Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil aroun...Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.展开更多
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis...Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.展开更多
Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect...Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.展开更多
Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed ...Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed an experimental method to reduce local scour around pipelines with a steady flow of clear water by installing cylindrical and cubical sacrificial piles.Three sizes of sacrificial piles were examined in a linear arrangement.Sacrificial piles were installed on the upstream side of the pipeline at three distances.Maximum scour depth reduction rates below the pipeline were computed.The results showed that sacrificial piles could protect a pipeline from local scour.A portion of scoured sediment around the sacrificial piles was deposited beneath the pipeline.This sediment accumulation reduced the scour depth beneath the pipeline.Analysis of the experimental results demonstrated that the size of piles(d),the spacing between piles,and the distance between the pipe and piles(Xp)were the variables that reduced the maximum scour beneath the pipeline with a diameter of D.For the piles with d=0.40D and 0.64D,X_(p)=4OD was the optimal distance to install a group of piles,and cubical piles could mitigate scour more effectively than cylindrical piles under similar conditions.For the piles with d=D,the greatest reduction in scour depth was achieved at X_(p)=50D with any desired spacings between piles,and cylindrical piles in this dimension could protect the pipeline against scour more effectively than cubical piles.展开更多
In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, ...In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers (microphone) which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.展开更多
Landslides are one of the key problems for stability analysis of pipelines in the western region of China where the geological conditions are extremely complicated. In order to offer a theoretical basis for the pipe-s...Landslides are one of the key problems for stability analysis of pipelines in the western region of China where the geological conditions are extremely complicated. In order to offer a theoretical basis for the pipe-soil interaction, the general finite element program ABAQUS is used to analyze the distribution of pipe strain caused by landslide through which the pipeline passes. In this paper the Ramberg-Osgood constitutive equation is used to study the strain-based mechanical characteristics of pipelines. Different calculation schemas are designed by considering the change of spatial relationship between pipeline and landslide, and the change of D/t, diameter-thickness ratio of pipeline. The results indicate that the pipeline is primarily subjected to tension stress when the landslide crosses the pipeline perpendicularly, the pipe strain is a maximum along the central axis of the landslide, and reverse bending occurs on pipeline at both edges of the landslide. The pipeline is primarily subjected to friction force caused by the downward movement of the landslide, and the friction force is relatively small when the landslide is parallel to the pipeline. The pipe strain is in proportional to D/t, and this means decreasing D/t can help to improve security of pipelines subjected to the landslide.展开更多
A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is establis...A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is established to identify potential hazards in time.First,a barrier model and fault tree analysis are used to establish an index system for oil and gas pipeline risk evaluation on the basis of five important factors:corrosion,external interference,material/construction,natural disasters,and function and operation.Next,the index weight for oil and gas pipeline risk evaluation is computed by applying the improved AHP based on the five-scale method.Then,the TOPSIS of a multi-attribute decision-making theory is studied.The method for determining positive/negative ideal solutions and the normalized equation for benefit/cost indexes is improved to render TOPSIS applicable for the comprehensive risk evaluation of pipelines.The closeness coefficient of oil and gas pipelines is calculated by applying the improved TOPSIS.Finally,the weight and the closeness coefficient are combined to determine the risk level of pipelines.Empirical research using a long-distance pipeline as an example is conducted,and adjustment factors are used to verify the model.Results show that the risk evaluation model of oil and gas pipelines based on the improved AHP–TOPSIS is valuable and feasible.The model comprehensively considers the risk factors of oil and gas pipelines and provides comprehensive,rational,and scientific evaluation results.It represents a new decision-making method for systems engineering in pipeline enterprises and provides a comprehensive understanding of the safety status of oil and gas pipelines.The new system engineering decision-making method is important for preventing oil and gas pipeline accidents.展开更多
