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N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats:Focus on oxidative and sex hormone receptors mechanisms
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作者 Victor Oghenekparobo Emojevwe Mega Obukohwo Oyovwi +7 位作者 Kayode Ezekiel Adewole Peggy Ejiro Ohwin Adeniran Oluwadamilare Akinola Alexander Obidike Naiho Eze Kingsley Nwangwa Victor Omo-Idonije Motunrayo Lade-Ige Benneth Ben-Azu 《Asian pacific Journal of Reproduction》 CAS 2024年第5期228-240,共13页
Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechan... Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechanisms,specifically oxidative stress and sex hormone receptor activity.Methods:Thirty-five male Wistar rats were randomly divided into five equal groups(n=7 per group).Group 1 was administered 0.5 mL of distilled water and served as the control group.Group 2 was given only DEHP(750 mg/kg/day),while group 3,4 and 5 were given DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day),DEHP(750 mg/kg/day)plus ZnSO_(4)(0.5 mg/kg/day),and DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day)as well as ZnSO_(4)(0.5 mg/kg/day),respectively.All treatments lasted for 21 days.Samples were obtained after the rats were sacrificed,and hormones levels in the serum and markers of oxidative stress in the testicles were analyzed using the enzyme-linked immunosorbent assay.The amount of androgen receptors in the testicles was determined by immunohistochemistry,and the susceptibility of testosterone and DEHP to bind to androgen receptor and 5α-reductase was determined by molecular docking studies.Results:DEHP decreased reproductive hormones,testicular antioxidant enzymes,increased malondialdehyde levels,and negatively impacted histology of the pituitary and testes.NAC or ZnSO_(4) treatment showed a marked improvement in testicular antioxidant status and hormone levels,as well as a positive effect on the histology of the pituitary and testes.The combination of both treatments appeared to be more effective.The affinity of DEHP to bind to androgen receptors may lead to disruption of androgen receptor signaling,which can further result in dysfunction of hormones related to androgen.However,NAC is more likely to form stronger binding interactions with follicle stimulating hormone and luteinizing hormone receptors,as well as gonadotropin-releasing hormone receptors,when compared to DEHP.Conclusions:The possibility that NAC and ZnSO_(4) could downregulate DEHP-induced sex hormone changes is suggested by their potential to reduce toxicity. 展开更多
关键词 Di-2-ethylhexyl phthalate TESTOSTERONE Androgen receptor 5Α-REDUCTASE OESTROGEN Luteinizing hormone
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Research Progress on Distribution,Sources and Ecological Effects of Phthalate in Soil
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作者 Hengrui ZHANG Shasha LIU 《Agricultural Biotechnology》 2024年第1期28-30,共3页
Phthalate esters(PAEs)are widely used as main plasticizers in plastic products,agricultural regulators,toys,and other fields.This paper reviewed the research progress on the distribution,sources,and ecological effects... Phthalate esters(PAEs)are widely used as main plasticizers in plastic products,agricultural regulators,toys,and other fields.This paper reviewed the research progress on the distribution,sources,and ecological effects of PAEs.The effects of PAEs on soil microorganisms,animals,plants and soil properties were explored in sequence,providing effective theoretical basis for future research on PAEs. 展开更多
关键词 phthalate ester DISTRIBUTION SOURCE Ecological effect
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Recent Advances of Sensitive Electrochemical Sensing Platforms for Rapid Detection of Phthalate Acid Esters
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作者 Xiuxiu Dong Lili Zhang +2 位作者 Meicai Ge Minfu Wu Qijian Niu 《Instrumentation》 2024年第2期9-23,共15页
