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Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca^(2+) channel internalization in mesenchymal stem cells 被引量:5
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作者 Bei Li Xiaoning He +9 位作者 Zhiwei Dong Kun Xuan Wei Sun Li Gao Shiyu Liu Wenjia Liu Chenghu Hu Yimin Zhao Songtao Shi Yan Jin 《Bone Research》 SCIE CAS CSCD 2020年第2期182-196,共15页
The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or ... The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain,chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells(BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific(Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δsubunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP. 展开更多
关键词 GSK3Β internalization HOMEOSTASIS
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EXTERNALIZATION AND INTERNALIZATION OF CARDIAC ENDOTHELIN RECEPTORS DURING DIFFERENT PHASES OF SEPSIS IN RAT 被引量:1
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作者 王晓红 杨军 +4 位作者 董林旺 庞永政 苏静怡 唐朝枢 刘乃奎 《Chinese Medical Sciences Journal》 CAS CSCD 2001年第1期10-14,共5页
To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced... To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced by cecal ligation and puncture (CLP). ET1 receptor was assayed by using [125I]- ET1 binding. Marker enzyme activities, protein yield, and dry- to- wet weight ratio of cardiac membranes were measured. Results. Septic rat heart exhibited two distinct phases: an initial hyperdynamic phase( 9h after CLP; early stage of sepsis) followed by a hypodynamic (18h after CLP, late stage of sepsis) phase. [125I]- ET1 binding study showed that during early stage of sepsis, the Bmax of ET1 receptors was increased by 30% in sarcolemma but decreased by 19% in light vesicles, while during late stage of sepsis, the Bmax was decreased by 24% in sarcolemma but increased by 38% in light vesicles.The total binding of sarcolemma and light vesicles was increased by 25% during early stage of sepsis but decreased by 17% during late stage of sepsis. Conclusions. These data indicated that ET1 receptors in the rat heart were externalized from light vesicles to sarcolemmal membranes during early hyperdynamic phase while internalized from surface membranes to intracellular compartment during late hypodynamic phase of sepsis. 展开更多
关键词 endothelial receptor SEPSIS EXTERNALIZATION internalization
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Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery 被引量:1
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作者 Jinmina Zhang Chunxi Wang +7 位作者 Mei Lu Haonan Xing Tianzhi Yang Cuifang Cai Xiaoyun Zhao Minjie Wei Jiankun Yu Pingtian Ding 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2018年第4期360-372,共13页
Guanidinylated bioresponsive poly(amido amine)s polymers, CAR-CBA and CHL-CBA, weresynthesized by Michael-type addition reaction between guanidine hydrochloride(CAR) orchlorhexidine(CHL) and N,N-cystaminebisacrylamide... Guanidinylated bioresponsive poly(amido amine)s polymers, CAR-CBA and CHL-CBA, weresynthesized by Michael-type addition reaction between guanidine hydrochloride(CAR) orchlorhexidine(CHL) and N,N-cystaminebisacrylamide(CBA). Previous studies have shownthat both polymers had high transfection efficiencies as gene delivery carriers. In this study,we investigated the nucleolus localization abilities and cellular internalization pathways ofthese two polymers in gene delivery. Each polymer condensed plasmid DNA(p DNA) andformed nanoparticle complexes, and then their transfection studies were performed inMCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection,and their transfection efficiencies were significantly improved when transfection was per-formed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNAwas inhibited by chlorpromazine, and cell endosomes were disrupted after being exposedto CAR-CBA-pDNA. In regards to CHL-CBA-pDNA, its transfection efficiency was not affected by three types of endocytosis inhibitors used in the study, and CHL-CBA-pDNA showed no effect on endosomes. Cellular lactate dehydrogenase release and membrane morphology were changed after cells were transfected by the two complexes. The results indicated that both CAR-CBA and CHL-CBA polymers demonstrated good nucleolus localization abilities. It was beneficial for transfection when cells were arrested at M phase. CAR-CBA-pDNA cellular internalization was involved with clathrin-mediated endocytosis pathway, and escaping from endosomal entrapment, while the cellular uptake of CHL-CBA-pDNA occurs via clathrin-and caveolae-independent mechanism. 展开更多
关键词 Guanidinylated poly(amido amine)s polymers NUCLEOLUS localization Cell cycle status internalization PATHWAYS
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Follicle-stimulating Hormone(FSH) Induced Internalization of Porcine FSH Receptor in Cultured Porcine Granulosa Cells and Chinese Hamster Ovary Cells Transfected with Recombinant Porcine FSH Receptor cDNA
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作者 朱长虹 田红 +1 位作者 熊忠明 肖惠珠 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2001年第3期188-190,共3页