Pipes inevitably encounter high ambient pressure and bending moment during the deepwater pipe-laying process,which can lead to elliptical buckling and even deterioration failure.For the safety of pipe-laying operation...Pipes inevitably encounter high ambient pressure and bending moment during the deepwater pipe-laying process,which can lead to elliptical buckling and even deterioration failure.For the safety of pipe-laying operation,available formulas for the pipe stability are established on the basis of the assumption of uniform deformation along the tube length and symmetrical buckling.This method can predict the nonlinear response of elliptical collapse of steel circular tubes for different ratios of diameter to thickness(D/t)under pure bending or combined bending and external pressure.In these formulas,the strain-displacement relationship is deduced from the nonlinear ring theory,and the Ramberg-Osgood constitutive model is applied to simulate the inelastic material behavior.Meanwhile,the principle of virtual work is adopted to derive the equilibrium equations.A set of equations is solved by the Newton-Raphson method,and the iterative scheme contains nested iteration for the constitutive relation.In order to check the effectiveness of this theoretical method,illustrative examples are presented in this paper.Besides,the numerical simulation is carried out by use of ANSYS.A comparison of the results shows that the theoretical method can provide reasonable prediction for engineering practice.展开更多
Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were ext...Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were extensively instrumented with strain gauges to measure the distribution of moment during lateral spreading.This allowed us to compute the loading condition,as well as to conduct damage and performance assessments on the piles and pipelines.This paper presents the test results and discussions on the response of single piles and pipelines observed from the full-scale experiments.Based on the test results,it can be concluded that using controlled blasting successfully liquefied the soil,and subsequently induced lateral spreading.The movements of the single pile,as well as the transverse pipelines,were approximately the same as the free field soil movement.Observed moment distribution of the single pile indicated that global translation of the liquefied soil layer provided insignificant force to the pile.In addition,the degree of fixity at the pile tip significantly affected the moment along the pile as well as the pile head displacement.The pile with a higher degree of fixity at the pile tip had smaller pile head displacement but larger maximum moment.展开更多
At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect ...At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect of internal and external fluid with the free span. In this paper, combining Iwan's wake oscillator model with the differential equation derived for the dynamic response of submarine free spanning pipelines with inclusion of internal flow, the pipe-fluid coupling equations are developed to investigate the effect of internal flow on the vortex-induced vibration of the free spans. The finite element approximation is implemented to derive the matrix equations of equilibrium. The Newmark method combined with simple iteration is used to solve the system of equations. The results indicate that the internal fluid flow may cause the shift of resonance band to the lower frequency and a slight decrease in the peak value; the effect will be more pronounced with the increase of the span length and can be weakened in the presence of the axial tension.展开更多
Seismic ground faulting is the greatest hazard for continuous buried pipelines.Over the years,researchers have attempted to understand pipeline behavior mostly via numerical modeling such as the finite element method....Seismic ground faulting is the greatest hazard for continuous buried pipelines.Over the years,researchers have attempted to understand pipeline behavior mostly via numerical modeling such as the finite element method.The lack of well-documented field case histories of pipeline failure from seismic ground faulting and the cost and complicated facilities needed for full-scale experimental simulation mean that a centrifuge-based method to determine the behavior of pipelines subjected to faulting is best to verify numerical approaches.This paper presents results from three centrifuge tests designed to investigate continuous buried steel pipeline behavior subjected to normal faulting.The experimental setup and procedure are described and the recorded axial and bending strains induced in a pipeline are presented and compared to those obtained via analytical methods.The influence of factors such as faulting offset,burial depth and pipe diameter on the axial and bending strains of pipes and on ground soil failure and pipeline deformation patterns are also investigated.Finally,the tensile rupture of a pipeline due to normal faulting is investigated.展开更多
The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered....The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded(intact) and corroded(deteriorated) to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting' corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement.展开更多
