Multi-systemic melioidosis

This editorial is a commentary on the article by Ni et al,which was published in the World Journal of Clinical Cases.The article discusses the diagnostic and therapeutic challenges of melioidosis caused by Burkholderia pseudomallei.The case study highlights a rare instance of multisystemic melioidosis in a female patient who did not have a travel history,emphasizing the significance of recognizing this condition in non-endemic regions.Diagnostic complexities and therapeutic strategies are addressed,emphasizing the need for heightened clinical suspicion,comprehensive evaluation,and multidisciplinary collaboration.The editorial delves into the clinical presentation,diagnostic dilemmas,therapeutic approaches,and their implications for patient care in managing multi-systemic melioidosis.

Nonalcoholic fatty liver disease as a multi-systemic disease

Nonalcoholic fatty liver disease(NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked with insulin resistance. NAFLD should be considered not only a liver specific disease but also an early mediator of systemic diseases. Therefore, NAFLD is usually associated with cardiovascular disease, chronic kidney disease, type 2 diabetes, obesity, and dyslipidemia. NAFLD is highly prevalent in the general population and is associated with increased cardiovascular morbidity and mortality. The underlying mechanisms and pathogenesis of NAFLD with regard to other medical disorders are not yet fully understood. This review focuses on pathogenesis of NAFLD and its relation with other systemic diseases.

从多系统年代学(Multi-System Geochronology)透视云开地块古生代—中生代的构造演化

云开地块位于华南板块南缘,经历了麻粒岩—高角闪岩相的高级变质作用,是华南地区为数不多的高级变质地体。研究表明,云开地块在古生代到中生代经历了复杂的构造演化过程,分别记录了早古生代末期、早中生代、晚中生代早期和晚中生代晚期的构造影响。这些构造事件在多系统年代学图上具有很好的表现,系统地揭示了云开地块的地质演化历史。

Multi-System Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease and Toxic Shock Syndrome so Different and Similar

Children are infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but they are asymptomatic or suffer a mild disease compared to adults. However, the post-infectious immune dysregulation may result in the Multisystem Inflammatory Syndrome in Children (MIS-C). The most common presentations of MIS are fever, gastrointestinal (diarrhea, vomiting, abdominal pain), cardiovascular, mucocutaneous (rash, mucus membrane changes, conjunctival injection), respiratory (including sore throat), headache, limb and periorbital edema, and elevated inflammation markers. Some clinical and laboratory features of MIS-C are similar to other systemic diseases of childhood as Kawasaki disease and Toxic Shock Syndrome. Here are reported three cases in children with MIS-C, Kawasaki disease and Toxic Shock Syndrome to highlight the similarities and differences of these diseases.

Modelling Reliability-adaptive Multi-system Operation

This contribution discusses the concept of Reliability-Adaptive Systems （RAS） to multi-system operation. A fleet of independently operating systems and a single maintenance unit axe considered. It is the objective in this paper to increase overall performance or workload respectively by avoiding delay due to busy maintenance units. This is achieved by concerted and coordinated derating of individual system performance, which increases reliability. Quantification is carried out by way of a convolution-based approach. The approach is tailored to fleets of ships, aeroplanes, spacecraft, and vehicles （trains, trams, buses, cars, trucks, etc.） - Finally, the effectiveness of derating is validated using different criteria. The RAS concept makes sense if average system output loss due to lowered performance level （yielding longer time to failure） is smaller than average loss due to waiting for maintenance in a non-adaptive case.

Theoretical Application to Understand Food Insecurity Among College Students: A Multi-Systems Life Course Perspective

Empirical studies have shown a distinct relationship between academic performance and food insecurity in college students. Specifically, food-insecure students are more likely to report a lower grade point average than their food secure counterparts. Since the Great Recession, more attention has been given to the topic of hunger and food insecurity among college students;however, the literature still lacks a comprehensive examination of various issues facing today’s college students. Using a multi-systems life course (MSLC) perspective, this paper provides a conceptual explanation of the lived experience of college students by offering a better understanding of the unique challenges faced by this population. Findings from this study will assist researchers, practitioners, and university administrators in their efforts to address hunger among this population.

