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Numerical simulation of liquid core reduction in thin-slab continuous casting
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作者 WANG Yingchun ZHANG Li XU Rongjun XU Hongwei 《Baosteel Technical Research》 CAS 2009年第1期15-21,共7页
Thin-slab continuous casting and rolling technology is a process integrating casting and plastic deformation. In this study,targeting actions such as slab deformation and liquid core flows during the process of liquid... Thin-slab continuous casting and rolling technology is a process integrating casting and plastic deformation. In this study,targeting actions such as slab deformation and liquid core flows during the process of liquid core reduction on thin-slab continuous casting, suggests the fluid-solid coupling method should be used to research the characteristic and patterns of slab deformation during the liquid core reduction process, as well as research liquid core backflows. A material model of the slab shell was obtained through the high-temperature compression test of the cast steel. The analysis of the fluid-solid coupling simulation for liquid core reduction shows that slab deformation concentrates on the narrow side due to the existence of the liquid core. Meanwhile,the stress and strain increases with the increase of the reduction rate and slab thickness. The changing trends of stress and strain are identical under various conditions. The results demonstrate that using greater reduction at the upper part of the slab, which has a higher temperature and thinner slab,is beneficial to the quality of the slab. Moreover,the liquid core is extruded as the reduction is implemented. The quantity of the extrusion increases with the increase of reduction rate and the thickness of thinner shell, which leads to fluctuation of the mould level, making the operation more difficult. 展开更多
关键词 thin-slab casting liquid core reduction fluid-solid coupling slab deformation liquid core backflow
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Stimulated supercontinuum-radiation generation of carbon disulfide by all-trans-β-carotene fluorescence enhancement effect in liquid core optical fibre 被引量:1
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作者 门志伟 房文汇 +5 位作者 里佐威 曲冠男 高淑琴 陆国会 杨健戈 孙成林 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第8期418-422,共5页
