人工法off-line HDF对血液透析充分性和高同型半胱氨酸血症的影响

目的探究人工法off-line HDF对维持性血液透析(MHD)患者透析充分性、高同型半胱氨酸血症(HHcy)的影响。方法随机选取2021至2023年于南昌大学第一附属高新医院血液透析中心稳定透析6个月以上的MHD患者30例,进行单中心自身对照研究,时长6个月。前3个月维持每周2次高通量血液透析(HFHD)联合1次on-line HDF,后3个月维持每周2次人工法off-line HDF联合1次on-line HDF。于研究第3个月、第6个月时用全自动生化分析仪检测透析前后血尿素氮(BUN)、血肌酐(SCr)、β2-微球蛋白(β2MG)、同型半胱氨酸(Hcy)、白蛋白(Alb)、C反应蛋白(CRP)、血红蛋白(Hb)、甲状旁腺素(iPTH)、磷(P)、钾(K)水平;计算血清尿素清除指数(Kt/V)、尿素下降率(URR)和β2MG清除率。结果人工法off-line HDF模式透析的Kt/V、URR及β2MG清除率均较显著高于HFHD模式透析(P<0.05);人工法off-lineHDF模式透析Kt/V、URR及β2MG清除率达到透析充分的百分率分别为83.33%、83.33%和93.33%,均显著高于HFHD模式透析(P<0.05)。与HFHD模式透析时相比,人工法off-lineHDF模式透析结束后,患者透析前Hcy水平降低,Alb水平升高(P<0.05)。结论人工法off-line HDF模式透析可显著增加Kt/V、URR和β2MG清除率,提高MHD患者的透析充分性达标率,且对HHcy具有改善作用。

Impact of Sedation Protocols on Elderly Patients Undergoing Mechanical Ventilation and Off-Line Weaning

The proportion of elderly patients in intensive care is increasing, and a significant proportion of them require mechanical ventilation. How to implement safe and effective mechanical ventilation for elderly patients, and when appropriate off-line is an important issue in the field of critical care medicine. Appropriate sedation can improve patient outcomes, but excessive sedation may lead to prolonged mechanical ventilation and increase the risk of complications. Elderly patients should be closely monitored and evaluated on an individual basis while offline, and the sedation regimen should be dynamically adjusted. This requires the healthcare team to consider the patient’s sedation needs, disease status, and pharmacodynamics and pharmacokinetics of the drug to arrive at the best strategy. Although the current research has provided valuable insights and strategies for sedation and off-line management, there are still many problems to be further explored and solved.

Effects of on-line solution and off-line heat treatment on microstructure and hardness of die-cast AZ91D alloy

The effects of on-line solution, off-line solution and aging heat treatment on the microstructure and hardness of the die-cast AZ91D alloys were investigated. Brinell hardness of die-cast AZ91D alloy increases through on-line solution and off-line aging treatment but decreases after off-line solution treatment. By X-ray diffractometry, optical microscopy, differential thermal analysis, scanning electron microscopy and X-ray energy dispersive spectroscopy, it is found that the microstructures of the die-cast AZ91D magnesium alloy before and after on-line solution and off-line aging are similar, consisting of α-Mg and β-Al12Mg17. The precipitation of Al element is prevented by on-line solution so that the effect of solid solution strengthening is enhanced. The β-Al12Mg17 phases precipitate from supersaturated Mg solid solution after off-line aging treatment, and lead to microstructure refinement of AZ91D alloy, so the effect of precipitation hardening is enhanced. The β-Al12Mg17 phases dissolve in the substructure after off-line solution treatment, which leads to that the grain boundary strengthening phase is reduced significantly and the hardness of die cast AZ91D is reduced.

分布式水文-土壤-植被模式的改进及气候水文Off-line模拟试验

文中对引进的高分辨率 (94 2 .5m× 94 2 .5m)分布式水文 土壤 植被模式 (DHSVM) ,针对海、滦河流域的特点进行了改进 ,主要包括 :(1)改变蒸散发模拟方法 ,用改进的Penman Monteith模式模拟海滦河流域的蒸发 ,较好地模拟出 1a内的两个峰值 ,最大值出现在 4～ 6月 ,次大值出现在 7～ 8月 ;(2 )改变水文模式结构 ,用多站点气候观测资料内插到模式网格点 ,充分实现了分布式水文模拟 ;(3)发展新的水文、植被、土壤参数化方案 ,对 33个参数分区计算和确定 ,并重点对土壤孔隙度 φ、土壤蓄水能力θfc、叶面指数LAI、随机阻抗γs 等 11个参数进行调试和修订 ,提高了水文模拟精度。用改进的DHSVM模式分别对滦河、桑干河流域蒸散发、地下水位、土壤湿度、土壤水下渗、产流、汇流与径流等水文过程进行Off line模拟试验 ,模拟结果与实测值一致性较好 ,滦河流域 1979～ 1991年、桑干河流域 1979～ 1987年水文模拟效率系数分别为 0 .89和 0 .82 。

