应用SF-36量表分析高血压患者生命质量(QOL)的影响因素

目的分析高血压患者生命质量(quality of life,QOL)的影响因素。方法应用SF-36量表(中文版)调查213例原发性高血压患者的QOL情况,以单因素方差分析、多元逐步线性回归对12种因素进行分析,寻找主要影响因素。结果年龄、居住地区、婚姻状况、在岗情况、血压控制情况、心功能、心血管系统合并症及家庭人均月收入对患者QOL总得分有显著影响。多元逐步线性回归分析显示,年龄、血压控制情况、心功能、心血管系统合并症及家庭人均月收入是主要影响因素,偏回归系数分别为-4.266、86.237、-48.048、-45.071和36.011。结论关注老龄及低收入高血压患者,积极控制血压、改善心功能、治疗心血管系统合并症对提高患者QOL有重要意义。

PC-QoL问卷评价中药联合耳穴治疗对1~6岁慢性咳嗽患儿生活质量的影响

目的应用父母代理咳嗽特异性生活质量问卷(PC-QoL)评价中药联合耳穴贴压对1~6岁慢性咳嗽患儿生活质量的影响。方法纳入2017年8月—2018年9月在上海中医药大学附属龙华医院、上海市奉贤区中医医院、上海市嘉定区中医医院、上海市第七人民医院、上海市浦东新区中医医院儿科门诊就诊的1~6岁慢性咳嗽患儿226例,随机分为单纯中药组和中药+耳穴组,每组113例。单纯中药组给予小儿久咳方加减治疗2周,痰湿恋肺证(湿咳)加半夏3 g、陈皮3 g、胆南星3 g;风邪伤肺证(干咳)加僵蚕5 g、射干3 g、木蝴蝶1.5 g。中药+耳穴组中药治疗同单纯中药组,同时给予耳穴贴压2周(选择肺、气管、神门穴,湿咳加脾穴,干咳加肝穴,单侧贴压,每周换药1次,贴压对侧耳穴)。制定PC-QoL问卷,并进行信度和效度检测;采用PC-QoL问卷评价治疗前后患儿生活质量。结果PC-QoL问卷的各项评分Cranbach’sα均>0.8,KMO均>0.8,有较好的信度和效度。不同病因患儿生理、心理、社会评分及总分比较差异均有统计学意义(P均<0.05),抽动症咳嗽、咳嗽变异性哮喘、上气道咳嗽综合征、过敏性咳嗽、感染后咳嗽患儿生活质量依次递增。湿咳和干咳患儿生理、心理、社会评分及总分比较差异均无统计学意义(P均>0.05)。2组患儿治疗后生理、心理、社会评分及总分均明显增高(P均<0.05),且中药+耳穴组生理、心理评分及总分均明显高于单纯中药组(P均<0.05)。结论中药联合耳穴贴压治疗可明显改善1~6岁慢性咳嗽患儿的生活质量,PC-QoL问卷可作为评价1~6岁慢性咳嗽患儿生活质量的有效工具。

应用UW-QOL评价口腔鳞癌患者的生存质量

目的:应用UW-QOL第4版评价口腔鳞癌患者的生存质量(quality of life,QOL)。方法:采用直接翻译并经过适当修改的UW-QOL第4版,对97例确诊为口腔鳞癌的连续患者的术前QOL进行测量,术后3个月对其中55例患者的QOL作重复测量。采用SPSS12.0软件包分析量表的信度、效度和反应度。结果:量表总的克朗巴赫系数和分半信度分别为0.725和0.701;12个条目可提取4个因子,累计方差贡献率为65.4%;以SF-36中文版和FACT-H&N的头颈特异性子量表FACT-HN为效标,其效标效度分别为0.543和0.738;量表能敏感地区分已知的2组口腔癌患者术前QOL的差异及口腔癌患者QOL随时间的变化。结论:UW-QOL第4版具有良好的信度和反应度,其测定结构呈多维性,可用于中国人口腔癌患者生存质量的测量。