In order to study the fate of human follicle-stimulating hormone (FSH) when hormone binds to its receptor, a quick biochemical method that can differentiate between the surface-bound and internalized hormone was used ... In order to study the fate of human follicle-stimulating hormone (FSH) when hormone binds to its receptor, a quick biochemical method that can differentiate between the surface-bound and internalized hormone was used to determine the internalization induced by FSH in cultured both porcine granulosa cells and Chinese hamster ovary (CHO) cells expressing recombinant porcine FSH receptor. The results showed that FSH was slowly internalized, and the internalized radioactivity (acid resistant) reached a peak 10-12 h after addition of 125 I-hFSH. It was suggested that FSHR do not get internalized rapidly under physiological circumstances precisely because the appropriate sequences are absent. 展开更多
关键词 follicle-stimulating hormone internalization granulosa cells
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Effect of Alternative Splicing of VLDL Receptor on its Ligand Binding and Internalization Capability
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作者 Ying-Hong LI Jun TIAN +4 位作者 Tao CHEN Yi-Qiang ZONG Yu WANG Pu YANG Shen QU 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2005年第S1期119-120,共2页
关键词 In VLDLR Effect of Alternative Splicing of VLDL Receptor on its Ligand Binding and internalization Capability
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GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization,mitochondria-targeting and-activating properties of human salivary histatin 1
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作者 Dandan Ma Wei Sun +6 位作者 Cuicui Fu Kamran Nazmi Enno C.I.Veerman Richard T.Jaspers Jan G.M.Bolscher Floris J.Bikker Gang Wu 《International Journal of Oral Science》 SCIE CAS CSCD 2022年第3期334-348,共15页
Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets an... Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular mechanism.However,its regulating signaling pathways remain to be elucidated.We investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated kinases1/2(ERK1/2)signaling,p38 signaling,mitochondrial respiration and Na+/K+-ATPase activity on the uptake,mitochondria-targeting and-activating properties of F-Hst1.We performed a si RNA knockdown(KD)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of Hst1.We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1.The inhibitors of GPCR,ERK1/2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic activity.Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of Hst1.We further showed the intracellular trafficking and targeting process of F-Hst1,in which early endosome plays an important role.Overall,phagocytosis,CME,GPCR,ERK signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular targeting.The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property. 展开更多
关键词 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization mitochondria-targeting and activating properties of human salivary histatin 1 ERK
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Body-focused Anxiety in Women: Associations with Internalization of the Thin-ideal, Dieting Frequency, Body Mass Index and Media Effects
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作者 Aileen Pidgeon Rachel A. Harker 《Open Journal of Medical Psychology》 2013年第4期17-24,共8页
Exposure to media that portrays thin women as ideal and attractive can lead to women internalizing the thin ideal, which results in incorporating societal standards of thinness into belief systems. Internalization of ... Exposure to media that portrays thin women as ideal and attractive can lead to women internalizing the thin ideal, which results in incorporating societal standards of thinness into belief systems. Internalization of the thin-ideal is associated with numerous detrimental effects on women, including decreased levels of self-esteem and increased levels of body-focused anxiety, negative emotions and disordered eating. The present study utilized a sample of women (N = 208) aged between 18 and 67 years (M = 29.44, SD = 13.08) to examine the relationship between internalization of the thin- ideal, body-focused anxiety, body mass index (BMI), and dieting frequency. Correlational, regression and mediation analyses conducted on the data showed that internalization of the thin-ideal, BMI and dieting frequency significantly contributed to body-focused anxiety in women. In addition, body-focused anxiety fully mediated the relationship between internalization of the thin-ideal and dieting frequency among women. BMI did not moderate the relationship between internalization of the thin-ideal and body-focused, indicating that women who internalize the thin-ideal are less vulnerable to dieting unless experiencing body-focused anxiety. The results of the current study enhance our understanding of the relationship between internalization of the thin-ideal, body-focused anxiety, BMI, and dieting frequency among women. Clinical implications will be discussed. 展开更多
关键词 Body-focused ANXIETY internalization of the Thin-ideal BMI DIETING
