Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal cancer.Nevertheless,LCE is not suitable for general population screening given its side effects.Linked color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal color.AIM To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions.METHODS In this prospective study,we enrolled 543 patients who underwent white light imaging(WLI),LCI and LCE successively.We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions.Clinicopathological features and color analysis of lesions were assessed.RESULTS In total,43 patients(45 neoplastic lesions)were analyzed.Among them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with LCE.The sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,P<0.001].The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI.However,the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer.CONCLUSION LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions,and LCI represents a promising screening strategy for general populations.

Clinical usefulness of linked color imaging in identifying Helicobacter pylori infection:A systematic review and meta-analysis

BACKGROUND Accurate diagnosis of Helicobacter pylori(H.pylori)infection status is a crucial premise for eradication therapy,as well as evaluation of risk for gastric cancer.Recent progress on imaging enhancement endoscopy(IEE)made it possible to not only detect precancerous lesions and early gastrointestinal cancers but also to predict H.pylori infection in real time.As a novel IEE modality,linked color imaging(LCI)has exhibited its value on diagnosis of lesions of gastric mucosa through emphasizing minor differences of color tone.AIM To compare the efficacy of LCI for H.pylori active infection vs conventional white light imaging(WLI).METHODS PubMed,Embase,Embase and Cochrane Library were searched up to the end of April 11,2022.The random-effects model was adopted to calculate the diagnostic efficacy of LCI and WLI.The calculation of sensitivity,specificity,and likelihood ratios were performed;symmetric receiver operator characteristic(SROC)curves and the areas under the SROC curves were computed.Quality of the included studies was chosen to assess using the quality assessment of diagnostic accuracy studies-2 tool.RESULTS Seven original studies were included in this study.The pooled sensitivity,specificity,positive likelihood rate,and negative likelihood rate of LCI for the diagnosis of H.pylori infection of gastric mucosa were 0.85[95%confidence interval(CI):0.76-0.92],0.82(95%CI:0.78-0.85),4.71(95%CI:3.7-5.9),and 0.18(95%CI:0.10-0.31)respectively,with diagnostic odds ratio=26(95%CI:13-52),SROC=0.87(95%CI:0.84-0.90),which showed superiority of diagnostic efficacy compared to WLI.CONCLUSION Our results showed LCI can improve efficacy of diagnosis on H.pylori infection,which represents a useful endoscopic evaluation modality for clinical practice.

Self-Cross-Linked Tannin-Aminated Tannin Surface Coatings for Particleboard

Aminated tannins were prepared by reacting mimosa condensed tannin extract with ammonia yielding the substitution of many,if not all of the tannin hydroxyl groups with–NH_(2)groups.A tannin-aminated tannin(ATT)particleboard coating was then prepared by reacting raw tannin extract with aminated tannin extract and thus cross-linking the two by substituting tannin’s hydroxyl groups with the–NH_(2)groups on the aminated tannin to form–NH-bridges between the two.The resulting particleboard coating gave encouraging results when pressed at 180℃for 3 min.Conversely,the system in which tannin was reacted/cross-liked with urea(ATU)by a similar amination reaction did not perform as well as the ATT system,and this even when a higher curing temperature and longer hot press time were used.In particular its water repellence was worse probably due to the presence of urea and such a system with lower reactivity.Nonetheless,substituting the tannin–OHs with the urea–NH_(2)groups appeared to also take place.ATT gave better results than ATU as regards water repellence and mechanical resistance as shown by the cross cut test.The ATT system was shown to be between 95%and 98%biosourced.The difference appeared to be due,by TMA analysis,to the much faster formation of the ATT hardened network leading to a better cross-linked polymer coating.The chemical species formed for both the ATT and ATU system were studied by MALDI ToF and CP MAS^(13)C NMR.

基于BIM和Linked Data的建筑业电子商务信息融合框架

建筑业电子商务平台信息存在海量、异构和分散等问题,影响了建筑业电子商务的发展。在分析现有电子商务平台信息特征,以及研究BIM和Linked Data技术在信息集成方面应用的基础上,提出一种基于BIM和Linked Data的建筑业电子商务信息融合框架。该框架以BIM作为商品信息模型;使用Linked Data将供应商信息、客户信息、配送信息、交易信息、采购合同信息关联到商品信息BIM模型中,形成融合的信息环境,为实现建筑业电子商务信息融合提供了一种有效的解决思路。

