Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac...Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.展开更多
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis...Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.展开更多
Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil aroun...Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.展开更多
Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect...Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.展开更多
Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed ...Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed an experimental method to reduce local scour around pipelines with a steady flow of clear water by installing cylindrical and cubical sacrificial piles.Three sizes of sacrificial piles were examined in a linear arrangement.Sacrificial piles were installed on the upstream side of the pipeline at three distances.Maximum scour depth reduction rates below the pipeline were computed.The results showed that sacrificial piles could protect a pipeline from local scour.A portion of scoured sediment around the sacrificial piles was deposited beneath the pipeline.This sediment accumulation reduced the scour depth beneath the pipeline.Analysis of the experimental results demonstrated that the size of piles(d),the spacing between piles,and the distance between the pipe and piles(Xp)were the variables that reduced the maximum scour beneath the pipeline with a diameter of D.For the piles with d=0.40D and 0.64D,X_(p)=4OD was the optimal distance to install a group of piles,and cubical piles could mitigate scour more effectively than cylindrical piles under similar conditions.For the piles with d=D,the greatest reduction in scour depth was achieved at X_(p)=50D with any desired spacings between piles,and cylindrical piles in this dimension could protect the pipeline against scour more effectively than cubical piles.展开更多
In the acoustic detection process of buried non-metallic pipelines,the echo signal is often interfered by a large amount of noise,which makes it extremely difficult to effectively extract useful signals.An denoising a...In the acoustic detection process of buried non-metallic pipelines,the echo signal is often interfered by a large amount of noise,which makes it extremely difficult to effectively extract useful signals.An denoising algorithm based on empirical mode decomposition(EMD)and wavelet thresholding was proposed.This method fully considered the nonlinear and non-stationary characteristics of the echo signal,making the denoising effect more significant.Its feasibility and effectiveness were verified through numerical simulation.When the input SNR(SNRin)is between-10 dB and 10 dB,the output SNR(SNRout)of the combined denoising algorithm increases by 12.0%-34.1%compared to the wavelet thresholding method and by 19.60%-56.8%compared to the EMD denoising method.Additionally,the RMSE of the combined denoising algorithm decreases by 18.1%-48.0%compared to the wavelet thresholding method and by 22.1%-48.8%compared to the EMD denoising method.These results indicated that this joint denoising algorithm could not only effectively reduce noise interference,but also significantly improve the positioning accuracy of acoustic detection.The research results could provide technical support for denoising the echo signals of buried non-metallic pipelines,which was conducive to improving the acoustic detection and positioning accuracy of underground non-metallic pipelines.展开更多
A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is establis...A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is established to identify potential hazards in time.First,a barrier model and fault tree analysis are used to establish an index system for oil and gas pipeline risk evaluation on the basis of five important factors:corrosion,external interference,material/construction,natural disasters,and function and operation.Next,the index weight for oil and gas pipeline risk evaluation is computed by applying the improved AHP based on the five-scale method.Then,the TOPSIS of a multi-attribute decision-making theory is studied.The method for determining positive/negative ideal solutions and the normalized equation for benefit/cost indexes is improved to render TOPSIS applicable for the comprehensive risk evaluation of pipelines.The closeness coefficient of oil and gas pipelines is calculated by applying the improved TOPSIS.Finally,the weight and the closeness coefficient are combined to determine the risk level of pipelines.Empirical research using a long-distance pipeline as an example is conducted,and adjustment factors are used to verify the model.Results show that the risk evaluation model of oil and gas pipelines based on the improved AHP–TOPSIS is valuable and feasible.The model comprehensively considers the risk factors of oil and gas pipelines and provides comprehensive,rational,and scientific evaluation results.It represents a new decision-making method for systems engineering in pipeline enterprises and provides a comprehensive understanding of the safety status of oil and gas pipelines.The new system engineering decision-making method is important for preventing oil and gas pipeline accidents.展开更多
At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect ...At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect of internal and external fluid with the free span. In this paper, combining Iwan's wake oscillator model with the differential equation derived for the dynamic response of submarine free spanning pipelines with inclusion of internal flow, the pipe-fluid coupling equations are developed to investigate the effect of internal flow on the vortex-induced vibration of the free spans. The finite element approximation is implemented to derive the matrix equations of equilibrium. The Newmark method combined with simple iteration is used to solve the system of equations. The results indicate that the internal fluid flow may cause the shift of resonance band to the lower frequency and a slight decrease in the peak value; the effect will be more pronounced with the increase of the span length and can be weakened in the presence of the axial tension.展开更多
Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were ext...Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were extensively instrumented with strain gauges to measure the distribution of moment during lateral spreading.This allowed us to compute the loading condition,as well as to conduct damage and performance assessments on the piles and pipelines.This paper presents the test results and discussions on the response of single piles and pipelines observed from the full-scale experiments.Based on the test results,it can be concluded that using controlled blasting successfully liquefied the soil,and subsequently induced lateral spreading.The movements of the single pile,as well as the transverse pipelines,were approximately the same as the free field soil movement.Observed moment distribution of the single pile indicated that global translation of the liquefied soil layer provided insignificant force to the pile.In addition,the degree of fixity at the pile tip significantly affected the moment along the pile as well as the pile head displacement.The pile with a higher degree of fixity at the pile tip had smaller pile head displacement but larger maximum moment.展开更多
The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered....The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded(intact) and corroded(deteriorated) to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting' corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement.展开更多
Submarine pipelines play an important role in offshore oil and gas development.A touchy issue in pipeline design and application is how to avoid the local collapse of pipelines under external pressure.The pipe diamete...Submarine pipelines play an important role in offshore oil and gas development.A touchy issue in pipeline design and application is how to avoid the local collapse of pipelines under external pressure.The pipe diameter-thickness ratio D/t is one of the key factors that determine the local critical collapse pressure of the submarine pipelines.Based on the pipeline collapse experiment and finite element simulation,this paper explores the pressure-bearing capacity of the pipeline under external pressure in a wide range of diameter-thickness ratio D/t.Some interesting and important phenomena have been observed and discussed.In the range of 16<D/t<80,both DNV specification and finite element simulation can predict the collapse pressure of pipeline quite well;in the range of 10<D/t<16,the DNV specification is conservative compared with the experimental results,while the finite element simulation results are slightly larger than the experimental results.Further parameter analysis shows that compared with thin-walled pipes,improving the material grade of thick-walled pipes has higher benefits,and for thin-walled pipes,the ovality f_(0)should be controlled even more.In addition,combining the results of finite element simulation and model experiment,an empirical formula of critical collapse pressure for thick-walled pipelines is proposed,which is used to correct the error of DNV specification in the range of 10<D/t<16.展开更多
Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Functi...Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Function (UDF), an Eulerian two-phase model, which includes an Euler-Euler coupled model for water and sediment phases, and a turbulent model for the fluid phase, is adopted to predict the scour depth around pipelines. The model is verified by observation data obtained from laboratory experiments. On the basis of the simulations, the factors affecting the scour depth, including the effects of incipient velocity, pipe diameter and sediment particle size and so on, were investigated. Meanwhile, according to formulas of incipient velocity of various sediments, approximate calculation on theoretical scour depths is developed for pipelines of seven stations in the South China Sea, where engineering application information is available.展开更多
Considering the effect of the internal flowing fluid and the external marine environmental condition, the differential equation for the vortex induced vibration (VIV) of the free spanning pipeline is derived and is d...Considering the effect of the internal flowing fluid and the external marine environmental condition, the differential equation for the vortex induced vibration (VIV) of the free spanning pipeline is derived and is discretized by the Hermit interpolation function. The free vibration equation with the damping term is solved by the complex damping method for the natural frequency, and then the effect of fluid damping on the natural frequency of the free spanning pipeline is analyzed. The results show that fluid damping has a significant influence on the damped natural frequency of the free spanning pipeline in the lock in state, while it has little influence when the pipeline is out of the lock in state. In the meantime, the change of the free span length has the same effect on the damped natural frequency and the undamped natural frequency.展开更多
With the rapid development of the offshore oil industries, submarine oil / gas pipelines have been widely used. Under the complicated submarine environmental conditions, the dynamic characteristics of pipelines show s...With the rapid development of the offshore oil industries, submarine oil / gas pipelines have been widely used. Under the complicated submarine environmental conditions, the dynamic characteristics of pipelines show some new features due to the existence of both internal and external flows. The paper is intended to investigate the vortex-induced vibration of the suspended pipeline span exposed to submarine steady flow. Especially, the effects of the flow inside the pipeline are taken into account. Its influences on the amplitude of pipeline response, and then on the fatigue life, are given in terms of the velocity of the internal flow.展开更多
