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Innovative Methods of Synthesis and Characterization for Molecularly Imprinted Polymers
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作者 Youyao Luo 《Open Journal of Applied Sciences》 2024年第9期2559-2579,共21页
The characterization of these molecularly imprinted polymers is essential to understanding their binding dynamics and structural properties. Through the analysis of the current research, it is found that there are ove... The characterization of these molecularly imprinted polymers is essential to understanding their binding dynamics and structural properties. Through the analysis of the current research, it is found that there are overlaps in the methods used by scholars. The Langmuir equation is frequently applied to model the adsorption isotherms of MIPs, providing critical insight into the capacity and affinity of the binding sites. Infrared Spectroscopy (IR) plays a crucial role in identifying the functional groups involved in the imprinting process and confirming the successful formation of specific binding sites. UV-visible spectrophotometry is employed to monitor the absorption characteristics of the polymers, offering data on the interactions between the template molecules and the polymer matrix. Transmission Electron Microscopy (TEM) provides detailed visualization of the internal structure of MIPs at the nanoscale, revealing the morphology and size of the imprinted cavities. Thermogravimetric Analysis (TGA) assesses the thermal stability and composition of the polymers, identifying decomposition patterns that are indicative of the material’s robustness under different conditions. Finally, the Laser Particle Size Analyzer is used to measure the size distribution of the polymer particles, which is critical for determining the uniformity and efficiency of the imprinting process. The six characterization methods discussed in this paper provide a comprehensive understanding of MIP, and it is hoped that in the future, more optimized design solutions will emerge and their applications in various fields will be enhanced. 展开更多
关键词 molecularly imprinted polymers Langmuir Equation Infrared Spectroscopy UV Visible Spectrophotometry Transmission Electron Microscopy
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虚拟模板MIPs-SPE联用技术对茶叶粗提物中咖啡因的分离纯化研究
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作者 何倩 孙亚坤 +2 位作者 程煜凤 杨建 王超 《新疆医科大学学报》 CAS 2024年第7期1014-1018,共5页
目的 采用儿茶素作为虚拟模板制备分子印迹聚合物(Molecular imprintingpolymers,MIPs)结合固相萃取(Solid phase extraction,SPE)技术对茶叶粗提物中的咖啡因进行分离纯化。方法 以儿茶素为虚拟模板,4-乙烯基吡啶为功能单体,乙二醇二... 目的 采用儿茶素作为虚拟模板制备分子印迹聚合物(Molecular imprintingpolymers,MIPs)结合固相萃取(Solid phase extraction,SPE)技术对茶叶粗提物中的咖啡因进行分离纯化。方法 以儿茶素为虚拟模板,4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,聚苯乙烯为大分子拥挤试剂,以原位聚合的方式制备虚拟模板分子印迹聚合物。测定该分子印迹聚合物的保留性能、形貌特征和孔径分布等性能,以该分子印迹聚合物作为固相萃取吸附剂,对茶叶粗提物中的咖啡因进行分离纯化。结果 所制备儿茶素分子印迹聚合物对咖啡因的最优印迹因子为4.57。对茶叶粗提物中的咖啡因进行分离纯化后,在咖啡因纯度高于95%的条件下,咖啡因的回收率可达85%以上。结论 以儿茶素为虚拟模板合成的分子印迹聚合物,可以用于茶叶粗提物中咖啡因的分离纯化。 展开更多
关键词 虚拟模板 分子印迹聚合物 固相萃取 儿茶素 咖啡因 分离纯化
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Synthesis and Solid Phase Extraction Performance Study of NNAL-specific Molecularly Imprinted Polymers Using Dummy Templates 被引量:2
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作者 张志丹 郑赛晶 +3 位作者 杨俊 王维妙 刘百战 朱晓兰 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第3期361-368,I0004,共9页
Dummy molecularly imprinted polymers (DMIPs) for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) were produced using three structural analogues as dummy template molecules. The chosen analogues were 4-(a... Dummy molecularly imprinted polymers (DMIPs) for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) were produced using three structural analogues as dummy template molecules. The chosen analogues were 4-(acetymethylamino)-1-(3-pyridyl)-butanol, 4- (methylamino)-1-(3-pyridyl)-1-butanol, and 1-(3-pyridyl)-1,4,-butanediol. The molecular recognition characteristics of the produced polymers were evaluated by X-ray photoelec- tron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR). Interactions between NNAL and methacrylic acid should be cooperative hydrogen bonds while the ni- trogen atom of the pyridine ring and the oxygen atom of the nitroso group in NNAL