AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and ...AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.展开更多
Accurately diagnosing Alzheimer's disease is essential for improving elderly health.Meanwhile,accurate prediction of the mini-mental state examination score also can measure cognition impairment and track the prog...Accurately diagnosing Alzheimer's disease is essential for improving elderly health.Meanwhile,accurate prediction of the mini-mental state examination score also can measure cognition impairment and track the progression of Alzheimer's disease.However,most of the existing methods perform Alzheimer's disease diagnosis and mini-mental state examination score prediction separately and ignore the relation between these two tasks.To address this challenging problem,we propose a novel multi-task learning method,which uses feature interaction to explore the relationship between Alzheimer's disease diagnosis and minimental state examination score prediction.In our proposed method,features from each task branch are firstly decoupled into candidate and non-candidate parts for interaction.Then,we propose feature sharing module to obtain shared features from candidate features and return shared features to task branches,which can promote the learning of each task.We validate the effectiveness of our proposed method on multiple datasets.In Alzheimer's disease neuroimaging initiative 1 dataset,the accuracy in diagnosis task and the root mean squared error in prediction task of our proposed method is 87.86%and 2.5,respectively.Experimental results show that our proposed method outperforms most state-of-the-art methods.Our proposed method enables accurate Alzheimer's disease diagnosis and mini-mental state examination score prediction.Therefore,it can be used as a reference for the clinical diagnosis of Alzheimer's disease,and can also help doctors and patients track disease progression in a timely manner.展开更多
Purpose： To investigate the profiles of cognitive impairment through Montreal Cognitive Assessment （MoCA） and Mini-Mental State Examination （MMSE） in patients with chronic traumatic brain injury （TBI） or stroke...Purpose： To investigate the profiles of cognitive impairment through Montreal Cognitive Assessment （MoCA） and Mini-Mental State Examination （MMSE） in patients with chronic traumatic brain injury （TBI） or stroke and to evaluate the sensitivity of the two scales in patients with TBI. Methods： In this cohort study, a total of 230 patients were evaluated, including TBI group （n = 103） and stroke group （n - 127）. The cognitive functions of two groups were evaluated by designated specialists using MoCA （Beijing version） and MMSE （Chinese version）. Results： Compared with the patients with stroke, the patients with TBI received significantly lower score in orientation subtest and recall subtest in both tests. MoCA abnormal rates in the TBI group and stroke group were 94.17% and 86.61% respectively, while MMSE abnormal rates were 69.90% and 57.48%, respectively. In the TBI group, 87.10% patients with normal MMSE score had abnormal MoCA score and in the stroke group, about 70.37% patients with normal MMSE score had abnormal MoCA score. The diagnostic consistency of two scales in the TBI group and the stroke group were 72% and 69%, re.spectively. Conclusion： In our rehabilitation center, patients with TBI may have mare extensive and severe cognitive impairments than patients with stroke, prominently in orientation and recall domain. In screening post- TBI cognitive impairment, MoCA tends to be more sensitive than MIV[SE.展开更多
Having the two largest nursing workforces across the globe,both China and the United States have implemented licensure examinations to standardize the qualifications of registered nurse.China established the National ...Having the two largest nursing workforces across the globe,both China and the United States have implemented licensure examinations to standardize the qualifications of registered nurse.China established the National Nursing Licensure Examination(NNLE)in 1995.Like the National Council Licensure Examination for Registered Nurses(NCLEX-RN)in the United States,the NNLE has become an important link in the nurse registration process and contributed a lot in quality assurance and development of nursing profession.It may be necessary for the NNLE to learn from NCLEX-RN in