A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model ...A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes.展开更多
To study the collapse of imperfect subsea pipelinos, a 2D high-order nonlinear model is developed. In this model, the large deformation of the pipes is considered by raiaining the high-order nonlinear terms of strain....To study the collapse of imperfect subsea pipelinos, a 2D high-order nonlinear model is developed. In this model, the large deformation of the pipes is considered by raiaining the high-order nonlinear terms of strain. In addi-tion, the J2 plastic flow theory is adopted to describe the elasioplastic constitutive relations of material. The quasi-static process of collapse is analyzed by the increment method. For each load step, the equations based on the principle of virtual work are presented and solved by the discrete Newton's method. Furthermore, finite element simulations and full-scale experiments were preformed to validate the results of the model. Research on the major influencing factors of collapse pressure, including D/t, material type and initial ovality, is also presented.展开更多
In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth...In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth of submarine pipelines, which are used for the transportation of oil and gas, has been increasing sharply. As the main failure pattern of deep-water pipelines, buckling and its propagation problem have drawn more attention of many research institutions and engineering units around the world. Based on the existing research, the summary of experiments and their outcomes of deep-water pipeline buckling failure is made in this paper. Research status and developing prospects of the experiments of buckling propagation and buckle arrestor are discussed in detail.展开更多
A new remediation technique is proposed to mitigate large deformations imposed on buried pipeline systems subject to permanent ground deformation.With this technique,low-density gravel(LDG)with high porosity,such as p...A new remediation technique is proposed to mitigate large deformations imposed on buried pipeline systems subject to permanent ground deformation.With this technique,low-density gravel(LDG)with high porosity,such as pumice,is used as backfill in the trench containing the pipe near an area susceptible to PGD.This countermeasure decreases soil resistance,soil-pipe interaction forces and strain on the pipe as the pipeline deformation mechanism changes to a more desirable shape.Expanded polystyrene geofoam has been introduced to decrease the density of the pipeline backfill;however,LDG is more efficient regarding workability during construction,environmental effects,durability,fire safety,and cost-effectiveness.A series of centrifuge model experiments in which the pipelines were subjected to reverse faulting was conducted to evaluate the proposed method.During faulting,the axial and bending strain and pipe deflection were measured.A comparison of the responses of the remediated pipeline and the pipeline without remediation indicates that the proposed technique substantially mitigates the effects of large deformation.展开更多
Buried natural gas pipelines are vulnerable to external corrosion because they are encased in a soil environment for a long time.Identifying the causes of external corrosion and taking specific maintenance measures is...Buried natural gas pipelines are vulnerable to external corrosion because they are encased in a soil environment for a long time.Identifying the causes of external corrosion and taking specific maintenance measures is essential.In this work,a risk analysis and maintenance decision-making model for natural gas pipelines with external corrosion is proposed based on a Bayesian network.A fault tree model is first employed to identify the causes of external corrosion.The Bayesian network for risk analysis is determined accordingly.The maintenance strategies are then inserted into the Bayesian network to show a reduction of the risk.The costs of maintenance strategies and the reduced risk after maintenance are combined in an optimization function to build a decision-making model.Because of the limitations of historical data,some of the parameters in the Bayesian network are obtained from a probabilistic estimation model,which combines expert experience and fuzzy set theory.Finally,a case study is carried out to verify the feasibility of the maintenance decision model.This indicates that the method proposed in this work can be used to provide effective maintenance schemes for different pipeline external corrosion scenarios and to reduce the possible losses caused by external corrosion.展开更多
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.
基金supported by the National Natural Science Foundation of China(32141003 and 82330110)the CAMS Innovation Fund for Medical Sciences(CIFMS+2 种基金2021-I2M-1-039)the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Fundamental Research Funds for the Central Universities(2021-PT350-001).
文摘Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.
基金China Postdoctoral Science Foundation,Grant/Award Number:2023M731999National Natural Science Foundation of China,Grant/Award Number:52301326。
文摘Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.
基金supported by the National Natural Science Foundation of China under Grant No.61976226the Research and Academic Team of South-CentralMinzu University under Grant No.KTZ20050.