Oil product pipelines have features such as transporting multiple materials, ever-changing operating conditions, and synchronism between the oil input plan and the oil offloading plan. In this paper, an optimal model ...Oil product pipelines have features such as transporting multiple materials, ever-changing operating conditions, and synchronism between the oil input plan and the oil offloading plan. In this paper, an optimal model was established for a single-source multi-distribution oil pro- duct pipeline, and scheduling plans were made based on supply. In the model, time node constraints, oil offloading plan constraints, and migration of batch constraints were taken into consideration. The minimum deviation between the demanded oil volumes and the actual offloading volumes was chosen as the objective function, and a linear programming model was established on the basis of known time nodes' sequence. The ant colony optimization algo- rithm and simplex method were used to solve the model. The model was applied to a real pipeline and it performed well.展开更多
Many years experience of the operation of high stress (>72% specified minimum yield strength, SMYS) gas pipelines and statistical analysis results of pipeline incidents showed that the operating pipelines at stress...Many years experience of the operation of high stress (>72% specified minimum yield strength, SMYS) gas pipelines and statistical analysis results of pipeline incidents showed that the operating pipelines at stress levels over 72% SMYS have not presented problems in USA and Canada, and design factor does not control incidents or the safety of pipelines. Enhancing pipeline safety management level is most important for decreasing incident rate. The application history of higher design factors in the U.S and Canada was reviewed. And the effect of higher factors to the critical flaw size, puncture resistance, change of reliability with time, risk level and the arrest toughness requirements of pipeline were analyzed here. The comparison of pipeline failure rates and risk levels between two design factors (0.72 and 0.8) has shown that a change in design factor from 0.72 to 0.8 would bring little effect on failure rates and risk levels. On the basis of the analysis result, the application feasibility of design factor of 0.8 in China was discussed and the related suggestions were proposed. When an operator wishes to apply design factor 0.8 to gas pipeline, the following process is recommended: stress level of line pipe hydro test should be up to 100% SMYS, reliability and risk assessment at the design feasibility or conceptual stage should be conducted, Charpy impact energy should meet the need of pipeline crack arrest; and establish and execute risk based integrity management plan. The technology of pipeline steel metallurgy, line pipe fabrication and pipeline construction, and line pipe quality control level in China achieved tremendous progresses, and line pipe product standards and property indexes have come up to international advanced level. Furthermore, pipeline safety management has improved greatly in China. Consequently, the research for the feasibility of application of design factor of 0.8 in China has fundamental basis.展开更多
This paper presents a method for analysis of stress and strain of gas pipelines under the effect of horizontal catastrophic landslides. A soil spring model was used to analyze the nonlinear characteristics concerning ...This paper presents a method for analysis of stress and strain of gas pipelines under the effect of horizontal catastrophic landslides. A soil spring model was used to analyze the nonlinear characteristics concerning the mutual effects between the pipeline and the soil. The Ramberg–Osgood model was used to describe the constitutive relations of pipeline materials. This paper also constructed a finite element analysis model using ABAQUS finite element software and studied the distribution of the maximum stress and strain of the pipeline and the axial stress and strain along the pipeline by referencing some typical accident cases. The calculation results indicated that the maximum stress and strain increased gradually with the displacement of landslide.The limit values of pipeline axial stress strain appeared at the junction of the landslide area and non-landslide area. The stress failure criterion was relatively more conservative than the strain failure criterion. The research results of this paper may be used as a technical reference concerning the design and safety management of large-diameter gas pipelines under the effects of catastrophic landslides.展开更多
In-service hydrocarbons must be transported at high temperature and high pressure to ease the flow and prevent the solidification of the wax fraction. The pipeline containing hot oil will expand longitudinally due to ...In-service hydrocarbons must be transported at high temperature and high pressure to ease the flow and prevent the solidification of the wax fraction. The pipeline containing hot oil will expand longitudinally due to the rise in temperature. If such expansion is resisted, for example by frictional effects over a kilometer or so of pipeline, compressive axial stress will be built up in the pipe-wall. The compressive forces are often so large that they induce vertical buckling of buffed pipelines, which can jeopardize the structural integrity of the pipeline. A typical initial imperfection named continuous support mode of submarine pipeline was studied. Based on this type of initial imperfection, the analytical solution of vertical thermal buckling was introduced and an elastic-plasticity finite element analysis (FEA) was developed. Both the analytical and the finite element methodology were applied to analyze a practice in Bohai Gulf, China. The analyzing results show that upheaval buckling is most likely to build up from the initial imperfection of the pipeline and the buckling temperature depends on the amplitude of initial imperfection. With the same amplitude of initial imperfection, the triggering temperature difference of upheaval buckling increases with covered depth of the pipeline, the soil strength and the friction between the pipeline and subsoil.展开更多
Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent ye...Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent years,non-metallic pipes,such as plastic pipes,ceramic pipes,and concrete pipes,are increasingly taking the place of pipes made from metal in various pipeline networks such as water supply,drainage,heat,industry,oil,and gas.The location technologies for the location of the buried metal pipeline have become mature,but detection and location technologies for the non-metallic pipelines are still developing.In this paper,current trends and future perspectives of detection and location of buried non-metallic pipelines are summarized.Initially,this paper reviews and analyzes electromagnetic induction technologies,electromagnetic wave technologies,and other physics-based technologies.It then focuses on acoustic detection and location technologies,and finally introduces emerging technologies.Then the technical characteristics of each detection and location method have been compared,with their strengths and weaknesses identified.The current trends and future perspectives of each buried non-metallic pipeline detection and location technology have also been defined.Finally,some suggestions for the future development of buried non-metallic pipeline detection and location technologies are provided.展开更多
In order to understand the dynamic behavior of submarine pipelines exposed to current and the mechanism of the interaction between current-induced vibration and scour of pipelines on a sandy bottom, an experimental in...In order to understand the dynamic behavior of submarine pipelines exposed to current and the mechanism of the interaction between current-induced vibration and scour of pipelines on a sandy bottom, an experimental investigation is conducted with a small scale model A test model which can be tested in the flume is set up by taking into account the typical working conditions of the pipelines and by applying the similarity theory. The interactions between the shape of the scour hole and the behavior of the pipeline as well as the flow patterns of the current are detailed, and the interaction mechanism outlined. The effect of vibration of the pipeline on the development of dynamic scour at different stages is found out. The proposed experimental method and test results provide an effective means for design of marine pipelines against scouring.展开更多
The mechanism of local scour around submarine pipelines is studied numerically based on a renormalized group (RNG) turbulence model. To validate the numerical model, the equilibrium profiles of local scour for two c...The mechanism of local scour around submarine pipelines is studied numerically based on a renormalized group (RNG) turbulence model. To validate the numerical model, the equilibrium profiles of local scour for two cases are simulated and compared with the experimental data. It shows that the RNG turbulence model can give an appropriate prediction for the configuration of equilibrium scour hole, and it is applicable to this situation. The local scour mechanism around submarine pipelines including the flow structure, shear stress distribution and pressure field is then analyzed and compared with experiments. For further comparison and validation, especially for the flow structure, a numerical calculation employing the large eddy simulation (LES) is also conducted. The numerical results of RNG demonstrate that the critical factor governing the equilibrium profile is the seabed shear stress distribution in the case of bed load sediment transport, and the two-equation RNG turbulence model coupled with the law of wall is capable of giving a satisfying estimation for the bed shear stress. Moreover, the piping phenomena due to the great difference of pressure between the upstream and downstream parts of pipelines and the vortex structure around submarine pipelines are also simulated successfully, which are believed to be the important factor that lead to the onset of local scour.展开更多
基金China Postdoctoral Science Foundation,Grant/Award Number:2023M731999National Natural Science Foundation of China,Grant/Award Number:52301326。
文摘Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.
基金supported by the National Natural Science Foundation of China(32141003 and 82330110)the CAMS Innovation Fund for Medical Sciences(CIFMS+2 种基金2021-I2M-1-039)the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Fundamental Research Funds for the Central Universities(2021-PT350-001).
文摘Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.
基金supported by the National Natural Science Foundation of China under Grant No.61976226the Research and Academic Team of South-CentralMinzu University under Grant No.KTZ20050.
文摘Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.
