A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was des...A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively;p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.展开更多
目的:体内外评价紫归润唇膏的抗炎功效。方法:建立脂多糖诱导的RAW 264.7细胞炎症模型,检测紫归醇提物对一氧化氮生成的影响。建立卡泊三醇诱导的特应性皮炎样小鼠模型,研究紫归润唇膏对小鼠耳皮肤厚度、耳皮肤炎症的严重程度、组织病...目的:体内外评价紫归润唇膏的抗炎功效。方法:建立脂多糖诱导的RAW 264.7细胞炎症模型,检测紫归醇提物对一氧化氮生成的影响。建立卡泊三醇诱导的特应性皮炎样小鼠模型,研究紫归润唇膏对小鼠耳皮肤厚度、耳皮肤炎症的严重程度、组织病理及安全性的影响。结果:25~200μg/mL紫归醇提物能够促进RAW 264.7细胞生长且显著降低一氧化氮水平。同时紫归润唇膏能够显著降低特应性皮炎样小鼠耳部厚度,降低湿疹面积及严重度指数(eczema area and severity index,EASI)评分,减少炎症细胞浸润,降低棘层增厚,改善小鼠耳廓皮损炎症情况,且对卡泊三醇诱导的特应性皮炎样小鼠肝脾肾无影响。结论:紫归润唇膏具有显著抗炎功效且具有安全性。展开更多
文摘A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively;p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
文摘目的:体内外评价紫归润唇膏的抗炎功效。方法:建立脂多糖诱导的RAW 264.7细胞炎症模型,检测紫归醇提物对一氧化氮生成的影响。建立卡泊三醇诱导的特应性皮炎样小鼠模型,研究紫归润唇膏对小鼠耳皮肤厚度、耳皮肤炎症的严重程度、组织病理及安全性的影响。结果:25~200μg/mL紫归醇提物能够促进RAW 264.7细胞生长且显著降低一氧化氮水平。同时紫归润唇膏能够显著降低特应性皮炎样小鼠耳部厚度,降低湿疹面积及严重度指数(eczema area and severity index,EASI)评分,减少炎症细胞浸润,降低棘层增厚,改善小鼠耳廓皮损炎症情况,且对卡泊三醇诱导的特应性皮炎样小鼠肝脾肾无影响。结论:紫归润唇膏具有显著抗炎功效且具有安全性。