As a kind of plasticizer,phthalic acid esters(PAEs)are often added to plastics to enhance elasticity,transparency,durability and prolong service life.However,it does not chemically bind to plastics and is easy to migr... As a kind of plasticizer,phthalic acid esters(PAEs)are often added to plastics to enhance elasticity,transparency,durability and prolong service life.However,it does not chemically bind to plastics and is easy to migrate to the environment.It is difficult to degrade in the environment,and it is also enriched in the human body through the food chain and respiration,which will lead to obvious adverse reactions such as decreased learning and memory function and neurobehavioral disorders.Due to the toxicity,universality and low concentration limitations of PAEs in the environment and food,it is essential to achieve rapid and sensitive detection of PAEs in soil,atmosphere,water and food.Electrochemical(EC)sensors have the advantages of simplicity,fast,low cost,portability,easy operation,high specificity and high sensitivity,so they are applied for the detection of PAEs.Although there are a large number of studies on the detection of PAEs by EC sensors,there is no review on this aspect.In this review,we introduce the detection of PAEs from classical EC sensors,electrochemiluminescence(ECL)sensors and photo-electrochemical(PEC)sensors in the past five years.This review is beneficial to understanding the construction of EC sensors and the detection mechanism of PAEs.We also propose that the development of rapid,accurate and real-time detection methods of PAEs is key to assessing risk and preventing related diseases. 展开更多
关键词 phthalate acid esters electrochemical sensor DETERMINATION
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Bis(2-butoxyethyl) Phthalate Delays Puberty Onset by Increasing Oxidative Stress and Apoptosis in Leydig Cells in Rats
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作者 LIU Miao Qing CHEN Hai Qiong +8 位作者 DAI Hai Peng LI Jing Jing TIAN Fu Hong WANG Yi Yan CHEN Cong De LI Xiao Heng LI Jun Wei LI Zhong Rong GE Ren Shan 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2023年第1期60-75,共16页
Objective This study investigated the effects of bis(2-butoxyethyl) phthalate(BBOP) on the onset of male puberty by affecting Leydig cell development in rats.Methods Thirty 35-day-old male Sprague-Dawley rats were ran... Objective This study investigated the effects of bis(2-butoxyethyl) phthalate(BBOP) on the onset of male puberty by affecting Leydig cell development in rats.Methods Thirty 35-day-old male Sprague-Dawley rats were randomly allocated to five groups mg/kg bw per day that were gavaged for 21 days with BBOP at 0, 10, 100, 250, or 500 mg/kg bw per day. The hormone profiles;Leydig cell morphological metrics;mRNA and protein levels;oxidative stress;and AKT,mTOR, ERK1/2, and GSK3β pathways were assessed.Results BBOP at 250 and/or 500 mg/kg bw per day decreased serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels mg/kg bw per day(P < 0.05). BBOP at 500 mg/kg bw per day decreased Leydig cell number mg/kg bw per day and downregulated Cyp11a1, Insl3, Hsd11b1,and Dhh in the testes, and Lhb and Fshb mRNAs in the pituitary gland(P < 0.05). The malondialdehyde content in the testis significantly increased, while Sod1 and Sod2 mRNAs were markedly downregulated, by BBOP treatment at 250–500 mg/kg bw per day(P < 0.05). Furthermore, BBOP at 500mg/kg bw per day decreased AKT1/AKT2, mTOR, and ERK1/2 phosphorylation, and GSK3β and SIRT1levels mg/kg bw per day(P < 0.05). Finally, BBOP at 100 or 500 μmol/L induced ROS and apoptosis in Leydig cells after 24 h of treatment in vitro(P < 0.05).Conclusion BBOP delays puberty onset by increasing oxidative stress and apoptosis in Leydig cells in rats.The graphical abstract is available on the website www.besjournal.com. 展开更多
关键词 Bis(2-butoxyethyl)phthalate Leydig cells Testosterone Oxidative stress Gonadotropin
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Green tea polyphenols alleviate di-(2-ethylhexyl)phthalate-induced liver injury in mice
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作者 Heng Shi Xin-Hai Zhao +6 位作者 Qin Peng Xian-Ling Zhou Si-Si Liu Chuan-Chuan Sun Qiu-Yu Cao Shi-Ping Zhu Sheng-Yun Sun 《World Journal of Gastroenterology》 SCIE CAS 2023年第34期5054-5074,共21页
BACKGROUND Di(2-ethylhexyl)phthalate(DEHP)is a common plasticizer known to cause liver injury.Green tea is reported to exert therapeutic effects on heavy metal exposureinduced organ damage.However,limited studies have... BACKGROUND Di(2-ethylhexyl)phthalate(DEHP)is a common plasticizer known to cause liver injury.Green tea is reported to exert therapeutic effects on heavy metal exposureinduced organ damage.However,limited studies have examined the therapeutic effects of green tea polyphenols(GTPs)on DEHP-induced liver damage.AIM To evaluate the molecular mechanism underlying the therapeutic effects of GTPs on DEHP-induced liver damage.METHODS C57BL/6J mice were divided into the following five groups:Control,model[DEHP(1500 mg/kg bodyweight)],treatment[DEHP(1500 mg/kg bodyweight)+GTP(70 mg/kg bodyweight),oil,and GTP(70 mg/kg bodyweight)]groups.After 8 wk,the liver function,blood