The key mechanisms of multi-system responses triggered by central nervous system damage in hand,foot,and mouth disease severity

Hand,foot,and mouth disease(HFMD)is a prevalent infectious affliction primarily affecting children,with a small portion of cases progressing to neurological complications.Notably,in a subset of severe HFMD cases,neurological manifestations may result in significant sequelae and pose a risk of mortality.We systematically conducted literature retrieval from the databases PubMed(1957–2023),Embase(1957–2023),and Web of Science(1957–2023),in addition to consulting authoritative guidelines.Subsequently,we rigorously selected the most relevant articles within the scope of this review for comprehensive analysis.It is widely recognized that the severity of HFMD is attributed to a multifaceted array of pathophysiological mechanisms.The implication of multi-system dysfunction appears to be perturbances of the human defense system;therefore,it contributes to the severity of HFMD.In this review,we provide an overview and analysis of recent insights into the molecular mechanisms contributing to the severity of HFMD,with a particular focus on cytokine release syndrome,the involvement of the renin-angiotensin system,regional immunity,endothelial dysfunction,catecholamine storm,viral invasion,and the molecular mechanisms of neurological damage.We speculate that the domino effect of diverse physiological systems,initiated by damage to the central nervous system,serve as the primary mechanisms governing the severity of HFMD.Simultaneously,we emphasize the knowledge gaps and research urgently required to delineate a quick roadmap for ongoing and essential studies on HFMD.

双回路控制下拖拉机发动机管理系统的设计

随着拖拉机发动机控制系统的复杂性在不断增加,拖拉机发动机扭矩管理系统需要满足多种工况需求,配备多种传感器和执行器,同时具备高效能和燃油经济性。为此,设计了基于双回路速度跟踪控制的拖拉机发动机扭矩管理系统,通过两个回路实现对发动机扭矩的精确控制,其中一个回路用于速度跟踪,另一个回路用于调节发动机扭矩。通过精确的速度控制和扭矩管理,系统可以在不同工况下实现高效的能量利用和优化的运行性能。试验结果表明:系统能够有效地实现发动机扭矩的准确控制,提高了拖拉机的整体性能和燃油经济性。研究结果旨在改进拖拉机发动机控制系统的性能,提高其适应多种工况的能力,并实现更高的燃油经济性。

离散时间多智能体系统间歇事件触发输出一致性

对离散时间多智能体系统间歇事件触发输出一致性进行了研究。首先,结合间歇控制和事件触发机制,针对离散多智能体系统提出一个输出一致性控制协议。然后,构造误差系统,基于Lyapunov稳定性理论得到了依赖于网络的Laplacian矩阵和系统增益的输出一致性条件,实现离散时间多智能体系统间歇事件触发输出一致性。最后,利用具体的仿真例子对结果的有效性进行分析验证。

The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.

岛礁风光柴储多能源独立微电网建模分析

岛礁多能源独立微电网是解决远海岛礁供电难题,确保岛上军民用电稳定及提高岛礁自然资源利用率的关键技术。传统岛礁独立微电网建模电源种类不够完备,交流母线应用较少。为此,建立了风、光、柴、储4种电源数学模型,在电力电子变换器中使用了基于扰动观察法的Boost升压电路与基于电网电压定向的矢量控制方式。系统模型中风、光、柴、储4种电源汇入交流母线,整体功率、电压趋于稳态。仿真结果表明:所构建的岛礁多能源独立微电网模型较为科学合理,可为开展岛礁多能源微电网健康管理等研究打下坚实基础。

考虑新能源消纳的黄河上游水电站群生态优化调度研究

为降低黄河上游水电站群调度中新能源消纳对河流径流情势和生态完整度的影响,以河流径流情势变化最小、水电站群发电量最大、发电出力平稳性最高为目标,建立了风水光多能互补系统生态调度模型,采用多目标进化算法求解,探讨了多能互补系统发电出力、新能源消纳及河流生态保护之间的均衡关系。结果表明:水电站群发电量和河流生态保护目标之间呈现明显的竞争关系,多能互补系统的发电出力波动越大,水电站群发电量越大,径流情势变化也越大;入库径流量越大,水电站群生态调度对径流情势的影响越小;多能互补系统生态调度对径流情势的影响主要集中在年发生高/低流量脉冲次数和流量平均增加率/减少率这两项指标,在枯水年发电量最大的调度结果中,年发生低流量脉冲次数和流量平均减少率指标的变化最大。

