to find effective Chinese materia medica （CMM） for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.

Moxa-Stick Suffumigation for Disinfecting Air in Hematology and Hematopoietic Stem Cell Transplantation Wards with Class 100 Laminar Flow

Objective： To evaluate the effect of moxa-stick suffumigation in the hematology and hematopoieticstem cell transplantation （HSCT） wards with luminar flow. Methods： The plate exposure method was usedto measure the effect of air-disinfection of moxa-stick suffumigation in hematology and HSCT wards. Theyearly average qualified rates of air sampling in HSCT wards were evaluated from 2007 to 2010. To furtherinvestigate the disinfecting effect of moxa-stick suffumigation, the colony counts of common pathogens（including Staphylcoccus aureus and Pseudomonas aeruginosa） before and after moxa-stick suffumigation werecompared. Results： The mean air quality rates of the HSCT wards with class 100 laminar flow were all above90.0% （91.2%-96.2%） from 2007 to 2010. Moxa-stick suffumigation effectively decreased the presence ofbacteria in the hematology ward＇s air （P〈0.01）. The most notable effect was the drastic reduction in the colonycounts of Staphylococcus aureus and Pseudomonas aeruginosa on the blood plates exposed to air treatedwith moxa-stick suffumigation （77.1 ± 52.9 cfu/m2 vs 196.1 ± 87.5 cfu/m2, P〈0.01; and 100.2±35.3 cfu/m2 vs371.5± 35.3 cfu/m2, P〈0.01）. Conclusion： Moxa-stick suffumigation proved to be a reliable and effective air-disinfection method for hematology and HSCT wards, and hence, it should be employed extensively.