are two of the hydrogen-bond acceptors. It was further demonstrated that DMIP synthesized by 4-(acetymethylamino)-1-(3-pyridyl)-butanol had the best binding performance by XPS and FT-IR. Then dummy molecularly imprinted solid phase extraction (DMISPE) was developed for the determination of the analyte using the hit polymer as the sorbing material. Under optimal conditions, the recovery of NNAL dissolved in standard solution reached 93%. And the investigated polymer exhibited much higher binding of NNAL when nicotine was acted as the competitive molecule. Also the proposed method was applied to the measurement of NNAL spiked in blank urine samples with recoveries ranging from 87.2% to 101.2%. 展开更多
关键词 molecularly imprinted polymer Dummy template 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Solid phase extraction
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基于硼亲和分子印迹策略的MOF/MIPs对沙丁胺醇的选择性吸附和计算模拟
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作者 李欣 周颖 +3 位作者 王鼎南 裴勇 武斌 张宜明 《高等学校化学学报》 SCIE EI CSCD 北大核心 2024年第1期136-144,共9页
为了探索所构筑的硼酸功能化金属有机框架(MOF)表面印迹材料(FSU-BA@MIP)对底物的亲和识别能力,对FSU-BA@MIP的金属-有机骨架材料(UiO-66-BA)中的3-羧基苯硼酸配体与沙丁胺醇间的硼亲和作用进行计算,再采用密度泛函理论(DFT)对FSU-BA@MI... 为了探索所构筑的硼酸功能化金属有机框架(MOF)表面印迹材料(FSU-BA@MIP)对底物的亲和识别能力,对FSU-BA@MIP的金属-有机骨架材料(UiO-66-BA)中的3-羧基苯硼酸配体与沙丁胺醇间的硼亲和作用进行计算,再采用密度泛函理论(DFT)对FSU-BA@MIP材料对沙丁胺醇的选择性机理进行模拟,最后进行选择性实验.计算结果表明,离子化的3-羧基苯硼酸与沙丁胺醇间存在的氢键作用使得这两种物质有较强的作用力,更容易形成硼酸环酯;与竞争物质相比,UiO-66-BA与沙丁胺醇的结合能与反应能最低,说明所形成的FSU-BA@MIP印迹材料对底物沙丁胺醇具有特异性吸附.分析结果与实验得到的沙丁胺醇的最高吸附量一致,说明UiO-66-BA是一种可用于分析顺式二醇化合物的理想硼酸功能化材料. 展开更多
关键词 硼亲和 分子印迹聚合物 金属有机框架 沙丁胺醇 计算模拟
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Preparation of high selective molecularly imprinted polymers for tetracycline by precipitation polymerization 被引量:4
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作者 Tao Jing Xiao Dan Gao +5 位作者 Peng Wang Yan Wang Yan Fei Lin Xu Chen zong Yi Kai Zhou Su Rong Mei 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第12期1535-1538,共4页
High selective molecularly imprinted polymers (MIPs) for tetracycline have been prepared by precipitation polymerization. Effects of monomer and solvent, the ratio of monomer and template and the characterization of... High selective molecularly imprinted polymers (MIPs) for tetracycline have been prepared by precipitation polymerization. Effects of monomer and solvent, the ratio of monomer and template and the characterization of the polymer were investigated by frontal chromatography and selectivity experiment. The results clearly indicated that the polymer, which had the highest molecular recognition abilities for tetracycline antibiotics, had been received. 展开更多
关键词 Precipitation polymerization Tetracycline antibiotics molecularly imprinted polymers mips HPLC
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Molecularly Imprinted Polymers for Selective Extraction of Crystal Violet from Natural Seawater coupled with HighPerformance Liquid Chromatographic Determination 被引量:2
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作者 LIAN Ziru WANG Jiangtao 《Journal of Ocean University of China》 SCIE CAS 2014年第2期236-242,共7页
Molecularly imprinted polymers (MIPs) were prepared by the bulk polymerization using crystal violet as the template molecule, and the methacrylic acid and ethylene glycol dimetheacrylate as functional monomer and cr... Molecularly imprinted polymers (MIPs) were prepared by the bulk polymerization using crystal violet as the template molecule, and the methacrylic acid and ethylene glycol dimetheacrylate as functional monomer and cross-linker, respectively. Sys- tematic investigations of synthetic conditions were conducted. The surface morphology and recognition mechanism of the obtained polymers were studied using scanning electron microscope and spectrophotometric analysis. MIPs showed high atTmity to template molecule and were successfully applied as special solid-phase extraction sorbent for selective extraction of crystal violet from natural seawater. An off-line molecularly imprinted solid-phase extraction (MISPE) method followed by high-performance liquid chroma- tography with diodearray detection for the analysis of crystal violet was also established. MISPE columns have good recoveries for crystal violet standard solutions and good linearity was obtained over the concentration range of 0-200 ~tg L-1 (R2 〉 0.99). Finally, two natural seawater samples were investigated. The recoveries of spiked seawater on the MISPE columns were from 44.47% to 62.34%, the relative standard deviation (n=3) being in the range of 2.89%-5.96%. 展开更多