We demonstrate stimulated supercontinuum-radiation of carbon disulfide (CS2) influenced by biological molecules all-trans-stimulated Raman scattering, stimulated Brillouin scattering, all-trans-β-carotene, liquid c... We demonstrate stimulated supercontinuum-radiation of carbon disulfide (CS2) influenced by biological molecules all-trans-stimulated Raman scattering, stimulated Brillouin scattering, all-trans-β-carotene, liquid core optical fibre-carotene in liquid core optical fibre (LCOF). By virtue of the broad fluorescence characteristics and large third-order optical nonlinearities of all-trans-β-carotene, the high-order Stokes lines of stimulated Raman scattering (SRS) and the multi-order Stokes lines of stimulated Brillouin scattering (SBS) excitated by SRS are observed at low input-laser energies. The results indicate that the fluorescence not only enhances the SRS, but also the SBS. These Stokes lines generate the SRS-SBS supercontinuum radiation (RBSR). A flat-amplitude bandwidth of 110 nm from 515 nm to 625 nm is observed when a frequency-doubled Nd:YAG laser at 532 nm with an energy of 0.86 mJ is used. This result is expected to be useful for the multi-wavelength fibre laser. 展开更多
关键词 stimulated Raman scattering stimulated Brillouin scattering all-trans-β-carotene liquid core optical fibre
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Two dimensional deformation characteristics of bloom CC with liquid core reduction
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作者 Guosen ZhiyuanShi 《Journal of University of Science and Technology Beijing》 CSCD 2002年第5期334-337,共4页
A two-dimensional model was applied to simulate the liquid core reduction (LCR) technology of bloom CC using ANSYS software. The deformation characteristics of bloom under different liquid fraction and reducing amount... A two-dimensional model was applied to simulate the liquid core reduction (LCR) technology of bloom CC using ANSYS software. The deformation characteristics of bloom under different liquid fraction and reducing amount are obtained. The results indicate that the main deformation condition of bloom shell is compressive strain, mainly undertaken by the liquid core, which increases with the enhancement of reducing amount. Solidified shell takes minor deformation. The longitudinal section of bloom appears sunken and the narrow side bulges, which grow serious when the liquid fraction increases. 展开更多
关键词 liquid core reduction numerical simulation BLOOM continuously casting (CC)
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The 3D Simulation of Liquid Core Change of Cylinder Steel Rolling Forming on Soft-reduction Continuous Casting Process
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作者 LUO Jian~(1.2) WANG Ying~1 LI Ainong~1 HUA Lin~1 1.Department of Material Science and Engineering,Wuhan University of Technology,Wuhan 430070,China 2.State Key Laboratory of Plastic Forming Simulation and Die & Mould Technology,Wuhan 430074,China 《武汉理工大学学报》 CAS CSCD 北大核心 2006年第S2期637-639,共3页