基于Linked Data技术的公安监控系统技术研究

信息化对传统的公安系统情报系统提出了前所未有的挑战,公安系统信息化是公安情报系统升级改造的重要工作。警用语义网情报系统对公安的情报信息的提取和共享等方面有很好的支持。运用基于Linked Data技术的语义网,对公安的重点人员监控系统进行研究分析,提出监控系统的工作流程。

基于Geo Linked Data的地理框架数据描述与发布

随着Web化地理信息共享平台成为GIS领域信息服务的主流形式，对来自不同数据源的地理信息进行深层共享与集成已经成为一个重要的问题。地理语义网技术通过结构化数据描述及发布技术，为异构地理空间数据提供了一种语义集成的方式。本文通过介绍基础地理框架数据的GeoLinkedData化过程．描述了整个发布及应用过程的相关流程和技术。

Linked Data数据集的主题模型建立方法

提出了建立Linked Data数据集主题模型的方法.首先,将数据集中的RDF陈述三元组转换成主谓宾结构的语句,从而将Linked Data数据集转化为文本文档;然后,使用LDA算法对所有数据集的文本文档进行主题建模,即可得到每个数据集的主题向量,该向量就是描述数据集内容主题的特征.在Linked Data数据集链接目标推荐问题上,引入数据集的主题特征进行实验.使用数据集主题向量的余弦相似度替换基于记忆的协同过滤推荐算法中的相似度计算模块.结果表明,推荐效果比原始的协同过滤算法有很大提升.

Linked Data-based Slide Repository： The Episodic Slide Retrieval Using the Episodic Keyword Networks

This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of the authors can be used as contextual keywords in query expressions to efficiently dig out the expected slides for reuse rather than using only the part-of-slide-descriptions-based keyword queries. As a system, a new slide repository is proposed, composed of slide material collections, slide content data and pieces of information from authors＇ episodic memories related to each slide and presentation together with a slide retrieval application enabling authors to use the episodic memories as part of queries. The result of our experiment shows that the episodic memory-used queries can give more discoverability than the keyword-based queries. Additionally, an improvement model is discussed on the slide retrieval for further slide-finding efficiency by expanding the episodic memories model in the repository taking in the links with the author-and-slide-related data and events having been post on the private and social media sites.

BioPW+:基于Linked Data的生物途径数据可视化系统

自Linked Data项目被提出以来,大量的开放关联数据被发布到语义Web上,这其中就包含了许多的生物途径数据集。为了使生物学家能够有效地利用这些开放的数据集,对基于Linked Data的生物途径数据可视化系统进行研究,提出了生物途径可视化模型和展示布局方案,并且采用标识符动态映射实现了多源生物途径数据的浏览,最终开发了基于Linked Data的生物途径数据查询可视化系统——BioPW+。该系统应用语义Web技术,依靠SPARQL查询来定位生物途径的基本信息,然后基于Open PHACTS平台获取生物途径元素的详细信息,最终Web界面采用力导向图布局、Sankey图布局对生物途径数据进行展示并提供多种交互操作。与已有的仅仅基于某一特定数据库的生物途径工具相比,BioPW+系统基于Linked Data,可以同时一次性展示多个数据集中的生物途径数据及与其相关的其他生物化学数据,极大节省了时间并增强了数据的完整性。

Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis.

LinkMF:结合Linked Data的协同过滤推荐算法

协同过滤(CF)是推荐系统中应用最为广泛的推荐算法之一,然而数据稀疏性和冷启动问题是协同过滤方法的两个主要挑战。由于Linked Data整合了关于实体的丰富且结构化的特征,可以作为额外的信息源来缓解以上两种挑战。该文中我们首次提出了结合Linked Data改进CF推荐算法,基于矩阵分解提出了一种新的CF模型——LinkMF,在保证推荐准确度的基础上利用Linked Data缓解数据稀疏性和冷启动问题。首先,我们从Linked Data中抽取项目的特征表示并为项目建模;然后提出新的相似度度量方法计算项目相似度;最后利用项目相似度约束和指导MF分解过程产生推荐。在MovielLens和YAGO标准数据集上的大量实验结果表明,LinkMF优于现有的一些CF方法,特别在缓解数据稀疏性和冷启动问题上取得很好地效果。

Prevalence of linked angina and gastroesophageal reflux disease in general practice