关键词 crystal violet molecularly imprinted polymer ADSORPTION solid-phase extraction natural seawater
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Theoretical Researches on the Self-assembly System of Molecularly Imprinted Polymers Formed via Phenobarbital and Acrylamide 被引量:1
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作者 WANG Guang-Yu LIU Jun-Bo +2 位作者 TANG Shan-Shan CHANG Hai-Bo JIN Rui-Fa 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第7期1069-1078,共10页
For preparing the phenobarbital(PHN) molecularly imprinted polymers(MIPs) with higher adsorption and selectivity properties, we used the M062 X/6-31 g(d,p) method of density functional theory to predict the various pr... For preparing the phenobarbital(PHN) molecularly imprinted polymers(MIPs) with higher adsorption and selectivity properties, we used the M062 X/6-31 g(d,p) method of density functional theory to predict the various properties of PHN-MIPs. Here PHN is as the imprinted molecule and acrylamide(AM) as the functional monomer. The ethylene glycol dimethacrylate,trimethylolpropane trimethacrylate, divinyl benzene, and pentaerythritol trimethacrylate are as the cross-linking agents, respectively. The acetonitrile, chloroform, toluene, and tetrahydrofuran are used as the solvents, respectively. The configurations of the molecular imprinting self-assembly system for PHN and AM have been simulated to study their bonding sites, binding energy, amount of hydrogen bond, and interaction mechanism. The essence of imprinting interaction for PHN and AM has been revealed by the atomic in the molecule theory. Meanwhile, the analogues of PHN were used to discuss the selectivity property of the stable PHN-AM complex. The results show that the PHN interacts with AM through hydrogen bonds. When the imprinting molar ratio of PHN-AM is1:6 and the THF is as the solvent, the amount of their hydrogen bonds is the most, the binding energy is the lowest, and their configuration is the most stable. In comparison with the other cross-linking agents(EGDMA, TRIM, and DVB), the PETA is more suitable for PHN-MIPs. The selective property of PHN-MIP to PHN is excellent when PHN and DMBA exist at the same time. 展开更多
关键词 PHN AM molecularly imprinted polymers COMPUTATIONAL simulation
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Fluorescent competitive assay for melamine using dummy molecularly imprinted polymers as antibody mimics 被引量:1
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作者 DU Xin-wei ZHANG Yan-xin +8 位作者 SHE Yong-xin LIU Guang-yang ZHAO Feng-nian WANG Jing WANG Shan-shan JIN Fen SHAO Hua JIN Mao-jun ZHENG Lu-fei 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2016年第5期1166-1177,共12页
A fluorescent competitive assay for melamine was first developed utilizing dummy molecularly imprinted polymers(DMIPs) as artificial antibodies. This method is based on the competition between fluorescent substances... A fluorescent competitive assay for melamine was first developed utilizing dummy molecularly imprinted polymers(DMIPs) as artificial antibodies. This method is based on the competition between fluorescent substances and the unlabeled analyte for binding sites in synthesized DMIPs and the decreased binding of fluorescent substances to DMIPs due to increased concentrations of melamine in the solutions. DMIPs for melamine were synthesized under a hot water bath in the presence of the initiator azobisisobutyronitrile(AIBN) using 2,4-diamino-6-methyl-1,3,5-triazine(DAMT) as a dummy template, methacrylic acid(MAA) as a functional monomer, and ethylene glycol dimethacrylate(EGDMA) as a crosslinking agent. The adsorption capacity and selectivity of DMIPs for melamine were evaluated by the isothermal adsorption curve and Scatchard analysis. The evaluation results showed that the synthesized DMIPs had specific recognition sites for melamine and the maximum adsorption amount was 1 066.33 μg g^(-1). Later, 5-(4,6-d ichlorotriazinyl) amino fluorescein(DTAF) with a