文摘Local scour around pipelines crossing rivers or in marine environments is a significant concern.It can lead to failure of the pipelines resulting in environmental side effects and economic losses.This study developed an experimental method to reduce local scour around pipelines with a steady flow of clear water by installing cylindrical and cubical sacrificial piles.Three sizes of sacrificial piles were examined in a linear arrangement.Sacrificial piles were installed on the upstream side of the pipeline at three distances.Maximum scour depth reduction rates below the pipeline were computed.The results showed that sacrificial piles could protect a pipeline from local scour.A portion of scoured sediment around the sacrificial piles was deposited beneath the pipeline.This sediment accumulation reduced the scour depth beneath the pipeline.Analysis of the experimental results demonstrated that the size of piles(d),the spacing between piles,and the distance between the pipe and piles(Xp)were the variables that reduced the maximum scour beneath the pipeline with a diameter of D.For the piles with d=0.40D and 0.64D,X_(p)=4OD was the optimal distance to install a group of piles,and cubical piles could mitigate scour more effectively than cylindrical piles under similar conditions.For the piles with d=D,the greatest reduction in scour depth was achieved at X_(p)=50D with any desired spacings between piles,and cylindrical piles in this dimension could protect the pipeline against scour more effectively than cubical piles.
文摘In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers (microphone) which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.
基金supported by the National Natural Science Foundation of China (Grant No. 50774090)
文摘Landslides are one of the key problems for stability analysis of pipelines in the western region of China where the geological conditions are extremely complicated. In order to offer a theoretical basis for the pipe-soil interaction, the general finite element program ABAQUS is used to analyze the distribution of pipe strain caused by landslide through which the pipeline passes. In this paper the Ramberg-Osgood constitutive equation is used to study the strain-based mechanical characteristics of pipelines. Different calculation schemas are designed by considering the change of spatial relationship between pipeline and landslide, and the change of D/t, diameter-thickness ratio of pipeline. The results indicate that the pipeline is primarily subjected to tension stress when the landslide crosses the pipeline perpendicularly, the pipe strain is a maximum along the central axis of the landslide, and reverse bending occurs on pipeline at both edges of the landslide. The pipeline is primarily subjected to friction force caused by the downward movement of the landslide, and the friction force is relatively small when the landslide is parallel to the pipeline. The pipe strain is in proportional to D/t, and this means decreasing D/t can help to improve security of pipelines subjected to the landslide.
基金supported by the National Key Research and Development Program of China(Grant Nos.2017YFC0805804,2017YFC0805801)
文摘A comprehensive and objective risk evaluation model of oil and gas pipelines based on an improved analytic hierarchy process(AHP)and technique for order preference by similarity to an ideal solution(TOPSIS)is established to identify potential hazards in time.First,a barrier model and fault tree analysis are used to establish an index system for oil and gas pipeline risk evaluation on the basis of five important factors:corrosion,external interference,material/construction,natural disasters,and function and operation.Next,the index weight for oil and gas pipeline risk evaluation is computed by applying the improved AHP based on the five-scale method.Then,the TOPSIS of a multi-attribute decision-making theory is studied.The method for determining positive/negative ideal solutions and the normalized equation for benefit/cost indexes is improved to render TOPSIS applicable for the comprehensive risk evaluation of pipelines.The closeness coefficient of oil and gas pipelines is calculated by applying the improved TOPSIS.Finally,the weight and the closeness coefficient are combined to determine the risk level of pipelines.Empirical research using a long-distance pipeline as an example is conducted,and adjustment factors are used to verify the model.Results show that the risk evaluation model of oil and gas pipelines based on the improved AHP–TOPSIS is valuable and feasible.The model comprehensively considers the risk factors of oil and gas pipelines and provides comprehensive,rational,and scientific evaluation results.It represents a new decision-making method for systems engineering in pipeline enterprises and provides a comprehensive understanding of the safety status of oil and gas pipelines.The new system engineering decision-making method is important for preventing oil and gas pipeline accidents.