通噎汤联合TP方案对晚期食管癌QOL KPS及近期疗效的影响

目的:观察通噎汤联合TP方案对晚期食管癌患者QOL、KPS及近期疗效的影响。方法:将食管癌患者60例随机均分为治疗组和对照组,治疗组给予中药通噎汤(每日1剂)联合TP方案化疗;对照组只给予TP方案化疗,每3周为1周期,共治疗2个周期;观察治疗前、第1周期后、第2周期后两组患者的安全性指标、一般状况、症状体征、生活质量及SCT的疗效评价等。结果:两组患者治疗后,一般状况、症状体征及生活质量均较治疗前改善(P<0.05或0.01),且治疗组优于对照组(P<0.01)。治疗组治疗2疗程后的总有效率高于对照组(P<0.05)。结论:通噎汤联合TP方案能明显改善晚期食管癌患者的一般状况和症状体征、提高患者的生活质量,减轻患者的临床症状。

PRO与QOL评价信息资源与服务平台构建

通过对生存质量(QOL)与患者报告结局指标(PRO)测量研究现状进行分析,提出构建PRO与QOL评价信息资源与服务平台的必要性,详细阐述构建平台的技术方案、功能实现、运行机制及该平台对人群健康促进和临床治疗实践的重要意义。

采用SS-QOL测量中国急性缺血性脑卒中患者生存质量和BI结果值的相关性研究

目的运用SS-QOL量表随机测量220例急性缺血性脑卒中患者就诊第0天、出院、第90天的生活质量,并与患者的BI评分进行相关性研究。方法通过SS-QOL量表获得急性缺血性脑卒中患者健康相关生存质量,并与BI指数进行同期的线性回归模型拟合研究,判断两者的相关性。结果 SS-QOL和BI评分对患者3个阶段生存质量的表达趋势一致,无控制变量和有控制变量的相关性分析均显示两者的相关系数较高(>0.500,P=0.000),且相关性的稳定性也较好。结论 SS-QOL和BI的相关性较好,SS-QOL量表对生存质量的测量能够反映患者的健康状况,也适宜做进一步的成本-效用分析。

QOL Scale-AMILY在喉癌患者照顾者生活质量评价中的应用

目的探讨由美国国家医学中心和贝克曼研究所研制的癌症患者照顾者生活质量量表(Quality of LifeFamily Version,QOLScale-FAMILY)用于中国喉癌患者照顾者生活质量测量的可能性,为喉癌患者照顾者生活质量的评定提供一个量化工具。方法通过对QOLScale-FAMILY量表的翻译、回译、文化调试制定出中文版的QOL Scale-FAMILY量表,并采用信访、电话访谈、面对面问卷访谈的方法,对100例喉癌患者照顾者(主要是患者配偶和子女)的生活质量进行测定,考核QOL Scale-FAMILY的可行性以及信度与效度。结果中文版的QOL Scale-FAMILY具有良好的内部一致性,总量表的Cronbach′sα系数为0.794,除了精神健康维度α=0.649外,其他3个维度满足群组比较的要求;重测信度γ=0.841。因子分析产生的4个公共因子与理论结构基本一致,结构效度的累积方差贡献率为60.2%。结论QOLScale-FAMILY中文版具有较好的信度和效度,对部分条目进行调整后,可以应用于喉癌患者照顾者生活质量的测定。

