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Ketone bodies and inflammation modulation:A mini-review on ketogenic diet’s potential mechanisms in mood disorders
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作者 YAN ZHENG SIHUI MA +2 位作者 KATSUHIKO SUZUKI HISANORI KATO HUIJUAN JIA 《BIOCELL》 SCIE 2023年第8期1897-1906,共10页
Mental disorders such as depression and anxiety inflict significant burdens on individuals and society.Commonly prescribed treatments often involve cognitive therapy and medications.However,for patients resistant to t... Mental disorders such as depression and anxiety inflict significant burdens on individuals and society.Commonly prescribed treatments often involve cognitive therapy and medications.However,for patients resistant to these conventional methods,alternative therapies like the Ketogenic Diet(KD)offer a promising avenue.KD and its key metabolite,β-hydroxybutyrate(BHB),have been hypothesized to alleviate mental disorders through antiinflammatory actions,a crucial pathway in the pathophysiology of depression.This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders.Both human and animal studies were scrutinized to elucidate possible cellular and molecular mechanisms.Out of the 15 trials,10 reported reduced levels of at least one inflammatory mediator or mRNA post KD or BHB treatment,while two observed an elevation in anti-inflammatory agents.These findings suggest that KD and BHB could modulate cellular inflammatory pathways,highlighting their potential for therapeutic application in mental disorders. 展开更多
关键词 ketone body Ketogenic diet DEPRESSION ANXIETY NEUROINFLAMMATION
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Copper-Catalyzed C-C(O)C Bond Cleavage of Monoalkylated β-Diketone: Synthesis of α,β-Unsaturated Ketones
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作者 Tony Wheellyam Pouambeka Victor N’goka +3 位作者 Narcisse Nicaise Obaya Guy Crépin Enoua Hubert Makomo Qian Zhan 《International Journal of Organic Chemistry》 2023年第2期41-49,共9页
A new and simple route for the synthesis of α,β-unsaturated ketones via cleavage of the C-C(O)C single bond of monoalkylated β-diketone has been described. The reaction was catalyzed by copper, a cheap transition m... A new and simple route for the synthesis of α,β-unsaturated ketones via cleavage of the C-C(O)C single bond of monoalkylated β-diketone has been described. The reaction was catalyzed by copper, a cheap transition metal in a weakly basic medium (K<sub>3</sub>PO<sub>4</sub>) at room temperature. To carry out this study, we first had to synthesize the monoalkylated β-diketones 1. Afterwards, α,β-unsaturated ketones 2 were obtained with high yields around 80%. Finally, all the products were characterized by 1H NMR, 13C NMR, and HRMS spectra. . 展开更多
关键词 Monoalkylated β-diketone α β-Unsaturated ketones COPPER-CATALYZED C-C(O)C Bond Cleavage
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Amine-functionalized metal organic framework@graphene oxide as filler in PAEK-containing carboxyl group membrane for ultrafiltration with ultra-high permeability and strong fouling resistance
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作者 Zhaoli Wang Wenjing Li +6 位作者 Yi Zhang Yanyin Cheng Junjian Yu Tianming Dong Xiaoyu Chi Di Liu Zhe Wang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第6期93-103,共11页
Achieving high fouling resistance and permeability using membrane separation technology in water treatment processes remains a challenge.In this work,a novel mixed-matrix membrane(MMM)(poly(arylene ether ketone)[PAEK]... Achieving high fouling resistance and permeability using membrane separation technology in water treatment processes remains a challenge.In this work,a novel mixed-matrix membrane(MMM)(poly(arylene ether ketone)[PAEK]-containing carboxyl groups[PAEK-COOH]/UiO-66-NH_(2)@graphene oxide[GO])with superb fouling resistance and high permeability was prepared by the nonsolvent-induced phase separation method,by in-situ growth of UiO-66-NH_(2) on the GO layer,and by preparing hydrophilic PAEK-COOH.On the basis of the structure