基金supported by the National High Technology Research and Development Programof China(863 Program,Grant No.2006AA09A105)
文摘Pipes inevitably encounter high ambient pressure and bending moment during the deepwater pipe-laying process,which can lead to elliptical buckling and even deterioration failure.For the safety of pipe-laying operation,available formulas for the pipe stability are established on the basis of the assumption of uniform deformation along the tube length and symmetrical buckling.This method can predict the nonlinear response of elliptical collapse of steel circular tubes for different ratios of diameter to thickness(D/t)under pure bending or combined bending and external pressure.In these formulas,the strain-displacement relationship is deduced from the nonlinear ring theory,and the Ramberg-Osgood constitutive model is applied to simulate the inelastic material behavior.Meanwhile,the principle of virtual work is adopted to derive the equilibrium equations.A set of equations is solved by the Newton-Raphson method,and the iterative scheme contains nested iteration for the constitutive relation.In order to check the effectiveness of this theoretical method,illustrative examples are presented in this paper.Besides,the numerical simulation is carried out by use of ANSYS.A comparison of the results shows that the theoretical method can provide reasonable prediction for engineering practice.
文摘Two full-scale experiments using controlled blasting were conducted in the Port of Tokachi on Hokkaido Island, Japan,to assess the behavior of piles and pipelines subjected to lateral spreading.Test specimens were extensively instrumented with strain gauges to measure the distribution of moment during lateral spreading.This allowed us to compute the loading condition,as well as to conduct damage and performance assessments on the piles and pipelines.This paper presents the test results and discussions on the response of single piles and pipelines observed from the full-scale experiments.Based on the test results,it can be concluded that using controlled blasting successfully liquefied the soil,and subsequently induced lateral spreading.The movements of the single pile,as well as the transverse pipelines,were approximately the same as the free field soil movement.Observed moment distribution of the single pile indicated that global translation of the liquefied soil layer provided insignificant force to the pile.In addition,the degree of fixity at the pile tip significantly affected the moment along the pile as well as the pile head displacement.The pile with a higher degree of fixity at the pile tip had smaller pile head displacement but larger maximum moment.
基金This Project was fincianlly supported by the National Natural Science Foundation of China (Grant No. 50379050)
文摘At present, most researches on the vortex-induced vibration of submarine free spanning pipelines ignore the effect of internal flowing fluid; furthermore, there are no research reports considering the coupling effect of internal and external fluid with the free span. In this paper, combining Iwan's wake oscillator model with the differential equation derived for the dynamic response of submarine free spanning pipelines with inclusion of internal flow, the pipe-fluid coupling equations are developed to investigate the effect of internal flow on the vortex-induced vibration of the free spans. The finite element approximation is implemented to derive the matrix equations of equilibrium. The Newmark method combined with simple iteration is used to solve the system of equations. The results indicate that the internal fluid flow may cause the shift of resonance band to the lower frequency and a slight decrease in the peak value; the effect will be more pronounced with the increase of the span length and can be weakened in the presence of the axial tension.
基金This work was conducted at the Physical Modeling and Centrifuge Laboratory of the Soil Mechanics and Foundation Engineering Department in the School of Civil Engineering,University of Tehran
文摘Seismic ground faulting is the greatest hazard for continuous buried pipelines.Over the years,researchers have attempted to understand pipeline behavior mostly via numerical modeling such as the finite element method.The lack of well-documented field case histories of pipeline failure from seismic ground faulting and the cost and complicated facilities needed for full-scale experimental simulation mean that a centrifuge-based method to determine the behavior of pipelines subjected to faulting is best to verify numerical approaches.This paper presents results from three centrifuge tests designed to investigate continuous buried steel pipeline behavior subjected to normal faulting.The experimental setup and procedure are described and the recorded axial and bending strains induced in a pipeline are presented and compared to those obtained via analytical methods.The influence of factors such as faulting offset,burial depth and pipe diameter on the axial and bending strains of pipes and on ground soil failure and pipeline deformation patterns are also investigated.Finally,the tensile rupture of a pipeline due to normal faulting is investigated.
文摘The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded(intact) and corroded(deteriorated) to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting' corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement.