一个改进的陆面过程模式及其模拟试验研究第一部分:陆面过程模式及其“独立(off-line)”模拟试验和模式性能分析

文中在综合比较过去各类陆面过程模式优缺点的基础上，主要参考ＢＡＴＳ模式，发展了一个陆面过程模式（ＬＰＭ－ＺＤ）。它具有以下几个特征：１．采用物理方程和经验解析公式相结合的方法进行土壤温度和土壤水汽的求解。在上层土壤，土壤分层较细并采用温度传导和水汽扩散方程求解，而在下层土壤，土壤分层较粗并利用经验方法处理。２．考虑了降水分布的次网格特征及其对陆面水文产生的重要影响。３．较全面地考虑了雪盖对陆面过程的各种影响：对陆面水文的影响、对土壤热传导的影响以及雪盖的高反照率对辐射收支的影响。利用３组单点观测试验资料对陆面过程模式ＬＰＭ－ＺＤ进行了“独立（ｏｆ－ｌｉｎｅ）”模拟试验。模拟结果表明陆面过程模式ＬＰＭ－ＺＤ具有较好的模拟性能，能够比较准确地模拟不同气候区的多种下垫面类型的陆面过程变化特点，模拟结果与观测基本一致。进而又利用一组观测资料和模式ＬＰＭ－ＺＤ进行了一系列敏感性模拟试验，试验结果表明模式ＬＰＭ－ＺＤ对一些参数的确定非常敏感，如初始土壤水汽、植被的物理特性参数以及降水次网格分布因子等，因此提高确定这些参数的准确性是改进陆面模式的重要内容之一。

A Land Surface Model(IAP94) for Climate Studies PartI:Formulation and Validation in Off-line Experiments

The IAP (Institute of Atmospheric Physics) land-surface model (IAP94) is described. This model is a comprehensive one with detailed description for the processes of vegetation, snow and soil. Particular attention has been paid to the cases with three water phases in the surface media. On the basis of the mixture theory and the theory of fluid dynamics of porous media, the system of universal conservational equations for water and heat of soil, snow and vegetation canopy has been constructed. On this background, all important factors that may affect the water and heat balance in media can be considered naturally, and each factor and term possess distinct physical meaning. In the computation of water content and temperature, the water phase change and the heat transportation by water flow are taken into account. Moreover, particular attention has been given to the water vapor diffusion in soil for arid or semi-arid cases, and snow compaction. In the treatment of surface turbulent fluxes, the difference between aerodynamic and thermal roughness is taken into account. The aerodynamic roughness of vegetation is calculated as a function of canopy density, height and zero-plane displacement. An extrapolation of log linear and exponential relationship is used when calculating the wind profile within canopy. The model has been validated against field measurements in off-line simulations. The desirable model′s performance leads to the conclusion that the IAP94 is able to reproduce the main physical mechanisms governing the energy and water balances in the global land surface. Part II of the present study will concern the validation in a 3-D experiment coupled with the IAP Two-Level AGCM.

Designing and Optimization of an Off-line Programming System for Robotic Belt Grinding Process

Off-line programming （OLP） system becomes one of the most important programming modules for the robotic belt grinding process, however there lacks research on increasing the grinding dexterous space depending on the OLP system. A new type of grinding robot and a novel robotic belt grinding workcell are forwarded, and their features are briefly introduced. An open and object-oriented off-line programming system is developed for this robotic belt grinding system. The parameters of the trimmed surface are read from the initial graphics exchange specification （IGES） file of the CAD model of the workpiece. The deBoor-Cox basis function is used to sample the grinding target with local contact frame on the workpiece. The numerical formula of inverse kinematics is set up based on Newton＇s iterative procedure, to calculate the grinding robot configurations corresponding to the grinding targets. After the grinding path is obtained, the OLP system turns to be more effective than the teach-by-showing system. In order to improve the grinding workspace, an optimization algorithm for dynamic tool frame is proposed and performed on the special robotic belt grinding system. The initial tool frame and the interval of neighboring tool frames are defined as the preparation of the algorithm. An optimized tool local frame can be selected to grind the complex surface for a maximum dexterity index of the robot. Under the optimization algorithm, a simulation of grinding a vane is included and comparison of grinding workspace is done before and after the tool frame optimization. By the algorithm, the grinding workspace can be enlarged. Moreover the dynamic tool frame can be considered to add one degree-of-freedom to the grinding kinematical chain, which provides the theoretical support for the improvement of robotic dexterity for the complex surface grinding.