lipid profile,and liver histopathology were examined.Differentially expressed micro RNAs(miRNAs)and mRNAs in the liver tissues were examined using high-throughput sequencing.Additionally,functional enrichment analysis and immune infiltration prediction were performed.The miRNA-mRNA regulatory axis was elucidated using the starBase database.Protein expression was evaluated using immunohistochemistry.RESULTS GTPs alleviated DHEP-induced liver dysfunction,blood lipid dysregulation,fatty liver disease,liver fibrosis,and mitochondrial and endoplasmic reticulum lesions in mice.The infiltration of macrophages,mast cells,and natural killer cells varied between the model and treatment groups.mmu-miR-141-3p(a differentially expressed miRNA),Zcchc24(a differentially expressed mRNA),and Zcchc24(a differentially expressed protein)constituted the miRNA-mRNA-protein regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage in mice.CONCLUSION This study demonstrated that GTPs mitigate DEHP-induced liver dysfunction,blood lipid dysregulation,fatty liver disease,and partial liver fibrosis,and regulate immune cell infiltration.Additionally,an important miRNAmRNA-protein molecular regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage was elucidated. 展开更多
关键词 Green tea polyphenols Di(2-ethylhexyl)phthalate Liver fibrosis Fatty liver disease MITOCHONDRIA IMMUNE
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Anodizing of AZ91D magnesium alloy using environmental friendly alkaline borate-biphthalate electrolyte 被引量:4
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作者 刘妍 杨富巍 +1 位作者 卫中领 张昭 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2012年第7期1778-1785,共8页
A kind of environmental friendly anodizing routine for AZ91D magnesium alloy,based on an alkaline borate-potassium acid phthalate(KAP) electrolyte,was studied.The effect of KAP on the properties of the anodized film... A kind of environmental friendly anodizing routine for AZ91D magnesium alloy,based on an alkaline borate-potassium acid phthalate(KAP) electrolyte,was studied.The effect of KAP on the properties of the anodized film was investigated by scanning electron microscopy(SEM),X-ray diffraction(XRD),energy dispersive spectrometry(EDS),potentiodynamic polarization and electrochemical impedance spectroscopy(EIS),respectively.The results showed that the anodizing process,surface morphology,thickness,phase structure and corrosion resistance of the anodized film were strongly dependent on the concentration of KAP.In the presence of adequate KAP,a compact and smooth anodized film with excellent corrosion resistance was obtained. 展开更多
关键词 ANODIZING magnesium alloy potassium acid phthalate environmental friendly electrolyte corrosion performance
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Determination of phthalate esters in fat-containing foods by packed nanofiber solid-phase extraction column and gas chromatography 被引量:2
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作者 邱金丽 王羽 +1 位作者 周小玲 康学军 《Journal of Southeast University(English Edition)》 EI CAS 2016年第3期322-326,共5页
A new method for simultaneous determination of four phthalate esters ( PAEs) in commercial fat-containing foods was developed by the combination of a packed nanofibers column based on solid-phase extraction with gas... A new method for simultaneous determination of four phthalate esters ( PAEs) in commercial fat-containing foods was developed by the combination of a packed nanofibers column based on solid-phase extraction with gas chromatography-flame ionization detector ( GC-FID ). Conditions for obtaining optimum extraction efficiency such as extraction solvents, morphologies of adsorbent, ion strength and pH were investigated and optimized in detail. Under the optimized conditions, the limits of detection (LODs) found for dibutyl phthalate (DBP) , butyl benzyl phthalate (BBP), diethyl hexyl phthalate (DEHP) and di-n-octyl phthalate (DNOP) were 50, 25, 50 and 25 ng/g, respectively. Good linearity of four PAEs was achieved in the range of 50 to 4 000 ng/g. The proposed method was applied for analyzing different kinds of fat-containing samples. PAEs in commercial fat-containing samples can be highly extracted by a packed solid-phase extraction column of 5 mg polystyrene ( PS) nanofibers. The satisfactory average recoveries were obtained in the range of 96. 7% to 102. 3% , and the relative standard deviations (RSDs) below 5% were achieved. The proposed method reduces the organic solvent consumption, the complex and tedious procedures for sample pretreatment, and achieves high sensitivity and reproducibility for the investigated PAEs. 展开更多