and performance analysis of the MMM,the maximum water flux reached 591.25 L·m^(-2)·h^(-1) for PAEK-COOH/UiO-66-NH_(2)@GO,whereas the retention rate for bovine serum albumin increased from 85.40%to 94.87%.As the loading gradually increased,the hydrophilicity of the MMMs increased,significantly enhancing their fouling resistance.The strongest anti-fouling ability observed was 94.74%,which was 2.02 times greater than that of the pure membrane.At the same time,the MMMs contained internal amide and hydrogen bonds during the preparation process,forming a cross-linked structure,which further enhanced the mechanical strength and chemical stability.In summary,the MMMs with high retention rate,strong permeability,and anti-fouling ability were successfully prepared. 展开更多
关键词 Poly(arylene ether ketone)-containing Carboxyl groups(PAEK-COOH) UiO-66-NH_(2)@graphene oxide Hydrophilic modification Ultra-high selectivity Strong anti-fouling
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Critical approaches in the catalytic transformation of sugar isomerization and epimerization after Fischer-History,challenges,and prospects
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作者 Da-Ming Gao Xun Zhang +5 位作者 Haichao Liu Hidemi Fujino Tingzhou Lei Fuan Sun Jie Zhu Taoli Huhe 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第3期435-453,共19页
The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and... The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and the synthesis of drugs.Nowadays,high-fructose corn syrup(HFCS)is industrially produced in more than 10 million tons annually using immobilized glucose isomerase.Some low-calorie saccharides such as tagatose and psicose,which are becoming popular sweeteners,have also been produced on a pilot scale in order to replace sucrose and HFCS.However,current catalysts and catalytic processes are still difficult to utilize in biomass conversion and also have strong substrate dependence in producing high-value,rare sugars.Considering the specific reaction properties of saccharides and catalysts,since the pioneering discovery by Fischer,various catalysts and catalytic systems have been discovered or developed in attempts to extend the reaction pathways,improve the reaction efficiency,and to potentially produce commercial products.In this review,we trace the history of sugar isomerization/epimerization reactions and summarize the important breakthroughs for each reaction as well as the difficulties that remain unresolved to date. 展开更多
关键词 Rare sugars ISOMERIZATION KETONIZATION EPIMERIZATION Catalytic transformation
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Direct oxidation of the C_(sp3)-H bonds of N-heterocyclic compounds to give the corresponding ketones using a reusable heterogeneous MnO_x-N@C catalyst 被引量:2
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作者 任兰会 王连月 +2 位作者 吕迎 李国松 高爽 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第8期1216-1221,共6页
Novel reusable MnOx‐N@C catalyst has been developed for the direct oxidation of N‐heterocycles under solvent‐free conditions using TBHP as benign oxidant to give the corresponding N‐heterocyclic ketones. The catal... Novel reusable MnOx‐N@C catalyst has been developed for the direct oxidation of N‐heterocycles under solvent‐free conditions using TBHP as benign oxidant to give the corresponding N‐heterocyclic ketones. The catalytic system exhibited a broad substrate scope and excellent regi‐oselectivity, as well as being amenable to gram‐scale synthesis. This MnOx‐N@C catalyst also showed good reusability and was successfully recycled six times without any significant loss of activity. 展开更多
关键词 Oxidation Heterogeneous catalyst ketone C-H bond Manganese
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SYNTHESIS AND PROPERTIES OF NOVEL POLY(IMINO KETONE)S AS HIGH-PERFORMANCE POLYMERS 被引量:11
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作者 Chang, Guan-jun Luo, Xuan +1 位作者 Zhang, Lin Lin, Run-xiong 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2008年第1期55-61,共7页
Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation... Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation reaction.The structures of PIKs are characterized by means of elemental analysis,FT-IR,~1H-NMR and UV-Vis spectroscopy. The results show a good agreement with the proposed structure.The general properties of PIKs are studied by DSC,TG and wide-angle X-ray diffraction,the solubility behavior is... 展开更多
关键词 Di(4-bromophenyl)ketone Aromatic diamines Palladium-catalyzed aryl amination High-performance Poly(imino ketone
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Synthesis and characterization of quaternized poly(phthalazinone ether sulfone ketone)for anion-exchange membrane 被引量:9
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作者 Xi Gao Jian Chun Yan +3 位作者 Hua Min Zhang Shou Hai Zhang Cheng Liu Ping Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第10期1269-1272,共4页
Chloromethylated poly(phthalazinone ether sulfone ketone) (CMPPESK) was prepared from poly(phthalazinone ether sulfone ketone) (PPESK) using chloromethyl octyl ethers (CMOE) with lower toxicity as chlorometh... Chloromethylated poly(phthalazinone ether sulfone ketone) (CMPPESK) was prepared from poly(phthalazinone ether sulfone ketone) (PPESK) using chloromethyl octyl ethers (CMOE) with lower toxicity as chloromethylated regent. CMPPESK was soluble in N-methyl-2-pyrrolidone (NMP), N,N-dimethylacetamide (DMAc) and chloroform. Quaternized poly(phthalazinone ether sulfone ketone) (QAPPESK) was prepared from CMPPESK by quaternization. QAPPESK had excellent solvent resistance, which was only partly soluble in sulfuric acid (98%) and swollen in N,N-dimethylformamide (DMF). The vanadium redox flow battery (V-RFB) using QAPPESK anion-exchange membrane had better performance with 88.3% of overall energy efficiency. 展开更多
关键词 CHLOROMETHYLATION QUATERNIZATION Poly(phthalazinone ether sulfone ketone Anion-exchange membrane Vanadium redox flowbattery
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UV-induced Self-initiated Graft Polymerization of Acrylamide onto Poly(ether ether ketone) 被引量:6
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作者 CHEN Rui-chao, SUN Hui, LI Ang and XU Guo-zhi College of Materials Science and Mechanical Engineering, National Center for Quality Supervision and Test of Plastic Products, Beijing Technology and Business University, Beijing 100048, P. R. China 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第1期162-165,共4页
Photo-grafting of hydrophilic monomer was used to enhance the hydrophilicity of poly(ether ether ketone) (PEEK) with the aim of extending its applications to biological fields. PEEK sheets were surface modified by... Photo-grafting of hydrophilic monomer was used to enhance the hydrophilicity of poly(ether ether ketone) (PEEK) with the aim of extending its applications to biological fields. PEEK sheets were surface modified by grafting of acrylamide(AAm) with ultraviolet(UV) irradiation in the presence or absence of benzophenone(BP). The effects of BP, irradiation time and monomer concentration on the surface wettability of PEEK were investigated. Characteriza tion of modified PEEK using scanning electron microscopy(SEM), energy-disperse spectrometer(EDS) and water contact angle measurements shows that AAm was successfully grafted on PEEK surface both in presence and absence of BP. With the increase in irradiation time and monomer concentration, contact angles decrease to as low as 30°, demonstrating a significant improvement of surface hydrophilicity. In agreement with the decrease in contact angle, under identical conditions, the nitrogen concentration increases, suggesting the increase in grafting degree of the grafting polymerization. This investigation demonstrates a self-initiation of PEEK due to its BP-like structure in the backbone of the polymer. Though the graft polymerization proceeds more readily in the presence of BP, the self-initiated graft polymerization is clearly observed. 展开更多
关键词 Poly(ether ether ketone)(PEEK) UV-grafting Surface modification Self-initiation Graft polymerization