triazine ring, which s lightly resembles m elamine, w as selected as the fluorescent substance. The fluorescent competitive assay using DMIPs as t he antibody mimics was finally established by selecting and optimizing the reaction solvents, DMIPs amount, DTAF concentration, and incubation time. The optimal detection system showed a linear response w ithin range of 0.05-40 mg L^(-1) and the limit of detection(LOD) was 1.23 μg L^(-1). It was successfully applied to the detection of melamine in spiked milk samples wi th satisfactory recoveries(71.9 to 86.3%). According to the comparative analysis, the result of optimized fluorescent competitive assay re vealed excellent agreement with the HPLC-MS/MS result for melamine. 展开更多
关键词 dummy molecularly imprinted polymers MELAMINE fluorescent competitive assay artificial antibody
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Preparation of Magnetic Molecularly Imprinted Polymers for Selective Isolation and Determination of Kaempferol and Protoapigenone in Macrothelypteris torresiana 被引量:1
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作者 蔡培珊 赵洋 +3 位作者 杨通华 陈静 熊朝梅 阮金兰 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2014年第6期845-855,共11页
Novel uniform-sized magnetic molecularly imprinted polymers (MMIPs) were synthe- sized for selective recognition of active antitumor ingredients of kaempferol (KMF) and protoapi- genone (PA) in Macrothelypteris ... Novel uniform-sized magnetic molecularly imprinted polymers (MMIPs) were synthe- sized for selective recognition of active antitumor ingredients of kaempferol (KMF) and protoapi- genone (PA) in Macrothelypteris torresiana (M. torresiana) by surface molecular imprinting tech- nique in this study. Super paramagnetic core-sheU nanoparticles (γ-MPS-SiO2@Fe3O4) were used as seeds, KMF as template molecule, acrylamide (AM) as functional monomer, and N, N'-methylene bisacrylamide (BisAM) as cross-linker. The prepared MMIPs were characterized by X-ray diffraction (XRD), Fourier transform infrared spectrum fiT/R), transmission electron microscopy (TEM) and thermo-gravimetric analysis (TGA), respectively. The recognition capacity of MMIPs was 2.436 times of non-imprinted polymers. The adsorption results based on kinetics and isotherm analysis were in accordance with the pseudo-second-order model (R2=0.9980) and the Langmuir adsorption model (R2=0.9944). The value of E (6.742 kJ/mol) calculated from the Dubinin-Radushkevich isotherm model suggested that the physical adsorption via hydrogen-bonding might be predominant. The Scatchard plot showed a single line (R2=0.9172) and demonstrated the homogeneous recognition sites on MMIPs for KMF. The magnetic solid phase extraction (MSPE) based on MMIPs as sorbent was established for fast and selective enrichment of KMF and its structural analogue PA from the crude extract of M. torresiana and then KMF and PA were detected by HPLC-UV. The established method showed good performance and satisfactory results for real sample analysis. It also showed the feasi- bility of MMIPs for selective recognition of active structural analogues from complex herbal extracts. 展开更多
关键词 magnetic molecularly imprinted polymers magnetic solid phase extraction KAEMPFEROL protoapigenone Maerothelypteris torresiana
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Molecularly Imprinted Polymers on Chloromethyl Polystyrene Resin Prepared via RAFT Polymerization 被引量:1
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作者 Zhen Xia DU Hong LIU Zhi Feng FU Wan Tai YANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第4期549-552,共4页
Surface molecularly imprinted polymers (SMIP) was prepared via the reversible addition-fragmentation chain transfer (RAFT) polymerization on the chloromethyl polystyrene resin (CPR) in the presence of the templa... Surface molecularly imprinted polymers (SMIP) was prepared via the reversible addition-fragmentation chain transfer (RAFT) polymerization on the chloromethyl polystyrene resin (CPR) in the presence of the template D-phenylalanine. The structure of SMIP was characterized by FTIR and SEM. The adsorption behavior of D-phenylalanine of SMIP was preliminarily investigated. 展开更多
关键词 Surface molecularly imprinted polymers reversible addition-fragmentation chain transfer.