Using ABAQUS FEM software,the Elastic-plastic with isotropic hardening model is applied to simulate 3D cylinder slab rolling forming in continuous casting (CC),the change of liquid core before slab solidification comp... Using ABAQUS FEM software,the Elastic-plastic with isotropic hardening model is applied to simulate 3D cylinder slab rolling forming in continuous casting (CC),the change of liquid core before slab solidification completely on soft re- duction process is studied,the analyse result shows the soft reduction technique can change the liquid core size,which is useful to cylinder slab forming in CC. 展开更多
关键词 continuous CASTING liquid core SOFT reduction simulation
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Tri-frequency spectrum method and results for resolving the parameters of Earth's liquid core free nutation 被引量:1
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作者 雷湘鄂 许厚泽 《Science China Earth Sciences》 SCIE EI CAS 2002年第4期325-336,共12页
The parameters of Earth free core nutation (FCN) are two relatively significant geophysical parameters. Sasao et al. (1980) and Wahr and Bergen (1986) provided the theoretical estimation values of FCN parameters. Gwin... The parameters of Earth free core nutation (FCN) are two relatively significant geophysical parameters. Sasao et al. (1980) and Wahr and Bergen (1986) provided the theoretical estimation values of FCN parameters. Gwinn, Herring and Shapiro (1987) first obtained the observational values of FCN parameters by very long base Interference (VLBI) at Cambridge University. In the same year, Neuberg and Zurn in former West Germany and Hinderer in France began to retrieve FCN parameters by the observation of gravity tides and introduced the stacking method. The other scholars who researched into the same geophysical problems by applying the data of gravity tides basically followed the stacking method. The results they reached were similar to the observational result of FCN parameters given by Neuberg et al. in 1987. But the observational results of FCN parameters gained from gravity tides were not identical with those from VLBI, mainly because of the large difference of quality of FCN. So there was not an affirmative observational result of FCN parameters since then. In this paper, The authors firstly introduce the tri-frequency spectrum method with clearly geometrical and geophysical meaning for the resolution of FCN parameters , and the observational results of FCN parameters obtained from tide data at three superconducting gravity stations were accordant with those from VLBI, which will be relatively important to arriving at a certain observational result of FCN parameters. 展开更多
关键词 gravity tides very long base interference (VLBI) gravity tide resonance of the earth's liquid core amplitude and phase frequency parameter amplitude and phase frequency spectrum extend range of amplitude frequency parameter FCN paramet