文摘Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.
文摘Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed an experimental method to reduce local scour around pipelines with a steady flow of clear water by installing cylindrical and cubical sacrificial piles.Three sizes of sacrificial piles were examined in a linear arrangement.Sacrificial piles were installed on the upstream side of the pipeline at three distances.Maximum scour depth reduction rates below the pipeline were computed.The results showed that sacrificial piles could protect a pipeline from local scour.A portion of scoured sediment around the sacrificial piles was deposited beneath the pipeline.This sediment accumulation reduced the scour depth beneath the pipeline.Analysis of the experimental results demonstrated that the size of piles(d),the spacing between piles,and the distance between the pipe and piles(Xp)were the variables that reduced the maximum scour beneath the pipeline with a diameter of D.For the piles with d=0.40D and 0.64D,X_(p)=4OD was the optimal distance to install a group of piles,and cubical piles could mitigate scour more effectively than cylindrical piles under similar conditions.For the piles with d=D,the greatest reduction in scour depth was achieved at X_(p)=50D with any desired spacings between piles,and cylindrical piles in this dimension could protect the pipeline against scour more effectively than cubical piles.
基金supported by Nanchong Southwest Petroleum University Science and Technology Strategic Cooperation Project(Nos.23XNSYSX0022,23XNSYSX0026)Provincial Science and Technology Plan Project(No.2023ZHCG0020)Southwest Petroleum University Natural Science“Sailing Plan”Project(No.2023QHZ003)。
文摘In the acoustic detection process of buried non-metallic pipelines,the echo signal is often interfered by a large amount of noise,which makes it extremely difficult to effectively extract useful signals.An denoising algorithm based on empirical mode decomposition(EMD)and wavelet thresholding was proposed.This method fully considered the nonlinear and non-stationary characteristics of the echo signal,making the denoising effect more significant.Its feasibility and effectiveness were verified through numerical simulation.When the input SNR(SNRin)is between-10 dB and 10 dB,the output SNR(SNRout)of the combined denoising algorithm increases by 12.0%-34.1%compared to the wavelet thresholding method and by 19.60%-56.8%compared to the EMD denoising method.Additionally,the RMSE of the combined denoising algorithm decreases by 18.1%-48.0%compared to the wavelet thresholding method and by 22.1%-48.8%compared to the EMD denoising method.These results indicated that this joint denoising algorithm could not only effectively reduce noise interference,but also significantly improve the positioning accuracy of acoustic detection.The research results could provide technical support for denoising the echo signals of buried non-metallic pipelines,which was conducive to improving the acoustic detection and positioning accuracy of underground non-metallic pipelines.
基金supported by the National Key Research and Development Program of China(Grant Nos.2017YFC0805804,2017YFC0805801)
文摘A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is established to identify potential hazards in time.First,a barrier model and fault tree analysis are used to establish an index system for oil and gas pipeline risk evaluation on the basis of five important factors:corrosion,external interference,material/construction,natural disasters,and function and operation.Next,the index weight for oil and gas pipeline risk evaluation is computed by applying the improved AHP based on the five-scale method.Then,the TOPSIS of a multi-attribute decision-making theory is studied.The method for determining positive/negative ideal solutions and the normalized equation for benefit/cost indexes is improved to render TOPSIS applicable for the comprehensive risk evaluation of pipelines.The closeness coefficient of oil and gas pipelines is calculated by applying the improved TOPSIS.Finally,the weight and the closeness coefficient are combined to determine the risk level of pipelines.Empirical research using a long-distance pipeline as an example is conducted,and adjustment factors are used to verify the model.Results show that the risk evaluation model of oil and gas pipelines based on the improved AHP–TOPSIS is valuable and feasible.The model comprehensively considers the risk factors of oil and gas pipelines and provides comprehensive,rational,and scientific evaluation results.It represents a new decision-making method for systems engineering in pipeline enterprises and provides a comprehensive understanding of the safety status of oil and gas pipelines.The new system engineering decision-making method is important for preventing oil and gas pipeline accidents.