新型电力系统中的规划运营与电力市场:研究进展与科研实践

“碳达峰、碳中和”战略目标下,能源结构清洁化—可再生能源并网比例不断提高、能源要素多元化—发输配用各环节海量灵活性资源接入两大趋势带来的挑战,对电力规划、调度运营、电力市场产生了重大影响。规划中如何综合考虑海量运行场景与多元化要素,运营中如何高效调度多样灵活性资源,市场如何设计机制激励主体提供灵活性,都是新型电力系统建设亟待解决的问题。该文从电力规划、调度运营、电力市场3个层面出发,对近年来新型电力系统中规划运营与电力市场的相关研究进展进行系统梳理,涵盖基础理论、机制设计、应用研究、系统研发等多类型研究文献。进一步从规划、调度、市场3个方面展望未来研究趋势,如新型要素接入下的电网韧性、电碳耦合调度理论与高效求解技术、辅助服务与容量市场交易品类、考虑储能等新型主体的市场交易机制等,以期为我国新型电力系统的建设提供有益参考。

基于多元储能的分布式能源系统优化调度方法研究

为进一步构建清洁低碳、经济节能的供能系统,研究建立了含风、光以及多元储能的分布式能源系统,针对北京某办公园区,采用DeST预测用户负荷以及当地风、光条件。以经济性、节能性和环保性三方面的综合效益最大为目标,提出一种自适应优化运行策略,分别采用穷举搜索法和遗传算法对系统优化调度方案进行优化。同时,采用以电定热运行策略作为对照,对比分析几种不同运行策略下系统的综合效益。结果表明:传统以电定热运行模式下的综合效益平均值为0.41;而在自适应优化运行策略下,使用遗传算法得到的调度方案,其综合效益平均值可达0.5,穷举搜索法得到的运行方案,其综合效益平均值可达0.51。

基于虚拟领导节点改进的孤岛微电网完全分布式二次调频策略

传统分布式二次调频策略在虚拟领导节点频率信息出现故障时会导致微电网系统频率无法恢复,针对该问题提出并设计一种完全分布式二次调频策略。首先分析传统分布式二次调频策略虚拟领导节点故障对二次调频过程产生的影响;然后,结合一致性算法对传统分布式二次调频控制器加以改进,通过将调频补偿量与频率偏差的对消作为“频率引导项”加入各分布式控制器中,使得各分布式发电单元完全对等,以保证虚拟领导节点去除后频率的正常恢复,实现完全分布式控制;最后,通过仿真验证所提方法在保证频率恢复方面的有效性与优越性。

都市圈轨道交通多网融合的信号系统方案研究

结合都市圈网络化、公交化特点,提出都市圈轨道交通信号系统融合的技术目标,即采用现有技术C2/C2+ATO与CBTC系统的融合以及采用新型互联互通技术的信号系统间的融合。分析现有信号主流的CTCS系统与CBTC系统的地面和车载设备在技术层面、工作机理、系统功能等差异的基础上提出“地对车兼容”和“车对地兼容”的互联互通方案,结合各目前相关单位在开展的研究情况,分析新型市域铁路互联互通技术路线。