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CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction 被引量:10
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作者 Yan Dai Chun Xu Lü 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第1期31-34,共4页
Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has... Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure. 展开更多
关键词 Cerium trichloride heptahydrate Mannich reaction β-Amino ketones Lewis acid
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Proton-Exchange Sulfonated Poly (ether ether ketone) (SPEEK)/SiOx-S Composite Membranes in Direct Methanol Fuel Cells 被引量:6
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作者 高启君 王宇新 +2 位作者 许莉 卫国强 王志涛 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2009年第2期207-213,共7页
A sulfonated poly(ether ether ketone) (SPEEK) membrane with a fairly high degree of sulfonation (DS) can swell excessively and even dissolve at high temperature. To solve these problems, insolvable functionalize... A sulfonated poly(ether ether ketone) (SPEEK) membrane with a fairly high degree of sulfonation (DS) can swell excessively and even dissolve at high temperature. To solve these problems, insolvable functionalized silica powder with sulfonic acid groups (SiOx-S) was added into the SPEEK matrix (DS = 55.1%) to prepare SPEEK/ SiOx-S composite membranes. The decrease in both the swelling degree and the methanol permeability of the membranes was a dose-dependent result of addition of the SiOx-S powder. Pure SPEEK membrane swelled 52.6% at 80℃, whereas the SPEEK/SiOx-S (15%, by mass) membrane swelled only 27.3% at the same temperature. From room temperature to 80℃, all SPEEK/SPEEK/SiOx-S composite membranes had methanol permeability of about one order of magnitude lower than that ofNafion115. Compared with pure SPEEK membranes, the addition of the SiOx-S powder not only leads to higher proton conductivity, but also increases the dimensional stability at higher temperatures, and greater proton conductivity can be achieved at higher temperature. The SPEEK/SiO4-S (20%, by mass) membrane could withstand temperature up to 145℃, at which in 100% relative humidity (RH) its proton conductivity exceeded slightly that of Nafion 1 15 membrane and reached 0.17 S·cm^-1, while pure SPEEK membrane dissolved at 90℃. The SPEEK/SiOx-S composite membranes are promising for use in direct methanol fuel cells because of their good dimensional stability, high proton conductivity, and low methanol permeability. 展开更多
关键词 sulfonated poly(ether ether ketone functionalized silica composite membrane direct methanol fuel cell
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Synthesis and Crystal Structure of Lanthanum Nitrate with Methyl-2-pyridyl Ketone Benzoyl Hydrazone 被引量:5
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作者 TAIXi-shi YINXian-hong +2 位作者 LIUDe-bo TANMin-yu YUKai-bei 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2003年第4期434-436,共3页
A novel La complex with methyl-2-pyridyl ketone benzoyl hydrazone has been synthesized and determined by single crystal X-ray diffraction. The crystal is monoclinic with space group C2/c, a =1 7081(3) nm, b =1 ... A novel La complex with methyl-2-pyridyl ketone benzoyl hydrazone has been synthesized and determined by single crystal X-ray diffraction. The crystal is monoclinic with space group C2/c, a =1 7081(3) nm, b =1 5660(3) nm, c =1 3512(3) nm, α=90 00°, β=94 39(1)°, γ=90 00°, V =3 6037(12) nm 3, Z =4 . The complex is a ten-coordinated one with a lanthanum ion surrounded by a N 4O 6 set. The crystal structure is stabilized by hydrogen bonds between water molecules and NO - 3 anions. 展开更多
关键词 SYNTHESIS Lanthanum complex Methyl-2-pyridyl ketone benzoyl hydrazone Crystal structure
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A Study on Stoichiometry of Complexes of Tributyl Phosphate and Methyl Isobutyl Ketone with Lithium in the Presence of FeCl_3 被引量:4
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作者 周智勇 秦炜 +1 位作者 费维扬 李以圭 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2012年第1期36-39,共4页