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Direct Synthesis of Monodisperse Hollow Molecularly Imprinted Polymers Based on Unfunctionalized SiO2 for the Recognition of Bisphenol A 被引量:1
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作者 Shao-min Liu Meng-xing Wei +1 位作者 Xin Fu Xue-bin Zhang 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2018年第2期229-237,246,共10页
A novel and effective approach was developed to synthesize monodisperse hollow molecularly imprinted polymers (MHMIPs) with unfunctionalized SiO2 spheres in a mixture of toluene and CH3CN. The factors that affected ... A novel and effective approach was developed to synthesize monodisperse hollow molecularly imprinted polymers (MHMIPs) with unfunctionalized SiO2 spheres in a mixture of toluene and CH3CN. The factors that affected the synthesis of MHMIPs were systematically investigated. It was determined that a suitable ratio of toluene to CH3CN and the use of a functional monomer that can generate double H-bonding interactions were the critical factors to obtain MHMIPs with high uniformity and rnonodispersion. The obtained MHMIPs exhibited a fast adsorption rate and high adsorption capacity (270 μmol/g) for bisphenol A. As the shell thickness increased from 90 nm to 130 nm, the binding capacity of the imprinted shells decreased gradually. The relative selectivity coefficients of MHMIPs for tetra-brornobisphenol A (TBBPA), phenol and p-tert-butylphenol (PTBP) were calculated as 1.53, 1.83 and 1.90, respectively. These findings indicate that MHMIPs have good adsorption performances and suggest applications in the selective removal or sensitive analysis of bisphenol A. 展开更多
关键词 Hollow molecularly imprint Molecular recognition Nanostructured polymers Bisphenol A
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The Development of Molecularly Imprinted Polymers in the Clean-Up of Water Pollutants: A Review 被引量:1
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作者 Kwabena Agyarko Sarpong Wanzhen Xu +1 位作者 Weihong Huang Wenming Yang 《American Journal of Analytical Chemistry》 2019年第5期202-226,共25页
In the last decades, the extensive use of chemical and biological materials has not only seen to an increased transport of environmental pollutants but also, it has interfered and compromised the pristine state of dif... In the last decades, the extensive use of chemical and biological materials has not only seen to an increased transport of environmental pollutants but also, it has interfered and compromised the pristine state of different environmental matrices with emphasis on waterbodies. This has stimulated studies to develop and adopt novel techniques which consider the removal of pollutants with premium on economic feasibility, simple instrumentation, and high performance. In the treatment of water, the removal of trace concentration organic compounds and other numerous polluted water effluents is difficult due to limited affinity of trace compound ions to ion exchange resins. Because of the selective nature;recognition properties;adsorption ability;high stability;and easier preparation of molecular imprints, they are considered attractive and suitable artificial receptors to be applied in analytical separations, drug delivery, and as chemical sensors. In this review, we touch on the fundamentals of molecularly imprinted technologies and underscore some recent advances made in the development of imprinted polymers that are compatible with water and how they can be used in the clean-up of pollutants. The paper finally presents a comprehensive report on some challenges and outlook in the use of MIPs as water treatment sorbent. 展开更多
关键词 WASTEWATER Treatment AQUEOUS Conditions molecularly imprinted polymers Water-Compatible
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Application of Molecularly Imprinted Polymers for the Analysis of Pesticide Residues in Food—A Highly Selective and Innovative Approach 被引量:11
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作者 Raquel Garcia Maria Joao Cabrita Ana Maria Costa Freitas 《American Journal of Analytical Chemistry》 2011年第8期16-25,共10页