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Experimental earth tidal models in considering nearly diurnal free wobble of the Earth's liquid core 被引量:9
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作者 SUNHeping XUJianqiao B.Ducarme 《Chinese Science Bulletin》 SCIE EI CAS 2003年第9期935-940,共6页
Based on the 28 series of the high precision and high minute sampling tidal gravity observations at 20 stations in Global Geodynamics Project (GGP) network, the resonant parameters of the Earth's nearly diurnal fr... Based on the 28 series of the high precision and high minute sampling tidal gravity observations at 20 stations in Global Geodynamics Project (GGP) network, the resonant parameters of the Earth's nearly diurnal free wobble (including the eigenperiods, resonant strengths and quality factots) are precisely determined. The discrepancy of the eigenperiod between observed and theoretical values is studied, the important conclusion that the real dynamic ellipticity of the liquid core is about 5% larger than the one under the static equilibrium assumption is approved by using our gravity technique. The experimental Earth's tidal gravity models with considering the nearly diurnal free wobble of the Earth's liquid core are constructed in this study. The numerical results show that the difference among three experimental models is less than 0.1%, and the largest discrepancy compared to those widely used nowdays given by Dehant (1999) and Mathews (2001) is only about 0.4%. It can provide with the most recent real experimental tidal gravity models for the global study of the Earth's tides, geodesy and space techniques and so on. 展开更多
关键词 地球潮汐模型实验 地球流体核心 动态椭圆率 日间自由振动 地球动力学工程 重力
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The Akp-Btk value method and the resultsfor the retrieval of the parameters of the Earth's free core nutation 被引量:1
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作者 雷湘鄂 贾民育 李辉 《Acta Seismologica Sinica(English Edition)》 CSCD 2000年第3期342-350,358,共10页
The rotation of the Earth's liquid core creates the Nearly Diurnal Free Wobble (NDFW). It is one of the problems of researching the Earth's liquid core for us to retrieve the parameters of the Earth's Free... The rotation of the Earth's liquid core creates the Nearly Diurnal Free Wobble (NDFW). It is one of the problems of researching the Earth's liquid core for us to retrieve the parameters of the Earth's Free Core Nutation (FCN),from the Earth's liquid core resonance of gravity tide waves on the diurnal frequency band. Since 1987, some scientists in many different countries have come to calculate the parameters of FCN by using the observational data of gravity tide waves on the