To study the characteristic of liquid-liquid extraction equilibrium of lithium from brine sources, the complexes formed from tributyl phosphate (TBP) and methyl isobutyl ketone (MIBK) with lithium were investi- ga... To study the characteristic of liquid-liquid extraction equilibrium of lithium from brine sources, the complexes formed from tributyl phosphate (TBP) and methyl isobutyl ketone (MIBK) with lithium were investi- gated using FeCl3 as coextracting agent. Liquid-liquid extraction reaction mechanisms were proposed and the stoichiometry of tetrachloroferrate(III) complex with lithium was obtained by regressing the experimental data. It is found that the stoichiometry of tetrachloroferrate(III) to lithium in the complex is 1 : 1 with either TBP or MIBK as extractant in kerosene. The stoichiometry of the complex of TBP with Li was 1 : 1 and that of MIBK with Li was 2 : 1. The formed complexes of TBP and MIBK with lithium are determined to be LiFeCla-TBP and LiFeC14.2MIBK, respectively, according to the rule of neutralization. 展开更多
关键词 LITHIUM extraction reaction equations formation tributyl phosphate methyl isobutyl ketone KEROSENE
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Gallium trichloride-catalyzed conjugate addition of indole and pyrrole to α,β-unsaturated ketones in aqueous media 被引量:5
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作者 Rong Xu Jin Chang Ding +2 位作者 Xi An Chen Miao Chang Liu Hua Yue Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第6期676-679,共4页
Michael addition of indole and pyrrole to a variety of α, β-unsaturated ketones was efficiently promoted by a catalytic amount of GaCl3 in aqueous media to afford the corresponding products in good to excellent yields.
关键词 Gallium trichloride Michael addition INDOLE PYRROLE α β-Unsaturated ketones
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Ambient Ionic Liquids Used in the Reduction of Aldehydes and Ketones 被引量:3
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作者 DanQianXU ShuPingLUO BaoYouLIU ZhenYuanXU YinChuSHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第6期643-645,共3页
The sodium borohydride reduction of aldehydes and ketones to corresponding alcohols has been accomplished via the use of ionic liquids. The alcohols are easily obtained with excellent yields and the ionic liquid BMImB... The sodium borohydride reduction of aldehydes and ketones to corresponding alcohols has been accomplished via the use of ionic liquids. The alcohols are easily obtained with excellent yields and the ionic liquid BMImBF4 could be reused. 展开更多
关键词 Ionic liquids sodium borohydride REDUCTION ALDEHYDE ketone.
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Synthesis of Methyl Isopropyl Ketone and Diethyl Ketone over Ni-Na/ZrO_2-MnO_2-ZnO Catalyst 被引量:3
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作者 JI Yongjun YANG Jianguo 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2011年第4期656-660,共5页
ZrO2-MnO2-ZnO supports were prepared by the co-precipitation method,and then Ni-Na/ZrO2-MnO2-ZnO catalysts were prepared by the impregnation method.In this paper,the reactions to synthesize methyl isopropyl ketone and... ZrO2-MnO2-ZnO supports were prepared by the co-precipitation method,and then Ni-Na/ZrO2-MnO2-ZnO catalysts were prepared by the impregnation method.In this paper,the reactions to synthesize methyl isopropyl ketone and diethyl ketone by the one-step synthesis method over this catalyst were studied,and meanwhile,the impact of the catalyst preparation conditions and the reaction conditions on catalyst performance was also investigated.It was observed that under the conditions when Ni loading was 25%,calcination temperature was 400℃ and reduction temperature was 410℃,this catalyst had good catalytic performance on the reaction.The suitable reaction conditions were achieved:reaction temperature was 400℃;reaction at atmospheric pressure;liquid hourly space velocity of raw material of 0.5 h 1 ;and the molar ratio of(methanol)/(methyl ethyl ketone)/(water) was equal to 1/1/1.Under such conditions,the conversion of methyl ethyl ketone could achieve 41.7%,and the overall selectivity of methyl isopropyl ketone and diethyl ketone could achieve 83.3%,which was comparable to the conversion of 38.1% and the selectivity of 82.2% achieved by using palladium as the active material.The good stability made this catalyst have good prospects for industrial application. 展开更多
