Influence of earthquake ground motion incoherency on multi-support structures

A linear response history analysis method is used to determine the influence of three factors:geometric incoherency,wave-passage,and local site characteristics on the response of lnulti-support structures subjected to differential ground motions.A one-span frame and a reduced model of a 24-span bridge,located in Las Vegas,Nevada are studied,in which the influence of each of the three factors and their combinations are analyzed.It is revealed that the incoherency of earthquake ground motion can have a dramatic influence on structural response by modifying the dynamics response to uniform excitation and inducing pseudo-static response,which does not exist in structures subjected to uniform excitation.The total response when all three sources of ground motion incoherency are included is generally larger than that of uniform excitation.

Wave passage and incoherency effects on seismic response of high arch dams

The effects ofincoherency and wave-passage on the nonlinear responses of concrete arch dams are investigated in this study. A double curvature arch dam is selected as a numerical example. The reservoir is modeled as a compressible material and the foundation is modeled as a massless medium. Ground motion time-histories are artificially generated using the Monte Carlo simulation approach. Four different finite element models （FEM） are considered： uniform excitation; incoherence effect; wave passage effect; and both incoherence and wave passage effects. It was revealed that modeling multiple-supports excitation could have a significant impact on the structural response of the dam by inducing a pseudo-static effect. Also, it was concluded that the coherency effect overshadows the wave passage effect and the results obtained from non-uniform excitation of FEM, including the wave passage effect, is close to the results of the FEM when it is uniformly excited.

Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver resection.Up to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after resection.AIM To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to surgery.METHODS In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after chemotherapy.Various parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were measured.The parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node status.The reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation coefficient.RESULTS Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of 0.873.Furthermore,parameters from SEM showed substantial repeatability.CONCLUSION The developed nomogram,incorporating the pre-treatment DDC and the short axis of the largest lymph node,can be used to predict the presence of hepatic LNM in CRLM patients undergoing chemotherapy before surgery.This nomogram was proven to be more valuable,exhibiting superior diagnostic performance compared to quantitative parameters derived from multiple b values of DWI.The nomogram can serve as a preoperative assessment tool for determining the status of hepatic lymph nodes and aiding in the decision-making process for surgical treatment in CRLM patients.

Analysis of the joint detection capability of the SMILE satellite and EISCAT-3D radar

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite is a small magnetosphere–ionosphere link explorer developed cooperatively between China and Europe.It pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and polar cusp regions.It uses a high-precision ultraviolet imager to image the overall configuration of the aurora and monitor changes in the source of solar wind in real time,using in situ detection instruments to improve human understanding of the relationship between solar activity and changes in the Earth’s magnetic field.The SMILE satellite is scheduled to launch in 2025.The European Incoherent Scatter Sciences Association(EISCAT)-3D radar is a new generation of European incoherent scatter radar constructed by EISCAT and is the most advanced ground-based ionospheric experimental device in the high-latitude polar region.It has multibeam and multidirectional quasi-real-time three-dimensional(3D)imaging capabilities,continuous monitoring and operation capabilities,and multiple-baseline interferometry capabilities.Joint detection by the SMILE satellite and the EISCAT-3D radar is of great significance for revealing the coupling process of the solar wind–magnetosphere–ionosphere.Therefore,we performed an analysis of the joint detection capability of the SMILE satellite and EISCAT-3D,analyzed the period during which the two can perform joint detection,and defined the key scientific problems that can be solved by joint detection.In addition,we developed Web-based software to search for and visualize the joint detection period of the SMILE satellite and EISCAT-3D radar,which lays the foundation for subsequent joint detection experiments and scientific research.

The nature of electron density enhancement over a wide altitude range during ionosphere heating experiments at EISCAT

During the course of ionospheric heating experiments, researchers at the European Incoherent Scatter Scientific Association (EISCAT) observed an apparent electron density enhancement. The enhancement extended over a wide range of altitudes, above the reflection altitude of the high-frequency pump wave. However, whether this enhancement actually corresponds to a true enhancement in electron density remains an open question. When the dispersion relation of ion acoustic waves is followed, the frequency ratio of the enhanced ion line to the background ion line suggests that the profile of the effective ion mass may have remained unchanged. Furthermore, the solar radio flux and ion drift velocity indicate no significant changes in the ion species and their densities. In conclusion, the electron density enhancement observed at EISCAT should not, in fact, be considered a true enhancement.

Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

BACKGROUND The consistency of pancreatic apparent diffusion coefficient(ADC)values and intravoxel incoherent motion(IVIM)parameter values across different magnetic resonance imaging(MRI)devices significantly impacts the patient’s diagnosis and treatment.AIM To explore consistency in image quality,ADC values,and IVIM parameter values among different MRI devices in pancreatic examinations.METHODS This retrospective study was approved by the local ethics committee,and informed consent was obtained from all participants.In total,22 healthy volunteers(10 males and 12 females)aged 24-61 years(mean,28.9±2.3 years)underwent pancreatic diffusion-weighted imaging using 3.0T MRI equipment from three vendors.Two independent observers subjectively scored image quality and measured the pancreas’s overall ADC values and signal-to-noise ratios(SNRs).Subsequently,regions of interest(ROIs)were delineated for the IVIM parameters(true diffusion coefficient,pseudo-diffusion coefficient,and perfusion fraction)using post-processing software.These ROIs were on the head,body,and tail of the pancrease.The subjective image ratings were assessed using the kappa consistency test.Intraclass correlation coefficients(ICCs)and mixed linear models were used to evaluate each device’s quantitative parameter values.Finally,a pairwise analysis of IVIM parameter values across each device was performed using Bland-Altman plots.RESULTS The Kappa value for the subjective ratings of the different observers was 0.776(P<0.05).The ICC values for interobserver and intra-observer agreements for the quantitative parameters were 0.803[95% confidence interval(CI):0.684-0.880]and 0.883(95%CI:0.760-0.945),respectively(P<0.05).The ICCs for the SNR between different devices was comparable(P>0.05),and the ICCs for the ADC values from different devices were 0.870,0.707,and 0.808,respectively(P<0.05).Notably,only a few statistically significant inter-device agreements were observed for different IVIM parameters,and among those,the ICC values were generally low.The mixed linear model results indicated differences(P<0.05)in the f-value for the pancreas head,D-value for the pancreas body,and D-value for the pancreas tail obtained using different MRI machines.The Bland-Altman plots showed significant variability at some data points.CONCLUSION ADC values are consistent among different devices,but the IVIM parameters’repeatability is moderate.Therefore,the variability in the IVIM parameter values may be associated with using different MRI machines.Thus,caution should be exercised when using IVIM parameter values to assess the pancreas.

Estimation of aboveground biomass of arboreal species in the semi-arid region of Brazil using SAR(synthetic aperture radar)images

The Caatinga biome is an important ecosystem in the semi-arid region of Brazil.It has significantly degraded due to human activities and is currently a region undergoing desertification.Thus,monitoring the variation in the Caatinga biome has become essential for its sustainable development.However,traditional methods for estimating aboveground biomass(AGB)are time-consuming and destructive.Remote sensing,such as optical and radar imaging,can estimate and correlate with vegetation.Nevertheless,radar imaging is still a novelty to be applied in estimating the AGB of this biome,which is an area with little research.Therefore,this study aimed to use Sentinel-1 images to estimate the AGB of the Caatinga biome in Sergipe State(northeastern Brazil)and to verify its influencing factors.Nineteen sample plots(30 m×30 m)were selected,and the stems of individuals with a circumference at breast height(1.3 m above the ground)equal to or greater than 6.0 cm were measured,and the AGB through an allometric equation was estimated.The Sentinel-1 images from 3 different periods(green,intermediate,and dry periods)were used to consider the phenological conditions of the Caatinga biome.All the pre-processing and extraction of attributes(co-polarized VV(vertical transmit and vertical receive),cross-polarized VH(vertical transmit and horizontal receive),and band ratio VH/VV backscatter,radar vegetation index,dual polarization synthetic aperture radar(SAR)vegetation index(DPSVI),entropy(H),and alpha angle(α))were performed with Sentinel’s Application Platform.These attributes were used to estimate the AGB through simple and multiple linear regressions and evaluated by the coefficients of determination(R2),correlation(r),and root mean squared error(RMSE).The results showed that the attributes individually had little ability to estimate the AGB of the Caatinga biome in the three periods.Combined with multiple regression,we found that the intermediate period presented the equation with the best results among the observed and estimated variables(R^(2)=0.73;r=0.85;RMSE=8.33 Mg/hm^(2)),followed by the greenness period(R2=0.72;r=0.85;RMSE=8.40 Mg/hm^(2)).The attributes contributing to these equations were VH/VV,DPSVI,H,α,and co-polarized VV for the green period and cross-polarized VH for the intermediate period.The study showed that the Sentinel-1 images could be used to estimate the AGB of the Caatinga biome in the green and intermediate phenological periods since the SAR attributes highly correlated with the estimated variable(i.e.,AGB)through multiple linear equations.