diumal frequency band. They basically followed the Stacking method, which needed five diurnal waves for the resolution. In this paper, authors introduced the Aky-Btk value method with clearly geometrical meaning as a new method, which only requires three very high signal-noise-ratio waves o1, K1 and P1 for the resolution. Authors chose the observational data of the three superconducting gravimeter stations respectively located in Cantley of Canada, Wuhan of China and Brussels of Belgium, to compute the parameters of FCN. It was the first time that the observational results of the parameters of FCN obtained from gravitational tide were in accord with the parameters of FCN gained from VLBI since 1987. 展开更多
关键词 Earth's liquid core resonance of gravity tide (LCR) parameters of Earth's free core nutation triangle of LCR Akp-Btk value method
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Preparation of Microcapsules with Liquid Droplet Coalescence Method Followed by Phase Separation 被引量:3
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作者 Yasushi Yokoyama Kiyomi Fuchigami +1 位作者 Yoshinari Taguchi Masato Tanaka 《Journal of Encapsulation and Adsorption Sciences》 2013年第3期93-97,共5页
Novel preparation method of microencapsules was developed on the basis of the liquid coalescence method followed by phase separation. Oil droplets of limonene dissolving expanded polystyrene as a shell material were f... Novel preparation method of microencapsules was developed on the basis of the liquid coalescence method followed by phase separation. Oil droplets of limonene dissolving expanded polystyrene as a shell material were forced to collide and coalesce with the Isopar oil droplets of core material in the continuous wates phase. When two kinds of oil droplets are collided and coalesced with each other, expanded polystyrene dissolved in the limonene oil may be phase-separated in the oil droplets newly formed to form the microcapsule shell, because the Isopar oil was a poor solvent for expanded polystyrene but a good solvent for the limonene oil. In the experiment, the diameter (or number) of limonene oil droplets dissolving expanded polystyrene was mainly changed, because the coalescence frequency between the droplets is strongly dependent on the number of droplets. Favorable core shell types of microcapsules with the shell thickness from 1.0 to 5.0 μm were able to be prepared under all the experimental conditions adopted here. 展开更多
关键词 core Shell MICROCAPSULE liquid DROPLET COALESCENCE METHOD Phase Separation LIMONENE Oil liquid-liquid Dispersion
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ZnO/TiO_(2)核-壳纳米结构的低温制备及其光电性能研究 被引量:1
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作者 李丽华 王贺 +1 位作者 王航 黄金亮 《功能材料》 CAS CSCD 北大核心 2024年第1期1217-1222,共6页