several aspects,including increasing the frequency of exam,providing examinees with individualized services,and continuing reforming exam content and format.By better aligning the content and format of the examination with the current nursing paradigm and clinical requirements,nurses may enter the healthcare field better prepared to care for patients.Considering the magnitude of their nursing workforce,both China and the United States have great potential to serve as a role model for other developing countries as they look towards establishing national nursing education programs.As new policies around standardized nurse education in China take form,we urge that the NNLE be included alongside curricular reforms.As these reforms are implemented,continued research will be needed to evaluate the effectiveness of curriculum and licensure exam regulations upon nurse preparedness and quality of nursing care in China.展开更多
On 46,Dec.1996 the members of specialist group organized by the Gvi1 Aviation Administration of China(CAAC)and the Aviation Industries of China(AIC)conduct the prelimi nary examination of“211 Project"(Constructi...On 46,Dec.1996 the members of specialist group organized by the Gvi1 Aviation Administration of China(CAAC)and the Aviation Industries of China(AIC)conduct the prelimi nary examination of“211 Project"(Construction of 100 key colleges a nd universities of China in 21 century)ofNanjing University of Aeronautics and Astronautics(NUAA).展开更多
BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secon...BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.展开更多
目的:探讨中文版约翰霍普金斯改编认知检查量表(the John Hopkins adapted cognitive exam,ACE)在呼吸危重症患者中应用的有效性,为其在国内临床应用提供客观依据。方法:选择2022年10月—2023年10月100例呼吸重症监护病房(respiratory i...目的:探讨中文版约翰霍普金斯改编认知检查量表(the John Hopkins adapted cognitive exam,ACE)在呼吸危重症患者中应用的有效性,为其在国内临床应用提供客观依据。方法:选择2022年10月—2023年10月100例呼吸重症监护病房(respiratory intensive care unit,RICU)患者作为RICU组和40例同期体检的健康人作为对照组,分别用简易精神状态量表(mini-mental state examination,MMSE)和中文版ACE评估其认知功能。结果:(1)RICU组ACE总分和MMSE总分呈显著相关(r=0.709,P<0.001);两者相同子项目相关系数在0.444—0.804,低度至高度相关;中文版ACE各子项目与ACE总分低度至高度显著相关,相关系数在0.438—0.769(P<0.001)。(2)RICU组和对照组间,在中文版ACE中定向力、模仿能力、记忆能力及总分均有显著性差异(P<0.05),在MMSE中定向力、注意力与计算力、回忆能力、语言能力和总分均有显著性差异(P<0.05)。(3)中文版ACE总分90.5时约登指数最大(0.49),MMSE总分26.5时约登指数最大(0.525)。受试者操作曲线曲线下面积ACE为(0.813±0.035),MMSE为(0.841±0.032),两者无显著差异(Z=1.00,P=0.317)。结论:中文版ACE可以作为RICU患者认知障碍筛查的工具,且较MMSE更适宜在气管插管、气管切开及使用机械通气患者中使用。展开更多
文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.
基金supported in part by the National Natural Science Foundation of China(No.62172444)Natural Science Foundation of Hunan Province(No.2022JJ30753)+1 种基金Central South University Innovation-Driven Research Programme(No.2023CXQD018)High Performance Computing Center of Central South University.
文摘Accurately diagnosing Alzheimer's disease is essential for improving elderly health.Meanwhile,accurate prediction of the mini-mental state examination score also can measure cognition impairment and track the progression of Alzheimer's disease.However,most of the existing methods perform Alzheimer's disease diagnosis and mini-mental state examination score prediction separately and ignore the relation between these two tasks.To address this challenging problem,we propose a novel multi-task learning method,which uses feature interaction to explore the relationship between Alzheimer's disease diagnosis and minimental state examination score prediction.In our proposed method,features from each task branch are firstly decoupled into candidate and non-candidate parts for interaction.Then,we propose feature sharing module to obtain shared features from candidate features and return shared features to task branches,which can promote the learning of each task.We validate the effectiveness of our proposed method on multiple datasets.In Alzheimer's disease neuroimaging initiative 1 dataset,the accuracy in diagnosis task and the root mean squared error in prediction task of our proposed method is 87.86%and 2.5,respectively.Experimental results show that our proposed method outperforms most state-of-the-art methods.Our proposed method enables accurate Alzheimer's disease diagnosis and mini-mental state examination score prediction.Therefore,it can be used as a reference for the clinical diagnosis of Alzheimer's disease,and can also help doctors and patients track disease progression in a timely manner.