一个实用的off-line公平电子现金系统

本文提出的off line公平电子现金系统具有以下特点 :能保护合法用户的匿名性 ;可追踪非法用户 ;非法者不能敲诈用户 ;他人获得合法用户的电子现金不可盗用 ;银行与用户之间发生重复花费的争议时可仲裁 ;银行与信任机构都是脱线的 .虽然信任机构要维护一个与银行相同数量级的数据库 ,但换来了申请。

An off-line simulation of land surface processes over the northern Tibetan Plateau

In order to further understand the land surface processes over the northern Tibetan Plateau, this study produced an off-line simulated examination at the Bujiao site on the northern Tibetan Plateau from June 2002 to April 2004, using the Noah Land Surface Model （Noah LSM） and observed data from the CAMP/Tibet experiment. The observed data were neces- sarily corrected and the number of soil layers in the Noah LSM was changed from 4 to 10 to enable this off-line simulation and analysis. The main conclusions are as follows： the Noah LSM performed well on the northern Tibetan Plateau. The simulated net radiation, upward longwave radiation, and upward shortwave radiation demonstrated the same remarkable annual and seasonal variation as the observed data, especially the upward longwave radiation. The simulated soil temperatures were acceptably close to the observed temperatures, especially in the shallow soil layers. The simulated freezing and melting processes were shown to start from the surface soil layer and spread down to the deep soil layers, but they took longer than the observed processes. However, Noah LSM did not adequately simulate the soil moisture. Therefore, additional high-quality, long-term observations of land surface-atmosphere processes over the Tibetan Plateau will be a key factor in proper adiustments of the model parameters in the future.

A word level segmentation for off-line Arabic characters

Segmentation of cursive text has been one of the major problems in Arabic writing. The problem is the shape of the letter which is context sensitive, depending on it’s location within a word. Many text recognition systems recognize text imagery at the character level and assemble words from the recognized characters. Unfortunately this approach does not work with Arabic text. In this paper we describe a new approach to segment Arabic text imagery at a word level, without analyzing individual characters. This approach avoids the problem of individual characters segmentation, and can overcome local errors in character recognition.

Off-line simulation of robot welding of radar pedestal

A study of the interference simulation based on robot welding of the radar pedestal was carried out by using the KUKA Sim Pro simulation software and off-line program technology. Compared with the actual robot welding process, it was found that the trajectory of the simulated robot welding process in line with that recorded in the actual welding process, and the actual limit and interference appeared at the same place as the simulation process. There was no interference phenomenon on the outside weld-seam; on the internal weld-seam, especially on the weld-joint of support plate connected to the cylinder, a phenomenon of interference appeared. It was helpful to use the simulation method to guide the actual robot welding so as to protect robot from impacting and reduce the weld defects.

Study on path planning and compensation of off-line programming for thick walled curve welding

Thick walled curve welding are usually joined by multi-layer and multi-pass welding, which quality and efficiency could be improved by off-line programming of robot welding. However, the precision of off-line programming welding path was decreased due to the deviation between the off-line planned welding path and the actual welding path. A path planning algorithm and a path compensation algorithm of multi-layer and multi-pass curve welding seam for off-line programming of robot welding are developed in this paper. Experimental results show that the robot off-line programming improves the welding efftcieney and precision for thick walled curve welding seam.

SPECTRAL TECHNIQUES FOR OFF-LINE TESTING AND DIAGNOSIS OF COMPUTER SYSTEMS

In this paper we present some of our recent results on applications of spectral techniques over finite fields to the problems of testing and diagnosis of computer systems.

Study on general inverse kinematics of rotating/tilting positioner for robotic arc welding off-line programming

Off line programming provides an essential link between CAD and CAM, whose development will result in greater use of robotic arc welding. An arc welding system with a robot and a rotating/tilting positioner is one of the most typical workcells. The inverse kinematics of robot and positioner is the foundation of the off line programming system. The previous researchers only focused on a special solution of the positioner inverse kinematics, which is the solution at down hand welding position. In this paper, we introduce a method for representing welding position. Then a general algorithm of rotating/tilting positioner inverse kinematics is presented, and an approach to find the unique solution of the inverse kinematics is discussed. The simulation experiment results show that the general algorithm can improve the ability of robotic arc welding off line programming system to program all types of welding positions.