ZnO因其自身的高电荷复合、化学性质活泼,导致其应用受到限制,通过表面修饰进行复合可实现电子-空穴的分离并提高其化学稳定性。以二水合醋酸锌、六水合硝酸锌、六氟钛酸铵为原料,采用溶胶-凝胶、水热和液相沉积相结合的方法,在低温条... ZnO因其自身的高电荷复合、化学性质活泼,导致其应用受到限制,通过表面修饰进行复合可实现电子-空穴的分离并提高其化学稳定性。以二水合醋酸锌、六水合硝酸锌、六氟钛酸铵为原料,采用溶胶-凝胶、水热和液相沉积相结合的方法,在低温条件下制备出ZnO/TiO_(2)单异质结。采用XRD、SEM、EDS、TEM、PL等对样品进行表征并对其光电性能进行测试。结果表明,在沉积时间为20 min时,ZnO/TiO_(2)核-壳结构形貌最规整,其中ZnO直径约115 nm,TiO_(2)薄膜厚度约7.6 nm;TiO_(2)的负载,降低了电极中光生电荷的复合,提高了ZnO对光子的收集能力,光电流密度提升大约10倍,达到0.21μA/cm^(2),表现出优异的光电化学性能。 展开更多
关键词 ZnO/TiO_(2) 核-壳结构 异质结 光电极材料 液相沉积
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气液两相条件下叶片开孔对电潜泵性能和内部流场的影响
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作者 王通 王健 +2 位作者 施卫东 韩勇 周岭 《排灌机械工程学报》 CSCD 北大核心 2024年第6期548-555,共8页
为了研究电潜泵内部流动机理,从而改善高含气工况下电潜泵的气液混输性能,文中基于欧拉-欧拉非均相流模型,对不同入口含气率工况下叶片开孔前后的气液两相流动特性进行了数值模拟分析,探究了气液两相流条件下叶片开孔对电潜泵性能和内... 为了研究电潜泵内部流动机理,从而改善高含气工况下电潜泵的气液混输性能,文中基于欧拉-欧拉非均相流模型,对不同入口含气率工况下叶片开孔前后的气液两相流动特性进行了数值模拟分析,探究了气液两相流条件下叶片开孔对电潜泵性能和内部流场的影响.结果表明,在纯水工况以及低含气率、小流量工况下,叶片开孔会降低电潜泵性能;但是叶片开孔可以改善电潜泵在大流量下的气液混输性能.叶片开孔后会改变叶轮内部压力分布,使电潜泵叶轮内部平均压力升高,进而改善叶轮内部流态.叶片开孔后会冲散气相聚集,使气体分布更加均匀,叶轮流道内涡核分布明显减少,减少了能量耗散.该研究为改善电潜泵气液混输性能提供了理论依据. 展开更多
关键词 电潜泵 叶片开孔 气液两相流 数值模拟 涡核分布
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稀释剂用量对铁硅铝软磁粉芯含浸强度的影响
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作者 李梦冉 李睿卿 +4 位作者 张学斌 刘伟 张华 邹中秋 苏海林 《功能材料》 CAS CSCD 北大核心 2024年第7期7001-7007,共7页
金属软磁粉芯生坯强度通常较低,在制造过程中需采用含浸树脂的方法提高强度。采用非活性稀释剂(四氯乙烯)和活性稀释剂636(三羟甲基丙烷三缩水甘油醚)作为135环氧树脂/甲基四氢苯酐含浸体系的混合稀释剂,研究了四氯乙烯的用量对于铁硅... 金属软磁粉芯生坯强度通常较低,在制造过程中需采用含浸树脂的方法提高强度。采用非活性稀释剂(四氯乙烯)和活性稀释剂636(三羟甲基丙烷三缩水甘油醚)作为135环氧树脂/甲基四氢苯酐含浸体系的混合稀释剂,研究了四氯乙烯的用量对于铁硅铝软磁粉芯抗压强度的影响以及含浸工艺对铁硅铝软磁粉芯磁性能的影响。同时,结合实测抗压强度和孔隙率对复合材料抗压强度公式进行了修正,得出了金属软磁粉芯抗压强度的计算公式。结果表明,经含浸处理后,软磁粉芯的抗压强度显著提高,在树脂与稀释剂的质量比约为1∶2时达到最大值18.43 MPa,且磁性能与含浸之前的样品相比没有明显变化。这表明在该配比下,稀释剂可以和环氧树脂充分均匀混合,并且可以与固化剂更好地发生交联固化,从而有效提高环氧树脂的力学性能。对含浸工艺和软磁粉芯抗压强度计算公式的研究结果,可为提高软磁粉芯强度的量产工艺开发提供参考。 展开更多
关键词 金属软磁粉芯 含浸 抗压强度 四氯乙烯
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Cu核微焊点液-固界面反应及剪切行为研究
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作者 钱帅丞 陈湜 +1 位作者 乔媛媛 赵宁 《电子元件与材料》 CAS 北大核心 2024年第3期367-373,共7页
相较于传统Sn基焊点,Cu核焊点具备更好的导热性、导电性及力学性能。为揭示尺寸效应对Cu核焊点界面反应及剪切强度的影响,制备了不同Sn镀层厚度的Cu核焊点(Cu@Ni-Sn/Cu)。观察回流不同时间后Cu核微焊点横截面微观组织,研究了Cu核微焊点... 相较于传统Sn基焊点,Cu核焊点具备更好的导热性、导电性及力学性能。为揭示尺寸效应对Cu核焊点界面反应及剪切强度的影响,制备了不同Sn镀层厚度的Cu核焊点(Cu@Ni-Sn/Cu)。观察回流不同时间后Cu核微焊点横截面微观组织,研究了Cu核微焊点在尺寸效应下的液-固界面反应。之后对Cu核微焊点进行剪切测试,结合断口形貌,分析断裂机理。界面反应结果表明:Cu@Ni-Sn/Cu焊点在250℃回流时,Sn/Ni界面生成Ni含量较高的针状(Cu,Ni)_(6)Sn_(5)IMC,Sn/Cu界面生成Ni含量较低的层状(Cu,Ni)_(6)Sn_(5)IMC。剪切测试结果表明:随着Sn镀层厚度增加,Cu@Ni-Sn/Cu焊点的剪切强度先增大后减小。基于Sn镀层厚度对界面(Cu,Ni)_(6)Sn_(5)IMC层体积的直接影响,Sn层厚度的增加提升了焊点剪切强度。然而Cu@Ni-Sn(60μm)/Cu焊点中Cu核位置的偏移,造成剪切强度略有降低。 展开更多
关键词 电子封装 Cu核焊球 液-固界面反应 金属间化合物 剪切强度
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双核酸性离子液体的合成及光谱表征