个人养老金税收优惠政策何以可为?——来自美国、德国和澳大利亚的经验与启示

发展个人养老金是健全养老保险体系和积极应对人口老龄化挑战的重要举措,而灵活高效的税收优惠政策则是推动个人养老金制度高质量发展的关键要素。虽然近年来我国制定了个人养老金税收优惠政策,但是仍存在诸多问题,严重掣肘个人养老金制度的高质量发展。基于文献研究法、比较分析法对美国、德国和澳大利亚等典型国家个人养老金税收优惠政策的主要实践、基本特征、实施效果以及对中国的启示等重要问题进行深入探讨。研究发现,经过数十年的积极探索,美国、德国和澳大利亚逐步建立了灵活高效的个人养老金税收优惠政策,主要体现在激励方式灵活多样、政策制定立法先行、政策调整循序渐进、关注低收入群体的需求以及鼓励以家庭为参保对象等五个方面,有效推动了其个人养老金制度的发展与成熟。不过,这些典型国家个人养老金税收优惠政策在取得瞩目成就的同时,仍然面临对低收入群体的吸引力不足等现实困境。结合典型国家的有益经验和深刻教训,对我国个人养老金税收优惠政策存在的主要问题进行剖析,并提出更具针对性的见解,认为我国个人养老金税收优惠政策应当从四个方面作出改进:一是引入多种税收优惠模式,增强政策的吸引力;二是凸显税收优惠政策的精准性,助推优惠资源向低收入群体倾斜;三是提升税收优惠政策的灵活性,鼓励个人合理配置税收优惠额度;四是税收优惠政策应支持以家庭形式参保。

海上浮式风机多体系统耦合动力模型研究

海上浮式风机是近年来随着海上风电的快速发展,为了捕获深海更丰富、更持久的风能而提出的一种风力发电装置,已成为当今风能开发的主要方向。作为一种多体系统,由于海上浮式风机结构特殊,加上环境复杂,对其进行准确的计算和分析尤为重要。本文对海上浮式风机的耦合动力模型进行了研究,建立了复杂工况下Spar型海上浮式风机改进的14-DOF耦合动力模型,包括气动力模块、水动力模块和结构分析模块等,用于扩展其适用范围和准确计算风机的动力响应,并通过数值仿真对所建模型进行了分析和验证。主要的改进有:不对平台和塔架的转动角度作小量近似,扩展其适用范围;考虑角速度和欧拉角速度的换算关系,不作等化处理。此外,所建模型考虑风机叶片扭转角对叶片变形的影响,得到了较为准确的叶片面内外响应。同时采用线性势流理论对水动力进行计算,较之Morison方程适用性更广。仿真分析表明,本文所建模型可以更准确地计算海上浮式风机系统的动力响应,且具有更广的适用范围。

基于非零和博弈的互联异构多微网系统电热碳优化调度策略

微电网规模随着新能源渗透比例的提高与日剧增,然而由于缺乏灵活的能量转移机制,针对单个微电网的低碳经济调度优化效果有限。有效利用多微网系统内部的结构差异,实现能源在空间与时间双重维度上的流动对促进新能源电力系统低碳经济发展具有重要意义。为此,该文在考虑多微网功能区差异的基础上,运用纳什谈判思想,制定了计及电、热、碳能源交易的多微网系统优化调度策略。首先,针对微网功能区差异性构建基于居民区、商业区与工业区的多微网系统运行框架;其次,根据不同功能区的负荷特性构建了计及电、热负荷可替代性的需求响应模型;最后,以纳什谈判思想为基础,结合交替方向乘子法与商业求解器达成多微网间电、热、碳互利共赢的交易策略。算例分析验证了所提方案能够在实现多微网隐私保护的前提下全面提高系统运行的低碳性与经济性。

计及深度调峰的风-光-水-火-抽蓄多能源联网系统优化调度研究

多种能源联网运行逐步成为未来电力系统发展的方向,多能源联网系统的优化调度是应对规模化新能源并网消纳的重要手段。文中建立了计及火电机组深度调峰成本的风-光-水-火-抽蓄联网系统成本模型和考虑调峰主动性的风-光-水-火-抽蓄联网系统日前优化调度模型。针对多能源耦合系统结构复杂的情况,提出了分层优化调度的模型求解策略。上层模型以净负荷波动最小为优化目标,得到等效负荷曲线;下层模型根据上层模型的调度结果,以调峰运行的经济性最优和新能源弃电率最低为目标函数,计及调峰主动性,求解考虑火电机组深度调峰煤耗特性的含新能源系统的经济调度问题。仿真算例表明所建模型实现了多能源联网系统的互补运行,提升了火电机组的深度调峰能力,降低新能源弃电率和系统运行成本。