考虑公平关切的On/off-line供应链延保服务渠道策略研究

企业通过搭建线上线下(On/off-line)多渠道以满足消费者的延保服务需求,但也因此引发渠道间冲突。本文基于制造商视角搭建On/off-line延保服务渠道,引入公平关切理念,构建考虑零售商公平偏好的On/off-line延保服务决策模型,对延保服务进行定价及利润分配,研究On/off-line渠道结构下的最优渠道策略。研究表明,当处于弱势地位的零售商存在公平关切偏好行为时,制造商可通过调整批发价以维护On/off-line渠道及供应链的稳定性;制造商增设线上渠道可增加自身利益,但会导致零售商利润降低;随着线上渠道的增设,公平关切程度的增加会降低零售商的效用。

Off-line Programming Technology Based on RPC Communication Method and its Application

This paper puts forward a communication programming method between robot and external computer based on RPC (Remote Produce Call) communication method, which realizes robot distributed controlling network system model. And a new Robot off line programming method is built based on this communication method and network model. Further more, as an example, robot auto marking and auto cutting of shipbuilding profile system is developed, which proves the ideas of author’s off line programming and development methods of robot flexible automation system. As a result, this paper presents a new method for developing robot flexible automation system.

Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection

Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic capacities.Methods: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular docking.Results: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory profile.Conclusion: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin.

Data-driven Robust State Estimation Through Off-line Learning and On-line Matching

To overcome the shortcomings of model-driven state estimation methods, this paper proposes a data-driven robust state estimation (DDSE) method through off-line learning and on-line matching. At the off-line learning stage, a linear regression equation is presented by clustering historical data from supervisory control and data acquisition (SCADA), which provides a guarantee for solving the over-learning problem of the existing DDSE methods;then a novel robust state estimation method that can be transformed into quadratic programming (QP) models is proposed to obtain the mapping relationship between the measurements and the state variables (MRBMS). The proposed QP models can well solve the problem of collinearity in historical data. Furthermore, the off-line learning stage is greatly accelerated from three aspects including reducing historical categories, constructing tree retrieval structure for known topologies, and using sensitivity analysis when solving QP models. At the on-line matching stage, by quickly matching the current snapshot with the historical ones, the corresponding MRBMS can be obtained, and then the estimation values of the state variables can be obtained. Simulations demonstrate that the proposed DDSE method has obvious advantages in terms of suppressing over-learning problems, dealing with collinearity problems, robustness, and computation efficiency.

A Proxy Blind Signature Scheme and an Off-Line Electronic Cash Scheme

To support withdrawing and storing money from all levels of the bank for the customers in the real world, in this paper, we propose a proxy blind signature scheme and an off-line e-cash scheme based on the new proxy blind signature scheme. The pro- posed proxy blind signature is proven secure in the random oracle model under chosen-target computational Diffie-Hellman assump- tions, and the e-cash scheme can satisfy the security requirements of unforgeability, anonymity, and traceability.

AN IMPROVED LAND-SURFACE PROCESS MODEL AND ITS SIMULATION EXPERIMENT——PART I:LAND-SURFACE PROCESS MODEL AND ITS“OFF-LINE”TESTS AND PERFORMANCE ANALYSES

Based on the existing land-surface schemes and models,an improved Land-surface Process Model(LPM-ZD)has been developed.It has the following major characteristics:(1)The combination of physical equations and empirical analytical formulae are used to construct the governing equations of soil temperature and moisture.Higher resolution of model level and physical equations are adopted for the upper soil layers,and for the lower soil layers,lower resolution of model level is adopted and empirical analytical formulae are used.(2)In land surface hydrological process,the sub-grid distribution of rainfall and its effects are taken into account. (3)A simple snow cover submodel has been used,which includes effects of snow cover on soil thermodynamics and hydrology,as well as albedo. By use of this model and three groups of point observation data,a series of“off-line”tests have been carried out.The simulation results indicate that land-surface process model has good performance and can well simulate diurnal and seasonal variation of land surface processes for many kinds of land surface covers(forest,grass,crops and desert)in different climate zone.The results simulated by the model are consistent with the observations.Later,by use of one group of observation data and the model,a series of sensitivity experiments have been done.It is shown that the model is much sensitive to some parameters,such as initial soil moisture,vegetation physical parameters as well as the proportion of the grid covered with rain.Therefore it is much important for land-surface process model to define these parameters as accurately as possible.