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作者 谢景雪 王恒 +2 位作者 冯咪 徐菲 王祝敏 《辽宁化工》 CAS 2024年第9期1391-1394,共4页
双核酸性离子液体以双核阳离子结构为基础,通过嫁接2个磺酸基使其具有较强的催化活性和较高的稳定性,在取代强腐蚀性的工业传统酸方面具有较大的应用潜力。设计合成了以三乙烯二胺为双核阳离子的5种双核酸性离子液体,并通过核磁共振光谱... 双核酸性离子液体以双核阳离子结构为基础,通过嫁接2个磺酸基使其具有较强的催化活性和较高的稳定性,在取代强腐蚀性的工业传统酸方面具有较大的应用潜力。设计合成了以三乙烯二胺为双核阳离子的5种双核酸性离子液体,并通过核磁共振光谱(NMR)和红外光谱(FT-IR)确定了离子液体的结构,进一步利用紫外分光光度计(UV-vis)测定其酸度(H_(0)),并探究了双核离子液体结构与酸度之间的关系。 展开更多
关键词 双核酸性离子液体 结构表征 酸度(H0)
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煤系沥青包覆再生石墨微观构造及电化学性能
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作者 岳彦龙 林雄超 +3 位作者 张玉坤 高红凤 张续春 王永刚 《煤炭学报》 EI CAS CSCD 北大核心 2024年第5期2507-2518,共12页
石墨负极材料易在石墨层间与电解液发生共嵌入导致石墨层膨胀、粉化脱落,严重影响石墨负极材料的循环稳定性。利用沥青对石墨负极进行包覆,形成不定型碳层包覆的“核壳”结构,可减少石墨层的膨胀脱落,提高石墨负极材料的电化学性能。以... 石墨负极材料易在石墨层间与电解液发生共嵌入导致石墨层膨胀、粉化脱落,严重影响石墨负极材料的循环稳定性。利用沥青对石墨负极进行包覆,形成不定型碳层包覆的“核壳”结构,可减少石墨层的膨胀脱落,提高石墨负极材料的电化学性能。以中温煤焦油沥青为原料,通过空气氧化和聚合交联制备得到高结焦值、高软化点的包覆沥青。通过液相包覆方法,考察了对再生石墨负极的包覆性能。采用X射线衍射(XRD)、拉曼光谱(Raman)、氮气吸附、扫描电镜(SEM)和透射电镜(TEM)等方法分析了再生石墨包覆形貌与界面微观结构变化,并对材料电化学性能进行了测试。结果表明,沥青包覆可有效完善再生石墨微观构造。随着沥青包覆量的增加,石墨表面缺陷减少,比表面积和孔容降低;炭化后包覆界面形成不定型碳层,包覆界面无序度随沥青包覆量的增加而升高。不定型碳包覆层的形成显著提高了石墨负极性能,包覆12%沥青的再生石墨比容量达到450 mA·h/g,相比未包覆石墨提升140 mA·h/g;沥青包覆石墨负极首次库伦效率增加11.5%,并且循环稳定性获得改善;在5 A·h下比容量提高至285 mA·h/g,相比未包覆再生石墨提高242.8 mA·h/g,倍率性能突出。 展开更多
关键词 包覆沥青 “核壳”结构 氧化交联 液相包覆 再生石墨
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具有高通液性能高吸水性树脂的制备及性能研究
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作者 李振 田春兰 +1 位作者 焦红岩 李哲 《浙江化工》 CAS 2024年第3期27-32,共6页
以丙烯酸、功能单体为聚合单体,N,N-亚甲基双丙烯酰胺为交联剂,过硫酸钾为引发剂,采用水溶液聚合法合成了一种具有优异通液性能和吸液性能的高吸水性树脂,研究了自制功能单体用量、交联剂用量、引发剂用量、中和度、引发温度对高吸水性... 以丙烯酸、功能单体为聚合单体,N,N-亚甲基双丙烯酰胺为交联剂,过硫酸钾为引发剂,采用水溶液聚合法合成了一种具有优异通液性能和吸液性能的高吸水性树脂,研究了自制功能单体用量、交联剂用量、引发剂用量、中和度、引发温度对高吸水性树脂吸液能力和通液能力的影响,并使用扫描电镜对高吸水性树脂的颗粒形态进行表征。结果表明,合成最佳条件为:丙烯酸用量为250 g,功能单体用量为25 g,交联剂用量为1.5 g,引发剂用量为0.375 g,氢氧化钠用量为97.2 g,引发温度为55℃。此条件下制备得到的高吸水性树脂具有良好的吸液性能和通液性能,吸盐水倍率为103.25 g/g,通液速度为201.55 mL/min。扫描电镜结果表明高吸水性树脂由于分子链的刚性变强,颗粒表面形状更规则。 展开更多
关键词 高吸水性树脂 功能高分子 高通液 丙烯酸 复合芯体
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10种有机酸对电子烟中陶瓷雾化芯的重金属迁移影响
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作者 杨文武 王晶 +5 位作者 张倩 余忠瑾 韦健 孙小彤 韦惠静 况利平 《分析测试学报》 CAS CSCD 北大核心 2024年第3期413-420,共8页
为研究10种有机酸对电子烟中陶瓷雾化芯的重金属迁移影响,配制不同含量有机酸的电子烟烟液,采用电感耦合等离子体质谱法(ICP-MS)对陶瓷雾化芯在加速老化条件下迁移至烟液及气溶胶中的金属元素进行测定,评估重金属在该陶瓷芯中的雾化效... 为研究10种有机酸对电子烟中陶瓷雾化芯的重金属迁移影响,配制不同含量有机酸的电子烟烟液,采用电感耦合等离子体质谱法(ICP-MS)对陶瓷雾化芯在加速老化条件下迁移至烟液及气溶胶中的金属元素进行测定,评估重金属在该陶瓷芯中的雾化效率及有机酸的影响。结果表明:烟液、气溶胶方法中各元素的检出限分别均<10µg/kg、≤0.055µg/100口;不同类型和含量的有机酸对重金属的迁移影响不一,柠檬酸、乳酸、苹果酸、乙酸对金属元素的迁移影响相对较大。各元素在气溶胶中的雾化效率为21.2%~45.9%。与未添加有机酸的空白对照组相比,柠檬酸、乳酸、乙酸、苯甲酸、苹果酸对气溶胶中Ni含量提升有显著影响(P<0.05),柠檬酸对气溶胶中Cu含量提升有显著影响,5种酸对其他元素无显著性差异(P>0.05)。该方法准确可靠,适用于评估电子烟烟液及气溶胶中有机酸对陶瓷芯的重金属迁移影响。 展开更多
关键词 陶瓷雾化芯 电子烟 烟液 气溶胶 重金属 电感耦合等离子体质谱法(ICP-MS)