The increasing application of pesticides for agricultural purposes involves serious risk to the environment and human health due to either exposure or through residues in food and drinking water. Since food safety is ... The increasing application of pesticides for agricultural purposes involves serious risk to the environment and human health due to either exposure or through residues in food and drinking water. Since food safety is of mandatory importance there is a growing interest on the development of selective, simple, rapid, cost-effective and reliable analytical methodologies in order to ensure that pesticides residues should not be found at levels above the established maximum pesticide residue limits (MRLs). In recent years, a new methodology based on the development of molecularly imprinting polymers (MIPs) allows not only pre-concentration and cleaning of the sample but also selective extraction of the target analyte, which is crucial, particularly when the sample is complex and impurities can interfere with quantification. The scope of this review is to provide a general overview on MIPs field, with emphasis on MIP preparation and its use as sorbents for solid-phase extraction. This paper will be focused on the review of the current state of the art in the use of MIPs as selective materials in molecularly imprinted solid-phase extraction (MISPE) for the analysis of pesticide residues from food matrices. A review of preparation and application of MIPs in food matrices, will also be discussed. 展开更多
关键词 molecularly imprinted Polymer Pesticide Residues FOOD
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STUDY ON THE NON-COVALENT INTERACTION OF APIGENIN MOLECULARLY IMPRINTED POLYMERS BY SPECTROMETRY 被引量:1
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作者 GUO Lifei HE Minqiang +3 位作者 CHEN Yongqiang SONG Chengcheng WAN Jincheng LI Chunxiang 《Chinese Journal of Reactive Polymers》 2008年第1期66-73,共8页
The non-covalent interaction between apigenin (API) and different functional monomers (α-methylacrylic acid (MAA), acrylamide (AM), 2-vinylpyridine (2-Vpy) and combined functional monomers (AM/2-Vpy)) was determined ... The non-covalent interaction between apigenin (API) and different functional monomers (α-methylacrylic acid (MAA), acrylamide (AM), 2-vinylpyridine (2-Vpy) and combined functional monomers (AM/2-Vpy)) was determined by UV spectrometry, and a series of apigenin molecularly imprinted polymers (API-MIPs) was synthesized with different functional monomers through molecular imprinting technology. The relationship between the non-covalent interaction of template/functional monomer and absorption of MIPs also was studied. The results showed that the order of the strength of the non-covalent interaction between API and different functional monomers in tetrahydrofuran (THF) is as follows: 2-Vpy> AM/2-Vpy>AM>MAA, which is positive correlation to the absorption capability of corresponding MIPs, and 2-Vpy is the optimum functional monomer among the used monomer for preparing API- MIPs. 展开更多
关键词 APIGENIN molecularly imprinted polymers Non-covalent interaction UV spectrometry.
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Preparation of High Selective Molecularly Imprinted Polymers for (S)-4-Phenyl-2-oxazolidinone
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作者 Yong LUO Lan LIU Li Hong LI Qin Ying DENG 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第12期1551-1554,共4页
(S)-4-Phenyl-2-oxazolidinone imprinted polymers were prepared by using methacrylic acid (MAA) as the functional monomer, and divinylbenzene (DVB) as crosslinker. The factors, which influence the selectivity of t... (S)-4-Phenyl-2-oxazolidinone imprinted polymers were prepared by using methacrylic acid (MAA) as the functional monomer, and divinylbenzene (DVB) as crosslinker. The factors, which influence the selectivity of the polymers were explored. Effective separation was observed for racemic 4-phenyl-2-oxazolidinone in mobile phase of acetonitrile. The investigation of mobile phase suggested that the hydrogen bonds between template and functional monomer was a primary factor in chiral recognition, while the preparation of polymers implied that the л-л stacking interaction between template and crosslinker played a role in imprinting procedure. 展开更多
关键词 molecularly imprinted polymers mips 4-phenyl-2-oxazolidinone HPLC.