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"Half-a-Day" Syndrome: A Mode of Internalization of Vocational and Technical Education by the Youths in the 20th Century Nigeria
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作者 Grace Oluremilekun Akanbi Alice Arinlade Jekayinfa 《History Research》 2012年第8期535-542,共8页
This research focused on "half-a-day" as a mode of internalizing vocational and technical education by the youths in Nigeria. It traced the origin of "half-a-day" linking it with the ingenuity of the youths to mak... This research focused on "half-a-day" as a mode of internalizing vocational and technical education by the youths in Nigeria. It traced the origin of "half-a-day" linking it with the ingenuity of the youths to make the formal education that they have acquired operational. It also discussed the traditional education with its apprenticeship system as being modified through the "half-a-day" syndrome. The study is historical and descriptive therefore, social survey method was employed using unscheduled interview and consulting relevant literature. It was discovered that, apart from the failure of the educational system due to lack of proper infrastructure, the youths, especially those from the lower class, have reasoned that the salaries from the white-collar jobs may not be enough to sustain them. It is, therefore, recommended, among others, that: Government can institutionalise the "half-a-day" as a form of summer school and certify both the centres of learning and learners. 展开更多
关键词 half-a-day internalization vocational and technical education national policy on education APPRENTICESHIP
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The Observation of FSH’s Cellular Internalization
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作者 Jizhong Han Jianwen Hu +3 位作者 Lanlan Liu Fei Chen Xian Zhang Bin Zeng 《Journal of Biosciences and Medicines》 2016年第12期37-41,共6页
Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein... Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein coupled receptor (GPCR), found in the ovary and testes, and its activation is required for the hormonal operation during the breeding period. In this study, an experimental model of FSHR mediated FSH into cell membrane, which exhibited a phenomenon of fluorescent localized on cell surfaces internalized into cell interior, was established to verify biological activity of FSH. 展开更多
关键词 FSH Receptor Target Binding Celluar internalization
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On the necessity and countermeasures of the "internalization" construction of the China-characterized public diplomacy under the new situations
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作者 Li Weitao 《International English Education Research》 2015年第6期115-118,共4页
In the era of the globalization of the economy, the network of the information, and the socialization of the citizens, there is the tendency that a country's domestic problems will be internationalized, while the int... In the era of the globalization of the economy, the network of the information, and the socialization of the citizens, there is the tendency that a country's domestic problems will be internationalized, while the international issues will be domestic. Combined with the background of China to realize the "China Dreams", in the field of the public diplomacy, we should pay sufficient attention to the "internalization" construction in the aspects of the value ideas, the mode of the systems, the political propositions, and the cultural influence and so on, which is the benign interaction involving the governments, the citizens and the social organizations. In this paper, the author casts a brick to attract jade. Through the discussion of the necessity of the "internalization" construction of the public diplomacy, the author carries out the discussion from the social and the cultural dimensions, in order to arouse the attention to the "internalization" construction of the public diplomacy, so that our country will be more influential in the politics, and more approachable in the images, and more appealing in the morality. 展开更多
关键词 Public diplomacy internalization construction Chinese characteristics
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Research for Competitiveness Enhancement Problem of Regional Industry Based on Brand Internalization Theory
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作者 Lihan Gu Huahua Li 《International English Education Research》 2014年第8期77-81,共5页
Along with the quick development of social economy, market competition has already entered into a new stage, namely brand competition era. This paper is to put forward scientifically rational countermeasures and sugge... Along with the quick development of social economy, market competition has already entered into a new stage, namely brand competition era. This paper is to put forward scientifically rational countermeasures and suggestions through taking brand internalization theory as basis and starting from regional industry competitiveness. Thus it would increase regional industry competitiveness of brand. 展开更多
关键词 BRAND brand internalization regional industry competitiveness.