微血管减压术治疗原发性三叉神经痛效果及对患者QOL评分的影响

目的探究微血管减压术(MVD)对原发性三叉神经痛(PTN)患者的效果及对患者生命质量(QOL)评分的影响。方法抽取接受治疗的原发性三叉神经痛患者62例进行对比研究,依据治疗方案的不同,将31例采用苯妥英钠治疗方案患者作为对照组,另外31例采用MVD治疗作为观察组,对不同治疗方案临床疗效进行观察。结果观察组31例患者均达到有效及以上效果,总有效率为100. 00%;对照组31例患者中有4例患者治疗效果不理想,总有效率为87. 10%;观察组31例患者QOL评分处于良好比例为80. 65%,明显大于对照组64. 29%,组间比较差异有统计学意义(P <0. 05);观察组QOL评分极差比例为0,明显低于对照组的12. 90%;观察组31例患者仅有1例出现头晕情况,不良反应发生率为3. 23%,并未有患者复发;对照组31例患者中有6例出现头晕恶心、肌张力不全、失眠等情况,不良反应发生率为19. 35%,复发率为9. 68%,2组对比差异有统计学意义(P <0. 05)。结论 PTN是一种以阵发性剧烈疼痛为主要临床表现的脑神经疾病,现代临床中针对此病症可采用药物治疗与外科手术治疗方案。研究结果证实,PTN采用微血管减压术进行治疗,更有助于提升整体治疗效果,同时治疗后患者生命质量评分较高,且与药物治疗进行对比其不良反应发生率与复发率相对较低,安全性较高。

EORTC QOL-C30中文版量表对胃癌患者护理前、后生存质量的评定

目的采用癌症患者生存质量测定量表(EORTC QOL-C30)中文版量表探讨综合护理干预联合常规护理在胃癌患者中的护理效果及对生存质量的影响.方法取2014-10/2016-12医院收治胃癌患者60例,随机数字法分为对照组(n=30)和观察组(n=30).对照组采用常规护理,观察组在对照组基础上联合综合护理干预,采用EORTC QOL-C30中文版量表对护理前、后生存质量进行评定,比较2组护理效果及对生存质量的影响.结果观察组护理后抑郁自评量表及焦虑自评量表评分,低于对照组(P<0.05);观察组护理后躯体功能、情绪功能、认知功能、角色功能及社会功能评分,高于对照组(P<0.05).观察组护理后1年、3年及5年生存率,高于对照组(P<0.05).结论胃癌患者治疗过程中在常规护理基础上联合综合护理干预效果理想,有助于提高生存质量,值得推广应用.

SF-36中文版和Haemo-QoL-A中文版在单中心血友病患者中的信效度测评及应用

目的应用SF-36(中文版)和Haem-QoL-A(中文版)评估其在单中心血友病患者中的信效度和生活质量。方法对原始问卷进行翻译、回译、校对后形成最终的Haem-QoL-A中文版。SF-36中文版采用标准版。两问卷通过信函在2011年8至12月间向南京鼓楼医院血友病登记中心登记的血友病患者邮寄并回收。采用SPSS 17.0软件对问卷进行信效度分析。结果两问卷内部一致性显示Cronbach’sα>0.7;重测信度显示组内相关系数ICC>0.8;分半信度显示Pearson相关系数>0.80。内容效度显示Haem-QoL-A中文版的各项Pearson相关系数均大于0.5,而SF-36中文版则除维度VT及部分条目外各项Pearson相关系数均大于0.5。结构效度显示两问卷各维度间相关系数小于各维度与总量表间的相关系数。Haem-QoL-A中文版与SF-36中文版相关系数为-0.799。69例血友病患者SF-36中文版问卷与我国常模及英国重型血友病患者相比在许多维度均存在显著差异。结论 Haem-QoL-A中文版和SF-36中文版信效度较好,可用以评估血友病患者生活质量;本中心血友病患者生活质量有待改善。