关键词 phthalate esters (PAEs nanofibers solid-phase extraction gas chromatography fat-containing foods
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Presence of phthalates in gastrointestinal medications: Is there a hidden danger? 被引量:2
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作者 Zane R Gallinger Geoffrey C Nguyen 《World Journal of Gastroenterology》 SCIE CAS 2013年第41期7042-7047,共6页
Pharmaceutical companies that produce gastrointestinal(GI)medications often utilize phthalates for their ability to localize medication release.Commonly prescribed GI medications that may utilize phthalates are 5-Amin... Pharmaceutical companies that produce gastrointestinal(GI)medications often utilize phthalates for their ability to localize medication release.Commonly prescribed GI medications that may utilize phthalates are 5-Aminosalicylates,proton pump inhibitors,and pancreatic enzymes.Our understanding of the cumulative health effects of phthalates from medications remains unclear,and there is increasing evidence that phthalates are not harmless.Experimental studies in animals have shown that phthalates,specifically dibutyl phthalate and Di-(2-ethyl-hexyl)phthalate,have the potential to alter and/or inhibit reproductive biology and in utero development.Despite the lack of definitive human data,many cohort and cross-sectional studies demonstrate concerning associations between phthalates and poor health status,specifically developmental problems.Longitudinal studies and studies with larger sample sizes are required to determine whether phthalates actually cause negative health consequences.It is also important that physicians regularly review and discuss with patients the medicinal ingredients in their medications and supplements,specifically in pregnant woman with inflammatory bowel disease. 展开更多
关键词 phthalateS Dibutyl phthalate 5-Aminosalicylates MEDICATIONS Development Pregnancy
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Isolation, Identification and Biodegradation Characteristics of a Phthalate Ester Degrading Bacterium
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作者 张敏 吴祥为 张付海 《Agricultural Science & Technology》 CAS 2015年第7期1363-1366,共4页
By using plate screening techniques with five phthalate esters (DMP, DEP, DBP, DEHP and DOP) as energy and carbon sources, an active strain was isolated from the sediments of Chaohu Lake, which was identified as Bur... By using plate screening techniques with five phthalate esters (DMP, DEP, DBP, DEHP and DOP) as energy and carbon sources, an active strain was isolated from the sediments of Chaohu Lake, which was identified as Burkholderia pickettil and named B. pickettii.z-1. The biodegradation of five phthalate esters by B. pick- ettii.z-1 strain was in accordance with the pseudo first-order kinetic equation: Ct = C0.e-kt. As the concentration of phthalate esters increased, the degradation rate of phthalate esters was reduced. B. pickettii.z-1 strain exhibited remarkably different degradation effects on various PAEs. Specifically, short-side-chain DMP and DEP were degraded rapidly, while long-side-chain DBP and DEHP were degraded slowly. 展开更多
关键词 phthalate esters MICROORGANISMS Biodegradation kinetics
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Characterization of V_2O_5/MoO_3 composite photocatalysts prepared via electrospinning and their photodegradation activity for dimethyl phthalate 被引量:8
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作者 揣宏媛 周德凤 +2 位作者 朱晓飞 李朝辉 黄唯平 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2015年第12期2194-2202,共9页
Vanadium pentoxide(V2O5)/molybdenum trioxide(MoO 3) composites with different molar ratios of vanadium(V) to molybdenum(Mo) were synthesized via a simple electrospinning technique. The photocatalytic activity ... Vanadium pentoxide(V2O5)/molybdenum trioxide(MoO 3) composites with different molar ratios of vanadium(V) to molybdenum(Mo) were synthesized via a simple electrospinning technique. The photocatalytic activity of the composites were evaluated by their ability to photodegrade methylene blue and dimethyl phthalate(DMP) under visible-light irradiation. Compared with pure V2O5 and MoO 3,the V2O5/MoO 3 composites showed enhanced visible-light photocatalytic activity because of a V 3d impurity energy level and the formation of heterostructures at the interface between V2O5 and MoO 3. The optimal molar ratio of V to Mo in the V2O5/MoO 3 composites was found to be around 1/2. Furthermore,high-performance liquid chromatographic monitoring revealed that phthalic acid was the main intermediate in the photocatalytic degradation process of DMP. 展开更多