基金This Project was fincianlly supported by the National Natural Science Foundation of China (Grant No. 50379050)
文摘At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect of internal and external fluid with the free span. In this paper, combining Iwan's wake oscillator model with the differential equation derived for the dynamic response of submarine free spanning pipelines with inclusion of internal flow, the pipe-fluid coupling equations are developed to investigate the effect of internal flow on the vortex-induced vibration of the free spans. The finite element approximation is implemented to derive the matrix equations of equilibrium. The Newmark method combined with simple iteration is used to solve the system of equations. The results indicate that the internal fluid flow may cause the shift of resonance band to the lower frequency and a slight decrease in the peak value; the effect will be more pronounced with the increase of the span length and can be weakened in the presence of the axial tension.
文摘Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were extensively instrumented with strain gauges to measure the distribution of moment during lateral spreading.This allowed us to compute the loading condition,as well as to conduct damage and performance assessments on the piles and pipelines.This paper presents the test results and discussions on the response of single piles and pipelines observed from the full-scale experiments.Based on the test results,it can be concluded that using controlled blasting successfully liquefied the soil,and subsequently induced lateral spreading.The movements of the single pile,as well as the transverse pipelines,were approximately the same as the free field soil movement.Observed moment distribution of the single pile indicated that global translation of the liquefied soil layer provided insignificant force to the pile.In addition,the degree of fixity at the pile tip significantly affected the moment along the pile as well as the pile head displacement.The pile with a higher degree of fixity at the pile tip had smaller pile head displacement but larger maximum moment.
文摘The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded(intact) and corroded(deteriorated) to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting' corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.U2106223 and 51979193)the Major Consulting Project of Academy-Local Cooperation of Chinese Academy of Engineering(Grant No.2021DFZD2)。
文摘Submarine pipelines play an important role in offshore oil and gas development.A touchy issue in pipeline design and application is how to avoid the local collapse of pipelines under external pressure.The pipe diameter-thickness ratio D/t is one of the key factors that determine the local critical collapse pressure of the submarine pipelines.Based on the pipeline collapse experiment and finite element simulation,this paper explores the pressure-bearing capacity of the pipeline under external pressure in a wide range of diameter-thickness ratio D/t.Some interesting and important phenomena have been observed and discussed.In the range of 16<D/t<80,both DNV specification and finite element simulation can predict the collapse pressure of pipeline quite well;in the range of 10<D/t<16,the DNV specification is conservative compared with the experimental results,while the finite element simulation results are slightly larger than the experimental results.Further parameter analysis shows that compared with thin-walled pipes,improving the material grade of thick-walled pipes has higher benefits,and for thin-walled pipes,the ovality f_(0)should be controlled even more.In addition,combining the results of finite element simulation and model experiment,an empirical formula of critical collapse pressure for thick-walled pipelines is proposed,which is used to correct the error of DNV specification in the range of 10<D/t<16.
基金Foundation item: Supported by the State Key Laboratory of Hydraulic Engineering Simulation and Safety (Grant No. HESS-1401), the National Natural Science Foundation of China (Grant No. 51279124), the Marine Science and Technology Foundation of South China Sea Branch, State Oceanic Administration (Grant No. 1417), and the National High Technology Research and Development Program of China (Grant No. 2008AA09A401). Acknowledgement We wish to thank Prof. Bai YC for stimulating discussions and reviewers for their helpful comments that led to considerable improvements to the paper.
文摘Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Function (UDF), an Eulerian two-phase model, which includes an Euler-Euler coupled model for water and sediment phases, and a turbulent model for the fluid phase, is adopted to predict the scour depth around pipelines. The model is verified by observation data obtained from laboratory experiments. On the basis of the simulations, the factors affecting the scour depth, including the effects of incipient velocity, pipe diameter and sediment particle size and so on, were investigated. Meanwhile, according to formulas of incipient velocity of various sediments, approximate calculation on theoretical scour depths is developed for pipelines of seven stations in the South China Sea, where engineering application information is available.
文摘Considering the effect of the internal flowing fluid and the external marine environmental condition, the differential equation for the vortex induced vibration (VIV) of the free spanning pipeline is derived and is discretized by the Hermit interpolation function. The free vibration equation with the damping term is solved by the complex damping method for the natural frequency, and then the effect of fluid damping on the natural frequency of the free spanning pipeline is analyzed. The results show that fluid damping has a significant influence on the damped natural frequency of the free spanning pipeline in the lock in state, while it has little influence when the pipeline is out of the lock in state. In the meantime, the change of the free span length has the same effect on the damped natural frequency and the undamped natural frequency.