中药制剂对慢性盆腔炎的治疗效果及其对QOL评分的影响

目的探讨中药制剂对慢性盆腔炎的治疗效果及其对生活质量(QOL)评分的影响。方法选取2019年1月至2020年5月,在湖州师范大学附属中心医院确诊并接受治疗的慢性盆腔炎患者96例作为研究对象,随机分为研究组(48例)和对照组(48例),对照组采用康妇消炎栓治疗,研究组使用紫英抗炎合剂进行治疗。收集并对比两组治疗前后的体征总积分、症状总积分、治疗有效率及QOL评分的差异情况。结果治疗前,两组患者的体征总积分、症状总积分及QOL评分无显著统计学差异(均P>0.05)。治疗后,研究组的体征总积分及症状总积分均显著低于对照组(t值分别为14.584、16.225,均P<0.05)。研究组的治愈率、显效率及有效率分别为27.1%、39.6%、31.3%,总有效率显著高于对照组(97.9%vs.83.3%,χ^(2)=6.162,P<0.05)。此外,治疗2疗程及3疗程后,研究组的QOL评分均显著高于对照组(t值分别为19.547、17.002,均P<0.05)。结论采用中药制剂治疗慢性盆腔炎可显著提高治疗有效率,改善患者的症状和体征,提高生活质量。紫英抗炎合剂可作为盆腔炎患者治疗用药的选择之一。

Quality of Life in Cancer Patients with Pain in Beijing

Objective： To investigate the quality of life （QOL） of cancer pain patients in Beijing, and explore the effect of cancer pain control on patients＇ QOL. Methods： Self-developed demographic questionnaire, numeric rating scale and SF-36 questionnaire were used together among 643 cancer pain patients in 28 Grade 2nd to 3rd general hospitals and 2 Grade 3rd cancer hospitals. Results： The SF-36 eight dimensions scores ranged from 31.75 to 57.22 in these cancer pain patients. The t test and Wilcoxon rank sum test were used to compare the QOL between pain controlled （PC） group and pain uncontrolled （PUC） group, and the results showed that patients in PC group had the higher O, OL scores in 6 areas of SF-36 （P〈0.05）. Binary logistic regression results found that pain management satisfaction scores （P〈0.001）, family average personal monthly income （P=0.029）, current receiving chemotherapy （P=0.009） and cancer stage （P〈0.001） were the predictors to cancer pain controlled results. Conclusion： Cancer patients with pain in Beijing had poor QOL. Pain control will improve the QOL of cancer pain patients.

The impact of hearing impairment and noise-induced hearing injury on quality of life in the active-duty military population:challenges to the study of this issue

The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among U.S.active-duty service members,2)describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life,3)examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members,and 4)provide recommendations for future studies that seek to quantify the impact of hearing loss in this population.There is a lack of literature that addresses the intersection of hearing impairment,the military population,and quality of life measures.For audiological research,U.S.military personnel offer a unique research population,as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these conditions.This review recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.

Correlations between the Profile of Mood States (POMS) and the WHOQOL-26 among Japanese University Students

In this study, we investigated six types of mood state (tension-anxiety, depression-dejection, anger-hostility, vigor, fatigue, and confusion) using the Profile of Mood States (POMS) with 40 Japanese university students. We examined five main quality of life (QOL) domains (physical health, psychological health, social relationships, and environmental health) using the World Health Organization Quality of Life Scale (WHOQOL-26). We also examined the total scale score. We examined Spearman’s rank correlations between POMS mood state and QOL scores and compared male and female students’ scores. The results indicated statistically significant correlations between all six mood states and three broad WHOQOL-26 domains (physical health, psychological health, and social relationships). Moreover, the relationship between mood state and QOL showed a gender difference. There were correlations between mood states and the QOL domains of social relationships and environmental health for males. In contrast, mood state correlated with the QOL domains of physical health and psychological health in females. The findings suggest that gender-specific health provision is needed to care for young university students in Japan. However, our study has several limitations;therefore, larger-scale studies with older subjects are needed in the future.

The Influence of Pain: Quality of Life after <i>Pectus excavatum</i>Correction

Introduction: The main indication for surgery of thoracic wall deformities (TWD) is psychological due to cosmetic complaints. The assumption is that appearances have a negative effect on?self-esteem and quality of life?(QoL). Correction should result in improvement. Methods: Prospective trial. QoL was assessed using the?CHQ and the WHOQOL-bref. Measurements were taken before surgery (T1) and 6 weeks thereafter (T2). Results: Forty-two patients were included.?WHOQOL-bref showed differences between pre-operative and?six weeks past surgery on facet body image (p = 0.003).?Self-esteem (CHQ) did not show a significant improvement at T2.?Concerning the scores on the single step questionnaire (SSQ),?33 patients were “very” to “extremely satisfied” with appearance and increased self-esteem (p < 0.001). Concerning the domain “pain and physical complaints”, CHQ did show a significant change (p < 0.001) with more complaints at T2. Conclusion: Six weeks after surgical correction of a TWD satisfaction with the “new” chest is good;pain seems to be a problem with possible negative influence on self-esteem.