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补肾活血方防治糖尿病性视网膜病变活性成分的快速筛选及含量测定
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作者 王宇 匡微 +2 位作者 黄宇霞 谢孟君 张梅 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第8期1226-1235,共10页
目的基于网络药理学和分子对接技术筛选补肾活血方防治糖尿病性视网膜病变的质量评价指标,同时建立活性成分的超高效液相色谱-三重四极杆质谱(UHPLC-QqQ-MS/MS)含量测定方法。方法利用网络药理学筛选补肾活血方防治糖尿病性视网膜病变... 目的基于网络药理学和分子对接技术筛选补肾活血方防治糖尿病性视网膜病变的质量评价指标,同时建立活性成分的超高效液相色谱-三重四极杆质谱(UHPLC-QqQ-MS/MS)含量测定方法。方法利用网络药理学筛选补肾活血方防治糖尿病性视网膜病变的关键化合物和靶点。基于分子对接技术验证化合物和靶点的相关性,确定补肾活血方的活性成分作为质量评价指标。建立补肾活血方活性成分的UHPLC-QqQ-MS/MS含量测定方法。采用ZORBAX SB-C_(18)(2.1 mm×50 mm,1.8μm)色谱柱,甲醇(A)-0.1%甲酸水溶液(B)作为流动相,在多反应监测模式下进行梯度洗脱。流速:0.3 mL·min^(-1);进样量:1μL。结果网络药理学及分子对接筛选出了5个核心靶点及12个活性成分(毛蕊花糖苷,松果菊苷,异类叶升麻苷,丹参酮ⅡA,隐丹参酮,二氢丹参酮I,人参皂苷Re、Rd和Rb1,葛根素,大豆苷,鹰嘴豆牙素A),其亲和力良好(结合能≤-5.0 kcal·mol^(-1))。含量测定结果表明,各成分在线性范围内相关性良好(r>0.9995),平均加样回收率在97.57%~101.48%。8批样品中12个成分含量分别为0.0279%~0.0506%、0.0064%~0.0220%、0.0171%~0.0415%、0.0092%~0.0154%、0.0126%~0.0205%、0.0044%~0.0076%、0.334%~0.643%、0.238%~0.530%、0.353%~0.693%、3.411%~6.048%、1.023%~1.352%和0.0008%~0.0018%。结论基于网络药理学、分子对接和UHPLC-QqQ-MS/MS技术,建立了快速筛选并测定补肾活血方中12个活性成分的方法,为全面评价其质量及有效性提供了参考。 展开更多
关键词 补肾活血方 含量测定 超高效液相色谱-质谱联用法 分子对接 核心靶点 活性成分 网络药理学
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提高光度分析灵敏度的两种新途径 被引量:9
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作者 陈焕文 曹彦波 +3 位作者 韩松柏 张寒琦 于爱民 金钦汉 《分析化学》 SCIE EI CAS CSCD 北大核心 2001年第4期478-483,共6页
吸收光度法是一种历史悠久而富有活力的分析方法。本文评述了液芯波导在吸收光度法中的最新进展,指出光强度差测量模式与长程吸收技术的结合将是提高光度法灵敏度的一种新的重要手段。
关键词 光度分析 液芯波导 光强度差测量 灵敏度 吸收光度法 吸收池改进
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静电喷雾法制备海藻酸钙-羧甲基纤维素钠液芯微胶囊的工艺选优 被引量:16
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作者 张武杰 李保国 +2 位作者 张超 谢鑫荟 汤亭亭 《上海理工大学学报》 EI CAS 北大核心 2007年第4期349-352,共4页
尝试用高压静电成囊装置(静电喷雾法)来制备一种强度高、生物相容性好的海藻酸钙-羧甲基纤维素钠液芯微囊.在初步试验的基础上,利用正交试验的方法考察了海藻酸钠、羧甲基纤维素钠以及氯化钙的浓度对成囊过程中微胶囊膜厚、粒径等的影响... 尝试用高压静电成囊装置(静电喷雾法)来制备一种强度高、生物相容性好的海藻酸钙-羧甲基纤维素钠液芯微囊.在初步试验的基础上,利用正交试验的方法考察了海藻酸钠、羧甲基纤维素钠以及氯化钙的浓度对成囊过程中微胶囊膜厚、粒径等的影响.同时结合不同制备条件下微胶囊的成囊性,优化海藻酸钙-羧甲基纤维素钠微胶囊制备工艺.在优化的工艺参数中海藻酸钠、氯化钙以及羧甲基纤维素钠的质量浓度分别为10,30,15 g/L. 展开更多
关键词 微胶囊 静电喷雾 液芯
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基于长光程技术的痕量海水营养盐自动分析仪的设计与测试 被引量:9
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作者 孙兆华 曹文熙 +2 位作者 赵俊 李彩 周雯 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2008年第12期3000-3003,共4页
海水中可溶性的营养盐浓度是海洋监测的常规项目之一;大洋水体中的营养盐含量很低,使用传统的分光光度计难于定量测量。文章基于液芯波导长光程技术,设计了高灵敏度的痕量海水营养盐光谱分析仪。分析仪以1.02 nm的光谱分辨率实现350-900... 海水中可溶性的营养盐浓度是海洋监测的常规项目之一;大洋水体中的营养盐含量很低,使用传统的分光光度计难于定量测量。文章基于液芯波导长光程技术,设计了高灵敏度的痕量海水营养盐光谱分析仪。分析仪以1.02 nm的光谱分辨率实现350-900 nm光谱范围的水样吸光度连续光谱测量,并由嵌入式PC104微机自动实现了水样采集、吸光度测量和数据分析的功能。针对亚硝酸盐的测试实验结果表明,仪器检出限达到nmol·L^-1的量级,比传统分光光度计的检测限提高了三个量级,且显色反应时间可缩短到3 min,能适用于大洋水体中营养盐的现场痕量分析。 展开更多
关键词 自动分析仪 液芯波导 长光程 营养盐
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