关键词 Ni-Na/ZrO2-MnO2-ZnO catalyst one-step synthesis methyl isopropyl ketone diethyl ketone
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Baeyer-Villiger oxidation of cyclic ketones utilizing potassium peroxydisulfate(K_2S_2O_8) or sodium perborate(NaBO_3) in acidic media 被引量:8
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作者 S.Zarrabi N.O.Mahmoodi +1 位作者 K.Tabatabaeian M.A.Zanjanchi 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第12期1400-1404,共5页
The efficient, green, facile, mild and straightforward conversion procedure for the oxidation of cyclic ketones to lactones at room temperature utilizing potassium peroxydisulfate (K2S2O8) in acidic media is satisfa... The efficient, green, facile, mild and straightforward conversion procedure for the oxidation of cyclic ketones to lactones at room temperature utilizing potassium peroxydisulfate (K2S2O8) in acidic media is satisfactory to high yields without using traditional chlorinated solvents is reported. This oxidative reagent is cheap and friendly environmental procedure for industrial purposes than use of organic peracids. 展开更多
关键词 Baeyer-Villiger oxidation Cyclic ketones Potassium peroxydisulfate (K2S208) Acidic media Sodium perborate (NaBO3)
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Synthesis and characterization of novel poly(aryl ether sulfone ketone)s containing phthalazinone and biphenyl moieties 被引量:3
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作者 Li Hong Xiao Cheng Liu Xi Gao Jian 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第2期227-229,共3页
A novel series of poly(aryl ether sulfone ketone)s (PPESKs) containing phthalazinone and biphenyl moieties were prepared by two-step nucleophilic polycondensation reaction. The ^-Mw values of these copolymers were... A novel series of poly(aryl ether sulfone ketone)s (PPESKs) containing phthalazinone and biphenyl moieties were prepared by two-step nucleophilic polycondensation reaction. The ^-Mw values of these copolymers were between 38,330 and 67,900. The glass transition temperatures (Tg) and 5% decomposition temperatures were ranged in 253-269 ℃ and 488-500 ℃, respectively, The structures of these copolymers were confirmed by FT-IR and ^1H NMR. Moreover, all the resultant copolymers were amorphous determined by wide angle X-ray diffraction (WAXD). 展开更多
关键词 Poly(aryl ether sulfone ketone PHTHALAZINONE BIPHENYL Thermal property Solubility
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Effects of ketogenic diet and ketone bodies on the cardiovascular system:Concentration matters 被引量:4
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作者 Souad Nasser Varvara Vialichka +2 位作者 Marta Biesiekierska Aneta Balcerczyk Luciano Pirola 《World Journal of Diabetes》 SCIE 2020年第12期584-595,共12页
Ketone bodies have emerged as central mediators of metabolic health,and multiple beneficial effects of a ketogenic diet,impacting metabolism,neuronal pathologies and,to a certain extent,tumorigenesis,have been reporte... Ketone bodies have emerged as central mediators of metabolic health,and multiple beneficial effects of a ketogenic diet,impacting metabolism,neuronal pathologies and,to a certain extent,tumorigenesis,have been reported both in animal models and clinical research.Ketone bodies,endogenously produced by the liver,act pleiotropically as metabolic intermediates,signaling molecules,and epigenetic modifiers.The endothelium and the vascular system are central regulators of the organism’s metabolic state and become dysfunctional in cardiovascular disease,atherosclerosis,and diabetic micro-and macrovascular complications.As physiological circulating ketone bodies can attain millimolar concentrations,the endothelium is the first-line cell lineage exposed to them.While in diabetic ketoacidosis high ketone