关键词 ELECTROSPINNING Vanadium pentoxide Molybdenum trioxide COMPOSITES Photodegradation activity Dimethyl phthalate
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Vapor Pressures of Di-n-Butyl Phthalate and Di-iso-Butyl Hexahydrophthalate at Reduced Pressures
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作者 齐欣 徐立勇 +1 位作者 高正红 刘志华 《Transactions of Tianjin University》 EI CAS 2004年第3期229-232,共4页
In this paper the measured values of the vapor pressures by ebulliometer method of two important maleic anhydride recovery solvents, di-n-butyl phthalate (DBP) and di-iso-butyl hexahydrophthalate (DIBE), between 0.63... In this paper the measured values of the vapor pressures by ebulliometer method of two important maleic anhydride recovery solvents, di-n-butyl phthalate (DBP) and di-iso-butyl hexahydrophthalate (DIBE), between 0.63—17.79 kPa and 0.49—30.95 kPa,are reported respectively.A comparison of the data of DBP with the published data has been made, which shows good consistency. For the convenient use of these vapor pressures, Cragoe equation, Antoine equation and Kirchhoff equation are selected to correlate them. The correlating results show that Antoine equation is the best one of the three equations to fit for the vapor pressures of the two solvents. According to Clausius-Clapeyron equation, the linear relationship between natural logarithm of pressure and reciprocal of temperature is used to calculate the molar latent heats of evaporation of the two organic solvents. The molar latent heats of evaporation of DBP and DIBE are 75.1 kJ/mol and 67.7 kJ/mol, respectively. 展开更多
关键词 vapor pressure measurement di-n-butyl phthalate (DBP) di-iso-butyl hexahydrophthalate (DIBE) correlation
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Cell Death Effects of the Phthalate 2-Ethyl-1-Hexanol on Human Linfoblast Cells
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作者 Karoline Rios Christian Vélez Beatriz Zayas 《Open Journal of Apoptosis》 2019年第1期1-15,共15页
Phthalates have been used in a wide variety of consumer goods. Their versatility as plasticizers has translated into worldwide use in a vast array of consumer products. These compounds can leach into matrices, such as... Phthalates have been used in a wide variety of consumer goods. Their versatility as plasticizers has translated into worldwide use in a vast array of consumer products. These compounds can leach into matrices, such as food and liquids that can be routed for human exposure. One of the most used phthalates is Diethylhexyl phthalate (DEHP). Diethylhexyl phthalate and its metabolite 2-ethyl-1-hexanol (2-EH) have demonstrated biological effects which merit further evaluation. In this work, we expand on our previous work with DEHP and screen the 2-EH metabolite for different cell death endpoints such as growth inhibition, apoptosis, autophagy, caspase activation, DNA fragmentation, and cell cycle arrest using fluorophores and the NC3000 instrument. Significant results (p 0.05) revealed higher toxicity for the 2-EH metabolite when compared to DEHP. Also, 2-EH presented apoptosis induction with characteristic hallmarks, such as loss of mitochondrial membrane potential, caspase activation, DNA fragmentation and cell cycle arrest at the S phase. In addition, the presence of autophagosome was detected through L3CB protein staining. We conclude that 2-EH presents differences in cell death endpoints that interestingly differ from the DEHP parent compound. Further studies are needed to establish the molecular pathways responsible for the observed effects. 展开更多
关键词 phthalateS 2-Ethyl-1-Hexanol Diethylhexyl phthalate Autophagy Apoptosis LYMPHOBLAST Caspase
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Cloud point extraction coupled with HPLC-UV for the determination of phthalate esters in environmental water samples 被引量:24
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作者 WANG Ling JIANG Gui-bin +3 位作者 CAI Ya-qi HE Bin WANG Ya-wei SHEN Da-zhong 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第7期874-878,共5页