基金part of the Program of"Study on the mechanism of complex heat and mass transfer during batch transport process in products pipelines"funded under the National Natural Science Foundation of China(grant number 51474228)
文摘Oil product pipelines have features such as transporting multiple materials, ever-changing operating conditions, and synchronism between the oil input plan and the oil offloading plan. In this paper, an optimal model was established for a single-source multi-distribution oil pro- duct pipeline, and scheduling plans were made based on supply. In the model, time node constraints, oil offloading plan constraints, and migration of batch constraints were taken into consideration. The minimum deviation between the demanded oil volumes and the actual offloading volumes was chosen as the objective function, and a linear programming model was established on the basis of known time nodes' sequence. The ant colony optimization algo- rithm and simplex method were used to solve the model. The model was applied to a real pipeline and it performed well.
基金supported by China National Petroleum Corporation Application Fundamental Research Foundation (Grant No. 07A40401)
文摘Many years experience of the operation of high stress (>72% specified minimum yield strength, SMYS) gas pipelines and statistical analysis results of pipeline incidents showed that the operating pipelines at stress levels over 72% SMYS have not presented problems in USA and Canada, and design factor does not control incidents or the safety of pipelines. Enhancing pipeline safety management level is most important for decreasing incident rate. The application history of higher design factors in the U.S and Canada was reviewed. And the effect of higher factors to the critical flaw size, puncture resistance, change of reliability with time, risk level and the arrest toughness requirements of pipeline were analyzed here. The comparison of pipeline failure rates and risk levels between two design factors (0.72 and 0.8) has shown that a change in design factor from 0.72 to 0.8 would bring little effect on failure rates and risk levels. On the basis of the analysis result, the application feasibility of design factor of 0.8 in China was discussed and the related suggestions were proposed. When an operator wishes to apply design factor 0.8 to gas pipeline, the following process is recommended: stress level of line pipe hydro test should be up to 100% SMYS, reliability and risk assessment at the design feasibility or conceptual stage should be conducted, Charpy impact energy should meet the need of pipeline crack arrest; and establish and execute risk based integrity management plan. The technology of pipeline steel metallurgy, line pipe fabrication and pipeline construction, and line pipe quality control level in China achieved tremendous progresses, and line pipe product standards and property indexes have come up to international advanced level. Furthermore, pipeline safety management has improved greatly in China. Consequently, the research for the feasibility of application of design factor of 0.8 in China has fundamental basis.
基金funded by the National Science and Technology Support Program (2015BAK16B02 and 2015BAK16B01)the Fundamental Research Funds of China Academy of Safety Science and Technology
文摘This paper presents a method for analysis of stress and strain of gas pipelines under the effect of horizontal catastrophic landslides. A soil spring model was used to analyze the nonlinear characteristics concerning the mutual effects between the pipeline and the soil. The Ramberg–Osgood model was used to describe the constitutive relations of pipeline materials. This paper also constructed a finite element analysis model using ABAQUS finite element software and studied the distribution of the maximum stress and strain of the pipeline and the axial stress and strain along the pipeline by referencing some typical accident cases. The calculation results indicated that the maximum stress and strain increased gradually with the displacement of landslide.The limit values of pipeline axial stress strain appeared at the junction of the landslide area and non-landslide area. The stress failure criterion was relatively more conservative than the strain failure criterion. The research results of this paper may be used as a technical reference concerning the design and safety management of large-diameter gas pipelines under the effects of catastrophic landslides.