body concentrations are detrimental to the vasculature,recent research revealed that ketone bodies in the low millimolar range may exert beneficial effects on endothelial cell(EC)functioning by modulating the EC inflammatory status,senescence,and metabolism.Here,we review the long-held evidence of detrimental cardiovascular effects of ketoacidosis as well as the more recent evidence for a positive impact of ketone bodies—at lower concentrations—on the ECs metabolism and vascular physiology and the subjacent cellular and molecular mechanisms.We also explore arising controversies in the field and discuss the importance of ketone body concentrations in relation to their effects.At low concentration,endogenously produced ketone bodies upon uptake of a ketogenic diet or supplemented ketone bodies(or their precursors)may prove beneficial to ameliorate endothelial function and,consequently,pathologies in which endothelial damage occurs. 展开更多
关键词 Endothelial cells ketone bodies Vascular physiology β-Hydroxybutyrate β-Hydroxybutyrylation Histone post-translational modifications
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Synthesis and Thermal Crosslinking Behavior of Poly(aryl ether ketone)s Containing 1,4-Naphthalene Moieties 被引量:3
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作者 NIUYa-ming ZHANGYun-he CHENXing-bo WANGGui-bin JIANGZhen-hua 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2005年第1期109-113,共5页
A new monomer, 1,4-bis(4-fluorobenzoyl) naphthalene(compound 2) was synthesized via a two-step reaction. 1,4-Naphthalenedicarboxylic acid chloride(compound 1) was prepared by using the acyl chlorization reaction of 1,... A new monomer, 1,4-bis(4-fluorobenzoyl) naphthalene(compound 2) was synthesized via a two-step reaction. 1,4-Naphthalenedicarboxylic acid chloride(compound 1) was prepared by using the acyl chlorization reaction of 1,4-naphthalenedicarboxylic acid with thionyl chloride. The Friedel-Crafts acylation of compound 1 with fluorobenzene afforded compound 2 in a 80% yield. The polycondensation of compound 2 with various bisphenols in tetramethylene sulfone(TMS) in the presence of excess potassium carbonate as a condensation reagent was carried out at 210 ℃ to quantitatively afford the corresponding poly(aryl ether ketone)s(compounds 3_8) containing 1,4-naphthalene moieties. Thermal analyses showed that the polymers have T g values ranging from 496 to 500 K and are thermally stable in air with initial mass loss above 500 ℃. These novel polymers exhibited an excellent solubility in organic solvents including NMP, DMAc, and chloroform, etc. In addition, the glass transition temperatures of these polymers increased and the polymers became insoluble in chloroform after treated at 260 ℃, indicating the occurrence of a thermal crosslinking reaction. 展开更多
关键词 Poly(aryl ether ketone) Naphthalene derivatives Friedel-Crafts acylation Thermal crosslinking properties
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Novel Chiral PNNP-Ru Complexes:Synthesis and Application in Asymmetric Transfer Hydrogenation of Ketones 被引量:3
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作者 CHENG Zhi-box YU Shen-luan +4 位作者 LI Yan-yun DONG Zhen-rong SUN Guo-song HUANG Ke-lin GAO Jing-xing 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第2期170-173,共4页
The efficient catalytic systems generated in situ from RuCl2(PPh3)3 and chiral ligands N,N-bis[2-(di-o-tolylphosphino)-benzyl]cyclohexane-1,2-diamine(2) were employed for asymmetric transfer hydrogenation of aro... The efficient catalytic systems generated in situ from RuCl2(PPh3)3 and chiral ligands N,N-bis[2-(di-o-tolylphosphino)-benzyl]cyclohexane-1,2-diamine(2) were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities(up to 99% conversion) and excellent enantioselectivities(up to 96% e.e.) under mild conditions. The chiral ruthenium(Ⅱ) complex (R,R)-3 has been prepared and characterized by NMR and X-ray crystallography. 展开更多
关键词 Chiral PNNP ligand Ru complex Asymmetric transfer hydrogenation Aromatic ketone
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