A method based on cloud point extraction was developed to determine phthalate esters including di-ethyl-phthalate (DEP), di- (2-ethylhexyl)-phthalate (DEHP) and di-cyclohexyl-phthalate (DCP) in environmental w... A method based on cloud point extraction was developed to determine phthalate esters including di-ethyl-phthalate (DEP), di- (2-ethylhexyl)-phthalate (DEHP) and di-cyclohexyl-phthalate (DCP) in environmental water samples using high-performance liquid chromatography separation and ultraviolet detection (HPLC-UV). The non-ionic surfactant Triton X-114 was chosen as extraction solvent. The parameters affecting extraction efficiency, such as concentrations of Triton X-114 and Na2SO4, equilibration temperature, equilibration time and centrifugation time were evaluated and optimized. Under the optimum conditions, the method can achieve preconcentration factors of 35, 88, 111 and detection of limits of 2.0, 3.8, 1.0 ng/ml for DEP, DEHP and DCP in 10-ml water sample, respectively. The proposed method was successfully applied to the determination of trace amount of phathalate esters in effluent water of the wastewater treatment plant and the lixivium of plastic fragments. 展开更多
关键词 phthalate esters cloud point extraction Triton X-114 non-ionic surfactant HPLC-UV
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An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men 被引量:12
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作者 LI ShuGuang DAI JiCan +3 位作者 ZHANG LiQian ZHANG Jing ZHANG ZiQiang CHEN Bo 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第1期31-39,共9页
Objective To investigate the associations of hormone circulation with phthalate exposure in adult men. Methods Semen and serum samples were collected from 118 men who were suspected of infertility. Phthalate diesters ... Objective To investigate the associations of hormone circulation with phthalate exposure in adult men. Methods Semen and serum samples were collected from 118 men who were suspected of infertility. Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E 2 ) and prolactin (PRL). Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10‐fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose‐response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; P for trend = 0.01), and serum DBP (1.0, 1.10, 2.62; P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E 2 ratio (Spearman correlation) were also established. Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men. 展开更多
关键词 phthalate diesters PROLACTIN TESTOSTERONE ESTRADIOL Male reproduction
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Effects of di-n-butyl phthalate on male rat reproduction following pubertal exposure 被引量:8
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作者 Ai-Mei Bao Xiao-Ming Man +6 位作者 Xue-Jiang Guo Hui-Bin Dong Fu-Qiang Wang Hong Sun Yu-Bang Wang Zuo-Min Zhou Jia-Hao Sha 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第5期702-709,共8页
Di-n-butyl phthalate (DBP) is an endocrine-disrupting chemical that has the potential to affect male reproduction. However, the reproductive effects of low-dose DBP are still not well known, especially at the molecu... Di-n-butyl phthalate (DBP) is an endocrine-disrupting chemical that has the potential to affect male reproduction. However, the reproductive effects of low-dose DBP are still not well known, especially at the molecular level. In the present study, pubertal male Sprague-Dawley rats were orally administered DBP at a wide range of doses (0.1, 1.0, 10, 100 and 500 mg kg^-1 day^-1) for 30 days. The selected end points included reproductive organ weights, testicular histopathology and serum hormonal levels. Additionally, proteomic analysis was performed to identify proteins that are differentially expressed as a result of exposure to DBP at low doses (0.1, 1.0 and 10 mg kg^-1 day^-1). Toxic effects were observed in the high-dose groups, including anomalous development of testes and epididymides, severe atrophy of seminiferous tubules, loss of spermatogenesis and abnormal levels of serum hormones. Treatment with low doses of DBP seemed to exert a 'stimulative effect' on the serum hormones. Proteomics analysis of rat testes showed 20 differentially expressed proteins. Among these proteins, alterations in the expression of HnRNPA2/B1, vimentin and superoxide dismutase 1 (SOD1) were further confirmed by Western blot and immunohistochemistry. Taken together, we conclude that high doses of DBP led to testicular toxicity, and low doses of DBP led to changes in the expression of proteins involved in spermatogenesis as well as changes in the number and function of Sertoli and Leydig cells, although no obvious morphological changes appeared. The identification of these differentially expressed proteins provides important information about the mechanisms underlying the effects of DBP on male rat reproduction. 展开更多
关键词 di-n-butyl phthalate HORMONES PROTEOMICS SPERMATOGENESIS TESTIS