Quality of life of parents and siblings of children with cochlear implants

Objectives: This study examined the quality of life(QoL) of the parents and siblings of hearing-impaired children with cochlear implants(CIs).Design: This is a cross-sectional, questionnaire-based study. The questionnaire consists of three sub-domains-interaction, emotional well-being and support for the hearing-impaired child and the overall QoL – and two open-ended questions for participants to provide comments and suggestions to enhance their family's QoL. A total of 63 questionnaires were e-mailed or mailed to families who met the inclusion criteria.Setting: The study was conducted under the Center for Rehabilitation & Special Needs, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur.Participants: A total of 79 parents and 23 siblings from 44 families of children with CI participated in this study.Main outcome measures: The mean score for each of the sub-domain and the overall QoL for both subject groups were computed. The answers for the open-ended questions were listed and organized into themes.Results: There were significant correlations between the overall QoL score and each of the test domains for the parents' group(p < 0.01). For the siblings' group, only the interaction and support domains were significant.Interaction was the main sub-domain affecting the parents' QoL but for siblings, this could not be determined. A total of 60% of the pooled comments were classified as ‘concerns'. As for the suggestions, 38.7% requested some form of support, mainly financial(41.7%).Conclusions: Families with hearing impaired children with CI have numerous concerns that need to be addressed, even though, on average, they were satisfied with their overall QoL.

Evaluating the around and after Menopausal Symptoms and Personal Perception of Quality of Life among Women in Qatif, Saudi Arabia, Attending the Hospital and PHCs

Background: Menopause is a period where natural cessation of menses occurs, some quality of life characteristics changes with some symptoms associated with this time such as hot flushes and anxiety. Objective: To evaluate and specify the level of impact of these symptoms on the quality of life among women in the Qatif area, Saudi Arabia and to study the factors that may involve in their perception. Methods: A cross-sectional study was conducted of 151 women aged 40 - 60 years old interviewed at either hospital or PHCs, a translated and revised questionnaire of other studies with some adoption. Results: 151 women out of 200 participated in questionnaires, majority of them were highly educated having at least a bachelor’s degree around 80%, and around 75% of participants were either working or retired, with a moderate level of income and enjoying a good lifestyle 93% in around and 97% in the after menopause. With the majority, were not used hormones 95% or conceptive pills 91%, personal perception of health were high around 93% for around and 97.2% for after menopause with no significant statistical difference between the two groups. Conclusion: Perception and knowledge of menopause were very high, with no differences in the severity of symptoms of the four QOL domains for the around or after menopause among the participants. High level of education and increased level of income and knowledge of the participants may play an important role in the result, so further investigation is advised.

Health-Related Quality of Life in HIV-positive Women on Long-Term Antiretroviral Therapy—A Study from Bangalore, South India