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The role repositioning of teacher and student in the process of knowledge internalization under flipped classroom
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作者 Ling ZHANG 《International Journal of Technology Management》 2015年第6期18-20,共3页
Flipped classroom model led to the transformation of university teachers' teaching role. From the perspective of the sociology of knowledge, the teacher professional development is a process of transformation of the ... Flipped classroom model led to the transformation of university teachers' teaching role. From the perspective of the sociology of knowledge, the teacher professional development is a process of transformation of the role of teachers, and role transformation and the way of actors involved in the knowledge are associated. Participating in knowledge in different ways, role types are also different. Thus, changing the way ofparticipating in knowledge is the basic way to participate in the transformation of the role. Classification of roles is not the classification ofhumans.A social may might play many roles of many types in his life andmay have the function of a variety of roles at the same time. Meanwhile, it can be transferred between characters, especially in the case of depending on the same knowledge system.As long as the ways of involvement are different,the functions and types of roles are also different. University teachers are those who play a variety of roles of knowledge and society, some being the teaching teachers of organization and dissemination of knowledge, some being scientific and teaching teachers who focus on organizing and disseminating knowledge as well as knowledge creation, and knowledge creation and heavy teacher teaching and research, while others are knowledge creation based research teachers. In the field of the sociology of knowledge, university teachers should be scientific teaching roles depending on a deep knowledge and participating in knowledge in a variety of ways. From the perspective of the sociology of knowledge, according to Eph · Znaniecki' s role classification, university teachers participate in knowledge in three ways: teaching, learning and researching. Teaching, learning and researching are relative but different ways of participating in knowledge. State they are relative because itshows teaching can promote learning, learning can promote researching, researching can also promote learning and teaching. The homochromous interaction of teaching, leaming and researching, knowledge is in constant state of development and generation. 展开更多
关键词 flipping the classroom internalization of knowledge role positioning between teachers and students
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CREG inhibits VSMCs proliferation by modulating the internalization of IGFII
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作者 YAN Cheng-hui,HAN Ya-ling,TAO Jie,DENG Jie,LUAN Bo,WU Guang-zhe,ZHANG Xiao-lin (Department of Cardiology,Cardiovascular Institute of PLA, Shenyang Northern Hospital,Shenyang 310016,China) 《岭南心血管病杂志》 2011年第S1期194-195,共2页
Background To study the molecular mechanisms of CREG(the cellular repressor of E1A-stimulated gene) on proliferation of VSMCs in vitro.Methods The pRc/CMV-CREG plasmid or the pSM2-siCREG plasmid was transferred into h... Background To study the molecular mechanisms of CREG(the cellular repressor of E1A-stimulated gene) on proliferation of VSMCs in vitro.Methods The pRc/CMV-CREG plasmid or the pSM2-siCREG plasmid was transferred into human vascular smooth muscle cells(hVSMCs) to produce the cell clone that over-expression or down-expression of CREG respectively.BrdU assay and FACS cell cycle analysis were used to detect the proliferation of cells.Western blotting and immunocytochemistry show the expression and localization of IGF2R in hVSMCs.RT-PCR and ELISA assay determined the expression and secretion of IGFII factor. Alex488-labeled rhIGFII was used to investigate the endocysis of cells.And the blockade of IGFII internalization by treatment both the neutralized antibody of anti-IGF2R and rsIGF2R detected the effect of IGFII on VSMCs growth. Furthermore,Western blotting and signal pathway inhibitor were used to analysis the activation of PI3K/AKT and ERK on VSMCs proliferation.Results Western blotting identified that the expression of CREG in hVSMCs-CREG cells increased compared to control cell,and the decreased obviously in hVSMCs-siCREG cells.Meanwhile,the overexpression of CREG in cells was detected to inhibit the proliferation of VSMCs and to enhance the distribution of IGF2R in cellular membrane.Furthermore,overexpression of CREG also accelerated the endocysis of IGFII in hVSMCs-CREG,and attenuate the secretion of IGFII into cell medium by ELISA analysis and Alex488 labeled IGFII analysis.Blockade experiments both neutralized antibody of IGF2R and rhIGF2R fragment determined that enhancement of IGFII secretion promoted the VSMCs proliferation,and PI3K/AKT and ERK signal pathway mediated the effect of IGFII on VSMCs.Conclusions Altogether, these data indicate that CREG inhibits the proliferation of hVSMCs through interfering into the internalization pathway of IGF2R-IGFII. 展开更多
关键词 CREG inhibits VSMCs proliferation by modulating the internalization of IGFII
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Study on the Promoting Mechanism of Teachers'Ethics Internalization in Universities
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作者 Shan Chang 《Journal of Contemporary Educational Research》 2021年第3期82-86,共5页