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Mechanistic studies on peroxymonosulfate activation by g-C3N4 under visible light for enhanced oxidation of light-inert dimethyl phthalate 被引量:8
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作者 Lijie Xu Lanyue Qi +4 位作者 Yang Sun Han Gong Yiliang Chen Chun Pei Lu Gan 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2020年第2期322-332,共11页
Excitation of metal-free graphitic carbon nitride(g-C3N4) under visible light can successfully achieve efficient activation of peroxymonosulfate(PMS). Synergistic effects and involved mechanism were systematically inv... Excitation of metal-free graphitic carbon nitride(g-C3N4) under visible light can successfully achieve efficient activation of peroxymonosulfate(PMS). Synergistic effects and involved mechanism were systematically investigated using a light-inert endocrine disrupting compound, dimethyl phthalate(DMP), as the target pollutant. Under visible light irradiation, DMP could not be degraded by direct g-C3 N4-mediated photocatalysis, while in the presence of PMS, the dominant radicals were converted from ·O2 to SO4·– and ·OH, resulting in effective DMP degradation and mineralization. Results showed that higher dosage of PMS or g-C3 N4 could increase the activation amount of PMS and corresponding DMP degradation efficiency, but the latter approach was more productive in terms of making the most of PMS. High DMP concentration hindered effective contact between PMS and g-C3 N4, but could provide efficient use of PMS. Higher DMP degradation efficiency was achieved at p H lower than the point of zero charge(5.4). Based on intermediates identification, the DMP degradation was found mainly through radical attack(·OH and SO4·–) of the benzene ring and oxidation of the aliphatic chains. 展开更多
关键词 Graphitic carbon nitride Visible light PEROXYMONOSULFATE Dimethyl phthalate ACTIVATION DEGRADATION
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Aerobic biodegradation of diethyl phthalate by Acinetobacter sp. JDC-16 isolated from river sludge 被引量:7
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作者 梁任星 吴学玲 +2 位作者 王兴娜 代沁芸 王洋洋 《Journal of Central South University》 SCIE EI CAS 2010年第5期959-966,共8页
A gram negative bacterium,named JDC-16,which can grow well on the substrate of phthalic acid esters(PAEs) as the sole source of carbon and energy,was isolated from river sludge.Based on the morphology,physiological an... A gram negative bacterium,named JDC-16,which can grow well on the substrate of phthalic acid esters(PAEs) as the sole source of carbon and energy,was isolated from river sludge.Based on the morphology,physiological and biochemical properties and analysis of 16S rRNA gene sequence,it was preliminarily identified belonging to the genus Acinetobacter.The result of substrates utilization range indicates that strain JDC-16 can utilize a variety of phthalates except for diisononyl phthalate(DINP) .The degradation tests using diethyl phthalate(DEP) as the model compound show that the optimal pH and temperature for DEP degradation by Acinetobacter sp.JDC-16 is 8.0 and 35℃,respectively.Meanwhile,degradation kinetics under various initial concentrations of DEP reveals that substrate depletion curves fit well with the modified Gompertz model with high correlation coefficient(R 2 >0.99) .Furthermore,the substrate induction test indicates that DEP-induction can apparently shorten the lag phase and enhance the degradation rate.This work highlights the potential of this isolate for bioremediation of phthalates-contaminated environments. 展开更多
关键词 BIODEGRADATION diethyl phthalate KINETICS Acinetobacter sp. river sludge
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Removal of a type of endocrine disruptors—di-n-butyl phthalate from water by ozonation 被引量:7
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作者 LI Hai-van QU Jiu-hui LIU Hui-juan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2006年第5期845-851,共7页