文摘Purpose： To investigate the profiles of cognitive impairment through Montreal Cognitive Assessment （MoCA） and Mini-Mental State Examination （MMSE） in patients with chronic traumatic brain injury （TBI） or stroke and to evaluate the sensitivity of the two scales in patients with TBI. Methods： In this cohort study, a total of 230 patients were evaluated, including TBI group （n = 103） and stroke group （n - 127）. The cognitive functions of two groups were evaluated by designated specialists using MoCA （Beijing version） and MMSE （Chinese version）. Results： Compared with the patients with stroke, the patients with TBI received significantly lower score in orientation subtest and recall subtest in both tests. MoCA abnormal rates in the TBI group and stroke group were 94.17% and 86.61% respectively, while MMSE abnormal rates were 69.90% and 57.48%, respectively. In the TBI group, 87.10% patients with normal MMSE score had abnormal MoCA score and in the stroke group, about 70.37% patients with normal MMSE score had abnormal MoCA score. The diagnostic consistency of two scales in the TBI group and the stroke group were 72% and 69%, re.spectively. Conclusion： In our rehabilitation center, patients with TBI may have mare extensive and severe cognitive impairments than patients with stroke, prominently in orientation and recall domain. In screening post- TBI cognitive impairment, MoCA tends to be more sensitive than MIV[SE.
基金This work was supported by Health Professional Education Foundation of Thailand and China Medical Board(12-121)
文摘Having the two largest nursing workforces across the globe,both China and the United States have implemented licensure examinations to standardize the qualifications of registered nurse.China established the National Nursing Licensure Examination(NNLE)in 1995.Like the National Council Licensure Examination for Registered Nurses(NCLEX-RN)in the United States,the NNLE has become an important link in the nurse registration process and contributed a lot in quality assurance and development of nursing profession.It may be necessary for the NNLE to learn from NCLEX-RN in several aspects,including increasing the frequency of exam,providing examinees with individualized services,and continuing reforming exam content and format.By better aligning the content and format of the examination with the current nursing paradigm and clinical requirements,nurses may enter the healthcare field better prepared to care for patients.Considering the magnitude of their nursing workforce,both China and the United States have great potential to serve as a role model for other developing countries as they look towards establishing national nursing education programs.As new policies around standardized nurse education in China take form,we urge that the NNLE be included alongside curricular reforms.As these reforms are implemented,continued research will be needed to evaluate the effectiveness of curriculum and licensure exam regulations upon nurse preparedness and quality of nursing care in China.
文摘On 46,Dec.1996 the members of specialist group organized by the Gvi1 Aviation Administration of China(CAAC)and the Aviation Industries of China(AIC)conduct the prelimi nary examination of“211 Project"(Construction of 100 key colleges a nd universities of China in 21 century)ofNanjing University of Aeronautics and Astronautics(NUAA).
文摘BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.
文摘目的:探讨中文版约翰霍普金斯改编认知检查量表(the John Hopkins adapted cognitive exam,ACE)在呼吸危重症患者中应用的有效性,为其在国内临床应用提供客观依据。方法:选择2022年10月—2023年10月100例呼吸重症监护病房(respiratory intensive care unit,RICU)患者作为RICU组和40例同期体检的健康人作为对照组,分别用简易精神状态量表(mini-mental state examination,MMSE)和中文版ACE评估其认知功能。结果:(1)RICU组ACE总分和MMSE总分呈显著相关(r=0.709,P<0.001);两者相同子项目相关系数在0.444—0.804,低度至高度相关;中文版ACE各子项目与ACE总分低度至高度显著相关,相关系数在0.438—0.769(P<0.001)。(2)RICU组和对照组间,在中文版ACE中定向力、模仿能力、记忆能力及总分均有显著性差异(P<0.05),在MMSE中定向力、注意力与计算力、回忆能力、语言能力和总分均有显著性差异(P<0.05)。(3)中文版ACE总分90.5时约登指数最大(0.49),MMSE总分26.5时约登指数最大(0.525)。受试者操作曲线曲线下面积ACE为(0.813±0.035),MMSE为(0.841±0.032),两者无显著差异(Z=1.00,P=0.317)。结论:中文版ACE可以作为RICU患者认知障碍筛查的工具,且较MMSE更适宜在气管插管、气管切开及使用机械通气患者中使用。