On the basis of clarifying the teachers'Ethics internalization theory,this paper analyzes the typical dilemma in teachers'Ethics internalization.To resolve these problems,this paper construct an overall framew... On the basis of clarifying the teachers'Ethics internalization theory,this paper analyzes the typical dilemma in teachers'Ethics internalization.To resolve these problems,this paper construct an overall framework,including security mechanism,normative mechanism,education mechanism,evaluation mechanism and supervision mechanism,which the external conditions are used to constantly strengthen the moral needs of the subject,then enhance the consciousness of moral internalization,improve the effectiveness of teachers'moral construction. 展开更多
关键词 Teachers'ethics internalization Promoting mechanism External driving force Ethics standard
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Erratum to“Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer”
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作者 Yun Zhou Mian Yu +8 位作者 Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu 《Research》 SCIE EI CSCD 2024年第3期797-798,共2页
In the Research Article “Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer,” the authors made an error in Fig. 6A. In Fig. 6A, the image of “pre” in the... In the Research Article “Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer,” the authors made an error in Fig. 6A. In Fig. 6A, the image of “pre” in the “Free Cy5-siRNA” group was misused. When incorporating the final images in Fig. 6A, another image of “24 h” in the “Free Cy5-siRNA” group was inadvertently chosen as the “Pre” image, so they appear to be remarkably similar. After the error was discovered, the authors repeated the experiments that concluded that this error did not affect the results, discussion, or conclusion of this paper. Figure 6A has now been corrected in the PDF and HTML (full text). 展开更多
关键词 INTERNAL CANCER BREAST
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Mechanism of internal thermal runaway propagation in blade batteries 被引量:3
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作者 Xuning Feng Fangshu Zhang +3 位作者 Wensheng Huang Yong Peng Chengshan Xu Minggao Ouyang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期184-194,I0005,共12页
Blade batteries are extensively used in electric vehicles,but unavoidable thermal runaway is an inherent threat to their safe use.This study experimentally investigated the mechanism underlying thermal runaway propaga... Blade batteries are extensively used in electric vehicles,but unavoidable thermal runaway is an inherent threat to their safe use.This study experimentally investigated the mechanism underlying thermal runaway propagation within a blade battery by using a nail to trigger thermal runaway and thermocouples to track its propagation inside a cell.The results showed that the internal thermal runaway could propagate for up to 272 s,which is comparable to that of a traditional battery module.The velocity of the thermal runaway propagation fluctuated between 1 and 8 mm s^(-1),depending on both the electrolyte content and high-temperature gas diffusion.In the early stages of thermal runaway,the electrolyte participated in the reaction,which intensified the thermal runaway and accelerated its propagation.As the battery temperature increased,the electrolyte evaporated,which attenuated the acceleration effect.Gas diffusion affected thermal runaway propagation through both heat transfer and mass transfer.The experimental results indicated that gas diffusion accelerated the velocity of thermal runaway propagation by 36.84%.We used a 1D mathematical model and confirmed that convective heat transfer induced by gas diffusion increased the velocity of thermal runaway propagation by 5.46%-17.06%.Finally,the temperature rate curve was analyzed,and a three-stage mechanism for internal thermal runaway propagation was proposed.In Stage I,convective heat transfer from electrolyte evaporation locally increased the temperature to 100℃.In Stage II,solid heat transfer locally increases the temperature to trigger thermal runaway.In StageⅢ,thermal runaway sharply increases the local temperature.The proposed mechanism sheds light on the internal thermal runaway propagation of blade batteries and offers valuable insights into safety considerations for future design. 展开更多
关键词 Lithium-ion battery Blade battery Thermal runaway Internal thermal runaway propagation
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Endoscopic polidocanol foam sclerobanding for the treatment of grade Ⅱ-Ⅲ internal hemorrhoids:A prospective,multi-center,randomized study 被引量:3
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作者 Chun-Ying Qu Fei-Yu Zhang +10 位作者 Yi Zhang Ming-Ming Li Zheng-Hong Li Mei-Hong Cai Lei-Ming Xu Feng Shen Wen Wang Wu-Lian Lin Feng-Yu Gao Hao Zhang Guang-Yu Chen 《World Journal of Gastroenterology》 SCIE CAS 2024年第27期3326-3335,共10页
BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural pain.AIM To evaluate satisfaction,long-... BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural pain.AIM To evaluate satisfaction,long-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and ERBL.METHODS This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary hospitals and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL group.All patients were followed-up for 12 months.Symptom-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile range.RESULTS One hundred and ninety-five patients were enrolled,with 98 in the EFSB group.HSS was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12-month[2.0(1.0-3.0)vs 3.0(2.0-3.0),P<0.001]of follow-up.The prolapse recurrence rate was lower in the EFSB group at 12 months(11.2%vs 21.6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.843,95%CI:0.595-1.092,P<0.001)were negatively and independently associated with the VAS score 24 hours post-procedure.The median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),P<0.001].CONCLUSION Cap-assisted EFSB provided long-term satisfaction and effective relief from the recurrence of prolapse and pain 24 hours post-procedure. 展开更多