Why the Incoherent Paradigm Is for the Future Wireless Networks?

This material is aimed to attract attention to the “incoherent approach for power NOMA-RIS-MIMO transmission in wireless channels”. Such kind of approach might be successfully applied in future dense networks formed by High-Speed Vehicles (HSV networks, etc.). Those scenarios take place in doubly selective communication channels typical for such kind of radio networks. The proposal for the presented hereafter incoherent view (“paradigm”) is based on several basic principles: 1) Shift from the “coherent “ideology”, i.e. rejection of the application of any type of Channel State Information (CSI, CSIT);2) Application of the so-called “invariant” to the communication channel’s features (distortions) modulation technique together with its incoherent demodulation;3) Orthogonal channel decomposition by means of “universal” eigen basis (in the form of Prolate Spheroidal Wave Functions, PSWF) as “artificial trajectories” of wave propagation;4) Chaotic filtering (chaos parameter settings as UE signatures) together with sequential multiuser parallel detection algorithms for users’ identification (classification). It is shown that the proposed approach might provide an effective use of the radio resource and it is relatively simple for implementation.

Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma

Objective To evaluate the value of texture features derived from intravoxel incoherent motion(IVIM) parameters for differentiating pancreatic neuroendocrine tumor(pNET) from pancreatic adenocarcinoma(PAC).Methods Eighteen patients with pNET and 32 patients with PAC were retrospectively enrolled in this study. All patients underwent diffusion-weighted imaging with 10 b values used(from 0 to 800 s/mm2). Based on IVIM model, perfusion-related parameters including perfusion fraction(f), fast component of diffusion(Dfast) and true diffusion parameter slow component of diffusion(Dslow) were calculated on a voxel-by-voxel basis and reorganized into gray-encoded parametric maps. The mean value of each IVIM parameter and texture features [Angular Second Moment(ASM), Inverse Difference Moment(IDM), Correlation, Contrast and Entropy] values of IVIM parameters were measured. Independent sample t-test or Mann-Whitney U test were performed for the betweengroup comparison of quantitative data. Regression model was established by using binary logistic regression analysis, and receiver operating characteristic(ROC) curve was plotted to evaluate the diagnostic efficiency.Results The mean f value of the pNET group were significantly higher than that of the PAC group(27.0% vs. 19.0%, P = 0.001), while the mean values of Dfast and Dslow showed no significant differences between the two groups. All texture features(ASM, IDM, Correlation, Contrast and Entropy) of each IVIM parameter showed significant differences between the pNET and PAC groups(P = 0.000-0.043). Binary logistic regression analysis showed that texture ASM of Dfast and texture Correlation of Dslow were considered as the specific imaging variables for the differential diagnosis of pNET and PAC. ROC analysis revealed that multiple texture features presented better diagnostic performance than IVIM parameters(AUC 0.849-0.899 vs. 0.526-0.776), and texture ASM of Dfast combined with Correlation of Dslow in the model of logistic regression had largest area under ROC curve for distinguishing pNET from PAC(AUC 0.934, cutoff 0.378, sensitivity 0.889, specificity 0.854). Conclusion Texture analysis of IVIM parameters could be an effective and noninvasive tool to differentiate pNET from PAC.

GLOBAL测井解释方法Incoherence函数性质研究

本文对GLOBAL测井解释方法的Incoherence函数进行了系统研究。讨论了Incoherence函数的建立;分析了解的意义,置信区间及减小非相干函数值的含义;检验了层参数,响应函数和误差项对求解结果的影响;最后,提出了改进GLOBAL方法求解效果的一些建议。本文的结论适合于测井资料最优化解释方法的理论和实际应用。建议:(1)慎重选择层参数、响应方程和有关误差项;(2)选用受初值影响小的算法,并求出极小最小二乘解;(3)对求解结果进行评价,即找出解的估值与真值的关系,以便由估值了解真值或真值的变化范围。

Simulation of spatially correlated earthquake ground motions for engineering purposes

A new model to simulate spatially correlated earthquake ground motions is developed. In the model, the main factors that characterize three distinct effects of spatial variability, namely, the incoherency effect, the wave-passage effect and the site-response effect, are taken into account, and corresponding terms/parameters are incorporated into the well known model of uniform ground motions. Some of these terms/parameters can be determined by the root operation, and others can be calculated directly. The proposed model is first verified theoretically, and examples of ground motion simulations are provided as a further illustration. It is proven that the ensemble expected value and the ensemble auto-/cross-spectral density functions of the simulated ground motions are identical to the target spectral density functions. The proposed model can also be used to simulate other correlated stochastic processes, such as wave and wind loads.