Ozonation of synthetic water containing a type of endocrine disruptor-di-n-butyl phthalate (DBP) was examined. Key impact factors such as pH, temperature, ionic strength, ozone dosage and initial DBP concentration w... Ozonation of synthetic water containing a type of endocrine disruptor-di-n-butyl phthalate (DBP) was examined. Key impact factors such as pH, temperature, ionic strength, ozone dosage and initial DBP concentration were investigated. In addition, the activities of radicals on uncatalysed and catalysed ozonation were studied. The degradation intermediate products were followed and the kinetic of the ozonation were assessed as well. Results revealed that ozonation of DBP followed two mechanisms. Firstly, the reaction rate of direct ozonation was slower at lower pH, temperature, and ionic strength. Secondly, when these factors were increased for indirect radical reaction, higher percentage of DBP was removed with the increase of the initial ozone dosage and the decrease of the initial DBP concentration. In addition, tea-butanol, humic substances and Fe(Ⅱ) affected DBP ozonation through the radical pathway. It was determined that ozonation was restrained by adding tea-butanol for its radical inhibition effect. Furthermore, humic substances enhanced the reaction to some extent, but a slight negative effect would be encountered if the optimum dosage was exceeded. As a matter of fact, Mn(Ⅱ) affected the ozonation by "active sites" mechanism. In the experiment, three different kinds of intermediate products were produced during ozonation, but the amount of products for each one of them decreased as pH, temperature, ionic strength and initial ozone dosage increased. A kinetic equation of the reaction between ozone and DBP was obtained. 展开更多
关键词 di-n-butyl phthalate (DBP) OZONATION key impact factors reaction kinetics degradation intermediate products
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Anoxic biodegradation of dimethyl phthalate (DMP) by activated sludge cultures under nitrate-reducing conditions 被引量:6
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作者 WU Dong-lei HU Bao-lan ZHENG Ping Qaisar Mahmood 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第10期1252-1256,共5页
Worldwide extensive use of plasticized plastics has resulted in phthalates pollution in different environment. Nitrates from industry and agriculture are also widely disseminated in the soils, natural waters and waste... Worldwide extensive use of plasticized plastics has resulted in phthalates pollution in different environment. Nitrates from industry and agriculture are also widely disseminated in the soils, natural waters and wastewaters. Dimethyl phthalate (DMP) biodegradation by activated sludge cultures under nitrate-reducing conditions was investigated. Under one optimized condition, DMP was biodegraded from 102.20 mg/L to undetectable level in 56 h under anoxic conditions and its reaction fitted well with the first-order kinetics. Using the high-performance liquid chromatography (HPLC) and liquid chromatography mass spectrometry (LC-MS) analysis, mono-methyl phthalate (MMP) and phthalic acid (PA) were detected as the major intermediates of DMP biodegradation. When combined with the determination of chemical oxygen demand (CODer) removal capacity and pH, DMP was found to be mineralized completely under anoxic conditions. The biodegradation pathway was proposed as DMP → MMP→ PA→…→ CO2 + H2O. The molar ratio of DMP to nitrate consumed was found to be 9.0:1, which agrees well with the theoretical stoichiometric values of DMP biodegradation by nitrate-reducing bacteria. The results of the non-linear simulation showed that the optimum pH and temperature for the degradation were 7.56 and 31.4℃, respectively. 展开更多
关键词 BIODEGRADATION dimethyl phthalate phthalic acid nitrate reduction MINERALIZATION
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Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Anfisolvent 被引量:8
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作者 金鹤阳 夏菲 +2 位作者 江翠兰 赵亚平 何琳 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2009年第4期672-677,共6页
Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate (HPMCP) to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lute... Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate (HPMCP) to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule. The effects of several operating parameters on the yield, lutein loading, encapsulation efficiency, particle size and particle size distribution of the nanocapsule were investigated. The mean diameter of nanocapsules ranged from 163 nm to 219 nm under appropriate experimental conditions. The result of scanning electron microscope showed that the nanocapsules were nearly spherical. The highest yield reached 95.35% when the initial concentration of lutein was saturated. The highest lutein loading of 15.80% and encapsulation efficiency of 88,41% were obtained under the conditions of 11 MPa, 40℃ and CHPMCP: Clutein= 5:1. The results may promote the application of lutein in food industry. 展开更多
关键词 NANOCAPSULE LUTEIN hydroxypropylmethyl cellulose phthalate supercritical antisolvent precipitation
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