关键词 Internal hemorrhoids Endoscopic therapy Polidocanol foam SCLEROTHERAPY Rubber band ligation Sclerobanding
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Selective internal radiation therapy segmentectomy:A new minimally invasive curative option for primary liver malignancies? 被引量:2
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作者 Riccardo Inchingolo Francesco Cortese +5 位作者 Antonio Rosario Pisani Fabrizio Acquafredda Roberto Calbi Riccardo Memeo Fotis Anagnostopoulos Stavros Spiliopoulos 《World Journal of Gastroenterology》 SCIE CAS 2024年第18期2379-2386,共8页
Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial deliv... Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial delivery of radioactive microspheres directly into the tumor.Historically employed as a palliative measure for liver malignancies,SIRT has gained traction over the past decade as a potential curative option,mirroring the increasing role of radiation segmentectomy.The latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods,particularly well-suited for patients where surgical resection or ablation is not feasible.Radiation segmentectomy is a more selective approach,aiming to deliver high-dose radiation to one to three specific hepatic segments,while minimizing damage to surrounding healthy tissue.Future research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments. 展开更多
关键词 Transarterial radioembolization Selective internal radiation therapy Radiation segmentectomy Hepatocellular carcinoma Primary liver malignancies Personalised dosimetry
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Seeing beneath the surface:Harnessing point-of-care ultrasound for internal jugular vein evaluation 被引量:2
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作者 Vichayut Chayapinun Abhilash Koratala Taweevat Assavapokee 《World Journal of Cardiology》 2024年第2期73-79,共7页
Point-of-care ultrasound(POCUS)of the internal jugular vein(IJV)offers a noninvasive means of estimating right atrial pressure(RAP),especially in cases where the inferior vena cava is inaccessible or unreliable due to... Point-of-care ultrasound(POCUS)of the internal jugular vein(IJV)offers a noninvasive means of estimating right atrial pressure(RAP),especially in cases where the inferior vena cava is inaccessible or unreliable due to conditions such as liver disease or abdominal surgery.While many clinicians are familiar with visually assessing jugular venous pressure through the internal jugular vein,this method lacks sensitivity.The utilization of POCUS significantly enhances the visualization of the vein,leading to a more accurate identification.It has been demonstrated that combining IJV POCUS with physical examination enhances the specificity of RAP estimation.This review aims to provide a comprehensive summary of the various sonographic techniques available for estimating RAP from the internal jugular vein,drawing upon existing data. 展开更多
关键词 Point-of-care ultrasound Bedside ultrasound Internal jugular vein Right atrial pressure Central venous pressure
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Utilization of Basalt Saw Mud as a Spherical Porous Functional Aggregate for the Preparation of Ordinary Structure Concrete 被引量:1
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作者 周永祥 关青锋 +2 位作者 LENG Faguang WANG Jing LI Tianjun 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第2期364-375,共12页
To promote the production and application of artificial aggregates,save natural sand resources and protect the ecological environment,we evaluated the feasibility of using spherical porous functional aggregates(SPFAs)... To promote the production and application of artificial aggregates,save natural sand resources and protect the ecological environment,we evaluated the feasibility of using spherical porous functional aggregates(SPFAs) formed by basalt saw mud under autoclave curing in ordinary structural concrete.In our work,two types of prewetted functional aggregates were taken as replacements for natural aggregates with different volume substitution rates(0%,5%,10%,15%,20%,25%,and 30%) in the preparation of ordinary structural concrete with water-to-binder ratios(W/B) of 0.48 and 0.33.The effects of the functional aggregate properties and content,W/B,and curing age on the fluidity,density,mechanical properties and autogenous shrinkage of ordinary concrete were analyzed.The experimental results showed that the density of concrete declined at a rate of not more than 5%,and the 28 d compressive strength could reach 31.0-68.2 MPa.Low W/B,long curing age and high-quality functional aggregates were conducive to enhancing the mechanical properties of SPFAs concrete.Through the rolling effects,SPFAs can optimize the particle gradation of aggregate systems and improve the fluidity of concrete,and the water stored inside SPFAs provides an internal curing effect,which prolongs the cement hydration process and considerably reduces the autogenous shrinkage of concrete.SPFAs exhibits high strength and high density,as well as being more cost-effective and ecological,and is expected to be widely employed in ordinary structural concrete. 展开更多
关键词 lightweight concrete civil concrete building basalt saw mud fly ash internal curing environmentally friendly
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