Simplified method for simulation of ergodic spatially correlated seismic ground motion

A simplified method for the simulation of the ergodic spatially correlated seismic ground motion is proposed based on the commonly used original spectral representation method. To represent the correlation in the ground motion, the phase angles are given by explicit terms with a clear physical meaning. By these explicit terms, the computational efficiency can be improved by converting the decomposition of the complex cross-spectral matrix into the decomposition of the real incoherence coefficient matrix. Double-indexing frequencies are introduced to simulate the ergodic seismic ground motion, and the ergodic feature of the improved method is demonstrated theoretically. Subsequently, an explicit solution of the elements of the lower triangular matrix under the Cholesky decomposition is given. With this explicit solution, the improved method is simplified, and the computational efficiency can be improved greatly by avoiding the repetitive Cholesky decomposition of the cross-spectral matrix in each frequency step. Finally, a numerical example shows the good characteristic of the improved method.

Comparison between Microwave Coherent and Incoherent Scattering Models in Corn Field

[Objective] The aim was to compare and analyze microwave coherent and incoherent scattering models in a corn field. [Method] In the research, based on a coherent scattering model （Stile）, we proposed a coherent scattering model exclusive for corn, in which, physical optics （PO） and infinite-length dielectric cylinder were used to calculate single-scattering matrices of corn leaves and stalks. In addition, coherent components produced from interaction among the scattering mechanisms were also considered and this coherent model was compared with the Michigan Mi- crowave Canopy Scattering （MIMICS） model. The measured data in a corn filed in Gongzhuling in Jilin Province were used as the input parameters of the coherent and incoherent models. We simulated backscattering coefficients of VV and HH po- larization at L and C bands and made a comparison between the simulation results. [Result] The simulation results at L-band were poor, which indicated that we could not find regularity at early growth stage of vegetation. In addition, comparisons be- tween coherent and incoherent scattering models proved that the coherence triggered by the scattering mechanism was small. [Conclusion] In the research, we analyzed differences between coherent and incoherent scattering models with change of incident angle, and further analysis on the differences with change of vegetation and soil needed to be made in future.

Near-ultraviolet Incoherent Broadband Cavity Enhanced Absorption Spectroscopy for OCIO and CH20 in Cl-initiated Photooxidation Experiment

Chlorine dioxide （OC10） is an important indicator for Cl-activation. The monitoring of OC10 appears to be crucial for understanding the chemistry of Cl-initialed oxidation and its impact on air quality in polluted coastal regions and industrialized areas. We report the development of a Xe arc lamp based near-ultraviolet （335-375 nm） incoherent broad- band cavity enhanced absorption spectroscopy （IBBCEAS） spectrometer for quantitative assessment of OC10 in an atmospheric simulation chamber. The important intermediate compound CH20, and other key atmospheric trace species （NO2） were also simultaneously measured. The instrumental performance shows a strong potential of this kind of IBBCEAS instrument for field and laboratory studies of atmospheric halogen chemistry.

Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma:Comparison with conventional diffusion-weighted imaging

AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate the correlation between the parameters and the histological grades.METHODS A retrospective study was performed. Sixty-two patients with surgically confirmed h CCs underwent diffusion-weighted magnetic resonance imaging with twelve b values(10-1200 s/mm^2). The apparent diffusion coefficient(ADC), pure diffusion coefficient(D), pseudo-diffusion coefficient(D*), and perfusion fraction(f) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance(ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic(ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade(grade 1, G1) and high-grade(grades 2 and 3, G2 and G3) hC C. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements.RESULTS The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of HCCs were statistically significant(P < 0.001). The D* and f values had no significant differences among the different histological grades of h CC(P > 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performance in differentiating the low-grade h CC from the high-grade h CC, with areas under the curve(AUCs) of 0.909 and 0.843, respectively, measured by radiologist 1 and of 0.911 and 0.852, respectively, measured by radiologist 2. The following significant correlations were obtained between the ADC, D, and D~* values and the histological grades: r =-0.619(P < 0.001), r =-0.628(P < 0.001), and r =-0.299(P = 0.018), respectively, as measured by radiologist 1; r =-0.622(P < 0.001), r =-0.633(P < 0.001), and r =-0.303(P = 0.017), respectively, as measured by radiologist 2. The intra-class correlation coefficient(ICC) values between the two observers were 0.996 for ADC, 0.997 for D, 0.996 for D*, and 0.992 for f values, which indicated excellent interobserver agreement in the measurements between the two observers.CONCLUSION The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade hC C from low-grade hC C, and there is a moderate to good correlation between the ADC and D values and the histological grades.

Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

AIM To evaluate the correlation between intravoxel incoherent motion(IVIM) diffusion-weighted imaging(DWI) parameters and the degree of hepatic steatosis and fibrosis in children.METHODS This retrospective study was approved by the institutional review board. The children(≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver(FAT), and fibrotic liver(FIB) groups. The slow diffusion coefficient(D), fast diffusion coefficient(D*), perfusion fraction(f), and apparent diffusion coefficient(ADC) were measured. MR proton density fat fraction(PDFF), MR elastography(MRE), and IVIM values were compared.RESULTS A total of 123 children(median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D* values were lower in the FIB group compared with those of the normal(P = 0.015) and FAT(P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group(P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value(β = 3.194, P < 0.001), and MRE value was negatively correlated with D* value(β =-7.031, P = 0.032). The D and ADC values were not influenced by PDFF or MRE value.CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

Initial Results of Lidar Measured Middle Atmosphere Temperatures over Tibetan Plateau

During August 2013,a mobile Rayleigh lidar was deployed in Lhasa,Tibet(29.6°N,91.0°E) for making measurements of middle atmosphere densities and temperatures from 30 to 90 km.In this paper,the authors present the initial results from this scientific campaign,Middle Atmosphere Remote Mobile Observatory in Tibet(MARMOT),and compared the results to the MSIS-00(Mass Spectrometer and Incoherent Scatter) model.This work will advance our understanding of middle atmosphere dynamic processes,especially over the Tibetan Plateau area.

Ground Surface Ruptures and Near-Fault,Large-Scale Displacements Caused by the Wenchuan Ms8.0 Earthquake Derived from Pixel Offset Tracking on Synthetic Aperture Radar Images

The 12 May 2008 Wenchuan Ms8.0 earthquake produced surface displacements along the causative fault, the Yingxiu-Beichuan Fault, which are up to several meters near the fault. Because of the large gradient, satellite synthetic aperture radar （SAR） interferometric data are strongly incoherent; the usual SAR interferometry method does not allow such displacements to be measured. In the present study, we employed another approach, the technique based on pixel offset tracking, to solve this problem. The used image data of six tracks are from the Advanced Land Observing Satellite, Phased Array type L-band Synthetic Aperture Radar （ALOS/PALSAR） dataset of Japan. The results show that the entire surface rupture belt is 238 km long, extending almost linearly in a direction of 42°north-east. It is offset left laterally by a north-west-striking fault at Xiaoyudong, and turns at Gaochuan, where the rupture belt shifts toward the south by 5 km, largely keeping the original trend. In terms of the features of the rupture traces, the rupture belt can be divided into five sections and three types. Among them, the Beichuan-Chaping and Hongkou-Yingxiu sections are relatively complex, with large widths and variable traces along the trend. The Pingtong-Nanba and Qingping-Jingtang sections appear uniform, characterized by straight traces and small widths. West of Yingxiu, the rupture traces are not clear. North of the rupture belt, surface displacements are 2.95 m on average, mostly 2-3.5 m, with 7-9 m the maximum near Beichuan. South of the rupture belt, the average displacement is 1.75 m, dominated by 1-2 m, with 3-4 m at a few sites. In the north, the displacements in the radar line of sight are of subsidence, and in the south, they are uplifted, in accordance with a right-slip motion that moves the northern wall of the fault to the east, and the southern wall to the west, respectively. Along the Guanxian-Jiangyou Fault, there is a uplift zone in the radar line of sight, which is 66 km long, 1.5-6 km wide, and has vertical displacements of approximately 2 m, but no observable rupture traces.

Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma

Hepatocellular carcinoma(HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization(TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections. The evaluation of the response to TACE treatment affects not only the assessment of the therapy efficacy but also the development of the next step in the treatment plan. The use of imaging to examine changes in tumor volume to assess the response of solid tumors to treatment has been controversial. In recent years, the emergence of new imaging technology has made it possible to observe the response of tumors to treatment prior to any morphological changes. In this article, the advances in studies reporting the use of computed tomography perfusion imaging, diffusionweighted magnetic resonance imaging(MRI), intravoxel incoherent motion, diffusion kurtosis imaging, magnetic resonance spectroscopy, magnetic resonance perfusionweighted imaging, blood oxygen level-dependent MRI, positron emission tomography(PET)/computed tomography and PET/MRI to assess the TACE treatment response are reviewed.

Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer

AIM: To assess intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for monitoring early efficacy of chemotherapy in a human gastric cancer mouse model.METHODS: IVIM-DWI was performed with 12 b-values (0-800 s/mm2) in 25 human gastric cancer-bearing nude mice at baseline (day 0), and then they were randomly divided into control and 1-, 3-, 5- and 7-d treatment groups (n = 5 per group). The control group underwent longitudinal MRI scans at days 1, 3, 5 and 7, and the treatment groups underwent subsequent MRI scans after a specified 5-fluorouracil/calcium folinate treatment. Together with tumor volumes (TV), the apparent diffusion coefficient (ADC) and IVIM parameters [true water molecular diffusion coefficient (D), perfusion fraction (f) and pseudo-related diffusion coefficient (D*)] were measured. The differences in those parameters from baseline to each measurement (ΔTV%, ΔADC%, ΔD%, Δf% and ΔD*%) were calculated. After image acquisition, tumor necrosis, microvessel density (MVD) and cellular apoptosis were evaluated by hematoxylin-eosin (HE), CD31 and terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) staining respectively, to confirm the imaging findings. Mann-Whitney test and Spearman’s correlation coefficient analysis were performed.RESULTS: The observed relative volume increase (ΔTV%) in the treatment group were significantly smaller than those in the control group at day 5 (ΔTVtreatment% = 19.63% ± 3.01% and ΔTVcontrol% = 83.60% ± 14.87%, P = 0.008) and day 7 (ΔTVtreatment% = 29.07% ± 10.01% and ΔTVcontrol% = 177.06% ± 63.00%, P = 0.008). The difference in ΔTV% between the treatment and the control groups was not significant at days 1 and 3 after a short duration of treatment. Increases in ADC in the treatment group (ΔADC%treatment, median, 30.10% ± 18.32%, 36.11% ± 21.82%, 45.22% ± 24.36%) were significantly higher compared with the control group (ΔADC%control, median, 4.98% ± 3.39%, 6.26% ± 3.08%, 9.24% ± 6.33%) at days 3, 5 and 7 (P = 0.008, P = 0.016, P = 0.008, respectively). Increases in D in the treatment group (ΔD%treatment, median 17.12% ± 8.20%, 24.16% ± 16.87%, 38.54% ± 19.36%) were higher than those in the control group (ΔD%control, median -0.13% ± 4.23%, 5.89% ± 4.56%, 5.54% ± 4.44%) at days 1, 3, and 5 (P = 0.032, P = 0.008, P = 0.016, respectively). Relative changes in f were significantly lower in the treatment group compared with the control group at days 1, 3, 5 and 7 follow-up (median, -34.13% ± 16.61% vs 1.68% ± 3.40%, P = 0.016; -50.64% ± 6.82% vs 3.01% ± 6.50%, P = 0.008; -49.93% ± 6.05% vs 0.97% ± 4.38%, P = 0.008, and -46.22% ± 7.75% vs 8.14% ± 6.75%, P = 0.008, respectively). D* in the treatment group decreased significantly compared to those in the control group at all time points (median, -32.10% ± 12.22% vs 1.85% ± 5.54%, P = 0.008; -44.14% ± 14.83% vs 2.29% ± 10.38%, P = 0.008; -59.06% ± 19.10% vs 3.86% ± 5.10%, P = 0.008 and -47.20% ± 20.48% vs 7.13% ± 9.88%, P = 0.016, respectively). Furthermore, histopathologic findings showed positive correlations with ADC and D and tumor necrosis (rs = 0.720, P < 0.001; rs = 0.522, P = 0.007, respectively). The cellular apoptosis of the tumor also showed positive correlations with ADC and D (rs = 0.626, P = 0.001; rs = 0.542, P = 0.005, respectively). Perfusion-related parameters (f and D*) were positively correlated to MVD (rs = 0.618, P = 0.001; rs = 0.538, P = 0.006, respectively), and negatively correlated to cellular apoptosis of the tumor (rs = -0.550, P = 0.004; rs = -0.692, P < 0.001, respectively).CONCLUSION: IVIM-DWI is potentially useful for predicting the early efficacy of chemotherapy in a human gastric cancer mouse model.