Novel p-Xylene Adsorbent Passed Technical Appraisal

The RAX-2000A type para-xylene adsorbent developed by SINOPEC Research Institute of Petroleum Processing (RIPP) has passed the technical appraisal organized by SINOPECS cience and Technology Development Division.

Synergistic Catalytic Action of Cobalt(Ⅱ) Hydroxamates and N-Hydroxyphthalimide in the Aerobic Oxidation of p-Xylene

The catalytic performance of a series of cobalt(Ⅱ) hydroxamates (CoL2) and the synergistic catalytic action of the cobalt complexes combined with N-hydroxyphthalimide (NHPI) in the aerobic oxidation of p-xylene to p-toluic acid (PTA) were investigated. The results showed that the existing synergistic action in the catalytic oxidation can shorten the induction period of the radical reaction and improve the yield of PTA.

Synthesis and Crystal Structure of 6-(3'-Indolyl)-8-(p-chlorophenyl)-10,10dimethyl-10H-pyrido [1,2-a] Indolium Perchlorate

The synthesis of the title compound ([C28H22ClN2]·ClO4) has been synthesized and its structure was determined by X-ray diffraction. The compound belongs to the monoclinic system, space group P21/n with a = 15.113(5), b = 8.616(3), c = 19.556(7) ?, β = 92.562(7)°, Z = 4, V = 2544(2) ?3, Mr = 521.38, Dc = 1.361 g/cm3, F(000) = 1080, μ = 0.293 mm-1, the final R = 0.0580 and wR = 0.0788 (I > 2σ(I)). The structure was solved by direct methods and refined by full-matrix least-squares techniques. X-ray analysis revealed that there exist four ring planes of 10H-indolium, pyridinium, p-chlorophenyl and indolyl in the molecule, of which the pyridinium ring forms a conjugated system with the p-chlorophenyl plane. According to the molecular structure of the title compound, it is presumed that the synthetic reaction may undergo the processes of C-addition, cyclization and aromatization.

Synthesis and reversal effect of a novel N-substituted phthalimidesugar on doxorubicin resistant of human breast cancer cells

Thalidomide （α-N-phthalimido-glutarimide, TLD） is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a novel N-sugar substituted phthalimide （STA-35） on the regulation of multidrug resistance （MDR） to doxorubicin （ADR） were investigated. The proliferation of cancer cells was detected by a SRB assay. The activity of P-glycoprotein （P-gp） was determined by a Flow cytometry. The expression of P-gp was measured by western blotting. The results showed that STA-35 inhibited the proliferation of human breast cancer cell line MCF-7 and its ADR resistant cell line MCF-7/ADR, and the relative resistance was only 1.19. Meanwhile, STA-35 could sensitize the cytotoxicity of ADR in MCF-7/ADR cells. In addition, we found that STA-35 reduced the activity of P-gp by suppressing the P-gp expression, which was indicated by the increase in the accumulation of rhodamine 123 in MCF-7/ADR cells. These results suggested a promising application of STA-35 as the MDR reversing agent. The underlying mechanism of the effects might be attributed to the inhibition of P-gp.

Adaptive Soft-sensor Modeling Algorithm Based on FCMISVM and Its Application in PX Adsorption Separation Process

To overcome the problem that soft sensor models cannot be updated with the process changes, a soft sensor modeling algorithm based on hybrid fuzzy c-means （FCM） algorithm and incremental support vector machines （ISVM） is proposed. This hybrid algorithm FCMISVM includes three parts： samples clustering based on FCM algorithm, learning algorithm based on ISVM, and heuristic sample displacement method. In the training process, the training samples are first clustered by the FCM algorithm, and then by training each clustering with the SVM algorithm, a sub-model is built to each clustering. In the predicting process, when an incremental sample that represents new operation information is introduced in the model, the fuzzy membership function of the sample to each clustering is first computed by the FCM algorithm. Then, a corresponding SVM sub-model of the clustering with the largest fuzzy membership function is used to predict and perform incremental learning so the model can be updated on-line. An old sample chosen by heuristic sample displacement method is then discarded from the sub-model to control the size of the working set. The proposed method is applied to predict the p-xylene （PX） purity in the adsorption separation process. Simulation results indicate that the proposed method actually increases the model＇s adaptive abilities to various operation conditions and improves its generalization capability.

Synthesis and Crystal Structure of Bridging Complex [Cu_2(bipy)_2·OAc·Cl·OH]·TsTausH·3H_2O

The title complex [Cu2(bipy)2OAcClOH]TsTausH3H2O(C31H37Cl- Cu2N5O11S2) has been synthesized by the reaction of 2,2?bipyridine(bipy), N-P-tolysulfony taurine (TsTausH) and copper acetate in water-ethanol solution, and its crystal structure was determined by X-ray diffraction method. The crystal belongs to triclinic, space group P with a = 0.74485(14), b = 1.6094(3), c = 1.7472(3) nm, a = 114.662(4), b = 99.997(4), g = 93.218(4), V = 1.8551(6) nm3, Mr = 882.31, Z = 2, Dc = 1.580 g/cm3, m = 1.395 mm-1 and F(000) = 906. The complex is a binuclear copper compound, and the two copper ions nearly have the same coordination environment. There exists MM bond in the complex. The distance of Cu(1)Cu(2) is 0.29747(7) nm. The two ions form two distorted octahedral geometries.

Adsorption and Transfer Properties for Toluene and pDichlorobenzene in Dense CO_2/Silica Gel Packed Bed System by Moment Method and Time-Domain Analysis

Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficient and effective intra-particle diffusivity) for toluene and p-dichlorobenzene on silica gel adsorbent in the subcritical and supercritical CO2. An apparatus based on supercritical fluid chromatography was established and the experiments were performed at temperatures of 298.15-318.15 K and pressures of 7.5-17.8 MPa. The two methods have been compared. The results show that for the systems studied here the moment method can give reasonable values for both adsorption equilibrium constant and mass transfer properties, but the time-domain analysis only can obtain the adsorption equilibrium constant. The dependence of adsorption equilibrium constant and mass transfer properties on temperature and pressure was investigated.