基金Project(51021004) supported by Innovative Research Groups of the National Natural Science Foundation of ChinaProject(40776055) supported by the National Natural Science Foundation of china+1 种基金Project(1002) supported by State Key Laboratory of Ocean Engineering Foundation, ChinaProject(NCET 11 0370) supported by the Program for New Century Excellent Talents in Universities of China
文摘In-service hydrocarbons must be transported at high temperature and high pressure to ease the flow and prevent the solidification of the wax fraction. The pipeline containing hot oil will expand longitudinally due to the rise in temperature. If such expansion is resisted, for example by frictional effects over a kilometer or so of pipeline, compressive axial stress will be built up in the pipe-wall. The compressive forces are often so large that they induce vertical buckling of buffed pipelines, which can jeopardize the structural integrity of the pipeline. A typical initial imperfection named continuous support mode of submarine pipeline was studied. Based on this type of initial imperfection, the analytical solution of vertical thermal buckling was introduced and an elastic-plasticity finite element analysis (FEA) was developed. Both the analytical and the finite element methodology were applied to analyze a practice in Bohai Gulf, China. The analyzing results show that upheaval buckling is most likely to build up from the initial imperfection of the pipeline and the buckling temperature depends on the amplitude of initial imperfection. With the same amplitude of initial imperfection, the triggering temperature difference of upheaval buckling increases with covered depth of the pipeline, the soil strength and the friction between the pipeline and subsoil.
基金Supported by Downhole Intelligent Measurement and Control Science and Technology Innovation Team of Southwest Petroleum University(Grant No.2018CXTD04)National Natural Science Foundation of China(Grant Nos.61701085,51974273)+1 种基金Chengdu Municipal international science and technology cooperation project of China(Grant Nos.2020-GH02-00016-HZ)2020 National Mountain Highway Engineering Technology Research Center Open Fund Project(Grant No.GSGZJ-2020-01).
文摘Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent years,non-metallic pipes,such as plastic pipes,ceramic pipes,and concrete pipes,are increasingly taking the place of pipes made from metal in various pipeline networks such as water supply,drainage,heat,industry,oil,and gas.The location technologies for the location of the buried metal pipeline have become mature,but detection and location technologies for the non-metallic pipelines are still developing.In this paper,current trends and future perspectives of detection and location of buried non-metallic pipelines are summarized.Initially,this paper reviews and analyzes electromagnetic induction technologies,electromagnetic wave technologies,and other physics-based technologies.It then focuses on acoustic detection and location technologies,and finally introduces emerging technologies.Then the technical characteristics of each detection and location method have been compared,with their strengths and weaknesses identified.The current trends and future perspectives of each buried non-metallic pipeline detection and location technology have also been defined.Finally,some suggestions for the future development of buried non-metallic pipeline detection and location technologies are provided.
基金Supported by the Ninth 5-Year Priorities Program(Project No.KZ951-A1-405),Chinese Academy of Sciences
文摘In order to understand the dynamic behavior of submarine pipelines exposed to current and the mechanism of the interaction between current-induced vibration and scour of pipelines on a sandy bottom, an experimental investigation is conducted with a small scale model A test model which can be tested in the flume is set up by taking into account the typical working conditions of the pipelines and by applying the similarity theory. The interactions between the shape of the scour hole and the behavior of the pipeline as well as the flow patterns of the current are detailed, and the interaction mechanism outlined. The effect of vibration of the pipeline on the development of dynamic scour at different stages is found out. The proposed experimental method and test results provide an effective means for design of marine pipelines against scouring.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University of China under contract No,IRT0420the National Natural Science Foundation of China under contract No.50409015.
文摘The mechanism of local scour around submarine pipelines is studied numerically based on a renormalized group (RNG) turbulence model. To validate the numerical model, the equilibrium profiles of local scour for two cases are simulated and compared with the experimental data. It shows that the RNG turbulence model can give an appropriate prediction for the configuration of equilibrium scour hole, and it is applicable to this situation. The local scour mechanism around submarine pipelines including the flow structure, shear stress distribution and pressure field is then analyzed and compared with experiments. For further comparison and validation, especially for the flow structure, a numerical calculation employing the large eddy simulation (LES) is also conducted. The numerical results of RNG demonstrate that the critical factor governing the equilibrium profile is the seabed shear stress distribution in the case of bed load sediment transport, and the two-equation RNG turbulence model coupled with the law of wall is capable of giving a satisfying estimation for the bed shear stress. Moreover, the piping phenomena due to the great difference of pressure between the upstream and downstream parts of pipelines and the vortex structure around submarine pipelines are also simulated successfully, which are believed to be the important factor that lead to the onset of local scour.