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Uniformly Sized Molecularly Imprinted Polymers: Their Applications to Chiral Separation and Bioanalysis
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作者 HAGINAKA Jun SANBE Haruyo 《色谱》 CAS CSCD 北大核心 2004年第4期306-308,共3页
关键词 手性分离 生物分析 分子印迹聚合物 高效液相色谱分析
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The Application of Molecularly Imprinted Polymers
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作者 Ming Zhao Guijun Shen 《Journal of Materials Science and Chemical Engineering》 2015年第7期87-89,共3页
Molecularly imprinted technology (MIT) has the characteristics of specificity and high selectivity, which is one of the most promising methodologies. Besides, the polymers are made using MIT as the functional material... Molecularly imprinted technology (MIT) has the characteristics of specificity and high selectivity, which is one of the most promising methodologies. Besides, the polymers are made using MIT as the functional material of solid-phase extraction and chromatographic fractionating and sensor, because of the characteristics of the high selectivity, the better stability and easy preparation. This review introduces the progress in the application of MIT and summarizes its application in the chemistry. 展开更多
关键词 molecularly imprinted polymers SOLID PHASE EXTRACTION CHROMATOGRAPHIC Fractionating
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RECENT ADVANCES IN THE PREPARATION OF MOLECULARLY IMPRINTED POLYMERS VIA CONTROLLED RADICAL POLYMERIZATION TECHNIQUES
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作者 ZHANG Ying ZHANG Huiqi 《Chinese Journal of Reactive Polymers》 2008年第1期1-11,共11页
Molecular imprinting technique is a simple and efficient method for the preparation of polymer materials (i.e., molecularly imprinted polymers, MIPs) with tailor-made recognition sites for certain target molecules. Th... Molecular imprinting technique is a simple and efficient method for the preparation of polymer materials (i.e., molecularly imprinted polymers, MIPs) with tailor-made recognition sites for certain target molecules. The resulting MIPs have proven to be versatile synthetic receptors due to their high specific recognition ability, favorable mechanical, thermal and chemical stability, and ease of preparation. Recent years have witnessed significant progress in the synthesis and applications of MIPs. This review focus on the recent developments and advances in the preparation of MIPs via various controlled radical polymerization techniques. 展开更多
关键词 Molecular imprinting molecularly imprinted polymers PREPARATION Controlled radical polymerization.
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Recent advances in magnetic molecularly imprinted polymers and their application in the food safety analysis 被引量:1
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作者 Beibei Jia Feng Feng +2 位作者 Xiujuan Wang Yaxuan Song Feng Zhang 《Journal of Future Foods》 2024年第1期1-20,共20页
Food safety is a worldwide concern and is directly related to human health.Therefore,convenient,effective,and economical methods and technologies for food safety analysis have been developed continuously.Magnetic mole... Food safety is a worldwide concern and is directly related to human health.Therefore,convenient,effective,and economical methods and technologies for food safety analysis have been developed continuously.Magnetic molecularly imprinted polymers(MMIPs)have gained extensive attention in recent years,as they have high selectivity,high adsorption capacity,and are easy to isolate from food samples.Recently,advanced strategies for the synthesis of MMIPs have been proposed to solve problems of template leakage and non-specific adsorption,and to increase the biocompatibility,adsorption rate,as well as adsorption capacity of the imprinted materials.In this review,we focus on new attempts at modification of magnetic core and MMIPs’surfaces,and the selection of template,functional monomer,cross-linker as well as porogen.Studies are summarized that used advanced MMIPs for the recognition and adsorption of pesticide residues,veterinary drug residues,mycotoxins,contaminants,and adulterations in foodstuffs over the last 5 years.Finally,some still existing challenges and future prospects to further promote MMIPs properties are also discussed. 展开更多
关键词 Food safety Magnetic molecularly imprinted polymers Pesticide residues Mycotoxins CONTAMINANTS
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A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples 被引量:6
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作者 Ningli Wu Zhimin Luo +7 位作者 Yanhui Ge Pengqi Guo Kangli Du Weili Tang Wei Du Aiguo Zeng Chun Chang Qiang Fu 《Journal of Pharmaceutical Analysis》 SCIE CAS 2016年第3期157-164,共8页
Surface molecularly imprinted polymers (SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support. The physical and morphological... Surface molecularly imprinted polymers (SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support. The physical and morphological characteristics of the polymers were investigated by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), elemental analysis and nitrogen adsorption-desorption test. The obtained results showed that the SMIPs displayed great adsorption capacity (13.5 lag/mg), high recognition ability (the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium. Finally, as solid phase extraction adsorbents, the SMIPs coupled with HPLC method were validated and applied for the enrichment, purification and determination of anapicillin sodium in real milk and blood samples. The averages of spiked accuracy ranged from 92.1% to 107.6%. The relative standard deviations of intra- and inter-day precisions were less than 4.6%. This study provides a new and promising method for enriching, extracting and determining ampicillin sodium in complex biological samples. 展开更多
关键词 Ampicillin sodium Surface molecularly imprinted polymers Solid phase extraction High performance liquid chromatography
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