文摘With the rapid development of the offshore oil industries, submarine oil / gas pipelines have been widely used. Under the complicated submarine environmental conditions, the dynamic characteristics of pipelines show some new features due to the existence of both internal and external flows. The paper is intended to investigate the vortex-induced vibration of the suspended pipeline span exposed to submarine steady flow. Especially, the effects of the flow inside the pipeline are taken into account. Its influences on the amplitude of pipeline response, and then on the fatigue life, are given in terms of the velocity of the internal flow.
基金supported jointly by the National Natural Science Foundation of China and Korea Scienceand Engineering Foundation(Grant No.50811140341)
文摘A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes.
基金Supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2011ZX05026-005)the National Natural Science Foundation of China(No.51239008)the National Basic Research Program of China("973"Program,No.2014CB046800)
文摘To study the collapse of imperfect subsea pipelinos, a 2D high-order nonlinear model is developed. In this model, the large deformation of the pipes is considered by raiaining the high-order nonlinear terms of strain. In addi-tion, the J2 plastic flow theory is adopted to describe the elasioplastic constitutive relations of material. The quasi-static process of collapse is analyzed by the increment method. For each load step, the equations based on the principle of virtual work are presented and solved by the discrete Newton's method. Furthermore, finite element simulations and full-scale experiments were preformed to validate the results of the model. Research on the major influencing factors of collapse pressure, including D/t, material type and initial ovality, is also presented.
基金Supported by the National Natural Science Foundation of China(No.51239008)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.51321065)the National Basic Research Program of China(“973”Program,No.2014CB046805)
文摘In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth of submarine pipelines, which are used for the transportation of oil and gas, has been increasing sharply. As the main failure pattern of deep-water pipelines, buckling and its propagation problem have drawn more attention of many research institutions and engineering units around the world. Based on the existing research, the summary of experiments and their outcomes of deep-water pipeline buckling failure is made in this paper. Research status and developing prospects of the experiments of buckling propagation and buckle arrestor are discussed in detail.
文摘A new remediation technique is proposed to mitigate large deformations imposed on buried pipeline systems subject to permanent ground deformation.With this technique,low-density gravel(LDG)with high porosity,such as pumice,is used as backfill in the trench containing the pipe near an area susceptible to PGD.This countermeasure decreases soil resistance,soil-pipe interaction forces and strain on the pipe as the pipeline deformation mechanism changes to a more desirable shape.Expanded polystyrene geofoam has been introduced to decrease the density of the pipeline backfill;however,LDG is more efficient regarding workability during construction,environmental effects,durability,fire safety,and cost-effectiveness.A series of centrifuge model experiments in which the pipelines were subjected to reverse faulting was conducted to evaluate the proposed method.During faulting,the axial and bending strain and pipe deflection were measured.A comparison of the responses of the remediated pipeline and the pipeline without remediation indicates that the proposed technique substantially mitigates the effects of large deformation.
基金supported by the National Key R&D Program of China(Grant No.2018YFC0809300)the National Natural Science Foundation of China(Grant No.51806247)+2 种基金the Key Technology Project of Petro China Co Ltd.(Grant No.ZLZX2020-05)the Foundation of Sinopec(Grant No.320034)the Science Foundation of China University of Petroleum,Beijing(Grant No.2462020YXZZ052)
文摘Buried natural gas pipelines are vulnerable to external corrosion because they are encased in a soil environment for a long time.Identifying the causes of external corrosion and taking specific maintenance measures is essential.In this work,a risk analysis and maintenance decision-making model for natural gas pipelines with external corrosion is proposed based on a Bayesian network.A fault tree model is first employed to identify the causes of external corrosion.The Bayesian network for risk analysis is determined accordingly.The maintenance strategies are then inserted into the Bayesian network to show a reduction of the risk.The costs of maintenance strategies and the reduced risk after maintenance are combined in an optimization function to build a decision-making model.Because of the limitations of historical data,some of the parameters in the Bayesian network are obtained from a probabilistic estimation model,which combines expert experience and fuzzy set theory.Finally,a case study is carried out to verify the feasibility of the maintenance decision model.This indicates that the method proposed in this work can be used to provide effective maintenance schemes for different pipeline external corrosion scenarios and to reduce the possible losses caused by external corrosion.