AIM： To evaluate the association between gastroesophageal reflux diseases （GERD） and coronary heart diseases. METHODS： One thousand nine hundred and seventy consecutive patients who attended our hospital were enrolled. All of the patients who first attend our hospital were asked to respond to the F-scale questionnaire regardless of their chief complaints. All patients had a careful history taken, and resting echocardiography （ECG） was performed by physicians if the diagnostic necessity arose. Patients with ECG signs of coronary artery ischemia were defined as ST- segment depression based on the Minnesota code. RESULTS： Among 712 patients （36%） with GERD, ECG was performed in 171 （24%）, and ischemic changes were detected in eight （5%）. Four （50%） of these patients with abnormal findings upon ECG had no chest symptoms such as chest pain, chest oppression, or palpitations. These patients （0.6%; 4/712） were thought to have non-GERD heartburn, which may be related to ischemic heart disease. Of 281 patients who underwent ECG and did not have GERD symptoms, 20 （7%） had abnormal findings upon ECG. In patients with GERD symptoms and ECG signs of coronary artery ischemia, the prevalence of linked angina was considered to be 0.4% （8/1970 patients）.CONCLUSION： The present study suggested that ischemic heart disease might be found although a patient was referred to the hospital with a complaint of GERD symptoms. Physicians have to be concerned about missing clinically important coronary artery disease while evaluating patients for GERD symptoms.

Optimized functional linked neural network for predicting diaphragm wall deflection induced by braced excavations in clays

Deep excavation during the construction of underground systems can cause movement on the ground,especially in soft clay layers.At high levels,excessive ground movements can lead to severe damage to adjacent structures.In this study,finite element analyses(FEM)and the hardening small strain(HSS)model were performed to investigate the deflection of the diaphragm wall in the soft clay layer induced by braced excavations.Different geometric and mechanical properties of the wall were investigated to study the deflection behavior of the wall in soft clays.Accordingly,1090 hypothetical cases were surveyed and simulated based on the HSS model and FEM to evaluate the wall deflection behavior.The results were then used to develop an intelligent model for predicting wall deflection using the functional linked neural network(FLNN)with different functional expansions and activation functions.Although the FLNN is a novel approach to predict wall deflection;however,in order to improve the accuracy of the FLNN model in predicting wall deflection,three swarm-based optimization algorithms,such as artificial bee colony(ABC),Harris’s hawk’s optimization(HHO),and hunger games search(HGS),were hybridized to the FLNN model to generate three novel intelligent models,namely ABC-FLNN,HHO-FLNN,HGS-FLNN.The results of the hybrid models were then compared with the basic FLNN and MLP models.They revealed that FLNN is a good solution for predicting wall deflection,and the application of different functional expansions and activation functions has a significant effect on the outcome predictions of the wall deflection.It is remarkably interesting that the performance of the FLNN model was better than the MLP model with a mean absolute error(MAE)of 19.971,root-mean-squared error(RMSE)of 24.574,and determination coefficient(R^(2))of 0.878.Meanwhile,the performance of the MLP model only obtained an MAE of 20.321,RMSE of 27.091,and R^(2)of 0.851.Furthermore,the results also indicated that the proposed hybrid models,i.e.,ABC-FLNN,HHO-FLNN,HGS-FLNN,yielded more superior performances than those of the FLNN and MLP models in terms of the prediction of deflection behavior of diaphragm walls with an MAE in the range of 11.877 to 12.239,RMSE in the range of 15.821 to 16.045,and R^(2)in the range of 0.949 to 0.951.They can be used as an alternative tool to simulate diaphragm wall deflections under different conditions with a high degree of accuracy.

Influence of dissolved oxygen content on oxidative stability of linked polymer solution

The influence of dissolved oxygen content on the oxidative stability of a linked polymer solution (LPS) was studied by micro-filtration, dynamic light scattering and viscosity measurements. The results showed that at the same temperature, the degree of the oxidative degradation of the LPS increased and the rapidity of the oxidative degradation was accelerated with the increase of the dissolved oxygen content. Consequently, the size of linked polymer coils (LPCs) of the LPS became small, and the plugging capability of the LPS decreased. At a fixed content of dissolved oxygen, with increasing degradation temperature, almost the same results were observed, namely, an increased degree of oxidative degradation, accelerated rapidity of the oxidative degradation and decreased plugging capacity, with decreased oxidative stability of LPS. At 90 °C, in the presence of oxygen, LPS lost its plugging capability after having been degraded for a period of time. But at 40 °C, LPS with low dissolved oxygen content could be stable for a long time. The decreased plugging ability of LPS after oxidative degradation is mainly caused by the decreased size and number of the LPCs due to the breaking of hydrolyzed polyacrylamide (HPAM) molecule segments and the structural changing of HPAM molecules.

Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of organoboronic acids with N-protected 4-iodophenyl alanine linked isoxazoles

Suzuki-Miyaura coupling reaction of N-protected 4-iodopheyl alanine isoxazoles with arylboronic acids,catalyzed by palladium,efficiently produce benzyl-N-（4-bipheyl）-2-（3-methyl-5（E）-2-aryl-1-ethenyl-4-isoxazolyl）-amino-2-oxoethyl）carba- mates in good yields.This process is first of its kind to construct carbon-carbon bond formation having biaryl motif on amino acid linked isoxazole moiety.

An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall

A total of 26 leptospirosis cases occurred in the outbreak, of whom six died after hospitalization. All 26 patients were clinically diagnosed as leptospirosis Microscopic agglutination test （MAT） revealed that 13 of 26 patients were affected with laboratory confirmed leptospirosis. Furthermore, MAT data suggested that serogroup Icterohaemorrhagiae were the main pathogens responsible for this outbreak. And the rainfall data suggested that the increased rainfall might be responsible for the leptospirosis outbreak in Lezhi County. This outbreak has reminded us that leptospirosis should not be neglected, especially during flood season, although its incidence rate is low.

Deformation of Linked Polymer Coils

Linked polymer solution (LPS) is defined as the solution of linked polymer coils (LPCs) dispersed in water, composed of low concentration partially hydrolyzed polyacrylamide (HPAM) and aluminum citrate (crosslinker). In the work, the conformational changes of LPCs under different conditions were investigated by the methods of membrane filtering under low pressure, dynamic light scattering and core flooding experiments. The results showed that in some conditions the LPCs could be compressed mechanically to 1/158.5 of their original volume because of relatively lower HPAM cross-linking. The hydration property of LPCs was similar to that of normal polymer coils. The deformation of LPCs was more restricted than that of ordinary polymer coils under the flow shear stress or the shift of hydration equilibrium caused in the variation of the electrolyte concentration which is responsible for the effective plugging in the throats of porous media when LPCs are used for deep diverting.

FAIR + FIT: Guiding Principles and Functional Metrics for Linked Open Data(LOD) KOS Products

Purpose:To develop a set of metrics and identify criteria for assessing the functionality of LOD KOS products while providing common guiding principles that can be used by LOD KOS producers and users to maximize the functions and usages of LOD KOS products.Design/methodology/approach:Data collection and analysis were conducted at three time periods in 2015–16,2017 and 2019.The sample data used in the comprehensive data analysis comprises all datasets tagged as types of KOS in the Datahub and extracted through their respective SPARQL endpoints.A comparative study of the LOD KOS collected from terminology services Linked Open Vocabularies(LOV)and BioPortal was also performed.Findings:The study proposes a set of Functional,Impactful and Transformable(FIT)metrics for LOD KOS as value vocabularies.The FAIR principles,with additional recommendations,are presented for LOD KOS as open data.Research limitations:The metrics need to be further tested and aligned with the best practices and international standards of both open data and various types of KOS.Practical implications:Assessment performed with FAIR and FIT metrics support the creation and delivery of user-friendly,discoverable and interoperable LOD KOS datasets which can be used for innovative applications,act as a knowledge base,become a foundation of semantic analysis and entity extractions and enhance research in science and the humanities.Originality/value:Our research provides best practice guidelines for LOD KOS as value vocabularies.

Building up a Mathematical Model of Shaftes System and CAD for Linked Tetra-Shaft and Double-Cantilever Flat Flap Gate

Linked tetra shaft and double cantilever flat flap gate is a new type of structure in water conservancy projects,but the traditional method is now adopted in its design.In order to the application and dissemination of the type of sluice,this paper researches the difficult points of design advance,through researching the motion locus & stress coundition of linked tetra shaft system.The writer will build up the mathmatical model and handle it with the computer.Thus,we can achieve the modern desing on the basis of the software of linked tetra shaft system development.

Quadrilateral 2D linked-interpolation finite elements for micropolar continuum

Quadrilateral finite elements for linear micropolar continuum theory are developed using linked interpolation.In order to satisfy convergence criteria,the newly presented finite elements are modified using the Petrov-Galerkin method in which different interpolation is used for the test and trial functions.The elements are tested through four numerical examples consisting of a set of patch tests,a cantilever beam in pure bending and a stress concentration problem and compared with the analytical solution and quadrilateral micropolar finite elements with standard Lagrangian interpolation.In the higher-order patch test,the performance of the first-order element is significantly improved.However,since the problems analysed are already describable with quadratic polynomials,the enhancement due to linked interpolation for higher-order elements could not be highlighted.All the presented elements also faithfully reproduce the micropolar effects in the stress concentration analysis,but the enhancement here is negligible with respect to standard Lagrangian elements,since the higher-order polynomials in this example are not needed.