Introduction: Lifelong Anti-Retroviral Therapy (ART) promotes good quality of life and health among HIV-positive men and women. However, simplified newer and effective ART has not increased retention in care, or long-term ART adherence, especially among women. There are many factors that impede long-term adherence in women. This includes among other things female gender, depression, greater than once-daily dosing, longer time since HIV diagnosis, and patient beliefs. This study measures the quality of life in women whose ART durations range from one to fifteen years, using the standardized WHO Quality of Life questionnaire. Material and Methods: One hundred and fourteen women were divided into three groups based on ART duration. Group 1 had 37 women on ART for less than five years, Group 2 had 48 women on ART from 5 to 10 years and Group 3 had 29 women on ART for more than ten years. They were administered the WHO Quality of Life (QOL) questionnaire, which assesses QOL in six domains. QOL was considered poor in scores between 4 - 9.9, medium in scores of 10 - 14.9 and good in scores of 15 - 20. Results: Scores in all 3 groups were more than 85% in five domains and around 74.5% in the psychological domain. Domain mean scores were Physical 18 (CI 17.63 - 18.37), Psychological 14.9 (CI 14.55 - 15.25), Independence 18.6 (CI 18.33 - 18.87), Social relationships 17.5 (CI 17.07 - 17.93), Environmental 17.6 (CI 17.25 - 17.95), Spiritual, Religious, Personal beliefs, 17.4 (CI 16.93 - 17.87). Scores for women on long-term ART (Group 3) are not different from the other 2 groups and the p-values were not statistically significant. Conclusion: Women on long-term ART fare extremely well compared to other groups with more than 93% showing good QOL and none showing poor Quality of Health in spite of being on ART for a longer period of time than the other two groups. Despite a multitude of impeding factors, women who continue ART faithfully and consistently enjoy a good quality of health and life. Adequate preparation and a supportive health system are essential for ensuring long-term adherence, but the attitude and commitment of women are also critical.

Deciphering the Quality of Life among Tuberculosis Patients under RNTCP in Karnataka, India

Background: The Tuberculosis (TB) disease has immense impact on physical, psychological, economic and social well-being of an individual. It is desired that the patient with any kind of TB disease should lead a respectable and happier life during their course of TB treatment. Currently, the quality of life (QOL) is an important indicator to assess the well-being of a person and there is paucity of such information among TB patients. Hence, we conducted to assess and compare the QOL of Revised National TB Control Programme registered Drug sensitive TB patients, Drug resistant TB patients and general population of Gadag district in Karnataka, India. Methods: A cross-sectional study was conducted in Gadag district, Karnataka from March 2017 through March 2018 among drug sensitive, drug resistant TB patients and general population. A Non-probability purposive sampling was adopted to select the samples that were matched for age, gender and ward. The select patients were administered WHO QOL-BREF questionnaire by trained personnel. Data were analyzed using SPSS version 12 analysis software. Results: The scores obtained for the four domains of QOL were (a) physical health: 69.62 + 18.29 (b) Psychological: 66.96 + 18.62 (c) Environment: 60.99 + 15.05 and (d) Social relationships: 53.5 + 19.93. Conclusions: The drug resistant TB patients have poor QOL when compared to drug sensitive and general population.

Prognostic Potential of B - type Natriuetic Peptide and Quality of Life in Patients with Chronic Heart Failure

Objectives To study wheth- er change of BNP levels reflect the change of cardiac function and to investigate the short - term prognostic potential of BNP and QOL in patients with CHF. Methods 96 consecutive patients admittedwith CHF between September 2002 and January 2003 were stud- ied , upon entry the study, BNP levels were measured, Patients administered the disease - specificquality of life questionnaire Minnesota living with heart failure questionnaire (LiHFe) within 1 day. BNP levels and administering LiHFe were repeated three months later. Results BNP levels were increased proportional to the severity of cardiac function. Physical domain and total score of LiHFe were significantly correlated to the severity of CHF ( p < 0. 05 ). BNP levels were de- creased in improving group(p =0. 032) . In deteriora- ting group BNP levels increased (P = 0. 043 ) . Kaplan - meier analysis according to BNP level cutoff point 150 ng/1, the life curve of higher BNP level group was significantly lower than the lower group ( p = 0. 001 ) . In univariate logistic regression, NYHA class, BNP, LVEF, LVEDD, heart size, total score of LiHFe, phys- ical domain of LiHFe and the emotional domain of LiH- Fe were all significant prognostic factors of CHF ( p < 0. 05 for all). While in multiple regression, only BNP level( p = 0. 036) and the emotional domain of LiHFe ( p = 0. 025 ) were independent prognostic factors. Conclusions Change of BNP reflects the treatment efficacy of CHF. BNP and QOL are the two major short - time prognostic factors of the chronic heart failure patients.